[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"unstable-angina-ua\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:unstable-angina-ua":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,51,78,117],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":30,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100545664","diagnostic-performance-of-artificial-intelligence-algorithms-in-prediction-of-acute-coronary-syndrome-based-on-white-blood-cell-properties-100545664",false,"NCT06384846","Diagnostic Performance of Artificial Intelligence Algorithms in Prediction of Acute Coronary Syndrome Based on White Blood Cell Properties","Diagnostic Performance of Artificial Intelligence Algorithms in Prediction of Acute Coronary Syndrome Based on White Blood Cell Properties (AI-ACS Trial)","Inclusion Criteria:\n\nGeneral inclusion criteria:\n\n* Male or female, aged 18 years or above.\n* Participant is willing and able to give informed consent for participation in the study.\n* Collection of WBC and hs-cTn data must be possible.\n* Criteria for timing of blood sampling for collection of WBC and hs-cTn data must be fulfilled, where applicable.\n\nCase cohort:\n\n* Suspicion of STEMI or NSTE-ACS according to current ESC guidelines.\n* Coronary angiography must have been performed within 72 hours after initial suspicion of ACS.\n* For patients qualifying for observation according to ESC guidelines, coronary angiography is not mandatory and time limits do not apply.\n* Confirmation of STEMI or NSTE-ACS by identification of a culprit lesion using coronary angiography; identical evaluation results by review board required.\n* For observation patients without coronary angiography, final discharge diagnosis is used to decide about the presence or absence of NSTEMI and\u002For ACS.\n* Criteria for timing of blood sampling for collection of WBC and hs-cTn data must be fulfilled.\n\nControl cohort:\n\n* Suspicion of STEMI or NSTE-ACS according to current ESC guidelines.\n* Coronary angiography must have been performed within 72 hours after initial suspicion of ACS.\n* No identification of a culprit lesion compatible with diagnosis of STEMI or NSTE-ACS during coronary angiography; identical evaluation results by review board required.\n* Criteria for timing of blood sampling for collection of WBC and hs-cTn data must be fulfilled.\n\nSupplementary cohort:\n\n* Subject presents without chest pain or with stable angina pectoris.\n* No indication for revascularization during coronary angiography; identical evaluation results by review board required.\n* Exclusion of elevated hs-cTn.\n* Criteria for timing of blood sampling for collection of WBC and hs-cTn data must be fulfilled.\n* Between initial blood sampling to collect WBC data and coronary angiography, the subject must not develop suspicion of ACS.\n\nRule-out cohort:\n\n* Suspicion of NSTE-ACS and NSTEMI rule-out according to current ESC guidelines, i.e. very low initial hs-cTn value, or low initial hs-cTn value and no significant 1-hour\u002F2-hour change in hs-cTn value.\n* No coronary angiography within 72 hours.\n* Criteria for timing of blood sampling for collection of WBC and hs-cTn data must be fulfilled.\n\nAll-comer cohort:\n\n* Subject presents to the emergency department with suspected ACS.\n* Clinical assessments, ECG, and measurements of hs-cTn, single or serial measurement, must be conducted according to ESC guidelines.\n* Collection of WBC data must be performed at initial blood withdrawal after admission to the emergency department.\n* Review board evaluations must confirm the presence or absence of a culprit lesion if coronary angiography was performed, as outlined for the case and control cohorts.\n\nExclusion Criteria:\n\n* Age below 18 years.\n* Subject refuses informed consent.\n* Collection of WBC and hs-cTn data is not possible.\n* Criteria for timing of blood sampling for collection of WBC and hs-cTn data cannot be fulfilled.\n* Suspicion of ACS occurs in subjects with no or stable angina pectoris any time between initial blood sampling and start of coronary angiography.",true,"ALL","18 Years",{"count":20,"type":21},3350,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to evaluate whether artificial intelligence (AI) algorithms can predict or exclude acute coronary syndrome (ACS) in adults using data generated by routine hematology testing. The main questions the study aims to answer are:\n\n* Can AI algorithms based on white blood cell (WBC) data predict or exclude ACS in subjects with suspected ACS?\n* Can erythrocyte (EC) and\u002For thrombocyte (TC) data, where available, improve or complement WBC-based AI prediction of ACS?\n* How does the diagnostic performance of the AI algorithms compare with high-sensitivity cardiac troponin (hs-cTn), and can the combination of AI algorithms and hs-cTn improve diagnostic performance?\n\nParticipants will undergo clinical assessment and blood testing as part of usual clinical care. Their previously generated clinical information, hematology data, and hs-cTn results will be used to train and test the AI algorithms. Participation in the study does not determine the indication for coronary angiography or treatment, and no additional study-specific treatments are performed.",[25,26,27,28,29],"Acute Coronary Syndrome","Angina Pectoris","NSTEMI - Non-ST Segment Elevation MI","STEMI - ST Elevation Myocardial Infarction","Unstable Angina (UA)",[31,32,33,34,35,36,37],"Artificial Intelligence","AI","hematology analyzer","ACS","white blood cell","Troponin","Machine learning","RECRUITING","2026-06-21",{"date":41,"type":42},"2026-06-24","ACTUAL",{"date":44,"type":42},"2024-02-01",{"date":46,"type":21},"2026-12-31",{"name":48,"class":49},"RobotDreams GmbH","INDUSTRY",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":50},"100602413","oregano-and-basil-leaves-and-coronary-artery-disease-100602413","NCT07123181","Oregano