[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"upper-extremity-dysfunction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:upper-extremity-dysfunction":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,54,88,117,144,172,193],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":33,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100488290","nerve-transfer-surgery-to-restore-upper-limb-function-after-cervical-spinal-cord-injury-100488290",false,"NCT05638191","Nerve Transfer Surgery to Restore Upper-limb Function After Cervical Spinal Cord Injury","Inclusion Criteria:\n\n* Traumatic, motor-complete cervical SCI (AIS A or B)\n* Male or female, ages 18-70\n* Consent and plan to undergo nerve transfer to restore grasp function in at least one limb\n* Motor grade 4-5 at C5\n* Motor grade 0-1 at C8\u002FT1\n* Injury duration within 6 months at the time of surgery\n* English-speaking and cognitively intact\n* Able to provide informed written consent\n* Able to attend and comply with the testing protocols\n\nExclusion Criteria:\n\n* Inability or unwillingness to participate in post-operative rehabilitation (in person or virtual)\n* Secondary complication of SCI (e.g., intractable neuropathic pain, edema, contracture) or major medical comorbidity (e.g., traumatic brain injury) that would independently influence response to surgery or ability to participate in rehabilitation","ALL","18 Years","70 Years",{"count":19,"type":20},40,"ESTIMATED","2 Years","OBSERVATIONAL","The goal of this prospective, open-label cohort study is to assess functional outcomes in individuals with cervical spinal cord injury who have undergone nerve transfer surgery to restore upper limb function. The main questions it aims to answer are:\n\n* Does nerve transfer improve hand function in individuals with cervical spinal cord injury?\n* What factors are associated with functional improvement following nerve transfer? Researchers will compare functional outcomes at 24 months post-surgery to 1) baseline outcomes and 2) individuals with cervical spinal cord injury who did not undergo nerve transfer.\n\nParticipants who have received nerve transfer surgery as part of their regular medical care will complete functional hand tests, electrodiagnostic assessments, and questionnaires on independence and mood every 3 months for 24 months after surgery.",[25,26,27,28,29,30,31,32],"Spinal Cord Injury","Spinal Cord Injury at C5-C7 Level","SCI - Spinal Cord Injury","Upper Extremity Paralysis","Upper Extremity Dysfunction","Tetraplegia","Upper Extremity Paresis","Cervical Spinal Cord Injury",[34,35,36,37,38,39,40],"spinal cord injury","upper extremity nerve transfer","nerve transfer","SCI","nerve reconstruction","quadriplegia","paresis","RECRUITING","2026-05-27",{"date":44,"type":45},"2026-05-29","ACTUAL",{"date":47,"type":45},"2021-06-03",{"date":49,"type":20},"2028-01",{"name":51,"class":52},"University of British Columbia","OTHER",4,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":15,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":74,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":87},"100573777","comparison-of-the-effects-of-mirror-therapyrtms-and-robotic-assisted-hand-therapy-in-stroke-patients-100573777","NCT06750692","Comparison of the Effects of Mirror Therapy,rTMS and Robotic-assisted Hand Therapy in Stroke Patients","Comparison of the Effects of Mirror Therapy,Repetitive Transcranial Magnetic Stimulation and Robotic-assisted Hand Therapy Added to Neurological Rehabilitation on Upper Extremity Functions, Quality of Life and Pain in Stroke Patients","Inclusion Criteria:\n\n* Patients who applied to Afyonkarahisar Health Sciences University Hospital Physical Medicine and Rehabilitation Polyclinic with the diagnosis of hemiplegia after a cerebrovascular accident in the inpatient ward or as an outpatient for neurological rehabilitation after taking the anamnesis and physical examination, who met the inclusion criteria and eliminated the exclusion criteria\n* Female and male patients between the ages of 40-80\n* stroke at least 3 months ago\n* voluntarily agreed to participate in the study regularly, whose health status is suitable for rehabilitation and who are medically stable\n* mini mental test score of 15 and above\n* Neurologically stable patient\n\nExclusion Criteria:\n\n* significant comorbidities such as serious heart disease (aortic stenosis, angina, hypertrophic cardiomyopathy, arrhythmia, pacemaker) and uncontrolled hypertension\n* history of epilepsy, antiepileptic drug use\n* intracranial metal objects\n* intraauricular implants\n* cognitive dysfunction\n* upper