[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ultrasonography\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ultrasonography":26},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,26,0,25,[9,46,74,103,137,167,197,230,260,286,318,346,374,405,429,460,483,512,554,581,605,626,647,669,696],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":43,"locationsCount":4},"100619603","evaluation-of-anterior-neck-ultrasound-in-predicting-difficult-airway-in-obese-patients-100619603",false,"NCT07346768","Evaluation of Anterior Neck Ultrasound in Predicting Difficult Airway in Obese Patients","Ultrasound Assessment of Anterior Neck Soft Tissue Thickness to Predict Difficult Airway Risk in Obese Patients Undergoing for Surgery Under General Anesthesia: an Observational Study","Inclusion Criteria:\n\n* Age 18-70 years\n* ASA physical status I-III\n\n  \\* BMI \\>25 kg\u002Fm²\n* Scheduled for elective surgery under general anesthesia\n\nExclusion Criteria:\n\n* Emergency surgery\n* Pregnancy\n* Maxillofacial anomalies or neck masses\n* Rapid sequence induction\n* Previous history of difficult intubation\n* BMI \\>60 kg\u002Fm²","ALL","18 Years","70 Years",{"count":21,"type":22},52,"ESTIMATED","OBSERVATIONAL","Obese patients are at increased risk of difficult airway management due to anatomical changes in the anterior neck soft tissues. Accurate preoperative prediction of difficult airway remains challenging using conventional clinical airway assessment tests alone.\n\nThis prospective observational study aims to evaluate the role of ultrasound assessment of anterior neck soft tissue thickness in predicting difficult airway risk in overweight and obese adult patients undergoing elective surgery under general anesthesia. Ultrasound-based anterior neck measurements will be compared with standard clinical airway assessment parameters to determine their diagnostic accuracy for difficult laryngoscopy and intubation.\n\nThe results of this study may contribute to improved preoperative airway risk stratification and safer airway management in obese patients.",[26,27,28,29],"Ultrasonography","Airway Management","Intubation, Intratracheal","Obesity and Overweight",[31,32,33,34],"Obesity","difficult airway","anterior neck ultrasound","ultrasonography","NOT_YET_RECRUITING","2026-06-12",{"date":38,"type":39},"2026-06-16","ACTUAL",{"date":41,"type":22},"2026-06-20",{"date":41,"type":22},{"name":44,"class":45},"Gaziantep City Hospital","OTHER",{"id":47,"slug":48,"hasResults":12,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":17,"minAge":18,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":73},"100637975","eswt-in-the-treatment-of-plantar-fasciitis-100637975","NCT07626723","ESWT in the Treatment of Plantar Fasciitis","The Effect of ESWT Session Count on Clinical Parameters in the Treatment of Chronic Plantar Fasciitis; Randomized Controlled Study","Inclusion Criteria:\n\n* Patients aged 18-65, both male and female, diagnosed with plantar fasciitis based on anamnesis and physical examination.\n* Patients must have had symptoms for at least 3 months.\n* Patients must consent to participate in the study according to the informed consent form.\n\nExclusion Criteria:\n\n* Complaint lasting less than 3 months\n* Having received an injection in the heel area within the last 6 months\n* Having applied physical therapy modalities to the heel area within the last 6 months\n* Bilateral complaint\n* Pregnancy\n* Malignancy\n* Epilepsy\n* History of cardiac pacemaker\n* Anticoagulant use\n* History of systemic inflammatory disease\n* History of fracture or surgery in the lower extremity\n* Presence of an open wound in the heel area\n* Hypersensitivity in the patient\n* Systemic infection in the patient\n* Uncontrolled hypertension in the patient\n* Uncontrolled diabetes in the patient\n* Inability of the patient to cooperate\n* History of neuromuscular disease affecting balance parameters\n* Patient's unwillingness to participate in the study",true,"65 Years",{"count":56,"type":22},57,"INTERVENTIONAL",[59],"NA","Extracorporeal shock wave therapy (ESWT) has become widely preferred in Turkey and worldwide in recent years for the treatment of musculoskeletal diseases due to its non-invasive nature, ease of application, and low risk of complications, as it does not require surgical intervention. However, there is no consensus in the literature regarding the energy level used in ESWT applications, the frequency of application, and especially the ideal number of sessions. Different centers apply varying protocols in clinical practice, which can lead to heterogeneity in treatment outcomes. Scientifically determining the effect of variation in the number of ESWT sessions on clinical outcomes is important for establishing standard treatment protocols. Therefore, the aim of our study is to contribute to the existing literature by investigating the effect of variation in the number of ESWT sessions on clinical parameters such as pain, functional status, and quality of life in the treatment of chronic plantar fasciitis, and to develop more effective and evidence-based treatment approaches in patient management.",[62,63,26],"Plantar Fasciitis","Extracorporeal Shock Wave Therapy","2026-06-01",{"date":66,"type":39},"2026-06-04",{"date":68,"type":22},"2026-07-01",{"date":70,"type":22},"2027-03-15",{"name":72,"class":45},"Kirsehir Ahi Evran Universitesi",1,{"id":75,"slug":76,"hasResults":12,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":53,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":57,"phases":83,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":73},"100578508","strategies-to-decentralize-breast-ultrasound-in-rwanda-100578508","NCT06812208","Strategies to Decentralize Breast Ultrasound in Rwanda","Implementation Strategies to Decentralize Breast Ultrasound Services and Facilitate Timely Breast Cancer Diagnoses in Rwanda","Enrollment in this cluster randomized clinical trial will occur at the health facility level.\n\nInclusion Criteria:\n\n1. District hospital in Rwanda;\n2. Already implementing the Women's Cancer Early Detection Program in their districts (i.e. clinicians in health centers and hospitals in the district have received the nationally-sponsored trainings in breast cancer early detection and cervical cancer screening);\n3. Already using the WCEDP electronic medical record in health centers and the district hospital, or prepared to start using it.\n\nExclusion Criteria:\n\n1\\. Already providing routine breast ultrasound in the district hospital.",{"count":82,"type":22},1792,[59],"Diagnosing breast cancer early is critical to reduce preventable breast cancer deaths in sub-Saharan Africa. This can be done in part through increasing patients' access to breast ultrasound, which is essential for evaluating breast masses. However, ultrasound is typically provided only by radiologists at urban referral hospitals. Training clinicians at rural district hospitals who are not radiologists could increase patients' access to breast ultrasound, but strategies to support and supervise these clinicians and ensure they are providing high-quality ultrasound services has not been studied.\n\nThis project will examine the effectiveness and cost of two strategies for training non-radiologist clinicians to perform breast ultrasound in Rwandan district hospitals.",[86,87,26],"Breast Cancer","Early Detection of Cancer",[89,90,91,92,93,94],"breast ultrasound","implementation strategies","low and middle income countries","breast cancer early detection","teleultrasound","Rwanda",{"date":96,"type":39},"2026-06-02",{"date":98,"type":22},"2027-01",{"date":100,"type":22},"2029-11-30",{"name":102,"class":45},"Brigham and Women's Hospital",{"id":104,"slug":105,"hasResults":12,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":111,"targetDuration":4,"studyType":57,"phases":112,"briefSummary":113,"conditions":114,"keywords":122,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":73},"100521365","ultrasound-and-respiratory-physiological-signals-in-lung-diseases-100521365","NCT06068647","Ultrasound and Respiratory Physiological Signals in Lung Diseases","Synergistic Assessment of Ultrasound Data and Respiratory physiOlogical Signals in luNg Diseases","SAURON","Inclusion Criteria:\n\n* inpatients admitted to the hospital due to diffuse interstitial lung diseases during exacerbation OR infectious interstitial pneumonia not caused by SARS-CoV-2 OR acute exacerbation of chronic obstructive pulmonary disease.