[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"unilateral-spatial-neglect-usn\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:unilateral-spatial-neglect-usn":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,48,78,109],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100615254","tridimensional-robotic-assessment-of-neglect-in-brain-injured-patients-100615254",false,"NCT07290218","Tridimensional Robotic Assessment of Neglect in Brain Injured Patients","NEGLECTARM3D","Inclusion Criteria:\n\n* Age \\> 18 years;\n* Diagnosis of ischemic or hemorrhagic stroke;\n* Diagnosis of Unilateral Spatial Neglect (assessed by The Hearts Test, Oxford Cognitive Screen, cut-off ± 2);\n* Signed informed consent form.\n\nExclusion Criteria:\n\n* Presence of language deficits (inability to complete the OCS test);\n* Presence of cognitive decline prior to the stroke event;\n* Presence of severe visual and\u002For hearing impairments;\n* Language barriers;\n* Orthopedic, neurological, or psychiatric conditions that could interfere with the study or with the assessment of motor and cognitive function;\n* Uncontrolled epilepsy despite antiepileptic treatment;\n* Behavioral disorders that may interfere with study participation;\n* Presence of medical devices whose functioning could be compromised (e.g., pacemaker, etc.);\n* Object-centered neglect (assessed by the OCS Hearts Test; object asymmetry ± 2).","ALL","18 Years",{"count":19,"type":20},15,"ESTIMATED","OBSERVATIONAL","The goal of this clinical trial is to assess the usability and feasibility of a robotic and virtual reality-based system called NeglectARm 3D for the three-dimensional assessment of unilateral spatial neglect (USN) in patients with brain injury due to ischemic or hemorrhagic stroke.\n\nThe main questions it aims to answer are:\n\n* Is the NeglectARm 3D system usable and feasible for patients with USN?\n* Do the robotic measurements show preliminary reliability and validity compared with conventional clinical neglect assessments (e.g., BIT, CBS)?\n\nParticipants will:\n\n* Perform two assessment sessions, three weeks apart (T0 and T1);\n* Interact with the NeglectARm 3D system using a robotic end-effector and a VR headset to reach sequentially presented targets in a 3D virtual space;\n* Receive robotic assistance if targets are not reached, allowing the system to record trajectories, spatial positions, and assistance applied;\n* Complete standard clinical neglect tests to enable comparison between robotic and conventional measures.\n\nThis study aims to develop a repeatable, standardized, and objective tool for the assessment of USN in patients with brain injury, potentially improving evaluation of depth perception and spatial attention deficits.",[24,25,26,27,28],"Neglect","Brain Injured Patients","Stroke","Unilateral Spatial Neglect (USN)","Post-stroke Cognitive Impairment",[24,30,31,32,33,34],"Brain injured patients","Tridimensional robotic assessment","Force-sensitive robot system","Virtual reality (VR) headset","Collaborative robotic system","NOT_YET_RECRUITING","2025-12-04",{"date":38,"type":39},"2025-12-18","ACTUAL",{"date":41,"type":20},"2026-01-01",{"date":43,"type":20},"2026-11-30",{"name":45,"class":46},"Fondazione Don Carlo Gnocchi Onlus","OTHER",3,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":57,"conditions":58,"keywords":62,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":77},"100615002","evaluation-of-the-variation-over-time-of-visuospatial-deficit-in-patients-with-parietal-lobe-glioma-100615002","NCT07286929","Evaluation of the Variation Over Time of Visuospatial Deficit in Patients With Parietal Lobe Glioma","neGLIO","Inclusion Criteria:\n\n* Patients \\>18 years old\n* Patients must understand the Italian Language\n* Patients with suspected parietal lobe glioma\n\nExclusion Criteria:\n\n* Tumor site other than parietal lobe.\n* Patients who cannot undergo surgical resection (stereotactic\u002Fopen biopsy).\n* Patients who received a previous chemotherapy and\u002For radiotherapy treatment.\n* Patients with a history of intracranial mass lesion or traumatic brain injury.\n* Patients with a history of other CNS diseases (e.g., stroke, metastasis).