[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"twin-reversal-arterial-perfusion-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:twin-reversal-arterial-perfusion-syndrome":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,53],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":36,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100520443","a-prospective-study-on-the-role-of-karl-storz-curved-and-straight-fetoscopes-11508aak-and-11506aak-for-fetoscopic-intrauterine-procedures-100520443",false,"NCT06056635","A Prospective Study on the Role of Karl Storz Curved and Straight Fetoscopes (11508AAK and 11506AAK) for Fetoscopic Intrauterine Procedures","Inclusion Criteria:\n\n* Pregnant patient with a condition requiring in-utero surgery\n* Patient must be eligible for anesthesia\n* Patient and father of the fetus (if available) are able to provide signed informed consent\n\nExclusion Criteria:\n\n* Allergy or previous adverse reaction to any ancillary medication specified in this protocol that has no alternative\n* Preterm labor, preeclampsia, or uterine anomaly (e.g., large fibroid tumor) in the index pregnancy\n* Suspicion of major recognized congenital syndrome on ultrasound or MRI that is not compatible with postnatal life\n* Pre-pregnancy maternal BMI greater than 40\n* High risk for fetal hemophilia\n* Fetal aneuploidy or variants of known significance if an amniocentesis was performed\n* Contraindication to abdominal surgery or fetoscopic surgery","FEMALE","18 Years","45 Years",{"count":19,"type":20},50,"ESTIMATED","INTERVENTIONAL",[23],"NA","In this research study, the investigators want to learn more about the role of new innovative surgical devices, the Karl Storz Curved and Straight Fetoscopes for in-utero surgery. A fetoscope is like a small telescope that can see inside of the uterus (womb) during minimally invasive surgery. The curved scope is used for patients with an anterior placenta (front of uterus), while the straight scope is used for patients with a posterior placenta (back of uterus). The scopes will be used to assist in procedures involving fetoscopic laser photocoagulation (FLP), which is a minimally invasive surgery that uses a small camera (fetoscope) to locate abnormal blood vessel connections in the placenta and seal them off using laser energy. These fetoscopes will be utilized in the diagnosis and management of various fetal conditions that can arise during pregnancy. Outcome data will be reported in a descriptive statistical analysis. The investigators will assess the surgical outcomes, short and long-term morbidity, complications, and gestational age of participants in order to evaluate the benefit of using these devices.",[26,27,28,29,30,31,32,33,34,35],"Fetal Conditions","Maternal; Procedure","Pregnancy Related","Twin to Twin Transfusion Syndrome","In Utero Procedure Affecting Fetus or Newborn","Chorion; Abnormal","Twin Reversal Arterial Perfusion Syndrome","Twin Monochorionic Monoamniotic Placenta","Chorioangioma","Vasa Previa",[37,38,39],"Fetoscope","Fetoscopic Laser Ablation","Diagnostic Fetoscopy","RECRUITING","2024-09-24",{"date":43,"type":44},"2024-09-25","ACTUAL",{"date":46,"type":44},"2024-08-15",{"date":48,"type":20},"2027-05-01",{"name":50,"class":51},"Boston Children's Hospital","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":21,"phases":63,"briefSummary":65,"conditions":66,"keywords":67,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":80},"100256780","phase-4-trap-intervention-study-early-versus-late-intervention-for-twin-reversed-arterial-perfusion-sequence-100256780","NCT02621645","TRAP Intervention STudy: Early Versus Late Intervention for Twin Reversed Arterial Perfusion Sequence","Early Versus Late Intervention for Twin Reversed Arterial Perfusion Sequence: an Open-label Randomized Controlled Trial: TRAPIST - TRAP Intervention STudy","TRAPIST","Inclusion Criteria:\n\n* TRAP sequence in a monochorionic diamniotic twin pregnancy diagnosed between 11.6 and 13.6 weeks, as determined by the crown-rump length of the pump twin in spontaneous conceptions and by the date of insemination or embryonic age at replacement in pregnancies resulting from subfertility treatment\n* Women aged 18 years or more, who are able to consent\n* Anatomically normal pump twin\n* Provide written informed consent to participate in this randomized controlled trial, forms being approved by the Ethical Committees\n\nExclusion Criteria:\n\n* Contraindication for an intervention due to a severe maternal medical condition or threatening miscarriage\n* Inaccessibility of the acardiac twin due to a retroverted uterus, severe maternal obesity, uterine fibroids, bowel or placental superposition\n* A major anomaly in the pump twin, requiring surgery or leading to infant death or severe handicap\n* Spontaneous arrest of the reverse flow and\u002For pump twin demise at diagnosis",{"count":62,"type":20},126,[64],"PHASE4","Multi-center open-label randomized controlled trial to assess if early intervention (12.0-14.0 weeks) (study group) improves the outcome of TRAP sequence as compared to late intervention (16.0-19.0 weeks) (control group). The investigators will randomly assign women diagnosed with TRAP sequence diagnosed between 12.0 and 13.6 weeks to an early or late intervention group (1:1), using a web-based application and a computer-generated list with random permuted blocks of sizes 2 or 4 (www.sealedenvelope.com), stratified by gestational age (GA) at inclusion (11.6 -12.6 weeks versus 13.0-13.6 weeks). Analysis will be by intention to treat.",[32],[68,69,70],"monochorionic","TRAP","acardiac twin","2024-07-09",{"date":73,"type":44},"2024-07-10",{"date":75,"type":44},"2016-05",{"date":77,"type":20},"2025-06",{"name":79,"class":51},"Universitaire Ziekenhuizen KU Leuven",14]