\n* Outpatients with pulmonary paraseptal and\u002For panlobular emphysema and\u002For chronic obstructive pulmonary disease during stable phase.\n* Patients able to give written informed consent.\n\nExclusion Criteria:\n\n* history of skin irritation, redness, itching or allergic cutaneous symptoms.\n* Allergic reactions to adhesives or hydrogels.\n* Family history of adhesive skin allergies.\n* Presence of severe skin conditions such as wounds, burns or on any damaged skin.\n* Presence of strong magnetic fields in the study setting.\n* Presence of electromagnetic disturbances or significant ionizing radiation sources which might lead to signal artifacts.\n* Use of external cardiac defibrillators.\n* Use of diaphragmatic pacers.\n* Use of extra cardiac stimulators.\n* Pregnancy.\n* Pediatric population.",{"count":7,"type":22},[59],"The use of lung ultrasound is instrumental in the evaluation of many chest pathologies and its ability to detect pleuro-pulmonary pathology is widely accepted.\n\nHowever, the use of ultrasound to explore the state of the peripheral lung parenchyma, when the organ is still aerated, is a relatively new application.\n\nHorizontal and vertical artifacts are separate and distinct artifacts that can be seen during ultrasound examination of the lungs. While the practical role of lung ultrasound artifacts is accepted to detect and monitor many conditions, further research is needed for the physical interpretation of ultrasound artifacts. These artifacts are diagnostic signs, but we don't fully understand their origin.\n\nThe artifactual information deriving from the surface acoustic interaction, beyond the pleural line, in the ultrasound images of the normally aerated and non-deflated lung, represents the final result of complex interactions of acoustic waves with a specific three-dimensional structure of the biological tissue. Thus, the umbrella term \"vertical artifacts\" oversimplifies many physical phenomena associated with a pathological pleural plane. There is growing evidence that vertical artifacts are caused by physiological and pathological changes in the superficial lung parenchyma.\n\nTherefore, the need emerges to explore the physical phenomena underlying the artifactual ultrasound information deriving from the surface acoustic interaction of ultrasound with the pleuro-pulmonary structures.",[115,116,117,118,119,26,120,121],"Interstitial Lung Disease","Interstitial Lung Diseases","Interstitial Pneumonia","Chronic Obstructive Pulmonary Disease","Emphysema or COPD","Ultrasound Imaging","Ultrasound",[121,120,26,123,124,125,126],"Emphysema","Chronic obstructive pulmonary disease","Interstitial pneumonia","Interstitial lung disease","RECRUITING","2026-05-19",{"date":130,"type":39},"2026-05-20",{"date":132,"type":39},"2023-03-22",{"date":134,"type":22},"2026-09-30",{"name":136,"class":45},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",{"id":138,"slug":139,"hasResults":12,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":143,"eligibilityCriteria":144,"healthyVolunteers":12,"sex":17,"minAge":145,"maxAge":146,"enrollmentInfo":147,"targetDuration":4,"studyType":57,"phases":149,"briefSummary":150,"conditions":151,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":4},"100636629","ultrasound-guided-long-vs-short-peripheral-iv-catheters-in-neonates-with-congenital-syphilis-receiving-antibiotics-100636629","NCT07568171","Ultrasound-Guided Long vs Short Peripheral IV Catheters in Neonates With Congenital Syphilis Receiving Antibiotics","Ultrasound-Guided Long Peripheral Intravenous Catheters Versus Conventional Short Peripheral Catheters for Reducing Post-Insertion Failure in Neonates With Congenital Syphilis Receiving Antibiotic Therapy: A Randomized Clinical Trial","ULTRA-ACCESS","Inclusion Criteria:\n\n* Newborns admitted to the Neonatal Intermediate Care Unit;\n* Diagnosis of congenital syphilis;\n* Indication for intravenous penicillin therapy for an estimated duration of 10 days;\n* Enrollment on the first day of treatment.\n\nExclusion Criteria:\n\n* Newborns who have received any type of peripheral venous catheter prior to study enrollment;\n* Clinical instability at the time of vascular access indication and\u002For requirement for admission to a Neonatal Intensive Care Unit;\n* Requirement for concomitant administration of another antimicrobial agent in addition to crystalline penicillin;\n* Need for catheter insertion outside the operating hours of the Vascular Access Program (7:00 AM to 7:00 PM, Monday to Friday).","1 Day","28 Days",{"count":148,"type":22},104,[59],"Congenital syphilis in newborns requires intravenous antibiotic therapy, making reliable peripheral venous access essential. However, high rates of catheter failure and repeated punctures remain a significant clinical challenge. This randomized, controlled, parallel clinical trial aims to compare ultrasound-guided long peripheral intravenous catheters inserted by a specialized vascular access team with conventional short peripheral catheters inserted by neonatal nurses. A total of 104 newborns with congenital syphilis receiving intravenous penicillin will be randomly assigned to either group. The primary outcome is functional dwell time. Secondary outcomes include catheter failure, number of insertion attempts, first-attempt success, complications, and total number of devices required. The study hypothesizes that ultrasound-guided long peripheral catheters will improve vascular access outcomes, reduce complications, and minimize the need for repeated punctures.",[152,153,154,26,155,156,157],"Infant, Newborn","Syphilis, Congenital","Catheterization, Peripheral","Advanced Practice Nursing","Patient Safety","Neonatal Nursing","2026-05-06",{"date":160,"type":39},"2026-05-11",{"date":162,"type":22},"2026-05",{"date":164,"type":22},"2028-12",{"name":166,"class":45},"Hospital de Clinicas de Porto Alegre",{"id":168,"slug":169,"hasResults":12,"nctId":170,"briefTitle":171,"officialTitle":172,"acronym":4,"eligibilityCriteria":173,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":174,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":176,"conditions":177,"keywords":184,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":4},"100636914","ultrasound-prediction-of-esophageal-variceal-bleeding-risk-100636914","NCT07571876","Ultrasound Prediction of Esophageal Variceal Bleeding Risk","Splenic Size and Portal Vein Diameter on Ultrasound in Predicting Esophageal Variceal Bleeding Risk","Inclusion Criteria:\n\n* Adult patients (age ≥18 years) with chronic liver disease and clinical\u002Flaboratory\u002Fradiological evidence of liver cirrhosis\n* Both compensated and decompensated cirrhosis (Child-Pugh classes A, B, and C)\n* Patients scheduled for upper gastrointestinal endoscopy\n* Patients who provide informed consent\n\nExclusion Criteria:\n\n* Previous history of endoscopic variceal band ligation or sclerotherapy\n* Prior surgical portosystemic shunt procedures or transjugular intrahepatic portosystemic shunt (TIPS)\n* Hepatocellular carcinoma with portal vein thrombosis\n* Previous splenectomy\n* Patients receiving beta-blockers for variceal bleeding prophylaxis\n* Poor quality ultrasound images due to obesity or ascites\n* Refusal to participate in the study",{"count":175,"type":22},165,"This prospective observational study aims to evaluate the accuracy of using routine abdominal ultrasound to predict the risk of esophageal variceal bleeding in adult patients with liver cirrhosis. Esophageal variceal bleeding is a serious complication of chronic liver disease. While upper gastrointestinal endoscopy is the current standard for diagnosing and grading these varices, it is an invasive procedure.