\n* Patients with diagnosis of neurodegenerative disease (i.e. Alzheimer's Disease, Frontotemporal Dementia, Parkinson's Disease, Lewy Body Dementia, Amyotrophic Lateral Sclerosis).",{"count":56,"type":20},40,"The goal of modern neurooncological surgery is to obtain maximum tumor resection while preserving neurological function. Parietal lobe gliomas often cause attention deficits (hemineglect) that are difficult to differentiate from other deficits. This study aims to evaluate the extent and variation over time of visuo-spatial deficits in patients undergoing surgical removal of parietal lobe gliomas. This will help characterize the cognitive profile of these patients to identify personalized treatment and rehabilitation paths.",[59,60,61,27],"Glioma","Parietal Lobe Glioma","Visuspatial Deficit",[63,59,64,65,66],"Visuospatial deficit","Parietal Lobe","Neuropsychological assessment","Hemineglect","RECRUITING","2025-12-03",{"date":70,"type":39},"2025-12-16",{"date":72,"type":39},"2024-12-03",{"date":74,"type":20},"2026-10",{"name":76,"class":46},"Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta",1,{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":93,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":108},"100577735","rehabilitation-methods-for-unilateral-spatial-neglect-in-stroke-patients-100577735","NCT06802159","Rehabilitation Methods for Unilateral Spatial Neglect in Stroke Patients","A Comparative Analysis of Methods for Rehabilitation of Unilateral Spatial Neglect (USN) in Stroke Patients: Conventional Therapy, Computerized Cognitive Training and Eye Movement Biofeedback Training","Inclusion Criteria:\n\n* Normal cognitive development in accordance with age and educational level;\n* diagnosis with codes I63, I61 (ICD);\n* presence of unilateral spatial neglect syndrome in the neuropsychological status.\n\nExclusion Criteria:\n\n* presence of mental and somatic pathology of severe degree and in decompensation stage;\n* the presence of gross oculomotor disorders;\n* presence of a sensory visual defect of moderate to severe severity","80 Years",{"count":87,"type":20},30,"INTERVENTIONAL",[90],"NA","Stroke remains one of the leading causes of mortality and disability worldwide. Between 30% and 40% of patients who have had an acute cerebral hemorrhage, develop unilateral spatial neglect syndrome (USN).\n\nUSN is observed in 24% of patients with left-hemispheric stroke and 45% of patients with right-hemispheric lesions in the acute phase acute phase and in 20% of patients in the chronic phase.\n\nThe presence of USN significantly complicates the rehabilitation process and negatively affects the functional outcomes. The complexity of USN correction is due to the heterogeneity of its manifestations and combination with other cognitive disorders. In 30-50% of patients with USN anosognosia is observed, in 60% - memory and attention disorders.\n\nTraditional methods of rehabilitation lead to significant improvement in 30-50% of patients with USN. The use of combined methods of treatment, including pharmacotherapy and non-medication methods, can improve efficacy by up to 70-80%. This indicates the need to develop and investigate new approaches to correct USN.\n\nDespite the growing number of studies in this area, there is still no unified approach to selecting the optimal method of USN correction for each individual patient.\n\nDifferent methods of rehabilitation may have different effects on neuroplasticity processes, which opens new perspectives for optimization of rehabilitation strategies.",[27],[94,95,96,97,98],"Unilateral spatial neglect","stroke","rehabilitation","eye-tracking","computerized cognitive training","2025-06-17",{"date":101,"type":39},"2025-06-22",{"date":103,"type":39},"2025-01-09",{"date":105,"type":20},"2025-12-15",{"name":107,"class":46},"Federal Center of Cerebrovascular Pathology and Stroke, Russian Federation Ministry of Health",2,{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":117,"targetDuration":4,"studyType":88,"phases":118,"briefSummary":119,"conditions":120,"keywords":123,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":108},"100594261","immersive-functional-virtual-reality-in-people-with-acquired-brain-injury-and-unilateral-spatial-neglect-100594261","NCT07017140","Immersive Functional Virtual Reality in People With Acquired Brain Injury and Unilateral Spatial Neglect","Immersive Functional Virtual Reality in People With Acquired Brain Injury and Unilateral Spatial Neglect: A Feasibility and Usability Study","REVINE","Inclusion Criteria:\n\n* Age 18 years or older.\n* Diagnosis of acquired brain injury (stroke or traumatic brain injury) in the subacute phase (\\>7 days to 6 months) or chronic phase (\\>6 months).\n* Presence of unilateral spatial neglect, defined as omission of 6 or more bells on the left hemifield in the Bells Cancellation Test.