[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"unilateral-cerebral-palsy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:unilateral-cerebral-palsy":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,47,71,106,136,159,209],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100639612","tdcs-and-bi-manual-training-in-cerebral-palsy-100639612",false,"NCT07573865","tDCS and Bi-manual Training in Cerebral Palsy","AI-Assisted Anodal tDCS Combined With Bimanual Motor Training in Children With Unilateral Spastic Cerebral Palsy: A Pilot Feasibility Study at Riphah Hospital","Inclusion Criteria:\n\n1. Children aged 6-17 years with unilateral spastic CP\n2. Wrist extension ≥ 20°, MCP\u002FPIP joints ≥ 10°\n\nExclusion Criteria:\n\n1. Any other neurological disorders\n2. An orthopedic condition affecting the participation in UE activities.\n3. Unable to understand the command.","ALL","6 Years","17 Years",{"count":20,"type":21},15,"ESTIMATED","INTERVENTIONAL",[24],"NA","Unilateral spastic cerebral palsy (USCP) is the most common subtype of cerebral palsy and significantly limits upper limb function. Traditional therapies such as constraint-induced movement therapy (CIMT) and bimanual intensive training offer limited benefits. Pharmacologic treatments often produce behavioral side effects and do not address underlying neuro-plastic deficits. There is an unmet need for safe, effective, non-invasive interventions targeting motor recovery through cortical modulation.",[27,28,29],"Cerebral Palsy (CP)","Unilateral Cerebral Palsy","Spastic Cerebral Palsy (sCP)",[31,32,33],"Cerebral Palsy","Spasticity","tDCS","NOT_YET_RECRUITING","2026-05-04",{"date":37,"type":38},"2026-05-07","ACTUAL",{"date":40,"type":21},"2026-04-30",{"date":42,"type":21},"2026-08-31",{"name":44,"class":45},"Riphah International University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":4},"100596168","hemimprove-10-in-children-and-adolescents-with-unilateral-cerebral-palsy-100596168","NCT07041944","HEMImprove 1.0 in Children and Adolescents With Unilateral Cerebral Palsy","\"Efficacy and Usability of HEMImprove 1.0 Gamified Mobile Application for Upper Limb Rehabilitation in Adolescents With Unilateral Cerebral Palsy: A Randomized Controlled Trial\"","HEMImprove-APP","Inclusion Criteria:\n\n* Adolescents aged 12 to 18 years diagnosed with unilateral cerebral palsy.\n* Ability to use the mobile app independently or with minimal assistance.\n* Informed consent provided.\n\nExclusion Criteria:\n\n* Severe cognitive impairment.\n* Recent upper limb surgery (within 6 months).\n* Recent botulinum toxin treatment (within 3 months).\n* Other neurological or orthopedic disorders affecting upper limb function.","12 Years","18 Years",{"count":58,"type":21},36,[24],"This study aims to evaluate the effectiveness and usability of HEMImprove 1.0, a gamified mobile application designed to improve upper limb motor function in adolescents with unilateral cerebral palsy. Participants will be randomly assigned to an intervention group using the app or a control group performing conventional home exercises. The intervention will last four weeks, with assessments before and after the intervention to measure motor function, motivation, and quality of life improvements.",[28],"2026-03-17",{"date":64,"type":38},"2026-03-18",{"date":66,"type":21},"2026-03-01",{"date":68,"type":21},"2027-12-01",{"name":70,"class":45},"University of Castilla-La Mancha",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":79,"sex":16,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":84,"phases":4,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":46},"100621326","neural-correlates-of-goal-directed-action-observation-and-execution-in-children-with-unilateral-cerebral-palsy-100621326","NCT07369167","Neural Correlates of Goal-directed Action Observation and Execution in Children With Unilateral Cerebral Palsy","Neurophysiological, Kinematics and Functional Correlates of Goal-directed Action Observation and Execution in Children With Unilateral Cerebral Palsy","EEG_AINCP","Children with Unilateral Cerebral Palsy\n\nInclusion Criteria:\n\n* Children with confirmed diagnosis of Unilateral Cerebral Palsy,\n* Manual ability levels from I to III in the Manual Ability Classification System (MACS);\n* Children's age from 5 to 15 years old.