[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"unicompartmental-knee-arthroplasty\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:unicompartmental-knee-arthroplasty":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,54,85,106],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100641778","early-cognitive-changes-after-same-day-discharge-hip-and-knee-arthroplasty-100641778",false,"NCT07598552","Early Cognitive Changes After Same-day Discharge Hip and Knee Arthroplasty","Early Cognitive Changes in Patients Aged 70 Years or Older After Same-day Discharge Hip and Knee Arthroplasty: A Prospective Cohort Study","Inclusion Criteria:\n\n* Unilateral elective primary Total Hip Arthroplasty, Total Knee Arthroplasty, or Unicompartmental Knee\n* Native Danish speaker\n* Spinal anesthesia\n\nExclusion Criteria:\n\n* Inability or unwillingness to provide informed consent\n* Inability to comply with virtual study procedures or follow-up sessions, including because of visual or hearing impairment\n* Known dementia or other diagnosed cognitive disorders or Brief Assessment of Impaired Cognition (BASIC)≤20\n* Parkinson's disease or other neurological conditions causing functional impairment\n* History of alcohol abuse (≥35 units per week)\n* Daily use of anxiolytics or hypnotics\n* Not discharged on the day of surgery","ALL","70 Years",{"count":19,"type":20},48,"ESTIMATED","7 Days","OBSERVATIONAL","The goal of this observational study is to explore early cognitive changes in patients aged 70 years or older undergoing same-day discharge after hip or knee replacement surgery. The main question it aims to answer is:\n\nDoes patients experience cognitive changes in cognitive test performance from before surgery to the first day after surgery?\n\nParticipants will:\n\n* Complete a cognitive test battery virtually about 14 days before surgery, and on the first and seventh day after their operation.\n* Record pain levels and pain medicine use during the first week after surgery",[25,26,27,28],"Postoperative Cognitive Dysfunction (POCD)","Cognitive Change","Total Knee Arthroplasty","Unicompartmental Knee Arthroplasty",[30,31,32,33,34,35,36,37,38,39,40],"Same-day discharge","Fast-track surgery","Hip arthroplasty","Knee arthroplasty","Unicompartmental knee arthroplasty","Cognitive function","SDMT","Stroop test","Verbal fluency","Older adults","recovery","RECRUITING","2026-06-17",{"date":44,"type":45},"2026-06-22","ACTUAL",{"date":47,"type":45},"2026-05-18",{"date":49,"type":20},"2026-11-30",{"name":51,"class":52},"Odense University Hospital","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":16,"minAge":61,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":71,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":53},"100640961","phase-4-post-op-prednisone-and-glucose-monitoring-in-tka-100640961","NCT07630896","Post-op Prednisone and Glucose Monitoring in TKA","Postoperative Prednisone Regimen in TKA and Its Effect on Continuous Glucose Levels","Inclusion Criteria:\n\n* Undergoing Primary Unicompartmental Knee Arthroplasty or Total Hip Arthroplasty\n* Age 18 and above\n\nExclusion Criteria:\n\n* Steroid therapy\n* Narcotic use within past 3 months\n* History of corticosteroid intolerance\n* Pregnancy\n* Uncontrolled diabetes\n* Doesn't own smart phone\n\nDrop Criteria:\n\n\\- 2nd dose of IV dexamethasone","18 Years",{"count":63,"type":20},104,"INTERVENTIONAL",[66],"PHASE4","This study compares the efficacy of a 5-day post-operative oral prednisone regimen (40 mg daily) with the standard intraoperative steroid regimen, focusing on pain, swelling, range of motion, opioid use, and glucose levels monitored continuously.",[69,28,70],"Osteoarthritis","Total Hip Arthroplasty (THA)",[72,73,74],"Post-operative pain","Prednisone","Continuous Glucose Monitoring","NOT_YET_RECRUITING","2026-06-03",{"date":78,"type":45},"2026-06-05",{"date":80,"type":20},"2026-07-01",{"date":82,"type":20},"2028-03",{"name":84,"class":52},"Columbia University",{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":11,"sex":16,"minAge":61,"maxAge":4,"enrollmentInfo":92,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":94,"conditions":95,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":53},"100506573","ambispective-multicentric-study-evaluating-uka-with-u-kneeuni-kroma-implants-100506573","NCT05876143","Ambispective Multicentric Study Evaluating UKA With U-Knee\u002FUni-Kroma Implants","Ambispective Open Multicentric Study Evaluating Clinical Results of Unicondylar Knee Arthroplasty Performed With U-Knee\u002FUni-Kroma Implants","Inclusion Criteria:\n\n\\- All patients using a U-Knee \u002F Uni-Kroma unicompartmental knee prosthesis and benefiting from the social security affiliation scheme.