[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"upper-extremity-impairments\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:upper-extremity-impairments":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,52],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100641665","efficacy-of-tele-cpass-compared-to-in-person-cpass-therapy-for-upper-extremity-motor-recovery-100641665",false,"NCT07661849","Efficacy of Tele-CPASS Compared to In-person CPASS Therapy for Upper Extremity Motor Recovery","Efficacy of Tele-CPASS, a Telerehabilitation Intervention Using Critical Periods After Stroke Study (CPASS) Compared to In-person CPASS for Upper Extremity Motor Recovery","Inclusion Criteria:\n\n* Age 21 years or older\n* Neuroimaging-confirmed stroke within 40 days prior to enrollment\n* Persistent hemiparesis resulting in impaired upper extremity function, defined by a score of 0 to 3 on the NIH Stroke Scale motor arm item\n* Able to participate in all study-related activities, including 1-year follow-up\n* Short Blessed Memory Orientation and Concentration Scale score less than 8\n* Able to follow 2-step commands\n* Montreal Cognitive Assessment (MoCA) score greater than 25\n* No upper extremity injury or condition that limited upper extremity use prior to the stroke\n\nExclusion Criteria:\n\n* Inability to provide informed consent\n* Persistent disabling neurologic condition, such as multiple sclerosis, Parkinsonism, amyotrophic lateral sclerosis, or dementia requiring medication\n* Clinically significant fluctuations in mental status within 72 hours prior to randomization\n* Active psychosis, psychosis within the prior 2 years, active substance abuse, or prior substance abuse\n* Dense sensory loss, defined by a score of 3 or 4 on the NIH Stroke Scale sensory item\n* Ataxia out of proportion to weakness in the affected arm, defined by a score greater than 1 on the NIH Stroke Scale ataxia item\n* Not expected to survive 12 months because of other illnesses\n* Pregnancy\n* Severe aphasia\n* Receipt of botulinum toxin or expectation of receiving botulinum toxin during the study period","ALL","21 Years",{"count":19,"type":20},42,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study evaluates whether a home-based telerehabilitation program (tele-CPASS) is as effective as an in-person rehabilitation program (CPASS) for improving arm and hand function after stroke. Stroke often leads to long-term difficulty using the affected arm in daily activities, and access to in-person therapy can be limited. This study aims to determine whether therapy delivered remotely can provide similar benefits to standard in-clinic care.\n\nParticipants who recently experienced a stroke will be randomly assigned to receive 20 hours of upper extremity rehabilitation therapy either in person or through a telehealth platform. Both groups will receive the same type and amount of therapy focused on practicing meaningful, patient-selected daily activities. Participants will complete assessments before treatment, immediately after treatment, and at 6 and 12 months to measure recovery of arm function, real-world arm use, and participation in daily life.\n\nThe results of this study will help determine whether telerehabilitation can improve access to effective stroke recovery interventions while maintaining clinical effectiveness comparable to in-person therapy.",[26,27,28,29],"Stroke","Hemiparesis","Upper Extremity Impairments","Stroke Rehabilitation",[31,32,33,34,35,36,37,38],"Telerehabilitation","Telehealth","Stroke rehabilitation","Upper extremity recovery","Motor recovery","Critical period plasticity","Wearable sensors","Accelerometry","RECRUITING","2026-06-16",{"date":42,"type":43},"2026-06-22","ACTUAL",{"date":45,"type":43},"2025-09-01",{"date":47,"type":20},"2029-08-31",{"name":49,"class":50},"University of Texas, El Paso","OTHER",3,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":21,"phases":61,"briefSummary":62,"conditions":63,"keywords":67,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":83},"100609855","low-intensity-focused-ultrasound-stimulation-in-stroke-patients---parameter-optimization-100609855","NCT07220005","Low Intensity Focused Ultrasound Stimulation in Stroke Patients - Parameter Optimization","LIFUS-OPTIMIZE","Inclusion Criteria:\n\n* age \\>=21 years old of any gender or race\n* First-ever ischemic or hemorrhagic stroke (neuroimaging verified) at least 6 months from the stroke onset of symptoms\n* Unilateral arm weakness measured by the Fugl-Meyer Upper-Extremity Scale ≤ 62\u002F64\n* Inducible rest motor threshold and testing motor threshold recorded from the affected abductor pollicis brevis muscle\n\nExclusion Criteria:\n\n* Bilateral strokes (infarcts and\u002For hematoma)\n* Other co-existent neuromuscular disorders affecting upper extremity motor impairment\n* History of medically uncontrolled depression or other neuropsychiatric disorders despite medications either before or after a stroke that may affect the subject's ability to participate in the study\n* History of confirmed dementia or taking dementia drugs\n* Uncontrolled hypertension despite medical treatment(s) at the time of enrollment, defined as SBP≥185 mmHg or DBP≥110 mmHg (patient can be treated, reassessed and enrolled later)\n* Presence of any MRI\u002FTMS\u002FLIFUS risk factors\n* Concurrent enrollment in another interventional stroke recovery study\n* Concerns that the subject cannot comply with study procedures and visits\n* Pregnant",{"count":60,"type":20},24,[23],"The goal of this research study is to optimize the parameter of Low-Intensity Focused Ultrasound Stimulation (LIFUS) that is most effective in changing cortical excitability and motor learning skills in patients who suffered a stroke. The researchers hope to answer two questions.\n\n* with increasing power, would LIFUS be more effective?\n* with the same power, what LIFUS timing is the best\n\nFor Aim 1, the study will compare 8, 4 W\u002Fcm\\^2 to a zero(sham) stimulation to see if higher power is the better.\n\nFor Aim 2, the study will compare 500 vs 1000 vs 2000 Hz \"timing\" to see which one is better.",[26,64,65,28,66],"Arm Weakness as a Consequence of Stroke","Upper Extremity Hemiparesis","Upper Extremity Weakness",[68,69,70,71,72,73],"Brain Stimulation","Transcranial Focused Ultrasound Stimulation","Low Intensity Focused Ultrasound Stimulation","Stroke Recovery","Motor Learning","Corticospinal Excitability","2025-12-19",{"date":76,"type":43},"2025-12-23",{"date":78,"type":43},"2025-12-10",{"date":80,"type":20},"2026-06-30",{"name":82,"class":50},"Duke University",1]