[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"upper-extremity-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:upper-extremity-pain":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,52],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100592267","web-based-mind-body-program-to-improve-resilience-among-risky-substance-users-with-persistent-upper-extremity-pain-100592267",false,"NCT06991205","Web-based Mind-body Program to Improve Resilience Among Risky Substance Users With Persistent Upper Extremity Pain","Feasibility RCT of Web-based Mind-body Treatment to Enhance Resilience Among Patients With Painful Nontraumatic Upper-extremity Conditions and Commorbid Risky Substance Use","Inclusion Criteria:\n\n1. Outpatient adults seeking care in the Hand and Arm Center\n2. Diagnosed with a non-traumatic painful upper-extremity condition (NPUC)\n3. Pain score \\> 4 on the Numerical Rating Scale (NRS)\n4. Risky substance use (scores \\>10 and \\\u003C27 for alcohol, and \\>3 and \\\u003C27 for cannabis, cocaine, amphetamine-type stimulants, inhalants, sedatives, hallucinogens, opioids, tobacco products, and e-cigarette on The World Health Organization's - Alcohol, Smoking and Substance Involvement Screening Test \\[WHO-ASSIST\\])\n5. Owns a smartphone, laptop, or computer with internet access\n6. Age ≥18yr\n7. English fluency\n8. Ability and willingness to participate in a live video focus group and the following asynchronous Web-based intervention\n\nExclusion Criteria:\n\n1. Participation in mind-body or specialized substance abuse treatment in the past 3 months\n2. Practice of mindfulness \\>45 minutes\u002Fweek in the past 3 months\n3. Psychotropic medications (e.g. antidepressants) changed in the past 3 months\n4. Serious untreated mental illness (e.g., Schizophrenia)\n5. Suicidal ideation with intent or plan\n6. Pregnancy\n7. Secondary gains that may bias motivation (e.g., pending disability claim),\n8. Moderate to severe cognitive impairment (score ≥4 on the Short Portable Mental Status Questionnaire (SPMSQ))\n9. History of surgery for the presented NPUC within the past 6 months OR future plans for surgery.","ALL","18 Years",{"count":19,"type":20},50,"ESTIMATED","INTERVENTIONAL",[23],"NA","The investigator aims to conduct a feasibility randomized controlled trial (RCT) (N=50) to test the feasibility, acceptability, and credibility of an asynchronous web-based mind-body intervention (Toolkit for Resilient Life beyond Pain and Substance Use; Web-TIRELESS) versus web-based minimally enhanced usual care (Web-MEUC) among adult patients with a painful non-traumatic upper-extremity condition(s) (PNUC) and commorbid risky substance use.\n\nDeliverables: \\[1\\] Adapt and refine open pilot protocol, patient recruitment, and other study materials. \\[2\\] Assess the feasibility, acceptability, and credibility of Web-TIRELESS and Web-MEUC in preparation for future research.",[26,27,28,29],"Orthopedic Disorder","Nontraumatic Injury","Upper Extremity Pain","Risky Substance Use",[31,32,33,34,35,36,37,38],"Upper Extremity Problem","Risky substance use","Randomized Controlled Trial (RCT)","Mindfulness","Nontraumatic conditions","Chronic pain","Psychiatry","Feasibility","RECRUITING","2026-03-11",{"date":42,"type":43},"2026-03-13","ACTUAL",{"date":45,"type":43},"2025-09-15",{"date":47,"type":20},"2027-03-01",{"name":49,"class":50},"Jafar Bakhshaie","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":21,"phases":60,"briefSummary":62,"conditions":63,"keywords":66,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":51},"100569511","phase-1-a-randomized-controlled-trial-of-oral-cbd-for-the-treatment-of-upper-extremity-musculoskeletal-pain-100569511","NCT06695195","A Randomized Controlled Trial of Oral CBD for the Treatment of Upper Extremity Musculoskeletal Pain","Inclusion Criteria:\n\n1. Provision of signed and dated informed consent form.\n2. Stated willingness to comply with all study procedures and availability for the duration of the study.\n3. Male or female, aged 18 years or older.\n4. Daily visual analog pain score \\>5\u002F10 and \\\u003C9\u002F10.\n5. Duration of pain for greater than or equal to 3 months.\n6. Presence of physician-diagnosed musculoskeletal pain in the upper extremities, including bone or joint-related pain, tendon or ligament-related pain, muscle-related pain, or fibromyalgia or physician-diagnosed postoperative pain in a discrete body region, limited to upper extremities.\n7. For females, must be willing to use an approved form of birth control during this study. Acceptable forms of birth control:\n\n   * Norplant\n   * Sterilization\n   * IUD (intrauterine device)\n   * Birth Control Patch\n   * Depo-Provera\n\n   The following may be used if combined with other birth control methods:\n   * Condoms\n   * Diaphragm\n   * Jellies or foam\n   * Sponge\n   * Cervical cap\n8. For males, must be willing to not father a baby for the duration of the study and for 90 days after the last dose of study drug, or donate to a sperm bank during this time. Must be willing to use an approved form of birth control during this time. Acceptable forms of birth control:\n\n   * Condoms\n   * Sterilization\n\nExclusion Criteria:\n\n1. Subject does not speak or read English fluently.