[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"twin-diseases\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:twin-diseases":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,40,70,100],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100497786","twin-pregnancy-a-challenge-for-patients-families-and-health-professionals-100497786",false,"NCT05761769","Twin Pregnancy: a Challenge for Patients, Families and Health Professionals","Inclusion Criteria:\n\n* Maternal age \\> 18 years\n* Twin pregnancy with two or more viable fetuses\n* Signature of the informed consent\n\nExclusion Criteria:\n\n* Women without the ability to understand the protocol\n* Women for whom the attending physician contraindicates participation in the study","FEMALE","18 Years","50 Years",{"count":19,"type":20},200,"ESTIMATED","OBSERVATIONAL","Twin pregnancies represent 3-4% of all births and in the last two decades the rate of twin pregnancies has steadily increased, essentially due to the spread of assisted fertilization techniques, the use of drugs that stimulate ovulation and increase in maternal age at conception.\n\nMultiple pregnancies pose unique challenges for the patient, families, caregivers and society. Indeed, twin pregnancy is associated with an increased risk compared with singleton pregnancies of all feto-maternal complications of pregnancy (Level of Evidence II-2).\n\nIn twin pregnancies (both monochorionic, MC, and bichorionic, BC) the incidence of preeclampsia is about 10%, 3 times higher than in singleton pregnancies. In singleton pregnancy, the mean gestational age (GE) at delivery is 39 weeks, the mean GA at delivery in twin pregnancies is less than 36 weeks, reflecting a 9-fold higher prevalence of spontaneous preterm delivery than in singleton pregnancy. Gestational diabetes complicates about 22% of twin pregnancies compared to 7-11% of singleton pregnancies. Twin pregnancy, compared to single pregnancy, has an increased incidence of perinatal and neonatal mortality, low birth weight, chromosomal or structural defects.\n\nA key factor to know is chorionicity. Chorionicity is a key data to acquire in the first trimester. Indeed, some complications of twin pregnancy are specific to MC pregnancy. About 20-33% of twins share the same placenta and it is precisely in these cases that a condition of greater risk is created. The most common complications of MC pregnancy are: twin-to-twin transfusion syndrome (TTTS), due to the presence of vascular anastomoses at the level of the placenta and a clear imbalance in blood flow between the twins; selective intrauterine growth restriction; the anemia-polycythemia sequence (TAPS); twin reversed arterial perfusion (TRAPS). Thus, the MC twin pregnancy is at increased risk of feto-maternal complications.\n\nThe complications of twin pregnancy place a heavy emotional and economic burden on parents, families and society.\n\nThere is no consensus in the literature on what should be the most appropriate methods for surveillance of multiple pregnancy: when to perform laboratory, instrumental and diagnostic tests for follow-up and monitoring of maternal-fetal well-being.\n\nThe aim of this project is to create a complete and accurate database that takes into consideration all aspects related to twin pregnancy. The twin pregnancy will be followed by a team of multiple pregnancy specialists who will follow the international guidelines for the surveillance of multiple pregnancy. The aim is to identify the optimal management of multiple pregnancy, collecting, studying and comparing the largest possible number of clinical, laboratory and ultrasound data from the beginning of pregnancy to the postpartum visit, developing clinical-diagnostic care pathways for follow-up and possible prevention of complications, personalized and adapted to each single woman with a twin pregnancy.\n\nThe women participating in the study will be able to enjoy close surveillance by a center specialized in the management of multiple pregnancies, this will allow for optimal management of the twin pregnancy with early identification and treatment of any complications identified.\n\nStudy typology Prospective observational longitudinal study of the overall management of patients with multiple pregnancies.",[24,25,26],"Twin Pregnancy With Antenatal Problem","Twin Diseases","Twin Placenta","RECRUITING","2025-03-10",{"date":30,"type":31},"2025-03-11","ACTUAL",{"date":33,"type":31},"2021-04-09",{"date":35,"type":20},"2025-12-01",{"name":37,"class":38},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":47,"minAge":16,"maxAge":17,"enrollmentInfo":48,"targetDuration":50,"studyType":21,"phases":4,"briefSummary":51,"conditions":52,"keywords":56,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":69},"100512448","selective-fetal-growth-restriction-in-monochorionic-twins---an-international-investigation-100512448","NCT05952583","Selective Fetal Growth Restriction in Monochorionic Twins - an International Investigation","CONTRAST","Inclusion Criteria:\n\n* MCDA twin pregnancy\n* Diagnosis of sFGR before 28+0 weeks of GA (independent of Doppler flows)\n* Pregnant woman ≥ 18 years and able to consent\n* Partner (who has (future) parental responsibility - if applicable) ≥ 18 years and able to consent\n* Written informed consent of both parents (if applicable) for participation in the longitudinal follow-up until 2 years after birth)\n\nExclusion Criteria:\n\n* The presence of lethal anomalies (one or both fetuses)\n* Multiple pregnancy higher order than twins;\n* TTTS\u002FTAPS present at moment of sFGR diagnosis.","ALL",{"count":49,"type":20},274,"2 Years","Optimal diagnostic management and underlying pathophysiological mechanisms of selective fetal growth restriction (sFGR) in monochorionic diamniotic (MCDA) twin pregnancies have not been fully clarified.