[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ultrasonography-doppler\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ultrasonography-doppler":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,54,83],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":26,"conditions":27,"keywords":34,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100629059","phase-2-pocus-intervention-for-tailoring-diuretic-strategy-in-acute-decompensated-heart-failure-100629059",false,"NCT07469722","POcus INTERvention for Tailoring Diuretic Strategy in Acute Decompensated Heart Failure","Point-of-care Ultrasound Intervention for Tailoring Diuretic Strategy in Acute Decompensated Heart Failure","POINTER-HF","Inclusion Criteria:\n\n* Men or women aged 18 years or older.\n* Diagnosis of acute decompensated heart failure (ADHF) with left ventricular ejection fraction \\\u003C50%, presenting with symptoms (dyspnea, orthopnea, fatigue) and\u002For signs (pulmonary crackles, peripheral edema, jugular venous distension, hepatomegaly, hepatojugular reflux) of decompensated heart failure.\n* Brain natriuretic peptide (BNP) ≥ 300 pg\u002FmL.\n* Signs of systemic and\u002For pulmonary congestion on POCUS, defined as DUCS ≥ 3 points.\n* Time from hospital admission ≤ 48 hours.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Patients under evaluation for heart transplantation or with prior heart transplantation.\n* Acute coronary syndrome as the primary cause of hospitalization.\n* Evidence of uncontrolled infection.\n* Cardiac surgery or percutaneous coronary or structural cardiac intervention within the previous 30 days.\n* Signs of hypoperfusion, defined as any of the following: mean arterial pressure \\\u003C 60 mmHg, capillary refill time \\> 4 seconds, arterial lactate \\> 2 mmol\u002FL or venous lactate \\> 2.5 mmol\u002FL.\n* Acute pulmonary embolism (segmental or more proximal) as the primary cause of hospitalization.\n* Acute stroke.\n* Chronic kidney disease stage 5 (estimated glomerular filtration rate \\\u003C 15 ml\u002Fmin\u002Fm²) or requirement for renal replacement therapy.\n* Liver cirrhosis with portal hypertension.\n* Known pulmonary disease with extensive parenchymal involvement, including interstitial lung disease, pulmonary metastases, prior pneumonectomy, lobectomy, or pleurodesis.\n* Severe hypokalemia (serum potassium \\\u003C 2.5 mmol\u002FL).\n* Pregnancy or breastfeeding.\n* Refusal to participate in the clinical trial.","ALL","18 Years",{"count":20,"type":21},128,"ESTIMATED","INTERVENTIONAL",[24,25],"PHASE2","PHASE3","Acute decompensated heart failure (ADHF) is a frequent cause of hospitalization and is associated with high morbidity and mortality. Congestion is the primary pathophysiological mechanism leading to clinical deterioration and hospitalization in ADHF. Diuretics remain the cornerstone of treatment for most ADHF phenotypes; however, evidence regarding optimal strategies to guide diuretic therapy during the decongestion process is limited. Recently, point-of-care ultrasound (POCUS) has emerged as a promising tool to support clinical assessment in ADHF, improving diagnostic accuracy, prognostication, and pre-discharge evaluation. Nevertheless, the role of POCUS in guiding therapeutic management in ADHF remains uncertain. To specifically assess congestion in patients with ADHF, a pragmatic POCUS-based score, the Dynamic Ultrasound Congestion Score (DUCS), was developed. DUCS integrates lung ultrasound and Venous Excess Ultrasound (VExUS) to dynamically evaluate congestion severity, treatment response, and therapeutic goals during ADHF management. Observational data suggest that DUCS is associated with in-hospital outcomes and short-term prognosis, and correlates with markers of decongestion such as urinary output and weight loss. This study is a randomized, single-center, single-blind clinical trial designed to evaluate whether a DUCS-guided POCUS strategy improves clinical and decongestion outcomes compared with standard of care. Eligible patients hospitalized due to ADHF will be randomized within 48 hours of admission to one of two groups: (1) diuretic treatment guided by institutional standard-of-care combined with information from the EVEREST congestion score assessment and guideline-based treatment recommendations; or (2) diuretic treatment guided by serial DUCS-based POCUS assessments used to inform diuretic adjustment recommendations. Participants in both groups will undergo evaluations at baseline (day 1), day 2, day 3 and day 5, including clinical data collection, physical examination using the EVEREST congestion score, and standardized DUCS-based POCUS assessments. Outcomes to be assessed include in-hospital mortality, length of hospital stay, decongestion parameters, and changes in biomarkers.",[28,29,30,31,32,33],"Acute Heart Failure (AHF)","Congestive Heart Failure Acute","Diuretic Effect","Lung Ultrasonography Score","Ultrasonography, Doppler","Point-of-care Ultrasound (POCUS)",[35,36,37,38,39,40],"Acute Heart Failure","Congestive Heart Failure","Point-of-Care