\n\nIn this study, researchers will use ultrasound to measure the patient's spleen size and portal vein diameter. These non-invasive measurements will then be compared to the results of a standard upper endoscopy performed within 48 to 72 hours. The goal is to determine if these simple ultrasound measurements can reliably predict the presence, grade, and bleeding risk of esophageal varices, which could potentially reduce the need for routine invasive endoscopic screenings in the future.",[178,26,179,180,181,182,183],"Variceal Bleeding","Esophageal Bleeding","Esophageal Varices","Liver Cirrhosis","Portal Hypertension","Chronic Liver Disease (CLD)",[185,186,187,188],"portal vein diameter","splenic size","ultrasound","esophageal variceal bleeding risk","2026-05-04",{"date":158,"type":39},{"date":192,"type":22},"2026-04",{"date":194,"type":22},"2027-05",{"name":196,"class":45},"Assiut University",{"id":198,"slug":199,"hasResults":12,"nctId":200,"briefTitle":201,"officialTitle":201,"acronym":202,"eligibilityCriteria":203,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":204,"targetDuration":4,"studyType":57,"phases":206,"briefSummary":207,"conditions":208,"keywords":212,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":222,"startDateStruct":224,"completionDateStruct":226,"leadSponsor":228,"locationsCount":73},"100522161","cooley--study-acute-on-chronic-liver-failure-using-the-cytosorb-device-100522161","NCT06079021","COOLEY- Study: aCute On chrOnic Liver failurE Using the cYtosorb Device","COOLEY","Inclusion Criteria:\n\n* adult patients (≥ 18 years) admitted to the University Hospital of Antwerp (UZA), Belgium.\n\n  * Written informed consent from patient or if not possible due to encephalopathy (\\> grade 2): legal representative\n  * acute-on-chronic liver failure (ACLF) grade ≥ 2:\n\n    * Acute decompensation event (identifiable trigger)\n    * Hepatic encephalopathy grade ≥ 2\n    * Acute kidney injury (AKI) according to Kidney Disease: Improving Global Outcome (KDIGO) criteria stage 3 (≥ 3-fold increase of serum creatinine OR increase of serum creatinine to ≥ 4 mg\u002Fdl OR urine output ≤ 0.3 ml\u002Fkg\u002Fh for ≥ 24 hours OR anuria for ≥ 12 hours)\n    * Serum bilirubin ≥ 10 mg\u002Fdl\n    * Hemodynamic instability with vasopressor support (norepinephrine \\> 0.05 mcg\u002Fkg\u002Fmin)\n\nExclusion Criteria:\n\n* • known patient will against participation in the study or against the measures applied in the study\n\n  * a decision made prior to inclusion to stop further treatment of the patient within the next 24 hours\n  * no complete remission of malignancy including hepatocellular carcinoma within the past 12 months\n  * ongoing intermittent or CRRT before study inclusion",{"count":205,"type":22},20,[59],"A Prospective, Single-Center trial, in Patients With Acute on Chronic Liver Failure. Study of Standard Medical Care Plus CytoSorb® Compared to Standard Medical Care Alone in a historical group.",[209,210,211,26],"Acute-On-Chronic Liver Failure","Anticoagulant Adverse Reaction","Sarcopenia",[213,214,215,216,217,218,219,220],"acute on chronic liver failure","sarcopenia","citrate anticoagulation","low molecular weight heparins","hand grip strength","skeletal muscle ultrasound","hemoadsorption","CRRT","2026-04-27",{"date":223,"type":39},"2026-05-01",{"date":225,"type":39},"2024-06-08",{"date":227,"type":22},"2027-12-31",{"name":229,"class":45},"University Hospital, Antwerp",{"id":231,"slug":232,"hasResults":12,"nctId":233,"briefTitle":234,"officialTitle":235,"acronym":4,"eligibilityCriteria":236,"healthyVolunteers":53,"sex":17,"minAge":237,"maxAge":238,"enrollmentInfo":239,"targetDuration":145,"studyType":23,"phases":4,"briefSummary":241,"conditions":242,"keywords":246,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":253,"startDateStruct":255,"completionDateStruct":256,"leadSponsor":257,"locationsCount":73},"100633151","comparison-of-two-airway-devices-i-gel-and-air-q-in-children-aged-1-10-years-during-general-anesthesia-100633151","NCT07522957","Comparison of Two Airway Devices (I-Gel and Air-Q) in Children Aged 1-10 Years During General Anesthesia","Effect of I-gel and Air-Q SP LMAs on Oropharyngeal Leak Pressure and Gastric Insufflation in Children: An Ultrasonography-Guided Randomized Study","Inclusion Criteria:\n\n* Children aged 1-10 years\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Scheduled for elective (non-emergency) surgery under general anesthesia\n* Planned use of a supraglottic airway device for airway management\n* Written informed consent obtained from a parent or legal guardian\n\nExclusion Criteria:\n\n* History of conditions associated with increased risk of aspiration (e.g., gastroesophageal reflux)\n* Known or predicted difficult airway (e.g., Mallampati score ≥ 3)\n* Congenital or acquired abnormalities of the face, neck, or upper airway\n* Active upper respiratory tract infection\n* Presence of significant pulmonary disease (e.g., asthma, bronchopulmonary dysplasia, cystic fibrosis)\n* Body mass index above the 95th percentile for age (morbid obesity)\n* Emergency surgery\n* Previous complications related to supraglottic airway device use\n* Failure of device placement or need to switch to an alternative airway management technique\n* Refusal of participation by parent or legal guardian","1 Year","10 Years",{"count":240,"type":22},60,"This study aims to compare two commonly used airway devices (I-gel and Air-Q) in children aged 1-10 years undergoing general anesthesia for surgery. These devices help doctors keep the airway open and support breathing during the operation. The study will evaluate how well each device works, how easy they are to place, and whether they cause air to enter the stomach. Ultrasound will be used to safely check the position of the device and detect any air in the stomach. The results of this study may help improve the safety and effectiveness of airway management in children during anesthesia.",[243,26,244,27,245],"Anesthesia General","Laryngeal Mask Airways","Child",[247,248,249,26,250,251],"Airway management","Laryngeal mask airway","Pediatric patients","Gastric insufflation","Supraglottic airway devices","2026-04-21",{"date":254,"type":39},"2026-04-23",{"date":192,"type":22},{"date":162,"type":22},{"name":258,"class":259},"Ankara Etlik City Hospital","OTHER_GOV",{"id":261,"slug":262,"hasResults":12,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":4,"eligibilityCriteria":266,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":267,"targetDuration":145,"studyType":23,"phases":4,"briefSummary":269,"conditions":270,"keywords":272,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":277,"lastUpdatePostDateStruct":278,"startDateStruct":280,"completionDateStruct":282,"leadSponsor":284,"locationsCount":73},"100634499","effect-of-internal-jugular-vein-catheterization-on-intracranial-pressure-and-intracranial-blood-flow-100634499","NCT07540481","Effect of Internal Jugular Vein Catheterization on Intracranial Pressure and Intracranial Blood Flow","Effect of Internal Jugular Vein Catheterization on Intracranial Pressure Assessed by Optic Nerve Sheath Diameter and Carotid Doppler Ultrasonography: a Prospective Observational Study","Inclusion Criteria:\n\n* Age ≥18 years\n* Patients undergoing surgery under general anesthesia\n* Patients requiring internal jugular vein catheterization as part of routine clinical care\n* Ability to obtain optic nerve sheath diameter measurements using transorbital ultrasonography\n* Provision of informed consent\n\nExclusion Criteria:\n\n* Known intracranial pathology affecting intracranial pressure\n* Ocular conditions preventing accurate ultrasonographic measurement (e.g., orbital trauma, ocular surgery, infection)\n* Hemodynamic instability\n* Contraindication to internal jugular vein catheterization\n* Inability to obtain adequate ultrasound images",{"count":268,"type":22},61,"This prospective observational study aims to evaluate the effect of internal jugular vein catheterization on intracranial pressure using optic nerve sheath diameter (ONSD) measurements and carotid artery Doppler ultrasonography in adult patients undergoing surgery under general anesthesia.\n\nONSD will be measured noninvasively using transorbital ultrasonography, and carotid Doppler parameters will be assessed at two time points: after endotracheal intubation and approximately 5 minutes after catheterization. The primary objective is to assess short-term changes in ONSD following catheterization.