[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"upper-abdominal-malignancies\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:upper-abdominal-malignancies":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":5},"100543440","liver-volume-variation-effect-on-sbrt-planning-and-delivery-for-upper-abdominal-malignancies-100543440",false,"NCT06355895","Liver Volume Variation Effect on SBRT Planning and Delivery for Upper Abdominal Malignancies","The Effect of Liver Volume Variation on Stereotactic Body Radiation Therapy (SBRT) Planning and Delivery for Upper Abdominal Malignancies","Inclusion Criteria:\n\n• Have primary upper abdominal (pancreatic, bile duct, liver) cancer or upper abdominal metastases (liver, adrenal, upper abdominal lymph nodes) planned to undergo SBRT.\n\nExclusion Criteria:\n\n* Had prior Radiation Therapy to the liver\n* Contraindication to receipt of iodinated IV contrast for CT (such as renal insufficiency or allergy that cannot be overcome by premedication)\n* Pregnancy\u002Flactation OR woman of childbearing potential who is unable or unwilling to use adequate contraception during Radiation Therapy.\n* Inability to fast.","ALL","18 Years",{"count":19,"type":20},17,"ESTIMATED","INTERVENTIONAL",[23],"NA","Standard planning constraints for liver SBRT incorporate strict dose-volume limits for normal liver parenchyma to minimize the risk of radiation-induced liver disease. The presence of diurnal and fasting\u002Ffed variations in liver volume therefore carry substantial potential for introducing errors into estimates of dose-volume distribution within normal liver tissue, as well as affecting day-to-day setup fidelity and organ alignment for treatment. This prospective study will examine how diurnal and fast-fed variations in liver volume affect treatment planning for abdominal SBRT.",[26],"Upper Abdominal Malignancies",[28,29],"Stereotactic Body Radiation Therapy (SBRT)","Four-Dimensional Computed Tomography","RECRUITING","2026-06-08",{"date":33,"type":34},"2026-06-11","ACTUAL",{"date":36,"type":34},"2024-05-16",{"date":38,"type":20},"2028-03-31",{"name":40,"class":41},"University of Pittsburgh","OTHER"]