[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tumor-predisposition-syndrome-tpds\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tumor-predisposition-syndrome-tpds":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":5},"100395586","prospective-evaluation-of-high-resolution-dual-energy-computed-tomographic-imaging-noninvasive-liquid-biopsies-and-minimally-invasive-surgical-surveillance-for-early-detection-of-mesotheliomas-in-patients-with-bap1-tumor-predisposition-syndrome-100395586",false,"NCT04431024","Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome","* ELIGIBILITY CRITERIA:\n\nInclusion Criteria for Genetic Testing\n\n-Eligible participants include:\n\n--Individuals with a history of any malignancy with known or suspected germline mutations involving BAP1\n\nOR\n\n--First- or second-degree relatives of patients (with or without cancer) with documented BAP1 tumor predisposition syndrome (TPDS)\n\n* Age \\>= 30 years.\n* All participants must understand and be willing to sign a written informed consent document.\n\nInclusion Criteria for Surveillance\n\n* Eligible participants include those who completed step 1 genetic testing with study-confirmed BAP1 or other germline TPDS mutation.\n* Completed co-enrollment on protocol 06C0014, \"Prospective Evaluation of Genetic and Epigenetic Alterations in Patients with Thoracic Malignancies.\"",true,"ALL","30 Years","120 Years",{"count":20,"type":21},300,"ESTIMATED","OBSERVATIONAL","Background:\n\nA germline mutation is a change to a person s genes that is carried through their DNA. These mutations can be passed on from parents to their offspring. Germline mutations in a gene called BAP1 are linked to the development of mesothelioma and other cancers. Researchers want to follow people with these mutations to learn more.\n\nObjective:\n\nTo see if researchers can improve how people who have or are suspected to have a BAP1 mutation are monitored over time.\n\nEligibility:\n\nPeople age 30 and older who are suspected to have a BAP1 germline mutation.\n\nDesign:\n\nParticipants will be screened with a personal and family medical history. Their medical records may be reviewed. They will give a blood or saliva sample to test for a BAP1 mutation. They will get genetic counseling.\n\nTo take part in this study, participants will enroll on 2 to 3 other protocols.\n\nParticipants will have a physical exam. They may have a tumor biopsy. They will give blood and urine samples. They will have skin and eye exams.\n\nSome participants will have video-assisted thoracoscopy to examine the chest and lungs and diagnose suspicious areas. For this, a small camera is inserted into the chest through a small incision.\n\nSome participants will have laparoscopy to examine the organs inside the abdomen. For this, a small camera is inserted into the abdomen through a small incision.\n\nParticipants will have imaging scans of the chest, abdomen, and pelvis. They may have brain scans.\n\nParticipants will visit the NIH once a year for follow-up exams.\n\nParticipation lasts indefinitely.",[25,26,27,28],"Familial Cancer","BRCA1-Associated Protein-1 (BAP1) Mutations","Tumor Predisposition Syndrome (TPDS)","Mesothelioma",[30,31,32,33,34,35],"Germline Mutation in the BAP1 Gene","BRCA1-Associated Protein-1","Genetics","Familial Background","Natural History","DECT","RECRUITING","2026-06-27",{"date":39,"type":40},"2026-06-30","ACTUAL",{"date":42,"type":40},"2021-03-30",{"date":44,"type":21},"2038-06-30",{"name":46,"class":47},"National Cancer Institute (NCI)","NIH"]