\n\nSecondary objectives include evaluating changes in carotid Doppler measurements and their relationship with ONSD, as well as associations with physiological parameters such as blood pressure, heart rate, oxygen saturation, and end-tidal carbon dioxide.",[271,26],"Intracranial Pressure",[273,274,26,275,271,276],"Internal Jugular Vein","Catheterization","Optic Nerve Sheath Diameter","General Anesthesia","2026-04-14",{"date":279,"type":39},"2026-04-20",{"date":281,"type":22},"2026-04-15",{"date":283,"type":22},"2027-03-16",{"name":285,"class":45},"Kanuni Sultan Suleyman Training and Research Hospital",{"id":287,"slug":288,"hasResults":12,"nctId":289,"briefTitle":290,"officialTitle":291,"acronym":292,"eligibilityCriteria":293,"healthyVolunteers":53,"sex":294,"minAge":18,"maxAge":295,"enrollmentInfo":296,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":298,"conditions":299,"keywords":302,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":309,"lastUpdatePostDateStruct":310,"startDateStruct":312,"completionDateStruct":314,"leadSponsor":316,"locationsCount":73},"100631419","construction-of-a-benchmark-for-breast-ultrasound-ai-interpretation-and-performance-evaluation-of-multimodal-ai-models-100631419","NCT07500428","Construction of a Benchmark for Breast Ultrasound AI Interpretation and Performance Evaluation of Multimodal AI Models","Construction of a Standardized Benchmark Evaluation System for Intelligent Breast Ultrasound Image Interpretation and Systematic Performance Assessment of Multimodal Artificial Intelligence Models Based on ACR BI-RADS v2025 Criteria","BUST-AI Bench","Inclusion Criteria:\n\n* B-mode breast ultrasound grayscale images from the institutional PACS database or from published open-access breast ultrasound datasets with documented original institutional ethics approval\n* Image quality adequate for clinical diagnosis with clear visualization of the region of interest\n* Pathological diagnosis confirmed (for benign and malignant lesion groups), or normal breast status confirmed by a senior radiologist with \\>15 years of breast ultrasound experience (for the normal group)\n* Complete de-identification with removal of all personally identifiable information\n\nExclusion Criteria:\n\n* Severely degraded image quality precluding meaningful BI-RADS assessment\n* Duplicate images from the same patient (only the most representative image retained per lesion)\n* Images with residual personally identifiable information after de-identification processing\n* Cases with ambiguous, disputed, or unavailable pathological results\n* Non-B-mode ultrasound images, including elastography, contrast-enhanced ultrasound, and Doppler imaging","FEMALE","75 Years",{"count":297,"type":22},1380,"This single-center, retrospective, observational study aims to construct a standardized benchmark evaluation system for intelligent breast ultrasound image interpretation and to systematically assess the diagnostic performance of current mainstream multimodal artificial intelligence (AI) models.\n\nDe-identified B-mode breast ultrasound images with confirmed pathological diagnoses will be retrospectively collected from the institutional archive (2018-2025) and supplemented with images from published open-access datasets. Expert radiologists with varying experience levels will independently annotate all images according to the American College of Radiology (ACR) Breast Imaging Reporting and Data System (BI-RADS) v2025 criteria, including glandular tissue composition, lesion characterization (mass vs. non-mass lesion), morphological descriptors, and final BI-RADS classification.\n\nBaseline deep learning models (CNN-based ResNet-50 and Transformer-based USFM) will be trained to establish performance baselines and to stratify cases by diagnostic difficulty through cross-architecture consensus. Multiple multimodal large language models (MLLMs), including both general-purpose and medical-domain models, will then be evaluated via standardized API calls using BI-RADS-guided chain-of-thought prompts at temperature 0 for reproducibility.\n\nPrimary endpoints include BI-RADS classification accuracy and diagnostic AUC for benign-malignant differentiation. Model robustness and safety will be assessed through out-of-distribution rejection testing, temperature-stability experiments, and thinking-mode ablation studies. This study adheres to the FLAIR and TRIPOD-LLM reporting guidelines.",[300,301,26],"Breast Neoplasms","Breast Diseases",[303,304,305,306,307,308],"Breast Ultrasound","BI-RADS","Artificial Intelligence","Multimodal Large Language Model","Benchmark","Computer-Aided Diagnosis","2026-03-24",{"date":311,"type":39},"2026-03-30",{"date":313,"type":39},"2026-03-12",{"date":315,"type":22},"2027-03-01",{"name":317,"class":45},"Peking Union Medical College Hospital",{"id":319,"slug":320,"hasResults":12,"nctId":321,"briefTitle":322,"officialTitle":323,"acronym":324,"eligibilityCriteria":325,"healthyVolunteers":53,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":326,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":328,"conditions":329,"keywords":332,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":337,"lastUpdatePostDateStruct":338,"startDateStruct":340,"completionDateStruct":342,"leadSponsor":344,"locationsCount":73},"100624567","internal-jugular-vein-ultrasound-for-predicting-hypotension-in-geriatric-patients-undergoing-spinal-anesthesia-100624567","NCT07411313","Internal Jugular Vein Ultrasound for Predicting Hypotension in Geriatric Patients Undergoing Spinal Anesthesia","The Role of Internal Jugular Vein Ultrasonography in Predicting Hypotension in Geriatric Patients Undergoing Spinal Anesthesia: A Prospective Observational Study (Protocol ID: 2023-12\u002F509)","IJV-SPINAL","Inclusion Criteria:\n\n* Age ≥65 years\n* Scheduled to undergo surgery under spinal anesthesia\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Able and willing to provide written informed consent\n\nExclusion Criteria:\n\n* Did not provide written informed consent\n* Undergoing emergency surgery\n* Body mass index (BMI) ≥40 kg\u002Fm²\n* Receiving angiotensin-converting enzyme (ACE) inhibitors\n* Pre-spinal systolic blood pressure \\\u003C90 mmHg or mean arterial pressure \\\u003C70 mmHg\n* Unable to tolerate the supine position\n* Left ventricular ejection fraction \\\u003C40%\n* Requiring sedoanalgesia in addition to spinal anesthesia or conversion to general anesthesia",{"count":327,"type":22},85,"Spinal anesthesia-induced hypotension is a common and clinically significant complication in geriatric patients. Accurate preoperative assessment of intravascular volume status may help identify patients at risk. Internal jugular vein (IJV) ultrasonography is a noninvasive and easily applicable bedside method that reflects venous volume status. This prospective observational study aims to evaluate the role of preoperative IJV ultrasonographic measurements in predicting hypotension following spinal anesthesia in geriatric patients. Patients aged 65 years and older undergoing elective surgery under spinal anesthesia will be included. Preoperative IJV diameter, cross-sectional area, and collapsibility index will be measured using ultrasonography. Hemodynamic parameters will be monitored intraoperatively, and the occurrence of hypotension after spinal anesthesia will be recorded. The predictive value of IJV ultrasonographic parameters for post-spinal hypotension will be analyzed",[330,331,273,26],"Spinal Anesthesia Induced Hypotension","Geriatric",[333,334,335,26,336],"Geriatric patients","Spinal anesthesia","Hypotension","Internal jugular vein","2026-02-11",{"date":339,"type":39},"2026-02-13",{"date":341,"type":39},"2024-01-03",{"date":343,"type":22},"2026-02-10",{"name":345,"class":45},"Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital",{"id":347,"slug":348,"hasResults":12,"nctId":349,"briefTitle":350,"officialTitle":351,"acronym":352,"eligibilityCriteria":353,"healthyVolunteers":12,"sex":294,"minAge":4,"maxAge":4,"enrollmentInfo":354,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":356,"conditions":357,"keywords":361,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":365,"lastUpdatePostDateStruct":366,"startDateStruct":368,"completionDateStruct":370,"leadSponsor":372,"locationsCount":73},"100570773","ultrasound-evaluation-of-two-anatomic-landmarks-in-spinal-anesthesia-for-cesarean-section-the-posterior-superior-iliac-spine-vs-iliac-crest-100570773","NCT06711601","Ultrasound Evaluation of Two Anatomic Landmarks in Spinal Anesthesia for Cesarean Section: the Posterior Superior Iliac Spine VS Iliac Crest","Ultrasound Evaluation Of Two Anatomic Landmarks In Spinal Anesthesia For Cesarean Section: The Posterior Superior Iliac Spine vs Iliac Crest","USPSISICL","Inclusion Criteria:\n\n* After obtaining written informed consents,pregnant women at 37-42 weeks of gestation\n\nExclusion Criteria:\n\n* BMI ≥ 40 kg\u002Fm² (to minimize palpation variability), History of lumbar surgery\u002Fdeformity (scoliosis, spondylolisthesis or osteoporotic