[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"twin-to-twin-transfusion-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:twin-to-twin-transfusion-syndrome":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,66],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100522563","the-efficacy-of-the-karl-storz-curved-fetoscope-and-straight-fetoscope-for-laser-photocoagulation-of-placental-anastomoses-100522563",false,"NCT06084247","The Efficacy of the KARL STORZ Curved Fetoscope and Straight Fetoscope for Laser Photocoagulation of Placental Anastomoses","An Open Label Randomized-control Study on the Efficacy of the KARL STORZ Curved Fetoscope (11508aak) and Its Straight Version (11506aak) for Laser Photocoagulation of Placental Anastomoses","Inclusion Criteria:\n\n* pregnancy\n* The patient fulfills the criteria for laser photocoagulation of placental anastomoses based on the standard of care\n* fetal diagnosis of twin-to-twin transfusion syndrome\n* Anterior placenta\n* The patient provides signed informed consent that details the maternal and fetal risks involved with the procedure\n\nExclusion Criteria:\n\n* Contraindication to abdominal surgery, fetoscopic surgery, or general anesthesia\n* Allergy or previous adverse reaction to a study medication specified in this protocol\n* The patient does not fulfill the conventional criteria to undergo in-utero surgery, which is specific for each surgery\n* Preterm labor, preeclampsia, or a uterine anomaly (e.g., large fibroid tumor) that is unavoidable during surgery in the index pregnancy\n* Fetal aneuploidy, genomic variants of known significance if an amniocentesis has been performed, other major fetal anomalies or disorders that may impact the fetal\u002Fneonatal survival, or a known syndromic mutation\n* Suspicion of a major recognized syndrome by ultrasound or MRI\n* Maternal BMI \\>40 kg\u002Fm2\n* High risk for fetal hemophilia","FEMALE","18 Years","45 Years",{"count":20,"type":21},160,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this study is to evaluate the efficacy of KARL STORZ curved fetoscope (11508AAK) and its straight version (11506AAK) for laser photocoagulation of placental anastomoses in patients with an anterior placenta and Twin to Twin Transfusion Syndrome (TTTS).",[27],"Twin to Twin Transfusion Syndrome","NOT_YET_RECRUITING","2025-08-11",{"date":31,"type":32},"2025-08-14","ACTUAL",{"date":34,"type":21},"2025-09-01",{"date":36,"type":21},"2027-12-01",{"name":38,"class":39},"Jimmy Espinoza","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":22,"phases":50,"briefSummary":51,"conditions":52,"keywords":54,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":40},"100592282","evaluation-of-laparotomy-with-trans-amniotic-suture-placement-in-ttts-surgery-100592282","NCT06991400","Evaluation of Laparotomy With Trans-Amniotic Suture Placement in TTTS Surgery","TTTS TAPS","Inclusion Criteria:\n\n* Diagnosis of TTTS or Twin Anemia-Polycythemia Sequence (TAPS)\n* Gestational age between 18 weeks and 23 weeks (18 0\u002F7 to 22 6\u002F7 weeks)\n* Cervical length \\>2.5 cm preoperatively\n* Identification of a safe percutaneous surgical window by a provider experienced in fetoscopic surgery prior to entering the operating room\n\nExclusion Criteria:\n\n* Higher order pregnancies, chromosomal or severe congenital anomalies, undergoing laser surgery for fetal growth restriction only, need for a second laser during pregnancy, failure to complete laser, PPROM prior to surgery. BMI\\> 40 at the start of pregnancy, emergent case (i.e. surgery occurs \\\u003C 6 hours from presentation), significant fetal anomalies expected to drastically alter the risk of neonatal morbidity or mortality (i.e. anencephaly, cyanotic heart disease), or any significant maternal comorbidities as determined by physician i.e.: clotting disorders\u002Fblood disorders.",{"count":49,"type":21},34,[24],"This is a randomized trial for patients that are diagnosed with Twin-Twin Transfusion Syndrome (TTTS) who are receiving a fetoscopic laser surgery to evaluate the effectiveness and safety of a laparotomy closure.",[27,53],"Twin Anemia-Polycythemia Sequence",[55],"fetoscopic surgery, laparotomy","RECRUITING","2025-05-23",{"date":59,"type":32},"2025-05-28",{"date":61,"type":32},"2024-11-01",{"date":63,"type":21},"2026-06-01",{"name":65,"class":39},"Children's Hospital Medical Center, Cincinnati",{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":70,"acronym":4,"eligibilityCriteria":71,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":72,"targetDuration":4,"studyType":22,"phases":74,"briefSummary":75,"conditions":76,"keywords":86,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":40},"100520443","a-prospective-study-on-the-role-of-karl-storz-curved-and-straight-fetoscopes-11508aak-and-11506aak-for-fetoscopic-intrauterine-procedures-100520443","NCT06056635","A Prospective Study on the Role of Karl Storz Curved and Straight Fetoscopes (11508AAK and 11506AAK) for Fetoscopic Intrauterine Procedures","Inclusion Criteria:\n\n* Pregnant patient with a condition requiring in-utero surgery\n* Patient must be eligible for anesthesia\n* Patient and father of the fetus (if available) are able to provide signed informed consent\n\nExclusion Criteria:\n\n* Allergy or previous adverse reaction to any ancillary medication specified in this protocol that has no alternative\n* Preterm labor, preeclampsia, or uterine anomaly (e.g., large fibroid tumor) in the index pregnancy\n* Suspicion of major recognized congenital syndrome on ultrasound or MRI that is not compatible with postnatal life\n* Pre-pregnancy maternal BMI greater than 40\n* High risk for fetal hemophilia\n* Fetal aneuploidy or variants of known significance if an amniocentesis was performed\n* Contraindication to abdominal surgery or fetoscopic surgery",{"count":73,"type":21},50,[24],"In this research study, the investigators want to learn more about the role of new innovative surgical devices, the Karl Storz Curved and Straight Fetoscopes for in-utero surgery. A fetoscope is like a small telescope that can see inside of the uterus (womb) during minimally invasive surgery. The curved scope is used for patients with an anterior placenta (front of uterus), while the straight scope is used for patients with a posterior placenta (back of uterus). The scopes will be used to assist in procedures involving fetoscopic laser photocoagulation (FLP), which is a minimally invasive surgery that uses a small camera (fetoscope) to locate abnormal blood vessel connections in the placenta and seal them off using laser energy. These fetoscopes will be utilized in the diagnosis and management of various fetal conditions that can arise during pregnancy. Outcome data will be reported in a descriptive statistical analysis. The investigators will assess the surgical outcomes, short and long-term morbidity, complications, and gestational age of participants in order to evaluate the benefit of using these devices.",[77,78,79,27,80,81,82,83,84,85],"Fetal Conditions","Maternal; Procedure","Pregnancy Related","In Utero Procedure Affecting Fetus or Newborn","Chorion; Abnormal","Twin Reversal Arterial Perfusion Syndrome","Twin Monochorionic Monoamniotic Placenta","Chorioangioma","Vasa Previa",[87,88,89],"Fetoscope","Fetoscopic Laser Ablation","Diagnostic Fetoscopy","2024-09-24",{"date":92,"type":32},"2024-09-25",{"date":94,"type":32},"2024-08-15",{"date":96,"type":21},"2027-05-01",{"name":98,"class":39},"Boston Children's Hospital"]