[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"upper-extremity-injuries\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:upper-extremity-injuries":36},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,63],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":44,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":52,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":62},"100633082","early-functional-response-as-a-predictor-of-clinical-outcomes-in-hand-rehabilitation-a-prospective-feasibility-study-using-a-digital-monitoring-system-100633082",false,"NCT07522060","Early Functional Response as a Predictor of Clinical Outcomes in Hand Rehabilitation: A Prospective Feasibility Study Using a Digital Monitoring System","Early Functional Response as a Predictor of Clinical Outcomes in Hand Rehabilitation: A Prospective Feasibility Study Using a Clinician-Developed Digital Monitoring System","HANDREHPREDICT","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Hand or upper extremity pathology requiring rehabilitation, including but not limited to: flexor or extensor tendon injuries, peripheral nerve injuries or compression syndromes (including carpal tunnel syndrome, cubital tunnel syndrome), distal radius fractures, metacarpal or phalangeal fractures, joint injuries and instabilities, arthropathy (osteoarthritis, rheumatoid arthritis), trapeziometacarpal osteoarthritis, trigger finger, Dupuytren's disease, DeQuervain tenosynovitis, lateral epicondylitis and post-surgical upper extremity conditions\n* Under clinical responsibility of the principal investigator at the Faculty of Physical Therapy and Rehabilitation, Hacettepe University\n* Expected to attend minimum 8 rehabilitation sessions\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* • Active psychiatric illness precluding participation or completion of assessment tools\n\n  * Severe cognitive impairment precluding understanding of patient-reported outcome measures\n  * Literacy difficulties preventing self-completion of questionnaires\n  * Concurrent enrollment in another interventional clinical study\n  * Refusal to provide written informed consent","ALL","18 Years",{"count":20,"type":21},60,"ESTIMATED","OBSERVATIONAL","This study investigates whether early changes observed during the first weeks of hand and upper extremity rehabilitation can predict patient outcomes months later. In rehabilitation practice, clinicians make numerous decisions each session regarding exercise type, frequency, duration, and treatment approach. Most of these decisions are currently made without systematic longitudinal data. This study addresses three fundamental questions using data collected during routine clinical care: (1) Can the rate of improvement in the first weeks of treatment predict functional status months later, across both session-based and milestone-based time points? (2) Are there meaningfully different recovery profiles among hand rehabilitation patients? (3) Is there measurable variation in clinical decision-making among patients with similar profiles, and does this variation relate to outcomes? A digital patient monitoring platform developed by the principal investigator, a physiotherapist and academic researcher specializing in hand rehabilitation serves as the data collection infrastructure. The platform records standard clinical assessment measures in a structured format and has been in active clinical use at Hacettepe University prior to this study. For research purposes, the system has been expanded to include structured capture of patient-reported outcomes, patient global impression of change, treatment protocol coding, home exercise adherence, and automated calculation of early response metrics.\n\nThis is a 12-month prospective observational cohort study enrolling a minimum of 60 patients. Data are stored securely on the university's institutional network. Patients are anonymized using identification codes. The study is subject to Hacettepe University Ethics Committee approval and participant informed consent. Findings are expected to generate evidence supporting data-driven clinical decision-making in rehabilitation and to provide a feasibility foundation for a larger multi-center study.",[25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43],"Hand","Hand Therapy","Upper Extremity","Prediction Models","Hand Injuries","Hand Injuries and Disorders","Hand Arthritis","Tendon Injuries","Wrist Fractures","Carpal Tunnel Syndrome (CTS)","Peripheral Nerve Injuries","Upper Extremity Injuries","Wrist Injuries","Finger Injuries","Trigger Finger","Trapeziometacarpal (TMC) Arthrosis","DeQuervain's Tenosynovitis","Cubital Tunnel Syndrome","Postoperative Rehabilitation",[45,46,47,48,49],"digital health monitoring","real-world evidence","clinical decision support","upper extremity rehabilitation","early response prediction","NOT_YET_RECRUITING","2026-04-03",{"date":53,"type":54},"2026-04-13","ACTUAL",{"date":56,"type":21},"2026-06-15",{"date":58,"type":21},"2027-06-01",{"name":60,"class":61},"Hacettepe University","OTHER",1,{"id":64,"slug":65,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":4,"eligibilityCriteria":69,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":70,"enrollmentInfo":71,"targetDuration":4,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":82,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":62},"100366928","craniomaxillofacial-and-upper-extremity-allotransplantation-100366928","NCT04057638","Craniomaxillofacial and Upper Extremity Allotransplantation","Combined Craniomaxillofacial and Upper Extremity Allotransplantation","Inclusion Criteria:\n\n* Signed and dated all required Institutional Review Board (IRB) approved consent forms.