Ultrasound","Lung Ultrasound","Venous Excess Ultrasound","Diuretic","NOT_YET_RECRUITING","2026-03-16",{"date":44,"type":45},"2026-03-18","ACTUAL",{"date":47,"type":21},"2026-03-23",{"date":49,"type":21},"2028-07-01",{"name":51,"class":52},"Hospital de Clinicas de Porto Alegre","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":65,"conditions":66,"keywords":71,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":53},"100593092","correlation-study-between-sma-blood-flow-reactivity-and-acute-gastrointestinal-injury-in-critically-ill-patients-100593092","NCT07001943","Correlation Study Between SMA Blood Flow Reactivity and Acute Gastrointestinal Injury in Critically Ill Patients","Correlation Study Between SMA Blood Flow Reactivity and Acute Gastrointestinal Functional Injury in Critically Ill Patients","Inclusion Criteria:\n\n* Adults aged ≥18 years and ≤80 years.\n* Admitted to the study with a expected stay of more than 72 hours.\n* Require initiation of enteral nutrition support.\n\nExclusion Criteria:\n\n* Pre-existing severe gastrointestinal diseases.\n* Patients with gastrointestinal bleeding.\n* Patients with bowel obstruction.\n* Pregnant or lactating women.\n* Patients with contraindications to bedside Doppler ultrasound.","80 Years",{"count":63,"type":21},80,"OBSERVATIONAL","This study aims to address the challenges of enteral nutrition support in critically ill ICU patients with varying gastrointestinal function. We'll use bedside Doppler ultrasound to monitor superior mesenteric artery (SMA) blood flow changes post - feeding, exploring its correlation with Acute Gastrointestinal Injury (AGI) and other hemodynamic indicators. Our goals are to identify the patterns of SMA blood flow changes, establish a predictive model linking SMA blood flow reactivity to AGI risk, and propose individualized enteral nutrition strategies based on intestinal hemodynamics. Through this innovative approach, we hope to enhance the safety of enteral nutrition, reduce AGI incidence, and improve patient outcomes.",[67,68,69,70,32],"Intestinal Ischemia","Critical Illness","Enteral Nutrition Feeding","Hemodynamics",[72,68,67,70],"Enteral Nutrition","RECRUITING","2025-08-28",{"date":76,"type":45},"2025-09-05",{"date":78,"type":45},"2025-06-01",{"date":80,"type":21},"2026-07-01",{"name":82,"class":52},"Peking Union Medical College Hospital",{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":89,"minAge":18,"maxAge":4,"enrollmentInfo":90,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":53},"100485292","doppler-findings-in-the-fetal-cerebral-blood-vessels-vamca-within-24-hours-before-delivery-and-relation-with-perinatal-outcome-100485292","NCT05599178","Doppler Findings in the Fetal Cerebral Blood Vessels (VA\u002FMCA) Within 24 Hours Before Delivery and Relation With Perinatal Outcome.","Inclusion Criteria:\n\n* Singleton pregnancy.\n* Term gestation (37-42 weeks).\n* Fetus in cephalic presentation.\n* No known fetal chromosomal or (severe) congenital anomaly.\n* Normally grown fetus (ultrasound scan demonstrating normal fetal growth between 30-37 weeks of gestation, defined as an estimated fetal weight\u002Fabdominal circumference \\> 10th centile or crossing \\\u003C2 quartiles compared to earlier growth ultrasound).\n* Absence of pre-existing doppler or amniotic fluid abnormalities.\n* Normal fetal heart rate tracing \u002F CTG (excluding pre-existing hypoxia).\n* Admission in early spontaneous labor or induction of labor with expected delivery \\\u003C 24 hours.\n* Maternal age \\>= 18 years\n* Willing to give written informed consent.\n\nExclusion Criteria:\n\n* Advanced labor (\\> 4cm of cervical dilatation) at the time of admission on the labor ward.\n* Severe pre-existing chronic maternal medical condition or poor obstetric history\u002Fantenatal complications associated with increased risk of adverse perinatal outcome (non-exhaustive e.g.: uncontrolled chronic hypertension, severe pre-eclampsia, uncontrolled (gestational) diabetes, maternal sepsis, major antepartum haemorrhage, intra-uterine infection, prolonged rupture of membranes \\> 18 hours, etc.).\n* Intra-uterine fetal demise \u002F death.\n* Prelabour rupture of membranes with meconium-stained amniotic fluid.\n* Patients not fulfilling all the inclusion criteria or refusing to give written informed consent.","FEMALE",{"count":91,"type":21},120,"1. Assess differences in flow patterns in the fetal cerebral blood vessels within 24 hours before delivery between fetuses with a normal vs. adverse perinatal outcome.\n2. Explore maternal and\u002For fetal characteristics that might influence technical feasibility of doppler sonography of the fetal cerebral blood vessels in early labor at term.\n3. Assess reliability of the technique by measuring intra- and inter-observer variation in a subset of participants.",[32,94],"Obstetric Labor Complications","2024-06-28",{"date":97,"type":45},"2024-07-01",{"date":99,"type":45},"2022-12-23",{"date":101,"type":21},"2025-12-31",{"name":103,"class":52},"Universitaire Ziekenhuizen KU Leuven"]