vertebral collapse), Inability to maintain the flexed lateral decubitus position, Participant withdrawal, Unforeseen anatomical anomalies discovered during screening.",{"count":355,"type":22},660,"Intercristal line as palpation landmarks to identifying the vertebral level is frequently inaccurate.To find more safe and reliable body surface markers and convenient methods to be solved in clinical work.The investigators performed a two-stage study to evaluated the accuracy of intercristal line and the The Posterior Superior Iliac Spine (PSIS) line to identify the lumbar interspinous spaces for spinal anesthesia using ultrasonography in pregnant woman which will provide a second option.",[358,26,359,360],"Spinal Anesthesia","Posterior Superior Iliac Spine","Intercristal Line",[362,34,363,359,364],"cesarean section","spinal anesthesia","intercristal line","2026-01-30",{"date":367,"type":39},"2026-02-03",{"date":369,"type":39},"2024-10-10",{"date":371,"type":22},"2026-01-23",{"name":373,"class":45},"The Third Affiliated Hospital of Guangzhou Medical University",{"id":375,"slug":376,"hasResults":12,"nctId":377,"briefTitle":378,"officialTitle":379,"acronym":4,"eligibilityCriteria":380,"healthyVolunteers":12,"sex":17,"minAge":381,"maxAge":54,"enrollmentInfo":382,"targetDuration":4,"studyType":57,"phases":384,"briefSummary":385,"conditions":386,"keywords":389,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":396,"lastUpdatePostDateStruct":397,"startDateStruct":399,"completionDateStruct":401,"leadSponsor":403,"locationsCount":73},"100619016","the-effects-of-intra-articular-and-peri-articular-platelet-rich-plasma-prp-injections-n-chronic-knee-osteoarthritis-100619016","NCT07339137","The Effects of Intra-articular and Peri-articular Platelet-rich Plasma (PRP) Injections ın Chronic Knee Osteoarthritis","The Effects of Platelet-rich Plasma (PRP) Injections Administered Into Intra-articular and Periarticular Regions Under Ultrasound Guidance in Chronic Knee Osteoarthritis on Pain, Function, Activities of Daily Living, Medial Collateral Ligament (MCL) and Distal Femoral Cartilage Thickness","Inclusion Criteria\n\n* Age between 40 and 65 years.\n* Patients with significant medial knee pain who have not responded to conservative treatment for at least 3 months.\n* Patients diagnosed with knee osteoarthritis according to the American College of Rheumatology (ACR) criteria and with Kellgren-Lawrence grade 2 or 3 radiographic osteoarthritis.\n* Intact cognitive function.\n* Willingness to participate in the study and provide signed informed consent.\n* Visual Analog Scale (VAS) score of 4 or higher.\n\nExclusion Criteria\n\n* History of previous knee trauma or surgery.\n* Physical therapy, intra-articular steroid, or hyaluronic acid injections in the knee within the last 3 months.\n* Active oncological diseases.\n* Local infection, sepsis, wounds, or scars in the injection area.\n* Systemic infections, hepatitis, or immunosuppression.\n* Bleeding diathesis or irregular International Normalized Ratio (INR) due to oral warfarin use.\n* Inflammatory arthropathies.\n* Uncontrolled hypertension, uncontrolled diabetes mellitus, decompensated heart failure, coronary artery disease, or asthma.\n* Suspected or confirmed pregnancy.\n* Use of corticosteroids or opioids.\n* Anemia.\n* Body mass index (BMI) greater than 35.\n* Allergy to citrate.\n* Use of nonsteroidal anti-inflammatory drugs (NSAIDs) within the last week that may affect platelet function analyzer-100 (PFA-100) activity.\n* Physical examination findings suggestive of patellar retinaculum, meniscus, or cruciate ligament injury.\n* General health impairment or lack of cooperation.\n* Refusal to participate in the study.","40 Years",{"count":383,"type":22},42,[59],"The primary objective of this study is to evaluate and compare the effectiveness of ultrasound-guided combined intra-articular and peri-articular platelet-rich plasma (PRP) injections with intra-articular PRP injections alone in patients with chronic knee osteoarthritis (OA). The study specifically examines the effects of these treatment approaches on pain, physical function, activities of daily living, and structural parameters, including medial collateral ligament (MCL) thickness and distal femoral cartilage thickness.\n\nOsteoarthritis is a degenerative joint disease characterized by progressive cartilage erosion, osteophyte formation, and subchondral sclerosis, leading to pain, stiffness, and functional disability. It is the most common form of arthritis and a leading cause of disability worldwide, affecting approximately 300 million individuals. Although the knee is the most frequently involved joint, OA is now recognized as a whole-joint disease, involving not only cartilage degeneration but also pathological changes in subchondral bone, synovium, and surrounding extra-articular structures.\n\nPlatelet-rich plasma is an autologous concentration of platelets suspended in a small volume of plasma and contains a variety of bioactive growth factors, such as transforming growth factor-beta (TGF-β), platelet-derived growth factor (PDGF), and vascular endothelial growth factor (VEGF). These factors play a crucial role in promoting cell proliferation, angiogenesis, and tissue repair. In knee OA, PRP has been shown to reduce matrix metalloproteinase (MMP) activity, particularly MMP-13, enhance endogenous hyaluronic acid production, and support chondrogenesis. Although intra-articular PRP injections are widely accepted as a safe and effective treatment and have demonstrated superiority over placebo and hyaluronic acid in long-term follow-up studies, most existing research has focused exclusively on intra-articular applications.\n\nKnee OA is a multifactorial condition frequently associated with extra-articular pathologies, including ligament laxity, peri-articular edema, and soft tissue inflammation. Limiting treatment to the intra-articular space alone may therefore overlook these important contributors to pain and functional impairment. Emerging evidence suggests that a combined treatment approach targeting both intra-articular and peri-articular structures may provide superior outcomes in terms of pain reduction and functional improvement.\n\nThis prospective randomized controlled trial will include 42 patients aged 40-65 years with chronic knee OA classified as Kellgren-Lawrence grade 2 or 3. Participants will be randomly assigned to one of three groups: a control group receiving conservative treatment only (exercise therapy and lifestyle modifications), a group receiving conservative treatment plus ultrasound-guided intra-articular PRP injections, and a third group receiving conservative treatment plus combined ultrasound-guided intra-articular and peri-articular PRP injections targeting the MCL and pes anserinus regions.\n\nClinical outcomes will be assessed using validated instruments, including the Visual Analog Scale (VAS), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the Short Form-36 (SF-36) Quality of Life Scale. In addition, ultrasonographic measurements of MCL thickness and distal femoral cartilage thickness will be performed to evaluate structural changes. By investigating the additional value of peri-articular PRP injections, this study aims to contribute to the development of more comprehensive and effective injection protocols for the management of chronic knee osteoarthritis.",[387,26,388],"Platelet Rich Plasma Injection","Gonarthrosis",[390,391,392,393,394,395],"knee osteoarthritis","periarticular","PRP","USG","Femoral Cartilage","Medial Collateral Ligament","2026-01-13",{"date":398,"type":39},"2026-01-15",{"date":400,"type":39},"2025-08-01",{"date":402,"type":22},"2026-04-30",{"name":404,"class":45},"Ankara City Hospital Bilkent",{"id":406,"slug":407,"hasResults":12,"nctId":408,"briefTitle":409,"officialTitle":409,"acronym":410,"eligibilityCriteria":411,"healthyVolunteers":12,"sex":17,"minAge":412,"maxAge":4,"enrollmentInfo":413,"targetDuration":4,"studyType":57,"phases":415,"briefSummary":416,"conditions":417,"keywords":4,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":420,"lastUpdatePostDateStruct":421,"startDateStruct":423,"completionDateStruct":425,"leadSponsor":427,"locationsCount":73},"100520751","variation-of-echocardiographic-parameters-after-red-blood-cell-transfusion-in-emergency-department-anemic-patients-100520751","NCT06060639","Variation of Echocardiographic Parameters After Red Blood Cell Transfusion in Emergency Department Anemic Patients","Trans-US","Inclusion Criteria:\n\n* patient needing red blood cell transfusion\n* consent\n* social protection\n\nExclusion Criteria:\n\n* fluid filing over 500 mL of crystalloids\n* transfusion in the last hour","60 Years",{"count":414,"type":22},116,[59],"The goal of this interventional study is to asses echocardiographic variations in emergency department's elderly patients receiving red blood cell transfusion. The main questions it aims to answer are :\n\n* is there a modification of echocardiographic parameters after red blood cell transfusion ?