\n\nExclusion Criteria:\n\n* Severe Upper Limb (UpL) impairment (MACS ≥ level IV: inability to grasp),\n* UpL surgery within 12 months prior to study entry and botulinum toxin injection within 6 months prior to study entry,\n* Severe comobordities,\n* Severe cognitive disability, clinically assessed by the cognitive scales Wechsler, Preschool and Primary Scale of Intelligence (WPPSI-IV) or Wechsler Intelligence Scale for Children (WISC-IV or V).\n\nTypically Developing children:\n\nInclusion Criteria\n\n* 5 to 15 year-old children with typical development,\n* No documented clinically relevant disorders",true,"5 Years","15 Years",{"count":83,"type":21},80,"OBSERVATIONAL","Cerebral palsy (CP) is the most common childhood-onset motor disorder, with Unilateral Cerebral Palsy (UCP)- motor impairment predominantly impacting one side of the body-representing the most frequent form of CP. Among available rehabilitation programs, Action Observation Treatment (AOT) has gained increasing attention for its demonstrated effectiveness in improving manual motor function. AOT involves the systematic observation of goal-directed actions followed by their execution\u002Fimitation and is thought to leverage the mirror mechanism and its role in motor learning. Specifically, it relies on the neurophysiological principle that observing others' actions activates the same neural structures involved in executing those actions, reflecting the engagement of the mirror neuron system (MNS). In children with CP, the feasibility and effectiveness of AOT have been shown functionally (Sgandurra et al., 2013, Buchignani et al., 2019). However, despite its theoretical grounding in MNS functioning, the neurophysiological correlates of this system in children with CP remain less characterized, with only limited investigations using functional neuroimaging (e.g., Sgandurra et al., 2020) or neurophysiological methods such as electroencephalography (EEG; e.g., Demas et al., 2019).\n\nThis observational study aims to characterize the neurophysiological signatures of action execution and action observation in children aged 5-15 years with a diagnosis of UCP compared to a group of age-matched typically developing (TD) peers. To this end, non-invasive high-density EEG (hdEEG) will be used to quantify sensorimotor cortex modulation through mu-rhythm reactivity-specifically event-related desynchronization (ERD) and synchronization (ERS)-and its topographical distribution during an active visuo-motor task involving upper limbs. Mu-rhythm desynchronization (or suppression) over sensorimotor regions is a well-established marker of MNS engagement. A secondary objective is to examine the relationship between EEG measures and participants' attention, upper-limb kinematics, and manual motor function. To this purpose, participants will wear non-invasive wearable sensors to capture arm\u002Fhand kinematics, and attention will be monitored with a non-invasive eye-tracking system. Validated scales will be used to assess manual motor function.\n\nParticipants will take part in one single visit of about 1.5 hours. During the EEG acquisition session, children will wear a 128-channel EEG net and complete an active visuo-motor paradigm including the observation and execution of unimanual and bimanual goal-directed actions (e.g., reaching-grasping). In the observation condition, children will watch videos depicting these actions on a computer screen while refraining from movement. In the subsequent execution condition, they will interact themselves with the same objects as in the observation condition. Throughout the same session, children's attention\u002Fgaze will be tracked via eye-tracking, and upper-limb kinematics will be recorded using wearable inertial measurement unit (IMU) sensors. Before or after EEG acquisition, manual motor function will be assessed using two standardized scales: the Assisting Hand Assessment (AHA) and the Melbourne Assessment-2 (MA-2).