extremity peripheral nerve injuries\n* malignancy\n* active infection\n* skin infections or open wounds in the application area\n* inflammatory diseases\n* orthopedic injuries that may limit maximum effort capacity\n* brain lesion or drug use history that may affect the seizure threshold\n* increased intracranial pressure\n* uncontrolled migraine\n* severe spasticity in the hand (MAS≥3)\n* contracture in the hand\n* have had a fracture or surgery on the hemiplegic side in the last 6 months\n* severe visual impairment\n* severe depression","40 Years","80 Years",{"count":64,"type":20},120,"INTERVENTIONAL",[67],"NA","The aim of the study is to investigate the comparison of the effects of mirror therapy, Repetitive Transcranial Magnetic Stimulation and robot-assisted hand therapy added to conventional neurological rehabilitation on upper extremity function, quality of life and pain in stroke.",[70,29,71,72,73],"Stroke","Neuropathic Pain","Quality of Life","Neurologic Disorder",[75,76,77],"Mirror Therapy","Repetitive Transcranial Magnetic Stimulation","Hand-Finger Robot","2026-03-11",{"date":80,"type":45},"2026-03-12",{"date":82,"type":45},"2024-12-27",{"date":84,"type":20},"2026-06-20",{"name":86,"class":52},"Afyonkarahisar Health Sciences University",1,{"id":89,"slug":90,"hasResults":11,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":4,"eligibilityCriteria":94,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":95,"enrollmentInfo":96,"targetDuration":4,"studyType":65,"phases":98,"briefSummary":99,"conditions":100,"keywords":102,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":112,"leadSponsor":114,"locationsCount":116},"100621911","wearable-focal-vibration-therapy-on-upper-extremity-function-of-people-with-multiple-sclerosis-a-pilot-study-100621911","NCT07376772","Wearable Focal Vibration Therapy on Upper Extremity Function of People With Multiple Sclerosis: A Pilot Study","Feasibility, Preliminary Efficacy, and User Perspective Usability of Wearable Focal Vibration Therapy on Upper Extremity Function of People With Multiple Sclerosis: A Pilot Study","Inclusion Criteria:\n\n* Aged over 18 years\n* Confirmed diagnosis of RRMS according to the McDonald criteria (33)\n* No MS relapse or exacerbation within the past 6 months (ensuring stability of symptoms)\n* Self-report on clinical evidence of UEx impairment (including reduced arm\u002Fhand function, muscle weakness, spasticity, or pain).\n* Stable on MS treatment for at least four weeks before recruitment, with no plans to initiate new treatments (participants may continue current treatments during the study)\n* Agree and are able to use the FVT device after training.\n* Sufficient proficiency in English to participate in interviews and follow instructions\n* Able to visit the laboratory for assessments\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* Evidence of cognitive impairment that could interfere with following instructions (Mini-Montreal Cognitive Assessment score (Mini-MoCA) \\\u003C 12)\n* Comorbid neurological or psychiatric conditions affecting the UEx (including stroke and severe carpal tunnel syndrome) that would confound results or make FVT unsafe\n* Unstable cardiac disease or any major medical illness that would preclude participation\n* Any known contraindications to vibration therapy (pregnancy, acute deep vein thrombosis, severe osteoporosis, chronic migraines, epilepsy, active malignancy in the target area, unstable cardiac disease, or an implanted pacemaker without clearance)","100 Years",{"count":97,"type":20},15,[67],"This pilot mixed-method study will evaluate the feasibility, preliminary efficacy, and user experience of a home-based wearable Focal Vibration Therapy (FVT) intervention for improving upper extremity (UEx) function in people with multiple sclerosis (MS). Fifteen adults with relapsing-remitting MS (PRMS) and self-reported UEx impairments will participate in a 4-week FVT program using MyovoltTM wearable FVT devices applied to arm muscles.",[101,29],"Multiple Sclerosis (MS) - Relapsing-remitting",[103,104,105,106,107],"focal vibration therapy","multiple sclerosis","upper extremity function","wearable","feasbility","2026-03-04",{"date":110,"type":45},"2026-03-06",{"date":108,"type":45},{"date":113,"type":20},"2026-06-30",{"name":115,"class":52},"University of Florida",2,{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":4,"eligibilityCriteria":123,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":124,"enrollmentInfo":125,"targetDuration":4,"studyType":65,"phases":127,"briefSummary":128,"conditions":129,"keywords":131,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":87},"100594353","mirror-vs-virtual-reality-therapy-for-upper-extremity-function-in-hemiplegic-patients-100594353","NCT07018336","Mirror vs Virtual Reality Therapy for Upper Extremity Function in Hemiplegic Patients","Comparison of the Acute Effects of Mirror Therapy and Virtual Reality Therapy on Upper Extremity Function and Performance in Hemiplegic Patients","Inclusion Criteria:\n\n* Hemiplegic patients in need of upper extremity rehabilitation.