\n* which parameter is the most impacted by red blood cell transfusion ? Participants will have a transthoracic echocardiography before, just after and 15 minutes after red blood cell transfusion.",[418,419,26],"Anemia","Age Problem","2025-12-22",{"date":422,"type":39},"2025-12-30",{"date":424,"type":39},"2023-11-09",{"date":426,"type":22},"2027-05-30",{"name":428,"class":45},"Centre Hospitalier Universitaire de Nīmes",{"id":430,"slug":431,"hasResults":12,"nctId":432,"briefTitle":433,"officialTitle":434,"acronym":4,"eligibilityCriteria":435,"healthyVolunteers":12,"sex":17,"minAge":436,"maxAge":54,"enrollmentInfo":437,"targetDuration":4,"studyType":57,"phases":439,"briefSummary":440,"conditions":441,"keywords":445,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":451,"lastUpdatePostDateStruct":452,"startDateStruct":454,"completionDateStruct":456,"leadSponsor":458,"locationsCount":73},"100605543","the-effect-of-fascial-treatment-in-patients-with-adhesive-capsulitis-100605543","NCT07163884","The Effect of Fascial Treatment in Patients With Adhesive Capsulitis","Adheziv kapsülit tanılı Hastalarda Fasyal Tedavinin ağrı, Normal Eklem Hareket açıklığı, Propriosepsiyon ve Fasya Mimarisine Etkisinin araştırılması","Inclusion Criteria:\n\n* Patients diagnosed with adhesive capsulitis by a specialist,\n* Patients between the ages of 35 and 60,\n* Those not diagnosed with cervical disc herniation that could cause other shoulder pathologies,\n* Those who have not participated in an upper extremity-related physiotherapy program within the last 6 months,\n* Individuals who volunteer to participate in the study,\n\nExclusion Criteria:\n\n* Individuals who have undergone shoulder surgery consistent with any pathology,\n* Individuals with a neurological history,\n* Individuals diagnosed with diabetes mellitus (DM)","35 Years",{"count":438,"type":22},36,[59],"Our study is unique in that it utilizes a self-designed fascial mobilization protocol and ultrasonographic evaluation for adhesive capsulitis. Therefore, the aim of our study is to investigate the effects of fascial therapy on pain, normal joint range of motion, proprioception, and fascial architecture in patients diagnosed with adhesive capsulitis.",[442,26,443,444],"Adhesive Capsulitis","Fascia","Treatment (ProudMe)",[446,447,448,449,450],"adhezsiv capsulitis","pain","range of motion","proprioception","fascia architecture","2025-09-01",{"date":453,"type":39},"2025-09-09",{"date":455,"type":22},"2025-09-15",{"date":457,"type":22},"2025-11-15",{"name":459,"class":45},"Hasan Kalyoncu University",{"id":461,"slug":462,"hasResults":12,"nctId":463,"briefTitle":464,"officialTitle":465,"acronym":4,"eligibilityCriteria":466,"healthyVolunteers":12,"sex":17,"minAge":436,"maxAge":54,"enrollmentInfo":467,"targetDuration":4,"studyType":57,"phases":469,"briefSummary":470,"conditions":471,"keywords":473,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":477,"lastUpdatePostDateStruct":478,"startDateStruct":480,"completionDateStruct":481,"leadSponsor":482,"locationsCount":73},"100605110","effects-of-exercise-on-adhesive-capsulitis-100605110","NCT07158255","Effects of Exercise on Adhesive Capsulitis","Effect of Exercise Training on Pain, Range of Motion, Functionality and Shoulder Architecture in Patients With Adhesive Capsulitis","Inclusion Criteria:\n\n* Diagnosed with adhesive capsulitis by a physician,\n* Between the ages of 35-60,\n* Not diagnosed with cervical disc herniation that could cause other shoulder pathologies,\n* Not participating in an upper extremity-related physiotherapy program within the last 6 months,\n* Volunteering individuals to participate in the study\n\nExclusion Criteria:\n\n* Individuals who have undergone shoulder surgery consistent with any pathology,\n* Individuals with a neurological history,\n* Individuals diagnosed with diabetes mellitus (DM)",{"count":468,"type":22},32,[59],"Our study aims to investigate the effects of exercise training on pain, range of motion, functionality and shoulder architecture in patients with adhesive capsulitis.",[442,472,26],"Exercise",[446,447,448,474,475,476],"functionality","shoulder architecture","exercise","2025-08-28",{"date":479,"type":39},"2025-09-05",{"date":479,"type":22},{"date":457,"type":22},{"name":459,"class":45},{"id":484,"slug":485,"hasResults":12,"nctId":486,"briefTitle":487,"officialTitle":488,"acronym":489,"eligibilityCriteria":490,"healthyVolunteers":53,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":491,"targetDuration":4,"studyType":57,"phases":493,"briefSummary":494,"conditions":495,"keywords":499,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":502,"lastUpdatePostDateStruct":503,"startDateStruct":505,"completionDateStruct":507,"leadSponsor":509,"locationsCount":511},"100540464","assessment-of-liver-diseases-using-a-deep-learning-approach-based-on-ultrasound-rf-data-100540464","NCT06317181","Assessment of Liver Diseases Using a Deep-Learning Approach Based on Ultrasound RF-Data","Acquisition and Frequency Spectroscopic Evaluation of Broadband Clinical Ultrasound Raw Data for Liver Cirrhosis and Focal Pathologies Using Neural Networks for Tissue and Pathology Differentiation","LivSPECTRUS","Inclusion Criteria:\n\n* scheduled for an ultrasound investigation by an independent physician\n* signed declaration of consent\n\nExclusion Criteria:\n\n* smaller interventions in the same liver during the last 2 Week (for example liver biopsy)\n* contrast enhanced ultrasound less than a day ago\n* major intervention at the liver (for example partial resection)",{"count":492,"type":22},200,[59],"The goal of this clinical trial is to test the performance of neuronal networks trained on ultrasonic raw Data (=radiofrequency data) for the assessment of liver diseases in patients undergoing a clinical ultrasound examination. The general feasibility is currently evaluated in a retrospective cohort.\n\nThe main questions the study aims to answer are:\n\n* Can a neuronal network trained on RF Data perform equally good as elastography in the assessment of diffuse liver diseases?\n* Can a neuronal network trained on RF Data perform better than a neuronal network trained on b-mode images in the assessment of diffuse liver diseases?\n* Can a neuronal network trained on RF Data distinguish focal pathologies in the liver from healthy tissue?\n\nTo answer these questions participants with a clinically indicated fibroscan will undergo:\n\n* a clinical elastography in Case ob suspected diffuse liver disease\n* a reliable ground truth (if normal ultrasound is not sufficient e.g. contrast enhanced ultrasound, biopsy, MRI or CT) in case of focal liver diseases, depending on the standard routine of the participating center\n* a clinical ultrasound examination during which b-mode images and the corresponding RF-Data sets are captured",[305,26,496,497,498],"Elasticity Imaging Techniques","Liver Diseases","Metastasis to Liver",[500,501],"Quantitative Ultrasound","Radiofrequency Data","2025-08-18",{"date":504,"type":39},"2025-08-20",{"date":506,"type":39},"2024-04-01",{"date":508,"type":22},"2025-12",{"name":510,"class":45},"Technische Universität Dresden",4,{"id":513,"slug":514,"hasResults":12,"nctId":515,"briefTitle":516,"officialTitle":516,"acronym":517,"eligibilityCriteria":518,"healthyVolunteers":12,"sex":17,"minAge":519,"maxAge":520,"enrollmentInfo":521,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":523,"conditions":524,"keywords":534,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":544,"lastUpdatePostDateStruct":545,"startDateStruct":547,"completionDateStruct":549,"leadSponsor":551,"locationsCount":553},"100601977","heterogeneity-index-in-neonatologist-performed-lung-ultrasound-in-neonates-receiving-respiratory-support---a-pilot-study-100601977","NCT07117513","Heterogeneity Index in Neonatologist-performed Lung Ultrasound in Neonates Receiving Respiratory Support - a Pilot Study","NPLUS HI","Inclusion Criteria:\n\n* Preterm neonates born between 28+0 and 36+6 weeks of gestation and term-born neonates (\\> 37+0 weeks of gestation) admitted to the NICU\n* Presence of respiratory distress requiring respiratory support (invasive and non-invasive) at the timepoint of NPLUS 1.