\n* Male or female recipient between the ages of 18-64 years. Recipients do not need to be of the same sex as the donor.\n* Facial composite tissue defect requiring facial transplantation as determined by the treating Plastic and Reconstructive Surgeon. Inclusive facial functional subunit tissue loss. Including but not limited to irreparable peri-oral, peri-orbital, and peri-nasal damage.\n* Missing part of one or both hands and forearms.\n* Must be HIV negative at the time of transplant.\n* Crossmatch is negative at the time of transplant.\n* Patient has been encouraged to seek a second opinion from a Plastic Surgeon with specialized focus in facial reconstruction.\n* Patient has been encouraged to seek a second opinion from a Plastic Surgeon with specialized focus in upper extremity reconstruction.\n* Willingness to participate in ongoing psychiatric, psychological and social work evaluations prior to and post-transplant surgery.\n* The subject is able to complete pre-transplant examination and screening procedures.\n* Patient has been approved by Patient Selection Committee for placement on the recipient waiting list.\n* The subject is willing to continue immunosuppression regimen as directed by treating physician.\n* Subject is willing and able to return to follow-up visits as described in treatment plan.\n* Subjects must have autogenous tissue options available for reconstruction in event of graft failure.\n* Normal glomerular filtration rate (GFR) \\>60.\n* Negative pregnancy test within 48hrs of transplant for women of childbearing age and who agree to use a reliable form of contraception for one year following transplant.\n\nExclusion Criteria:\n\n* Uncontrolled infection or severe concomitant diseases which would exclude the recipient from transplantation\n* Serious co-morbidities\n* Positive serology for HIV; Hepatitis B Antigen\n* Active malignancy within 5 years with the exclusion of non-melanoma\n* Substance abuse disorders not currently under control (as determined by the Michigan Alcohol Screening Test - see Appendix N.1: Subjects with a score of 3 or more will be excluded)\n* Body Dysmorphic disorder (see Appendix N.2 for screening tool). Less severe psychiatric conditions are addressed on a case by case basis\n* Active Severe Psychiatric Illness\n* Cognitive limitations affecting the patient's ability to provide informed consent\n* Recent history of medical non-adherence\n* Unstable social situation as evidence by lack of stable housing and\u002For lack of a supportive significant other.\n* Recent history of medical non-adherence.\n* Lack of stable housing and\u002For supportive significant other\u002Fcaregiver throughout all phases of the study\n* Currently active smoker within 1 year\n* Subjects with any cognitive deficits related to a traumatic brain injury (TBI) and or any organic neurological disorders\n* Any other psychological status that would hinder the success or safety of the transplantation.\n* Level of amputation proximal to mid-humerus: some presence of proximal muscles is required to motor a functioning hand.\n* Congenital Abnormalities: co-existent absence\u002Fatrophy\u002Fagenesis of any tissue may affect post-transplant results\n* History of amputation of less than six months: subject must be allowed to attempt prosthetic use prior to hand transplantation. This can be waived in cases where the recipient requires amputation\u002Frevision of the transplant site at the time of transplantation. However, if at all possible, it is highly encouraged that the patient has ruled out prosthetics as an alternative to transplantation.\n* Blindness: blind amputees may be poor candidates because sensory return in the hand may not provide sufficient protective sensation\n* Pregnancy","64 Years",{"count":72,"type":21},10,"INTERVENTIONAL",[75],"NA","The purpose of this study is to evaluate functional and aesthetic outcomes of combined facial and upper extremity composite tissue allografts on patients who have not achieved functional and aesthetic outcomes with conventional reconstructive surgical strategies and prosthetic devices.",[78,29,79,36,80,81],"Face Injuries","Craniofacial Injuries","Facial Injuries","Facial Deformity",[83,84,85,86,87],"Transplants","Transplantation","Craniomaxillofacial Transplantation","Upper Extremity Transplantation","Vascularized Composite Allotransplantation (VCA)","RECRUITING","2025-12-08",{"date":91,"type":54},"2025-12-16",{"date":93,"type":54},"2019-06-17",{"date":95,"type":21},"2026-01-01",{"name":97,"class":61},"NYU Langone Health"]