[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"twin\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:twin":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100624387","prospective-twin-pregnancy-cohort-at-montpellier-university-hospital-100624387",false,"NCT07408973","Prospective Twin Pregnancy Cohort at Montpellier University Hospital","Twin Pregnancy Cohort at Montpellier University Hospital for a Study of the Impact of the Exposome: Pilot Study","COGEM","Mother's inclusion Criteria:\n\n* Patient of legal age (≥ 18 years)\n* Patient pregnant with a twin pregnancy ≥ 25 weeks of gestation\n* Pregnancy initially twin, triplet, or quadruplet, progressing to a twin pregnancy after spontaneous or medical embryo reduction, or after selective termination of pregnancy\n* Delivery planned at Montpellier University Hospital\n\nTwins' inclusion Criteria:\n\n* Twins born in a twin pregnancy ≥ 25 weeks of gestation\n\nMother's exclusion Criteria:\n\n* Pregnant woman with at least one fetus presenting with a chromosomal or genetic abnormality or a polymalformative syndrome, and for whom early postnatal death is anticipated.\n* Planned travel preventing the study from being completed\n* Failure to obtain informed and written consent from the patient for participation in the study and the collection of biological samples\n* Patient unable to read and\u002For write French\n* Patient unable to understand and\u002For speak French\n* Patient not benefiting from a national health insurance scheme\n* Person under legal protection, guardianship or curatorship\n* Person participating in other interventional research study\n\nTwins' exclusion Criteria:\n\n* Mother's absence from or withdrawal from the study\n* Birth in a facility other than Montpellier University Hospital\n* One or two children under guardianship\n* Lack of informed and written consent from legal representatives\n* One of the two fetuses is expected to die\n* Lack of informed and written consent from the prospective parent(s) for participation in the study and the collection of biological samples\n* Parents unable to read and\u002For write French\n* Parents not understanding and\u002For speaking French","ALL","18 Years",{"count":20,"type":21},360,"ESTIMATED","OBSERVATIONAL","This prospective observational cohort study aims to investigate the impact of the maternal and early-life exposome on neonatal and early childhood health outcomes in twin pregnancies followed at University Hospital of Montpellier (France). Grounded in the Developmental Origins of Health and Disease (DOHaD) framework, the study focuses on how environmental, biological, and lifestyle exposures during pregnancy and the first year of life influence fetal growth, neonatal health, and early development.\n\nA total of 120 women with monochorionic or dichorionic twin pregnancies and their 240 children will be included. Maternal exposome assessment includes air pollution exposure, lifestyle, diet, medical history, and biological measurements. Neonatal outcomes, including abnormal birth weight, will be evaluated at birth, and children will be followed until one year of age to assess growth, health events, and developmental outcomes. Biological samples collected at different times during the study will allow the assessment of chemical exposures and epigenetic markers. This study aims to generate original French twin pregnancy data and to improve understanding of environmental determinants of early-life health.",[25,26],"Pregnancy","Twin",[28,29,30,31,32,33,34],"Exposome","Air Pollutants","Lead","Diet, Food, and Nutrition","Healthy Lifestyle","Obstetric Labor Complications","Children Health","NOT_YET_RECRUITING","2026-06-17",{"date":38,"type":39},"2026-06-18","ACTUAL",{"date":41,"type":21},"2026-12",{"date":43,"type":21},"2030-12-01",{"name":45,"class":46},"University Hospital, Montpellier","OTHER"]