\n* Written informed consent obtained from the parents prior to the measurement.\n\nExclusion Criteria:\n\n* cardiopulmonary malformations\n* pleural effusion\n* pneumothorax","1 Hour","7 Days",{"count":522,"type":22},40,"Lung ultrasound is an increasingly valuable diagnostic tool in neonatal intensive care due to its safety and accessability.\n\nThis pilot study investigates whether a quantitative approach - the heterogeneity index, previously only used in fetal lung assessment - can enhance the diagnostic accuracy of neonatologist-performed lung ultrasound (NPLUS). The index will be calculated from raw ultrasound images of preterm and term neonates and compared with conventional lung ultrasound scores to evaluate its clinical relevance.",[525,152,526,527,26,528,529,530,531,532,533],"Intensive Care Units, Neonatal","Infant, Premature","Point-of-Care Systems","Lung Ultrasound","Lung Ultrasound Score","Image Interpretation, Computer Assisted","Reproducibility of Results","Respiratory Distress Neonatal","Respiratory Support",[535,528,529,536,537,538,539,540,541,542,543],"Neonatologist-Performed Lung Ultrasound","Quantitative Lung Ultrasound","Neonatal Intensive Care Unit","Observer Variability in Imaging","Ultrasound Artifact Interpretation","Respiratory Distress Syndrome in Neonates","respiratory support","preterm neonate","newborn","2025-08-05",{"date":546,"type":39},"2025-08-12",{"date":548,"type":22},"2025-08-15",{"date":550,"type":22},"2026-08-01",{"name":552,"class":45},"Medical University of Graz",2,{"id":555,"slug":556,"hasResults":12,"nctId":557,"briefTitle":558,"officialTitle":559,"acronym":4,"eligibilityCriteria":560,"healthyVolunteers":12,"sex":17,"minAge":561,"maxAge":19,"enrollmentInfo":562,"targetDuration":4,"studyType":57,"phases":564,"briefSummary":565,"conditions":566,"keywords":569,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":573,"lastUpdatePostDateStruct":574,"startDateStruct":576,"completionDateStruct":578,"leadSponsor":579,"locationsCount":73},"100599274","the-use-of-diaphragmatic-ultrasonography-in-mechanical-ventilation-weaning-decision-in-copd-patient-100599274","NCT07082361","The Use of Diaphragmatic Ultrasonography in Mechanical Ventilation Weaning Decision in COPD Patient","The Use of Diaphragmatic Ultrasonography: Does It Change Mechanical Ventilation Weaning Decision and Predict Outcome in COPD Patient?","Inclusion Criteria:\n\n* Adult patient more than 21 years old of both sexes, coming to our intensive care unit with acute exacerbation of Chronic obstructive pulmonary disease \\& need mechanical ventilation at least 48 hr.\n\nExclusion Criteria:\n\n* Patient refusal.\n\n  * Morbid obesity with body mass index \\> 35 kg\u002Fm2.\n  * Patients with a history of recent thoracic surgery.\n  * Neuromuscular disorders affecting the diaphragm e.g.(myopathy).\n  * Congenital diaphragmatic disorders (Hiatal hernia).","21 Years",{"count":563,"type":22},140,[59],"The aim of this study is to evaluate the use of diaphragmatic ultrasonography in taking mechanical ventilation weaning decision and predicting outcome in Chronic obstructive pulmonary disease patient.\n\nPrimary outcome:\n\n• Number of patients with failed weaning trial and need reintubation.\n\nSecondary outcomes:\n\n* Time till extubation trial.\n* Ventilation free days after extubation less or more than 48h .\n* Number of Intensive care unit discharges.\n* Sensitivity and specificity of diaphragmatic assessment as a predictor of weaning.",[26,567,568],"Mechanical Ventilation Weaning","Chronic Obstructive Pulmonary Disease (COPD)",[26,570,571,572],"Diaphragmatic","Mechanical Ventilation","Weaning","2025-07-16",{"date":575,"type":39},"2025-07-24",{"date":577,"type":22},"2025-10-30",{"date":422,"type":22},{"name":580,"class":45},"Tanta University",{"id":582,"slug":583,"hasResults":12,"nctId":584,"briefTitle":585,"officialTitle":585,"acronym":4,"eligibilityCriteria":586,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":587,"targetDuration":4,"studyType":57,"phases":589,"briefSummary":590,"conditions":591,"keywords":594,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":596,"lastUpdatePostDateStruct":597,"startDateStruct":599,"completionDateStruct":601,"leadSponsor":603,"locationsCount":73},"100580568","ultrasonographic-patterns-and-pathological-correlation-in-the-diagnosis-of-subcutaneous-nodules-100580568","NCT06838988","Ultrasonographic Patterns and Pathological Correlation in the Diagnosis of Subcutaneous Nodules","Inclusion Criteria:\n\n* Patients aged 18 years and older who presented with subcutaneous nodules\n* Indicated for pathological examination for disease diagnosis.\n* Patients with subcutaneous nodules located in areas where a tissue sample can be taken down to the fat layer.\n* Patients who agree to participate in the project by signing the consent form.\n\nExclusion Criteria:\n\n* Presence of inflammation or other tumors that can mimic panniculitis, such as painful lipomas, cellulitis, and leg interstitial edema.\n* Patients with diseases that significantly alter the structure of the skin or subcutaneous tissue, such as scleroderma or severe edema.\n* A history of previous treatments in the area of the subcutaneous mass (e.g., surgery, radiation therapy, or high-dose steroid treatment) that may interfere with ultrasound results.\n* Patients with lesions on the head or mucous membranes of the body.\n* Pregnant or breastfeeding patients.\n* Presence of wounds or open sores in the area to be examined with ultrasound.\n* A history of coagulopathy (blood clotting disorders).\n* Patients with metal implants in the area of interest that may interfere with ultrasound imaging.\n* Participants who refuse or withdraw from the study.",{"count":588,"type":22},100,[59],"The objective of this study is to explore the role of ultrasonography (non-invasive imaging device) in the diagnosis of subcutaneous nodules (mass\u002Fbumb underneath the skin).\n\nPatients who presented with subcutaneous nodules and was indicated for diagnostic skin biopsies were recruited. Prior to skin biopsies (not part of the study's intervention), ultrasonography(intervention) was used to examine the characteristics of the nodules. The ultrasonographic findings are then compared to the pathological results to explore the role of ultrasonography in differentiating each disease or group of diseases that presented with skin nodules.",[592,26,593],"Nodules","Panniculitis",[592,26,595],"panniculitis","2025-05-07",{"date":598,"type":39},"2025-05-09",{"date":600,"type":39},"2025-02-24",{"date":602,"type":22},"2026-01",{"name":604,"class":45},"Mahidol University",{"id":606,"slug":607,"hasResults":12,"nctId":608,"briefTitle":609,"officialTitle":609,"acronym":4,"eligibilityCriteria":610,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":611,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":612,"conditions":613,"keywords":4,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":618,"lastUpdatePostDateStruct":619,"startDateStruct":621,"completionDateStruct":622,"leadSponsor":624,"locationsCount":73},"100580189","added-value-of-ultrasonography-in-the-diagnosis-management-and-follow-up-of-carpal-tunnel-syndrome-100580189","NCT06834061","Added Value of Ultrasonography in the Diagnosis, Management, and Follow-Up of Carpal Tunnel Syndrome","Inclusion Criteria:\n\n* Age ≥18 years old.\n* Both sexes.\n* Patients with carpal tunnel syndrome.\n\nExclusion Criteria:\n\n* History of wrist surgery (including carpal tunnel injection) or fracture.\n* Clinical or electrophysiological evidence of an accompanying condition that mimics carpal tunnel syndrome or interferes with its evaluation, such as proximal median neuropathy, cervical radiculopathy or polyneuropathy.\n* History of underlying disorders associated with carpal tunnel syndrome such as diabetes mellitus, rheumatoid arthritis, pregnancy, acromegaly or hypothyroidism.\n* Electrodiagnostic findings suggestive of co-existing neurological disorders.