[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"twin-monochorionic-diamniotic-placenta\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:twin-monochorionic-diamniotic-placenta":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100547951","multicenter-prospective-cohort-study-of-twin-maternal-child-dyads-in-china-100547951",false,"NCT06414655","Multicenter Prospective Cohort Study of Twin Maternal-Child Dyads in China","ChiTwiMC","Inclusion Criteria:\n\n* Twin pregnancies\n* Female aged between 18-45 years\n* Gestational age is less than 14 weeks\n* Planning to receive prenatal healthcare and delivery service at the study hospital\n* Signing informed concent and willing to participate\n\nExclusion Criteria:\n\n* Women with mental disorders or serious maternal illness that is not eligible to participate\n* Inability to provide informed consent\n* Pregnant women not registered in our hospital",true,"FEMALE","18 Years","45 Years",{"count":21,"type":22},2000,"ESTIMATED","OBSERVATIONAL","Multicenter Prospective Cohort Study of Twin Maternal-Child Dyads in China (ChiTwiMC) is supported by National Key Research and Development Program of China - Reproductive Health and Women's and Children's Health Protection Project. This project is funded by the Ministry of Science and Technology of China under grant number 2023YFC2705900. The ChiTwiMC cohort is led by Professor Wei Yuan from the Department of Gynecology and Obstetrics at Peking University Third Hospital.",[26,27,28,29,30,31,32,33],"Twin Pregnancy, Antepartum Condition or Complication","Twin to Twin Transfusion as Antepartum Condition","Pre-Term","Pre-Eclampsia","Twin Monochorionic Diamniotic Placenta","Twin Dichorionic Diamniotic Placenta","High Risk Pregnancy","Twin Placenta","RECRUITING","2024-05-09",{"date":37,"type":38},"2024-05-16","ACTUAL",{"date":40,"type":38},"2024-03-01",{"date":42,"type":22},"2026-11-30",{"name":44,"class":45},"Peking University Third Hospital","OTHER",11,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":54,"minAge":18,"maxAge":55,"enrollmentInfo":56,"targetDuration":58,"studyType":23,"phases":4,"briefSummary":59,"conditions":60,"keywords":64,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":77},"100512448","selective-fetal-growth-restriction-in-monochorionic-twins---an-international-investigation-100512448","NCT05952583","Selective Fetal Growth Restriction in Monochorionic Twins - an International Investigation","CONTRAST","Inclusion Criteria:\n\n* MCDA twin pregnancy\n* Diagnosis of sFGR before 28+0 weeks of GA (independent of Doppler flows)\n* Pregnant woman ≥ 18 years and able to consent\n* Partner (who has (future) parental responsibility - if applicable) ≥ 18 years and able to consent\n* Written informed consent of both parents (if applicable) for participation in the longitudinal follow-up until 2 years after birth)\n\nExclusion Criteria:\n\n* The presence of lethal anomalies (one or both fetuses)\n* Multiple pregnancy higher order than twins;\n* TTTS\u002FTAPS present at moment of sFGR diagnosis.","ALL","50 Years",{"count":57,"type":22},274,"2 Years","Optimal diagnostic management and underlying pathophysiological mechanisms of selective fetal growth restriction (sFGR) in monochorionic diamniotic (MCDA) twin pregnancies have not been fully clarified.\n\nThe current diagnostic classification system based on three different umbilical artery flow patterns has no increasing scale of severity and the predictive value is limited. Since there is no treatment available for sFGR, predicting fetal deterioration is key in preventing single or double fetal demise. Outcome prediction is furthermore important in the selection of cases that will be offered selective reduction (to provide the larger twin with better prospects), as well as determining monitor frequency and possible hospital admission. As outcome prediction is clinically challenging, patient counselling is too, and parents often encounter a great deal of uncertainty during the pregnancy.\n\nFurthermore, little is known about the brain development of sFGR children (both during pregnancy and after birth). Moreover, the psychological impact of an sFGR pregnancy of the future parent)s) has not been studied before. The impact of these factors should be taken into account during patient counseling, which is currently not the case.\n\nBy our knowledge, this is the first international, multicenter, prospective cohort study on that will address the abovementioned questions and knowledge gaps in MCDA pregnancies complicated by selective fetal growth restriction.",[61,62,30,63],"Twin; Pregnancy, Affecting Fetus or Newborn","Fetal Growth Retardation","Twin Diseases",[65,66,67],"sFGR","sIUGR","selective fetal growth restriction","2024-04-12",{"date":70,"type":38},"2024-04-15",{"date":72,"type":38},"2023-02-17",{"date":74,"type":22},"2028-03-01",{"name":76,"class":45},"Leiden University Medical Center",6]