[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"twin-pregnancy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:twin-pregnancy":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,45,79,112],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100623814","phase-4-carbetocin-uterotonic-treatment-in-twin-pregnancies-for-prevention-of-postpartum-hemorrhage-100623814",false,"NCT07401524","Carbetocin Uterotonic Treatment in Twin Pregnancies for Prevention of Postpartum Hemorrhage","Carbetocin Administration for the Prevention of Postpartum Hemorrhage in Twin Deliveries: A Randomized Controlled Trial","CUTT-PPH","Inclusion Criteria:\n\n* Pregnant individuals aged ≥18 years\n* Twin pregnancies\n* Gestational age ≥23 weeks\n\nExclusion Criteria:\n\n* Known hypersensitivity or contraindication to carbetocin\n* Higher-order multiple gestation (triplets or more)\n* Maternal age \\\u003C18 years\n* Known placenta accreta spectrum\n* Known bleeding disorder\n* Intrauterine fetal death of one or more fetuses\n* Hyponatremia precluding oxytocin use\n* Planned delivery at a non-participating hospital","FEMALE","18 Years",{"count":20,"type":21},120,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","The goal of this clinical trial is to learn if the drug carbetocin works better than standard care to prevent heavy bleeding after childbirth in people carrying twin pregnancies. Heavy bleeding after delivery, also called postpartum hemorrhage, is more common after twin births and can lead to anemia, blood transfusions, and other serious health problems.\n\nIn this study, bleeding will be evaluated by measuring how much blood hemoglobin levels drop from before delivery to the day after delivery.\n\nThe main questions this study aims to answer are:\n\n* Does giving carbetocin after delivery lower blood loss compared with standard oxytocin treatment?\n* Is carbetocin safe and practical to use in twin deliveries?\n\nResearchers will compare carbetocin to standard oxytocin treatment to see which approach better prevents bleeding after twin vaginal or cesarean delivery.\n\nParticipants will:\n\n* Be randomly assigned to receive either carbetocin or standard oxytocin after the second twin is delivered\n* Have blood tests before delivery and on the day after delivery\n* Be followed during their hospital stay and for up to six weeks after delivery for safety outcomes",[27,28],"Postpartum Hemorrhage","Twin Pregnancy",[30,31,32,27],"Carbetocin","Oxytocin","Twin Delivery","RECRUITING","2026-05-05",{"date":36,"type":37},"2026-05-08","ACTUAL",{"date":34,"type":37},{"date":40,"type":21},"2028-12-01",{"name":42,"class":43},"Sheba Medical Center","OTHER_GOV",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":17,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":44},"100632043","comparison-of-bone-mineral-density-in-the-third-trimester-between-women-in-singleton-and-twin-pregnancies-using-questionnaires-and-rems-densitometric-examination-100632043","NCT07508553","Comparison of Bone Mineral Density in the Third Trimester Between Women in Singleton and Twin Pregnancies Using Questionnaires and REMS Densitometric Examination","Pregnancy-associated Reduction in Bone Mineral Density: a Comparative Study Using REMS Technology Between Singleton and Twin Pregnancies in the Third Trimester","TWINBONE","INCLUSION CRITERIA\n\n1. Signed informed consent\n2. Willingness to participate in the study and ability to complete the study questionnaires\n3. Women between 35 and 41 weeks of gestational age at the time of study inclusion\n4. Singleton or twin pregnancy (dichorionic or monochorionic)\n5. Age between 30 and 45 years at the time of study recruitment\n6. No history of recent or previous bone fractures or traumatic fractures, and no motor disabilities (in the mother).\n7. Absence of a diagnosis of osteopenia or osteoporosis according to the criteria of the Italian Society for Osteoporosis, Mineral Metabolism and Bone Diseases (SIOMMMS).\n8. No intake of vitamin D or other medications during pregnancy.\n9. Absence of current or previous conditions that could potentially interfere with bone metabolism (e.g., thyroid, kidney, or liver disease).\n10. Women of normal weight or with class I obesity (BMI between 18.5 and 34).\n\nEXCLUSION CRITERIA\n\nPatients will not be included in the study if at least one of the following exclusion criteria is met:\n\n1. Failure to sign the informed consent form\n2. Poor compliance and\u002For inability to complete the study questionnaires\n3. Women with previous or newly diagnosed comorbidities during pregnancy\n4. Age \\\u003C30 and \\>45 years\n5. Previous diagnosis of osteopenia or osteoporosis according to the criteria of the Italian Society for Osteoporosis, Mineral Metabolism and Bone Diseases (SIOMMMS)\n6. BMI \\\u003C18.5 or \\>34",true,"30 Years","45 Years",{"count":57,"type":21},100,[59],"NA","This clinical study aims to monitor and evaluate bone mineral density and fracture risk in women with singleton and twin pregnancies through the combined use of:\n\n* two specific questionnaires developed by the Fragility Fracture Observatory (OFF), and\n* a bone densitometric examination using REMS technology, performed between the 35th and 41st week of gestation.