\n* Subclinical sensory polyneuropathy.",{"count":240,"type":22},"This study aims to assess the ultrasound (US) and nerve conduction studies (NCS) as a tool for diagnosis, treatment planning and follow-up of patients with carpal tunnel syndrome (CTS).",[26,614,615,616,617],"Diagnosis","Management","Follow-Up","Carpal Tunnel Syndrome","2025-02-19",{"date":620,"type":39},"2025-02-20",{"date":618,"type":39},{"date":623,"type":22},"2025-07-01",{"name":625,"class":45},"Kafrelsheikh University",{"id":627,"slug":628,"hasResults":12,"nctId":629,"briefTitle":630,"officialTitle":631,"acronym":4,"eligibilityCriteria":632,"healthyVolunteers":53,"sex":17,"minAge":238,"maxAge":633,"enrollmentInfo":634,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":636,"conditions":637,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":638,"lastUpdatePostDateStruct":639,"startDateStruct":641,"completionDateStruct":643,"leadSponsor":645,"locationsCount":73},"100576975","detection-of-muscle-quality-in-children---protocol-for-a-validation-study-100576975","NCT06792279","Detection of Muscle Quality in Children - Protocol for a Validation Study","Use of Ultrasound Echo Intensity for the Detection of Muscle Quality in Children - Protocol for a Validation Study","Inclusion Criteria:\n\n• Generally healthy children\n\nExclusion Criteria:\n\n* Acute illnesses\n* Chronic or acute diseases of the endocrine or musculoskeletal systems\n* Post-traumatic conditions","14 Years",{"count":635,"type":22},120,"The goal of this observational study is to evaluate the validity and reliability of ultrasound echo intensity (EI) as a diagnostic tool for assessing muscle quality in children aged 10-14 years, including normal-weight, obese, and trained young athletes. The main questions it aims to answer are:\n\nCan EI reliably and accurately measure muscle quality in children when validated against gold-standard techniques like DXA and isokinetic dynamometry? What are the age-, sex-, and fitness-specific benchmarks for EI to differentiate between normal and pathological muscle quality?",[26],"2025-01-20",{"date":640,"type":39},"2025-01-24",{"date":642,"type":22},"2025-03-01",{"date":644,"type":22},"2026-03-31",{"name":646,"class":45},"Charles University, Czech Republic",{"id":648,"slug":649,"hasResults":12,"nctId":650,"briefTitle":651,"officialTitle":652,"acronym":4,"eligibilityCriteria":653,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":654,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":656,"conditions":657,"keywords":4,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":660,"lastUpdatePostDateStruct":661,"startDateStruct":663,"completionDateStruct":665,"leadSponsor":667,"locationsCount":553},"100572212","prospective-study-of-classification-and-activity-assessment-of-psoriatic-arthritis-based-on-power-doppler-pd-ultrasonography-pdus-100572212","NCT06730334","Prospective Study of Classification and Activity Assessment of Psoriatic Arthritis Based on Power Doppler (PD) Ultrasonography (PDUS)","A Single Centre Prospective Cohort Study of Classification and Activity Assessment of Psoriatic Arthritis Based on Power Doppler (PD) Ultrasonography (PDUS)","Inclusion Criteria:\n\n* PsA patients as defined by CASPAR criteria\n* Patients must be able to comply with the visit schedule, treatment plan, laboratory tests and other study procedures\n* Patients must be given informed consent\n\nExclusion Criteria:\n\n* History of other arthritis within the last 12 months\n* Concomitant disease with acute or chronic infectious diseases\n* Pregnancy or laction\n* Poorly tolerated with venipuncture required for blood sampling during the study",{"count":655,"type":22},400,"Psoriatic arthritis (PsA) is a complex inflammatory disease with heterogeneous clinical features, which complicates psoriasis in 30% of patients. PsA involves multiple tissues and clinical domains including skins and nails as well as arthritis, spondylitis, enthesitis, and dactylitis. Power Doppler (PD) ultrasonography (PDUS) is a sensitive non-invasive imaging technology used to assess disease activity and treatment response in PsA. This is a prospective, observational, open-label study to investigate disease activity, therapeutic response and bone destruction based on ultrasonography findings in patients with PsA.",[658,659,26],"Psoriatic Arthritis","Secukinumab","2024-12-18",{"date":662,"type":39},"2024-12-20",{"date":664,"type":39},"2023-09-01",{"date":666,"type":22},"2028-06-01",{"name":668,"class":45},"Nanjing Medical University",{"id":670,"slug":671,"hasResults":12,"nctId":672,"briefTitle":673,"officialTitle":674,"acronym":4,"eligibilityCriteria":675,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":676,"enrollmentInfo":677,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":679,"conditions":680,"keywords":685,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":687,"lastUpdatePostDateStruct":688,"startDateStruct":690,"completionDateStruct":692,"leadSponsor":694,"locationsCount":73},"100438450","comparison-of-computertomography-scan-electrical-impedance-tomography-and-ultrasound-of-the-lung-in-infants-100438450","NCT04989439","Comparison of Computertomography Scan, Electrical Impedance Tomography, and Ultrasound of the Lung in Infants","Comparison of Computertomography Scan, Electrical Impedance Tomography, and Ultrasound of the Lung in Infants - a Prospective Explorative Observational Study","Inclusion Criteria:\n\n* Patients hospitalized at the Department of Pediatrics of the Medical University of Vienna who will get a CT scan of the thorax.\n* Patients aged up to 12 months\n\nExclusion Criteria:\n\n* Unstable cardiovascular, respiratory and\u002For neurological conditions.\n* Sternotomy during the previous 15 days.\n* Thoracic skin lesions or wounds (including burns) on the thorax, where the EIT-electrode-belt would be placed.","12 Months",{"count":678,"type":22},10,"The study focuses on regional lung examination, in particular on the differentiation between collapsed and hyperinflated lung areas. The purpose of the study is to elaborate common and discriminative elements between different lung imaging modalities in infants and to generate hypotheses for the bedside use of EIT and LUS in infants.",[681,682,683,26,684],"Infant ALL","Computed Tomography","Electric Impedance","Lung Injury",[686],"CT, electrical impedance tomography, ultrasound","2024-11-18",{"date":689,"type":39},"2024-11-20",{"date":691,"type":39},"2021-07-19",{"date":693,"type":22},"2025-12-31",{"name":695,"class":45},"Medical University of Vienna",{"id":697,"slug":698,"hasResults":12,"nctId":699,"briefTitle":700,"officialTitle":701,"acronym":4,"eligibilityCriteria":702,"healthyVolunteers":53,"sex":17,"minAge":18,"maxAge":703,"enrollmentInfo":704,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":706,"conditions":707,"keywords":711,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":714,"lastUpdatePostDateStruct":715,"startDateStruct":717,"completionDateStruct":719,"leadSponsor":721,"locationsCount":73},"100557670","positive-association-of-us-fli-with-the-severity-of-cad-100557670","NCT06541132","Positive Association of US-FLI With the Severity of CAD","Positive Association Between Ultrasonographic Fatty Liver Indicator and the Severity of Coronary Artery Disease","Inclusion Criteria:\n\n* Patients older than 18 years old\n* Patients underwent ICA due to chest pain, chest tightness or other reasons in our hospital from August 2022 to December 2023 were included in our study\n\nExclusion Criteria:\n\n* Incomplete clinical data\n* previous coronary stent implantation\n* no abdominal ultrasound examination\n* poor ultrasound image quality\n* congenital heart disease\n* tumor\n* thyroid diseases and infectious diseases","90 Years",{"count":705,"type":22},190,"As a multisystem disease, metabolic dysfunction-associated fatty liver disease (MAFLD) is closely linked to the onset and progression of coronary heart disease (CHD). Ultrasonographic fatty liver indicator (US-FLI) is a semi-quantitative tool for evaluating the degree of hepatic steatosis. Our study aims to explore the relationship between US-FLI based on MAFLD and the severity of CHD.",[708,709,710,26],"Coronary Artery Disease of Significant Bypass Graft","Metabolic Dysfunction-associated Fatty Liver Disease","SYNTAX Score",[712,709,713,26],"Coronary Artery Disease","SYNTAX score","2024-08-19",{"date":716,"type":39},"2024-08-21",{"date":718,"type":39},"2022-07-01",{"date":720,"type":22},"2025-04-28",{"name":722,"class":45},"Chongqing Medical University"]