\n* Having had a stroke 6 to 12 months prior to the study.\n* Being at least Stage 3 for the upper extremity according to the Brunnstrom motor recovery stages.\n* Age range: between 18 and 75 years.\n* Individuals who volunteer to participate in the study.\n* Individuals who are cognitively suitable for mirror therapy and virtual reality applications (a score of at least 24 on the Mini Mental State Examination)\n\nExclusion Criteria:\n\n* Patients with severe spasticity (score ≥ 3 on the Modified Ashworth Scale)\n* Individuals with secondary neurological conditions (e.g., Parkinson's disease, multiple sclerosis).\n* Individuals diagnosed with vestibular dysfunction (as virtual reality equipment may cause issues like nausea or dizziness).\n* Individuals with communication issues, such as hearing or vision loss.","75 Years",{"count":126,"type":20},42,[67],"Upper extremity impairment in hemiplegic patients significantly impacts daily activities and reduces quality of life. Although traditional rehabilitation methods can help, some patients experience limited progress. Recently, modern techniques such as mirror therapy and virtual reality (VR) have emerged, demonstrating promising results in motor skill improvement.\n\nThis study aims to directly compare the acute effects of mirror therapy and VR therapy on upper limb motor function in hemiplegic patients. Forty-two participants aged 18-75 with hemiplegia due to stroke (6-12 months post-stroke) will be randomly assigned to either mirror therapy or VR therapy. The evaluation includes motor function (Fugl-Meyer Assessment), spasticity (Modified Ashworth Scale), activities of daily living (Barthel Index), fine motor skills (Box and Block Test), proprioception, and reaction time.\n\nThe goal is to identify the effectiveness of the mirror therapy and VR therapy on motor function, spasticity control, proprioception, daily activity performance, and reaction times, contributing valuable insights to clinical rehabilitation practices.",[130,70,29],"Hemiplegia",[70,132,133,134],"Spasticity","Proprioception","Reaction Time","2026-02-26",{"date":137,"type":45},"2026-03-02",{"date":139,"type":45},"2025-05-30",{"date":141,"type":20},"2026-07",{"name":143,"class":52},"Istinye University",{"id":145,"slug":146,"hasResults":11,"nctId":147,"briefTitle":148,"officialTitle":149,"acronym":4,"eligibilityCriteria":150,"healthyVolunteers":11,"sex":15,"minAge":61,"maxAge":62,"enrollmentInfo":151,"targetDuration":4,"studyType":65,"phases":153,"briefSummary":154,"conditions":155,"keywords":157,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":87},"100615184","effects-of-combined-vs-sequential-attentional-focus-instructions-on-upper-extremity-function-in-subacute-stroke-100615184","NCT07289308","Effects of Combined vs. Sequential Attentional Focus Instructions on Upper Extremity Function in Subacute Stroke","The Effect of Combined Versus Sequential Attentional Focus Instructions on Upper Extremity Function in Subacute Stroke Patients: An Assessor-Blinded Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age 40-80 years at enrollment (Kwakkel et al., 1996; Coupar et al., 2012).\n2. Stroke diagnosed by a neurologist between 1 week and 6 months before enrollment (Langhorne et al., 2020; Bernhardt et al., 2017).\n3. Medically stable, as confirmed by a neurologist, with controlled and non-fluctuating vital signs (Stinear et al., 2020; Powers et al., 2019; Winstein et al., 2016).\n4. Sufficient cognitive function to follow instructions, sustain attention, and actively participate in rehabilitation, as judged by the treating therapist (Stinear et al., 2020; Boyd et al., 2018).\n5. Brunnstrom stage 2-5 in the affected upper limb (Brunnstrom, 1970; Langhorne et al., 2020).\n6. Individuals with a Modified Ashworth Scale (MAS) score \\\u003C3: Participants were required to have a MAS score of less than 3 in both the upper and lower extremities to ensure that spasticity remained at a manageable level and to allow safe participation in upper-limb motor rehabilitation (Pandyan et al., 2005; Li \\& Francisco, 2015; Ada et al., 2020).