\n\nData analysis will characterize the mu rhythm ERD topography and temporal dynamics during both action execution and action observation, within and between groups. Correlation analyses will explore associations between neurophysiological measures, gaze and attentional patterns, kinematic data, and motor assessments scores to elucidate how motor and attentional factors modulate sensorimotor cortical activation.",[27,28,87,88],"EEG","Action Observation",[28,90,87,91,92,93,94,88,95,96],"Mirror Neuron System","Mu rhythm","Sensorimotor","eye-tracker","wearable sensors","manual function","UCP","2026-01-16",{"date":99,"type":38},"2026-01-27",{"date":101,"type":21},"2026-01",{"date":103,"type":21},"2027-07",{"name":105,"class":45},"IRCCS Fondazione Stella Maris",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":110,"acronym":111,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":56,"enrollmentInfo":113,"targetDuration":4,"studyType":22,"phases":115,"briefSummary":116,"conditions":117,"keywords":119,"overallStatus":126,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":46},"100557324","effects-and-mechanisms-of-sensory-afferent-electrostimulation-on-upper-limb-function-in-patients-with-hemiparesis-100557324","NCT06536634","Effects and Mechanisms of Sensory Afferent Electrostimulation on Upper Limb Function in Patients With Hemiparesis","SAES","Inclusion Criteria:\n\n* Diagnosis of unilateral cerebral palsy\u002Fhemiparesis, following unilateral brain lesion, e.g. perinatal\u002Fchildhood stroke (acquired prior to the age of 16 years)\n* consistent and stable limitation of hand functions\n* chronic state (time since lesion \\>2 years)\n* aged 6-18 years\n* parental informed consent if \\\u003C14 years, informed consent of the patient if \\>14 years\n\nExclusion criteria:\n\n* psychiatric disease that prevents the participant form informed participation and compliance in an adequate manner\u002Fsetting\n* Bilateral brain lesion\n* Recent Botulinum toxin-injections injections (UL, \\\u003C 6 months)\n* Hand surgery on paretic hand \\\u003C 2 years\n* Trauma to UL in the last year\n* Medical conditions that prevent training of the UL\n* Participation in other afferent stimulation studies\n* Electrical stimulation therapy in the last 6 months\n* Intensive training of the UL (therapy more than 1x\u002Fweek, \\\u003C 6 months)\n\nIf MRI and TMS is performed, additionally:\n\n• MRI and TMS contradictions, such as\n\n* implanted Metal devices (e.g. braces, implant)\n* implanted shunt system\n* in girls and women: pregnancy\n* claustrophobia\n* Active epilepsy",{"count":114,"type":21},34,[24],"The goal for this project is to investigate the effects of a 5-week SAES therapy in addition to conventional therapy on both behavioural (sensory and motor) and neurological measures and the underlying mechanisms of treatment response.\n\nThe goal of this project to investigate the effects of a 5-week SAES therapy in addition to conventional therapy.\n\nThe aim is to investigate whether SAES is more effective than conventional therapy alone in children with hemiparesis. The investigators will assess the efficacy of SAES using novel clinical assessment such as kinematic evaluations and modern neurophysiological measures, namely transcranial magnetic stimulation (TMS) and resting-state functional MRI (rs-fMRI).\n\nIt will be expected a benefit for children with hemiparesis after SAES training which may lead to improved bimanual and unimanual functions. Benefits have been reported in adults and in preliminary studies also in children.\n\nType of study: Randomised controlled clinical trial\n\nParticipants with hemiparesis will be included in the study. The study group will receive the SAES training with a glove or adhesive electrodes as a home-based training during 30 minutes per day, 5x\u002Fweek, for 5 weeks, combined with conventional occupation therapy.