[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"upper-extremity-hemiparesis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:upper-extremity-hemiparesis":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100609855","low-intensity-focused-ultrasound-stimulation-in-stroke-patients---parameter-optimization-100609855",false,"NCT07220005","Low Intensity Focused Ultrasound Stimulation in Stroke Patients - Parameter Optimization","LIFUS-OPTIMIZE","Inclusion Criteria:\n\n* age \\>=21 years old of any gender or race\n* First-ever ischemic or hemorrhagic stroke (neuroimaging verified) at least 6 months from the stroke onset of symptoms\n* Unilateral arm weakness measured by the Fugl-Meyer Upper-Extremity Scale ≤ 62\u002F64\n* Inducible rest motor threshold and testing motor threshold recorded from the affected abductor pollicis brevis muscle\n\nExclusion Criteria:\n\n* Bilateral strokes (infarcts and\u002For hematoma)\n* Other co-existent neuromuscular disorders affecting upper extremity motor impairment\n* History of medically uncontrolled depression or other neuropsychiatric disorders despite medications either before or after a stroke that may affect the subject's ability to participate in the study\n* History of confirmed dementia or taking dementia drugs\n* Uncontrolled hypertension despite medical treatment(s) at the time of enrollment, defined as SBP≥185 mmHg or DBP≥110 mmHg (patient can be treated, reassessed and enrolled later)\n* Presence of any MRI\u002FTMS\u002FLIFUS risk factors\n* Concurrent enrollment in another interventional stroke recovery study\n* Concerns that the subject cannot comply with study procedures and visits\n* Pregnant","ALL","21 Years",{"count":19,"type":20},24,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this research study is to optimize the parameter of Low-Intensity Focused Ultrasound Stimulation (LIFUS) that is most effective in changing cortical excitability and motor learning skills in patients who suffered a stroke. The researchers hope to answer two questions.\n\n* with increasing power, would LIFUS be more effective?\n* with the same power, what LIFUS timing is the best\n\nFor Aim 1, the study will compare 8, 4 W\u002Fcm\\^2 to a zero(sham) stimulation to see if higher power is the better.\n\nFor Aim 2, the study will compare 500 vs 1000 vs 2000 Hz \"timing\" to see which one is better.",[26,27,28,29,30],"Stroke","Arm Weakness as a Consequence of Stroke","Upper Extremity Hemiparesis","Upper Extremity Impairments","Upper Extremity Weakness",[32,33,34,35,36,37],"Brain Stimulation","Transcranial Focused Ultrasound Stimulation","Low Intensity Focused Ultrasound Stimulation","Stroke Recovery","Motor Learning","Corticospinal Excitability","RECRUITING","2025-12-19",{"date":41,"type":42},"2025-12-23","ACTUAL",{"date":44,"type":42},"2025-12-10",{"date":46,"type":20},"2026-06-30",{"name":48,"class":49},"Duke University","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":21,"phases":61,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":81},"100466599","patient-tailored-transcranial-direct-current-stimulation-to-improve-stroke-rehabilitation-100466599","NCT05355831","Patient-tailored Transcranial Direct Current Stimulation to Improve Stroke Rehabilitation","PRACTISE","Patients - Inclusion Criteria:\n\n1. Age \\>18 years\n2. Ischemic stroke confirmed by clinical and imaging criteria\n3. Hemiparesis including reduced upper-extremity function\n4. Location of stroke either cortically involving middle cerebral artery or the anterior cerebral artery circulation or subcortical (involving thalamus, basal ganglia).\n5. NIHSS score \\>2 and \\\u003C8\n6. Modified Rankin Scale (mRS) ≤ 3\n7. Index of stroke within 4 weeks of inclusion\n8. Signed informed consent\n\nPatients - Exclusion Criteria:\n\n1. \\>50% stenosis of extra- or intracranial artery as well as vascular malformations or aneurisms detected by brain CT-angiography.\n2. Exclusively ischemic stroke in spine, pons, brainstem, medulla or cerebellum.\n3. History of seizures, epilepsy, anxiety, dementia alcohol- or drug abuse.\n4. Prior serious head injury or neurosurgery\n5. Frequent severe headaches or migraine.\n6. Pregnancy or breastfeeding\n7. Current use of neuro-receptor\u002Ftransmitter modulating medication, or medication interfering with seizure threshold (such as antiepileptic medication, some antidepressants, anxiety medication, antihistamines, stimulant drugs for attention deficit hyperactivity disorder).\n8. Pacemaker, implantable cardiac device unit (ICD-unit), metal fragments or other materials implanted not compatible with MRI (see appendix B).\n9. Claustrophobia\n10. Prior adverse effect to TDCS or Transcranial Magnetic Stimulation.\n11. Not able to provide informed consent.\n12. Terminally ill or short life expectancy.\n\nHealthy controls - Inclusion criteria:\n\n1. Age between \\>18 years (matched to patients)\n2. Sex and age matched to patients\n3. Able bodied\n4. Have the ability to comply with all requirements of the study protocol, as determined by the investigator\n5. No history of stroke or dementia\n6. Eligible for MRI and TMS\n\nHealthy controls - Exclusion Criteria:\n\n1. History of neurologic disease\n2. History of cerebral haemorrhage or brain damage\n3. Pregnancy\n4. Pacemaker or other implanted electronic devices\n5. Claustrophobia\n6. Psychiatric disorder\n7. Epilepsy or close relatives suffering from epilepsy\n8. Migraine\n9. Any contraindication to MRI or TMS","18 Years",{"count":60,"type":20},22,[23],"In a double-blinded sham-controlled study the effect of patient-tailored transcranial direct current stimulation during rehabilitation training will be examined.",[64,28],"Ischemic Stroke",[66,67,68,69,70,71],"non-invasive brain stimulation","transcranial direct current stimulation","effective connectivity","functional connectivity","Fugl-Meyer Assessment","Functional Magnetic Resonance Imaging","2024-07-10",{"date":74,"type":42},"2024-07-11",{"date":76,"type":42},"2022-08-28",{"date":78,"type":20},"2024-12",{"name":80,"class":49},"Christina Kruuse",3]