\n\nPrimary objective:\n\n• To identify, in the third trimester of pregnancy (between the 35th and 41st gestational week), any differences in bone mineral density (BMD) between women with singleton pregnancies and women with dichorionic and monochorionic twin pregnancies.\n\nSecondary objectives:\n\n* Evaluate the relationship between bone mineral density (BMD) values and maternal clinical and historical parameters, such as age, body mass index (BMI), and obstetric and medical history.\n* Evaluate the association between BMD values and scores obtained from validated questionnaires administered to investigate fracture risk and bone health-related quality of life in women with singleton and twin pregnancies.",[62,63,28],"Osteoporosis","Pregnancy",[65,66,67,68],"pregnancy","twin pregnancy","bone mineral density","ultrasound densitometry","2026-03-27",{"date":71,"type":37},"2026-04-02",{"date":73,"type":37},"2025-12-23",{"date":75,"type":21},"2027-12-23",{"name":77,"class":78},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","OTHER",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":22,"phases":89,"briefSummary":90,"conditions":91,"keywords":92,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":4},"100605552","twins-with-specific-vs-traditional-fetal-growth-charts-100605552","NCT07164001","Twins With Specific vs. Traditional Fetal Growth Charts","Twins With Specific vs. Traditional Fetal Growth Charts (TWiST): A Randomized Controlled Trial","TWiST","Inclusion Criteria:\n\n* Pregnant individuals with a twin pregnancy of at least 18 weeks gestation.\n* Willing and able to provide informed consent.\n* Planning to deliver at a participating center.\n\nExclusion Criteria:\n\n* Major fetal anomalies or known aneuploidy.\n* Significant maternal medical conditions that might confound study outcomes.\n* Inability to comply with study procedures.",{"count":88,"type":21},150,[59],"This study aims to compare how well two different types of fetal growth charts work in tracking the growth of twins during pregnancy. These charts help doctors decide if a fetus is growing normally. One type is commonly used for all pregnancies, while the other is specially designed for twin pregnancies. The study will enroll pregnant individuals carrying twins. Participants will be randomly assigned to have their care guided by either the traditional chart or the twin-specific chart. Researchers will compare outcomes such as birth weight, timing of delivery, and newborn health. The goal is to find out if using twin-specific charts can improve care and reduce unnecessary interventions.",[28],[93,94,95,96,97,98,99,100,101],"Twin-Specific Growth Chart","Singleton-Based Growth Chart","Fetal Biometry","Small for Gestational Age","Growth Assessment","Perinatal Outcomes","Randomized Controlled Trial","Prenatal Ultrasound","Twin Gestation","NOT_YET_RECRUITING","2025-09-09",{"date":105,"type":37},"2025-09-15",{"date":107,"type":21},"2026-01-01",{"date":109,"type":21},"2030-01-28",{"name":111,"class":78},"Indiana University",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":116,"acronym":117,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":119,"targetDuration":4,"studyType":121,"phases":4,"briefSummary":122,"conditions":123,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":44},"100495123","cohort-of-twin-pregnancy-and-the-offspring-100495123","NCT05727085","Cohort of Twin Pregnancy and the Offspring","CTPO","Inclusion Criteria:\n\n1. Maternal age \\>18 years old.\n2. Twin pregnancy.\n\nExclusion Criteria:\n\n1. Fetal chromosomal or congenital abnormalities.\n2. Stillbirth.",{"count":120,"type":21},1000,"OBSERVATIONAL","Twin pregnancy increases the risk of maternal and fetal complications, which include gestational hypertension, premature labor, twin-to-twin transfusion syndrome, intrauterine growth restriction, anemia, amniotic fluid abnormalities. Comprehensively understanding the molecular mechanisms of the disease and identification of markers contribute to development of novel therapeutic approaches. In addition, the twin pregnancy, especially the monochorionic, is an essential model of \"experiments of nature\". This model can be applied to distinguish the epigenetic differences of twins in utero and after birth in the same genomic context. The aim of the study is to constitute a prospective cohort of twin pregnancies and the offspring.",[28],"2025-03-12",{"date":126,"type":37},"2025-03-14",{"date":128,"type":37},"2023-10-15",{"date":130,"type":21},"2029-06-15",{"name":132,"class":78},"Fudan University"]