\n2. Subject is blind.\n3. Severe cardiac, pulmonary, liver and \u002For renal disease, or any other major organ dysfunction.\n4. Subject with a history of symptoms (e.g., dizziness, light-headedness, blurred vision, palpitations, weakness, syncope) related to a drop in blood pressure due to postural changes.\n5. Coumadin use at time of screening.\n6. History of mental illness.\n7. Subjects who are incarcerated.\n8. Subjects who satisfy any DSM-V criteria for current psychiatric illness such as bipolar disorder, depression, anxiety, schizophrenia, psychosis, substance use disorder or any other psychiatric diagnosis\n9. Subjects who have used intra-articular corticosteroids 30 days prior to screening.\n10. History of drug or substance abuse.\n11. Pre-existing CBD product usage currently (or within the prior 3 months) using recreational or medicinal cannabis, any cannabinoid-based medications, and is unwilling to abstain for the duration of the study.\n12. Subject has had a corticosteroid injection ≤ 60 days prior.\n13. Subjects who are unwilling to agree to no opioid medications or topical analgesic medications during the study period.\n14. Any woman of child bearing potential or male patient's partner unwilling to ensure that they or their partner use effective contraception, for example, hormonal contraception, double barrier, intra-uterine device, during the study and for females, through 30 days thereafter, and for males, three months thereafter.\n15. Any male not willing to avoid donating sperm during the duration of the study treatment period and for three months thereafter.\n16. Any patient with aberrant liver function as defined by either of the following:\n\n    * ALT \\>5x ULN or total bilirubin\\>2×ULN\n    * ALT or AST\\>3 × ULN and total bilirubin\\>2xULN or INR \\>1.5\n17. Participants within 14 days of the study procedure taking prescription or non-prescription medication which are substrates of CYP3A4 :\n\n    * Itraconazole,\n    * Ketoconazole,\n    * Azamulin,\n    * Troleandomycin,\n    * Verapamil,\n    * John's wart,\n    * Phenobarbital,\n18. Participants within 14 days of the study procedure taking prescription or non-prescription medication which are substrates of CYP2C19:\n\n    * Nootkatone,\n    * Ticlopidine,\n    * Rifampin,\n    * Omeprazole),\n19. Subjects taking prescription or non-prescription medication which are substrates of CYP2C8:\n\n    * Montelukast,\n    * Quercetin,\n    * Phenelzine,\n    * Rifampin,\n    * Clopidogrel) ,\n20. Participants within 14 days of the study procedure taking prescription or non-prescription medication which are substrates ofCYP2C9:\n\n    * Sulfaphenazole,\n    * Tienilic acid,\n    * Carbamazepine,\n    * Apalutamide,\n    * Fluconazole,\n    * Celecoxib\n21. Participants within 14 days of the study procedure taking prescription or non-prescription medication which are substrates of CYP1A2:\n\n    * alpha-Naphthoflavone,\n    * Furafylline,\n    * Phenytoin,\n    * Rifampin,\n    * Ritonavir,\n    * smoking,\n    * Teriflunomide,\n    * Ciproflaoxacin,\n    * oral contraceptives,\n    * Allopurinol\n22. Participants within 14 days of the study procedure taking prescription or non-prescription medication which are substrates of CYP2B6:\n\n    * Sertraline,\n    * Phencyclidine,\n    * Thiotepa,\n    * Ticlopidine,\n    * Carbamazepine,\n    * Efavirenez,\n    * Rifampin,\n    * Bupropion.",{"count":59,"type":20},100,[61],"PHASE1","The goal of this clinical trial is to learn about the use of cannabidiol (CBD) capsules as a treatment for musculoskeletal pain. CBD is commonly being used as an over-the-counter treatment for musculoskeletal pain. Clinical trials have demonstrated a pain-relief benefit for hand and wrist osteoarthritis with topical CBD, however patients prefer oral CBD and no clinical trial has been performed to establish efficacy of oral CBD in humans for upper extremity musculoskeletal pain. The main questions it aims to answer are:\n\nIs CBD more effective than placebo at relieving pain for upper extremity musculoskeletal pain ? Is CBD safe for participants with upper extremity musculoskeletal pain?\n\nParticipants will:\n\ntake 4 weeks of daily CBD capsules take 4 weeks of daily placebo capsules answer surveys about how they are feeling and functioning.\n\nParticipants will \\[describe the main tasks participants will be asked to do, interventions they'll be given and use bullets if it is more than 2 items\\].",[64,65,28],"Upper Extremity Muscle Pain","Upper Extremity Bone Pain",[67,68,69,70,71,72,73,74,75,76,77,78],"Wrist Muscular Pain","Forearm Bone Pain","Forearm Muscular Pain","Hand Pain","CBD","oral CBD","Upper Arm Muscular Pain","Upper Arm Bone Pain","Wrist Joint Pain","Wrist Bone Pain","Forearm Joint Pain","Upper Arm Joint Pain","NOT_YET_RECRUITING","2025-04-08",{"date":82,"type":43},"2025-04-09",{"date":84,"type":20},"2025-06",{"date":86,"type":20},"2026-03",{"name":88,"class":50},"Brent DeGeorge"]