\n7. Preserved corticospinal tract integrity, confirmed by a positive Motor Evoked Potential (MEP) response (Stinear et al., 2017; Byblow et al., 2015; Stinear et al., 2020).\n8. Moderate to severe upper-extremity motor impairment, determined by Fugl-Meyer Assessment (FMA) scores of 0-47 (0-19 severe, 20-47 moderate) (Fugl-Meyer et al., 1975).\n\nExclusion Criteria:\n\n* Spasticity level: Individuals with a Modified Ashworth Scale (MAS) score ≥3 in either the upper or lower extremities were excluded, as marked hypertonicity and severe spastic contractions could negatively affect proximal stabilization and movement strategies, thereby interfering with upper-limb task performance (Pandyan et al., 2005).\n* Fractures: Participants with a current or recent fracture on the affected side of the body were excluded from the study.\n* Botulinum toxin injections: Individuals who had received Botulinum Toxin (Botox) injections within the previous three months were excluded due to the potential effects of the intervention on muscle tone and motor performance.\n* Communication disorders: Participants with motor or global aphasia, or other communication impairments that could interfere with understanding instructions or performing the required tasks, were excluded.\n* Concurrent rehabilitation: Individuals who were concurrently receiving rehabilitation treatment at another facility were excluded to prevent potential confounding effects from parallel interventions (Winstein et al., 2016).\n* Non-adherence to treatment sessions: Participants who failed to attend all required treatment sessions were excluded to ensure consistency and fidelity of the intervention protocol (Winstein et al., 2016).",{"count":152,"type":20},36,[67],"Stroke is a leading cause of long-term disability, and upper extremity impairments-affecting about 80% of survivors-limit functional reach, grasp, and manipulation more severely than lower limb deficits. Despite partial recovery of walking ability, meaningful functional use of the paretic arm remains limited. Conventional rehabilitation often lacks sufficient intensity, task specificity, and motor learning principles, highlighting the need for more effective approaches.\n\nThe subacute phase of stroke (up to 6 months post-onset) represents a period of heightened neuroplasticity and strong rehabilitation potential. During this time, integrating cognitive and motor training-such as attentional focus strategies-has gained attention. External focus enhances movement efficiency through motor automaticity, whereas internal focus supports early motor control. Evidence suggests that combining these strategies may optimize recovery, yet their relative effectiveness in stroke rehabilitation remains unclear.\n\nTwo main instructional approaches exist: combined attentional focus (internal and external cues delivered within the same session) and sequential attentional focus (internal focus first, followed by external focus as control improves). While both show therapeutic promise, comparative data in stroke populations are lacking.\n\nThis study aims to compare combined versus sequential attentional focus instructions in improving upper extremity function in subacute stroke. We hypothesize that a combined approach-starting with internal focus early, then integrating external focus-will yield superior motor improvements.",[70,29,156],"Cue, Threat",[158,159,160,161,162],"Wolf Motor Function Test","Motor Learning","Functional Recovery","Fugl-Meyer Assessment","Action Research Arm Test","2026-01-16",{"date":165,"type":45},"2026-01-20",{"date":167,"type":45},"2025-01-02",{"date":169,"type":20},"2026-07-30",{"name":171,"class":52},"Bahçeşehir University",{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":176,"acronym":4,"eligibilityCriteria":177,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":62,"enrollmentInfo":178,"targetDuration":4,"studyType":65,"phases":180,"briefSummary":181,"conditions":182,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":87},"100542943","the-utilization-effects-of-powered-wearable-orthotics-in-improving-upper-extremity-function-and-adl-in-persons-with-sci-100542943","NCT06349434","The Utilization Effects of Powered Wearable Orthotics in Improving Upper Extremity Function and ADL in Persons With SCI","Inclusion Criteria:\n\n* Be between ages 18-80\n* Be able to activate certain muscles in my arm and forearm on my own a sufficient amount as measured by EMG amplitude. This will be determined by the study OT\u002FPT.