\n\nThe current diagnostic classification system based on three different umbilical artery flow patterns has no increasing scale of severity and the predictive value is limited. Since there is no treatment available for sFGR, predicting fetal deterioration is key in preventing single or double fetal demise. Outcome prediction is furthermore important in the selection of cases that will be offered selective reduction (to provide the larger twin with better prospects), as well as determining monitor frequency and possible hospital admission. As outcome prediction is clinically challenging, patient counselling is too, and parents often encounter a great deal of uncertainty during the pregnancy.\n\nFurthermore, little is known about the brain development of sFGR children (both during pregnancy and after birth). Moreover, the psychological impact of an sFGR pregnancy of the future parent)s) has not been studied before. The impact of these factors should be taken into account during patient counseling, which is currently not the case.\n\nBy our knowledge, this is the first international, multicenter, prospective cohort study on that will address the abovementioned questions and knowledge gaps in MCDA pregnancies complicated by selective fetal growth restriction.",[53,54,55,25],"Twin; Pregnancy, Affecting Fetus or Newborn","Fetal Growth Retardation","Twin Monochorionic Diamniotic Placenta",[57,58,59],"sFGR","sIUGR","selective fetal growth restriction","2024-04-12",{"date":62,"type":31},"2024-04-15",{"date":64,"type":31},"2023-02-17",{"date":66,"type":20},"2028-03-01",{"name":68,"class":38},"Leiden University Medical Center",6,{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":47,"minAge":4,"maxAge":16,"enrollmentInfo":79,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":81,"conditions":82,"keywords":87,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":39},"100311188","twins-born-in-guangzhou-100311188","NCT03331133","Twins Born in Guangzhou","Twins Born in Guangzhou Cohort Study","2-BIG","Inclusion Criteria:\n\n1. Live twins delivered in Guangzhou Women and Children's Medical Center\n2. Permanent residents or families intended to remain in Guangzhou with their children for no less than 3 years\n3. Baseline information during pregnancy available",true,{"count":80,"type":20},1000,"The 2-BIG is a twin birth cohort study located in Guangzhou, China.Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology. Data are collected regarding environmental, family and lifestyle exposures on twins from birth to 18 years old. Biological samples including blood and tissue samples are also collected from the twins and their parents.",[25,83,84,85,86],"Immune Development","Childhood Obesity","Host and Microbiome","Neurodevelopment",[88,89,90],"Twin","Early Development","Cohort","2024-02-22",{"date":93,"type":31},"2024-02-26",{"date":95,"type":31},"2012-02-01",{"date":97,"type":20},"2038-12-31",{"name":99,"class":38},"Guangzhou Women and Children's Medical Center",{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":107,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":109,"conditions":110,"keywords":111,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":39},"100435606","the-prognosis-of-fetoscopy-treatment-of-twin-transfusion-syndrome-100435606","NCT04952415","the Prognosis of Fetoscopy Treatment of Twin Transfusion Syndrome","the Prognosis of Fetoscopy Treatment of Twin Transfusion Syndrome in Shengjing Hospital","Inclusion Criteria:\n\nTTTS after fetoscopic laser surgery.\n\nExclusion Criteria:\n\nPregnant women who refuse to take part in the study",{"count":108,"type":20},100,"Fetal medicine in China is still a new, young discipline, and the development is very rapid. After nearly 10 years of development, the clinical diagnosis and treatment guidelines of some complicated twin diseases has been established. Among them, twin-to-twin-transfusion syndrome (TTTS) is serious disease in twin pregnancy, and the factors affecting prognosis after fetoscopic laser surgery are part of the study. Through this study, the investigators expect to achieve better prediction indicators of the prognosis of TTTS.",[25],[112],"TTTS","NOT_YET_RECRUITING","2021-06-27",{"date":116,"type":31},"2021-07-07",{"date":118,"type":20},"2021-07-01",{"date":120,"type":20},"2026-07-01",{"name":122,"class":38},"Shengjing Hospital"]