\n\nResearchers will compare the SAES group with a group of patients with comparable conditions who receive the prescribed conventional occupational therapy and\u002For physiotherapy (treatment as usual, TAU)",[118,28],"Hemiparesis",[120,121,122,123,124,125],"Sensory afferent electrostimulation","MRI","TMS","Motor function","Sensory function","Sensor","RECRUITING","2025-11-17",{"date":129,"type":38},"2025-11-20",{"date":131,"type":38},"2025-01-01",{"date":133,"type":21},"2027-10-01",{"name":135,"class":45},"Insel Gruppe AG, University Hospital Bern",{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":140,"acronym":4,"eligibilityCriteria":141,"healthyVolunteers":11,"sex":16,"minAge":142,"maxAge":143,"enrollmentInfo":144,"targetDuration":4,"studyType":22,"phases":146,"briefSummary":147,"conditions":148,"keywords":4,"overallStatus":126,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":46},"100522484","school-readiness-in-preschool-aged-children-with-cerebral-palsy-100522484","NCT06083220","School Readiness in Preschool-Aged Children With Cerebral Palsy","Inclusion Criteria:\n\n* ages 3 years to 5 years 11 months\n* unilateral cerebral palsy\n* ability to visually attend to objects\n* demonstrates an interest in objects\n* attempt to reach for or grasp an item with the impaired upper extremity\n* English-speaking participants\n\nExclusion Criteria:\n\n* uncontrolled epilepsy\n* significant visual impairment\n* severe behavioral problems\n* inability to complete the assessment protocol","36 Months","71 Months",{"count":145,"type":21},20,[24],"The goal of this feasibility and proof of concept study is to learn about the feasibility, acceptability, and impact of a school readiness program for preschool-aged children with unilateral cerebral palsy. The main question\\[s\\] it aims to answer are:\n\n1. Is it feasible to implement an intensive school readiness program for preschool-aged children with UCP?\n2. Is the program acceptable to the children and their caregivers?\n3. What is the impact of the program on school readiness?\n\nParticipants will complete two pre-intervention assessments, participate in an intensive, goal directed, school readiness program, and complete 1 post-intervention assessment.",[28,149],"School Readiness","2025-04-07",{"date":152,"type":38},"2025-04-08",{"date":154,"type":38},"2023-12-12",{"date":156,"type":21},"2026-07",{"name":158,"class":45},"Texas Scottish Rite Hospital for Children",{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":165,"eligibilityCriteria":166,"healthyVolunteers":11,"sex":16,"minAge":167,"maxAge":168,"enrollmentInfo":169,"targetDuration":4,"studyType":22,"phases":171,"briefSummary":174,"conditions":175,"keywords":176,"overallStatus":126,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":46},"100583162","phase-2-wereables-for-upper-limb-functionality-in-hemiparesis-100583162","NCT06872736","Wereables for Upper Limb Functionality in Hemiparesis","Innovative Use of Wereable Technology for Improving Functionality in Children with Unilateral Cerebral Palsy","WeFun","Inclusion Criteria:\n\n* Confirmed diagnosis of UCP.\n* Children aged between 3 and 8 years old.\n* Children rated on levels I to III on the Manual Ability Classification System (MACS).\n\nExclusion Criteria:\n\n* Botulinum toxin injection or surgical interventions in the upper limb within 6 months prior to study entry.\n* Medical complications non-controlled that would interfere with study participation (e.g., not controlled epilepsy).\n* Predominantly athetoid or dystonia movement patterns.\n* Insufficient cognitive level to follow instructions,\n* Non-corrected marked visual impairments.\n\nFamilies can be retired from the study after starting if:\n\n* Families don't assist or don't collaborate in the weekly sessions with the reference person.\n* Wearable activity if presumably lower than expected (few recordings of activity, \\\u003C20%).\n* Families don't provide feedback about daily sessions through the satisfaction system in the app\u002Fregistration sheet.","3 Years","8 Years",{"count":170,"type":21},40,[172,173],"PHASE2","PHASE3","The project is configured as a national interventional study that aims to determine the effectiveness of an intervention strategy using wearable technology, tailored to improve function (WeFun-wearable), on the spontaneous use of the affected upper extremity, activities of daily living and the participation in children with unilateral cerebral palsy.",[28],[177,178,179,180,181,182,183,184,185,186,187,188,189,190,191,192,193,194,195,196,197,198,199],"children","unilateral cerebral palsy","function","mobility","upper limb","weareable","technology","routines","family centered approach","activity","participation","family","developmental disregard","environmental enrichment","natural environment","quality of life","movement analysis","fatigue","upper extremity","family