\n* Currently receiving care at the Outpatient Rehabilitation Service of the Consorci Hospitalari de Vic or at Vall d'Hebron University Hospital, or listed in the historical patient registry of these centers.\n* Presence of mild to moderate upper limb impairment, defined as a score \\>29 on the Fugl-Meyer Upper-Extremity scale.\n* Medically stable and eligible to begin a rehabilitation program.\n* Willing to participate in the study and able to provide signed informed consent.\n\nExclusion Criteria:\n\n* Delirium and\u002For behavioral disturbances that prevent the participant from following simple instructions.\n* Severe cognitive impairment, defined as a Mini-Mental State Examination (MMSE) score below 18, that interferes with the use of virtual reality.\n* Severe visual and\u002For auditory impairment that prevents the use of immersive VR goggles.\n* Severe language comprehension difficulties that interfere with the instructions during the intervention.\n* Hypersensitivity that prevents the placement of the VR headset.\n* Headache or dizziness induced by the use of VR goggles.\n* History of photosensitive epilepsy.",{"count":87,"type":20},[90],"Unilateral spatial neglect (USN) is a common and highly disabling condition following acquired brain injury (ABI), significantly impairing individuals' ability to perform daily activities and reducing their autonomy. It frequently affects patients who have suffered a stroke or traumatic brain injury, and it is often associated with worse functional outcomes and increased care needs. Despite advances in neurorehabilitation, conventional assessment and treatment tools for USN have shown limitations in sensitivity and ecological validity.\n\nImmersive Functional Virtual Reality (IFVR) is an emerging and promising technology that creates controlled, interactive environments, facilitating both assessment and rehabilitation in a motivating and safe way. The REVINE study explores the feasibility, usability, and preliminary clinical effects of an immersive VR-based intervention tailored to address motor and spatial deficits in adults with ABI and USN.\n\nThis is a prospective, non-controlled feasibility study using a single-group interrupted time series design. Participants (N=30) will be recruited from two neurorehabilitation services in Catalonia (Spain): the Neurological Rehabilitation and Brain Injury Unit at Vall d'Hebron University Hospital and the Outpatient Rehabilitation Service at Consorci Hospitalari de Vic. Eligible participants will be adults with ABI in the subacute or chronic phase, presenting USN (as measured by the Catherine Bergego Scale and the Bells Cancellation Test) and mild-to-moderate upper limb impairment.\n\nThe intervention consists of 12 supervised individual IFVR sessions (30 minutes\u002Fsession, 3 times\u002Fweek for 4 weeks), using the KINESIX system (NeuroGroup XR Inc., Montreal, Canada). A progressive series of gamified tasks will be delivered through immersive VR, targeting spatial exploration and upper limb function, with adjustable difficulty and real-time feedback.\n\nParticipants will undergo three pre-intervention and three post-intervention evaluations, spaced one month apart. Clinical outcomes include the degree of USN (measured by the Catherine Bergego Scale, the Bells Cancellation Test, and the KINESIX light-reaching test), usability (System Usability Scale), and satisfaction (User Satisfaction Evaluation Questionnaire). Feasibility outcomes include recruitment and retention rates, adherence to treatment, session completion times, adverse events, and therapist assistance level.\n\nWe hypothesize that IFVR will be a viable and well-accepted intervention, with high user satisfaction, minimal adverse effects, and measurable improvements in neglect-related outcomes. This study aims to inform the future design of larger-scale trials and support the integration of IFVR into routine neurorehabilitation settings or home-based telerehabilitation programs.",[121,27,26,122],"Acquired Brain Injury Including Stroke","Traumatic Brain Injury",[124,125,95,126,127,128,129],"acquired brain injury","unilateral spatial neglect","traumatic brain injury","cognitive and motor rehabilitation","virtual reality-based therapy","virtual reality","2025-06-10",{"date":132,"type":39},"2025-06-12",{"date":134,"type":20},"2025-10-01",{"date":136,"type":20},"2029-02-01",{"name":138,"class":46},"University of Vic - Central University of Catalonia"]