\n\nExclusion Criteria:\n\n* Patients who objected to participating in the study and the processing of their data\n* Patients unable to understand the surgeon's instructions to complete their questionnaires or perform postoperative follow-up\n* Patients who already have a unicompartmental prosthesis on the knee in question that need to be revised.",{"count":93,"type":20},400,"This clinical investigation was led as a post-market clinical follow-up study (post-market device development stage).The main objective of this study is to collect short- and medium-term clinical data on the unicondylar knee prosthesis U-Knee \u002F Uni-Kroma, in order to evaluate the performance of these implants.",[28],"2026-04-21",{"date":98,"type":45},"2026-04-22",{"date":100,"type":45},"2023-01-01",{"date":102,"type":20},"2035-01-31",{"name":104,"class":105},"Societe dEtude, de Recherche et de Fabrication","INDUSTRY",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":114,"targetDuration":116,"studyType":22,"phases":4,"briefSummary":117,"conditions":118,"keywords":120,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":4},"100598097","risk-of-serious-adverse-events-following-unsupervised-vs-supervised-rehabilitation-after-knee-arthroplasty-100598097","NCT07067060","Risk of Serious Adverse Events Following Unsupervised vs Supervised Rehabilitation After Knee Arthroplasty","Risk of Serious Adverse Events Following Unsupervised vs Supervised Rehabilitation After Knee Arthroplasty: Protocol For An Emulated Noninferiority Trial (SAFE-T)","SAFE-T","Inclusion Criteria:\n\n* Adults undergoing primary total or unicompartmental knee arthroplasty (KA) for osteoarthritis in Denmark\n\nExclusion Criteria:\n\n* None",{"count":115,"type":20},40000,"2 Years","SUMMARY\n\nBackground:\n\nAfter knee arthroplasty (KA), rehabilitation is widely recommended, yet its clinical effectiveness-especially the need for supervision-has been challenged. While some argue that supervised rehabilitation may prevent serious adverse events (SAEs), previous trials show no superiority of rehabilitation, supervised or not, over no rehabilitation in terms of function. However, these trials were underpowered for safety outcomes. A large-scale evaluation is needed to determine if supervision impacts SAE risk, thereby informing rational use of health care resources.\n\nRationale for the proposed study. A conventional randomized trial to assess the safety of supervised versus unsupervised rehabilitation after KA would require an ethically and logistically infeasible sample size. By emulating such a trial using routinely collected registry data, the investigators can estimate the causal effect of supervision on the risk of serious adverse events-while accounting for confounding and preserving real-world relevance.\n\nActionable objective and hypothesis: To test whether unsupervised rehabilitation after knee arthroplasty increases the risk of serious adverse events over a 2-year period compared with supervised rehabilitation. The investigators hypothesize that unsupervised rehabilitation is non-inferior, defined as a hazard ratio for SAE risk below 1.4.\n\nDesign: Target trial emulation (TTE) using nationwide registry data to replicate the design and intent of a pragmatic randomized trial.\n\nSetting: Danish hospitals and municipalities. Patients: Adults undergoing primary total or unicompartmental knee arthroplasty for osteoarthritis, identified from Danish registries. The target trial assumes consecutive recruitment at hospital discharge to mirror real-world referral practices.\n\nInterventions: Referral to unsupervised home-based exercise or supervised municipal physiotherapy, defined by referral to rehabilitation pathways initiated at hospital discharge.\n\nMethods: Primary outcome is serious adverse events; secondary is number of hospital contacts. Propensity score-based weighting will adjust for confounding using patient and administrative covariates (e.g. age, BMI, comorbidities, surgery year), enabling causal inference from observational data.\n\nResults: Findings will inform clinical practice by estimating the comparative safety of unsupervised versus supervised rehabilitation after knee arthroplasty, based on real-world data from over 40,000 patients.\n\nLimitations: As with all non-randomized studies, residual confounding is possible. Despite adjustment strategies, causal interpretations should be made with caution due to reliance on observational data.\n\nConclusion: While TTE can provide valuable insight, the causal inferences made with TTE should be interpreted with caution, when not supported with an RCT.\n\nFunding: Section for Biostatistics and Evidence-Based Research, the Parker Institute, Bispebjerg and Frederiksberg Hospital is supported by a core grant from the Oak Foundation (OFIL-24-074).\n\nExternal funding: in process. Registration: TBD (registration on ClinicalTrials.Gov)",[27,119,28],"Knee Arthroplasty",[121,122,123,124,125,126],"emulated target trial","total knee replacement","arthroplasty","serious adverse events","supervised rehabilitation","unsupervised rehabilitation","2025-07-29",{"date":129,"type":45},"2025-07-31",{"date":131,"type":20},"2026-01-01",{"date":133,"type":20},"2027-12-31",{"name":135,"class":52},"Copenhagen University Hospital, Hvidovre"]