and Basil Leaves and Coronary Artery Disease","Effects of Increasing Polyphenol Intake by Consumption of Oregano and Basil Leaves on Plasma Inflammatory and Lipid Factors and Total Urinary Polyphenol in Patients With Unstable Angina","Inclusion Criteria:\n\n* Patients diagnosed with unstable angina\n\nExclusion Criteria:\n\n* Patients diagnosed with STEMI\n* Patients undergoing coronary artery bypass grafting\n* Liver cirrhosis and advanced chronic kidney disease (CKD 5)\n* Having known inflammatory and autoimmune diseases, such as inflammatory bowel disease (IBD) and rheumatoid arthritis, or taking glucocorticoid medications\n* Pregnancy or breastfeeding","30 Years","75 Years",{"count":61,"type":21},70,"INTERVENTIONAL",[64],"NA","The present study will examine the effects of increasing dietary polyphenol intake by consumption of oregano and basil leaves, on plasma inflammatory and lipid factors and total urinary polyphenol levels in patients who have recently had unstable angina.",[67,29],"Acute Coronary Syndromes","2026-06-13",{"date":70,"type":42},"2026-06-16",{"date":72,"type":42},"2025-09-01",{"date":74,"type":21},"2026-10-22",{"name":76,"class":77},"Shahid Beheshti University of Medical Sciences","OTHER",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":62,"phases":88,"briefSummary":89,"conditions":90,"keywords":92,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":50},"100592685","breaking-fasts-ahead-of-cardiac-caths-100592685","NCT06996639","Breaking Fasts Ahead of Cardiac Caths","Breaking Fasts Ahead of Cardiac Caths: an Open Label Non-Blinded RCT (BACON-RCT)","BACON-RCT","Inclusion Criteria:\n\n* All scheduled urgent inpatient non-high risk cardiac catheterizations for worsening angina (cardiac chest pain or anginal equivalent), unstable angina, or non-high risk NSTEMI-NSTEMI's with GRACE score \\\u003C140 points) utilizing proceduralist guided sedation\n\nExclusion Criteria:\n\n* High risk NSTEMI's defined as NSTEMI's with a GRACE score \\>140 points\n* Hemodynamic instability (\\\u003CSBP 90)\n* Unstable arrythmias\n* Chest pain refractory to nitroglycerin drip\n* New ejection fraction less than 25%\n* Evidence of severe decompensated heart failure on presentation requiring BiPAP or mechanical intubation\n* Inability to consent\n* Patients \\\u003C18 years old\n* Pregnant patients\n* Need for general anesthesia\n* Acute hypoxic respiratory failure requiring \\>6L Nasal Cannula Supplementation, BiPAP, or invasive ventilation\n* Emergent interventions: STEMI\u002Fhigh risk NSTEMI\n* Need for mechanical circulatory support-ECMO, Impella or intra-aortic balloon pump",{"count":87,"type":21},400,[64],"The goal of this clinical trial is to find out whether fasting is necessary before urgent inpatient cardiac catheterizations. For patients presenting with urgent heart-related pain or even mild heart attacks, researchers want to know whether eating and drinking before their procedure improves comfort without raising the risk of complications.\n\nThe study will answer:\n\n* Does eating and drinking before the procedure improve patient comfort?\n* Does it increase the risk of adverse events like vomiting, aspiration (food or liquid entering the lungs), breathing problems, or death, etc?\n\nParticipants will be randomly assigned to either:\n\n* A standard fasting group (no food for 6 hours, no clear liquids for 2 hours), or\n* A no-fasting group (able to eat and drink as usual).\n\nPatients will complete brief surveys before the procedure to assess comfort and satisfaction. Researchers will also review medical records weekly and 30 days later to monitor for safety outcomes.",[91,29,27],"Stable Angina (SA)",[93,94,95,34,96,97,98,99,100,25,101,102,103,104,105,106,107],"Fasting","NPO","Cardiac Catheterization","Angina","Unstable Angina","Worsening Angina","Low Risk NSTEMI","NSTEMI","Urgent Cardiac Catheterization","Patient satisfaction","Periprocedural care","Non-fasting","Safety outcomes","Pre-procedural protocol","Survey-based research","2025-12-08",{"date":110,"type":42},"2025-12-16",{"date":112,"type":42},"2025-10-13",{"date":114,"type":21},"2026-07",{"name":116,"class":77},"University of South Florida",{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":4,"eligibilityCriteria":123,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":124,"targetDuration":126,"studyType":22,"phases":4,"briefSummary":127,"conditions":128,"keywords":4,"overallStatus":129,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":4},"100582816","scientific-rationale-and-design-for-a-prospective-study-to-codify-coronary-lesions-based-on-fluid-mechanics-and-acoustic-mechanisms-100582816","NCT06868225","Scientific Rationale and Design for a Prospective Study to Codify Coronary Lesions Based on Fluid Mechanics and Acoustic Mechanisms","Prospective Study to Codify Coronary Lesions Based on Fluid Mechanics and Acoustic Mechanisms","Inclusion Criteria: Patients were included in the study if they had one or two lesions in coronary angiograms. -\n\nExclusion Criteria: Patients with history of prior percutaneous coronary intervention (PCI), coronary artery bypass graft surgery (CABG) were excluded.\n\n\\-",{"count":125,"type":21},100,"3 Months","From January 2020 to June 2025, patients coming to the cardiac catheterization laboratories (CCL) for out-patient coronary angiography with diagnosis of unstable angina were screened for inclusion. Patients were included in the study if they had previously undergone one or more coronary angiograms, allowing for a longitudinal comparison of dynamic flow and phenomena between the two or more angiograms.",[29],"NOT_YET_RECRUITING","2025-04-14",{"date":132,"type":42},"2025-04-17",{"date":134,"type":21},"2025-04-20",{"date":136,"type":21},"2025-08-30",{"name":138,"class":77},"Tan Tao University, School of Medicine"]