involvement in research","hemiparesis","cerebral palsy","early intervention","2025-03-07",{"date":202,"type":38},"2025-03-12",{"date":204,"type":38},"2024-06-07",{"date":206,"type":21},"2026-12-20",{"name":208,"class":45},"Universidade da Coruña",{"id":210,"slug":211,"hasResults":11,"nctId":212,"briefTitle":213,"officialTitle":214,"acronym":215,"eligibilityCriteria":216,"healthyVolunteers":79,"sex":16,"minAge":80,"maxAge":81,"enrollmentInfo":217,"targetDuration":4,"studyType":84,"phases":4,"briefSummary":219,"conditions":220,"keywords":221,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":233,"lastUpdatePostDateStruct":234,"startDateStruct":236,"completionDateStruct":237,"leadSponsor":239,"locationsCount":240},"100521740","validation-of-ai-for-personalized-assessment-and-rehabilitation-of-upper-limb-in-children-with-unilateral-cerebral-palsy-100521740","NCT06073522","Validation of AI for Personalized Assessment and Rehabilitation of Upper Limb in Children With Unilateral Cerebral Palsy","Clinical Validation of Artificial INtelligence for Providing a Personalized Motor Clinical Profile Assessment and Rehabilitation of Upper Limb in Children With Unilateral Cerebral Palsy","AInCP","For the group of children with UCP:\n\nInclusion criteria\n\n* Children with confirmed diagnosis of UCP mainly spastic form\n* Ages from 5 to 15 years old\n* Manual ability levels from I to III in the Manual Ability Classification System (MACS) Exclusion criteria\n* Severe Upper Limb (UpL) impairment (MACS ≥ level IV: inability to grasp)\n* Botulinum toxin-A injections in UpL within 6 months prior to study entry\n* UpL surgery within 12 months prior to study entry\n* Severe comobordities and\u002For severe cognitive disability\n\nFor Typically developing children:\n\n* Ages from 5 to 15 years old\n* No documented clinically relevant disorders",{"count":218,"type":21},500,"Unilateral Cerebral palsy (UCP) is the most common neurological chronic disease in childhood with a significant burden on children, their families and health care system.\n\nAInCP aims to develop evidence-based clinical Decision Support Tools (DST) for personalized functional diagnosis, Upper Limb (UpL) assessment and home-based intervention for children with UCP, by developing, testing and validating trustworthy Artificial Intelligence (AI) and cost-effective strategies. The AInCP approach will: i) establish a clinical diagnosis and accurate prognosis for treatment response of individual UCP profiles, by employing a multimodal approach including clinical phenotyping, advanced brain imaging and real-life monitoring of UpL function, and ii) provide personalized home-based treatment, from advanced ICT and AI technologies.\n\nThe AInCP will build upon personalized diagnostic and rehabilitative DST (dDST and rDST) to be developed and validated through large observational and rehabilitation studies, including at least 200 and 150 children with UCP, respectively. Using data driven and AI approach, dDST and rDST will be combined for developing a theranostic DST (tDST) that will allow the re-designing of an economical, ethical, sustainable decision-making process for delivering a personalized and validated approach, focused on the care, monitoring and rehabilitation of UpL in children with UCP. AInCP is a significant example of a transdisciplinary approach, where all project collaborators (clinicians, data scientists, physicists, engineers, economists, ethicists, SMEs, children and parent associations) will work closely together in building the AInCP approach. This approach will, therefore, hinge on transdisciplinary contributions, multi- dimensional data, sets of innovative devices and fair AI-based algorithms, clinically effective and able to reduce users? and market barriers of acceptability, reimbursability and adoption of the proposed solution.",[28],[31,222,223,224,225,226,227,228,229,230,231,232],"Paediatric Stroke","Predictive Biomarkers","Brain structure","Upper limb assessment","Upper limb Rehabilitation","Machine Learning","Data science","Telerehabilitation","Multi agent systems","intelligent systems","Artificial intelligence","2023-10-07",{"date":235,"type":38},"2023-10-10",{"date":235,"type":21},{"date":238,"type":21},"2027-06-30",{"name":105,"class":45},2]