\n* Be diagnosed with spinal cord injury (SCI) with level C1-C8 and ASIA Impairment Scale (AIS) C or D, as determined by study staff. If I have not had an exam to determine my injury level and impairment scale recently, I may participate in an examination of my sensation and strength in my arms, legs, trunk and rectum as was done in the hospital soon after my injury.\n* Be at least 1-year post injury\n* Have sufficient ability to move my shoulder (active shoulder flexion of 30 degrees and active shoulder abduction 20 degrees), as determined by study staff\n* Be medically stable\n* Have sufficient learning and memory abilities and abilities to communicate in English to be able to participate and follow directions during my rehabilitation\n* Continue to take all prescribed medication (e.g., oral or via pump baclofen) without any dosing changes\n* Be able to tolerate functional tasks for 60 minutes with periodic rests without excessive fatigue\n* Have minimal strength in the muscles that bend and straighten my elbow, as determined by study staff\n* Have full range of motion in my elbow when it is moved by the study therapist\n\nExclusion Criteria:\n\n* Be younger than 18 years old or older than 80\n* Have excessive pain in my arm, wrist, or hand that limits providing rehabilitation\n* Have excessive spasticity in my elbow or wrist, as determined by study staff\n* Be participating in any experimental rehabilitation or drug studies\n* Have history of nervous system disorder other than SCI\n* Have difficulty following multiple step directions\n* Have severe cognitive or psychiatric problems might be contraindications to start training.\n* Have skin issues or severe sensory deficits that would prevent wearing the Myo-Pro device safely\n* Be pregnant\n* Have other conditions or circumstances that, in the opinion of the investigators, would affect the safety or effectiveness of the training in which I would participate",{"count":179,"type":20},60,[67],"To evaluate the usefulness of an upper extremity assistive device, called (MyoPro) in improving upper extremity activities in people with incomplete spinal cord injury. The Department of Defense is supporting this study.",[27,29,183],"Upper Extremity Problem","2025-11-19",{"date":186,"type":45},"2025-11-24",{"date":188,"type":45},"2023-10-15",{"date":190,"type":20},"2028-10-01",{"name":192,"class":52},"Kessler Foundation",{"id":194,"slug":195,"hasResults":11,"nctId":196,"briefTitle":197,"officialTitle":198,"acronym":199,"eligibilityCriteria":200,"healthyVolunteers":201,"sex":15,"minAge":202,"maxAge":203,"enrollmentInfo":204,"targetDuration":4,"studyType":65,"phases":205,"briefSummary":206,"conditions":207,"keywords":210,"overallStatus":213,"whyStopped":4,"lastUpdateSubmitDate":214,"lastUpdatePostDateStruct":215,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":4},"100521451","trunk-and-upper-extremities-program-effect-in-decreasing-compensation-patterns-in-unilateral-cerebral-palsy-children-100521451","NCT06069765","Trunk and Upper Extremities Program Effect in Decreasing Compensation Patterns in Unilateral Cerebral Palsy Children","Trunk and Upper Extremities Program Effect in Decreasing Compensation Patterns in Unilateral Cerebral Palsy Children: Randomized Control Trial","TUPEX","Inclusion Criteria:\n\n* Unilateral cerebral palsy diagnostic\n* Level I or II of the Manual Ability Scale Classification\n\nExclusion Criteria:\n\n* Have received any intervention with botulinum toxin or shock waves in the previous six months or have them scheduled during the intervention\n* Are undergoing treatment with intensive therapies.\n* To have known alteration in the hips\n* Have very serious attention or comprehension difficulties that prevent them from following instructions.\n* Suffer uncontrolled epilepsies\n* Suffer from severe visual problems.",true,"8 Years","16 Years",{"count":19,"type":20},[67],"The goal of this clinical trial is to test the effectiveness of a trunk and upper extremities exercise program. The main questions it aims to answer are:\n\nWhether the program decreases compensation patterns in unilateral cerebral palsy children Whether the program decreases pain in unilateral cerebral palsy children Whether the program improves bimanual ability in unilateral cerebral palsy children Participants will undertake and 8-week program exercise at home If there is a comparison group: Researchers will compare with the control group to see if this program decreases compensation patterns.",[208,209,29],"Cerebral Palsy Infantile","Chronic Pain",[211,212],"compensation patterns","unilateral cerebral palsy","NOT_YET_RECRUITING","2025-02-12",{"date":216,"type":45},"2025-02-14",{"date":218,"type":20},"2025-09",{"date":220,"type":20},"2027-07",{"name":222,"class":52},"Fundacio Aspace Catalunya"]