[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"upper-extremity-paresis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:upper-extremity-paresis":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,15,0,[8,49,87,116,141,163,183,214,247,280,309,337,369,394,418],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100638666","rhythmic-initiation-vs-isometric-training-for-arm-recovery-after-stroke-100638666",false,"NCT07598435","Rhythmic Initiation vs Isometric Training for Arm Recovery After Stroke","Comparative Effects of Rhythmic Initiation and Isometric Resistance Training on Upper Limb Motor Function, Strength, and Coordination in Subacute Stroke Patients","RIITSTROKE","Inclusion Criteria:\n\n* Clinically diagnosed subacute stroke (1 to 6 months post-onset)\n* Unilateral upper limb involvement\n* Age 40 to 60 years\n* Both genders\n* Medically stable and able to participate in physical therapy\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Severe spasticity (Modified Ashworth Scale score \\>3)\n* Recurrent or bilateral stroke\n* Shoulder subluxation\n* Shoulder or upper limb pain limiting active movement\n* Cognitive or perceptual deficits impairing ability to follow instructions\n* Other neurological disorder affecting upper limb (e.g., Parkinson's disease, multiple sclerosis)\n* Orthopedic condition affecting upper limb function","ALL","40 Years","60 Years",{"count":21,"type":22},40,"ESTIMATED","INTERVENTIONAL",[25],"NA","Stroke is a leading cause of long-term disability worldwide. Many stroke survivors experience persistent weakness, loss of motor control, and poor coordination in their upper limb, which limits their ability to perform daily activities and return to independent living. This study compares two physical therapy approaches for patients in the subacute stage of stroke recovery (1 to 6 months after stroke). The first approach is Rhythmic Initiation, a technique from Proprioceptive Neuromuscular Facilitation (PNF) that uses smooth, guided movement patterns progressing from passive to active movement. The second approach is Isometric Resistance Training, which involves holding static muscle contractions against resistance without moving the joint. The study will enroll 40 patients aged 40 to 60 years with unilateral upper limb weakness from a first-time stroke. Participants will be randomly assigned to receive either Rhythmic Initiation or Isometric Resistance Training for 30 minutes per session, 5 days per week, for 4 weeks. The researchers will measure changes in motor function, muscle strength, coordination, and spasticity before and after the 4-week intervention. The results will help physiotherapists understand which approach is more effective for upper limb rehabilitation in subacute stroke patients.",[28,29],"Stroke","Upper Extremity Paresis",[31,32,33,34,35],"Stroke Rehabilitation","PNF","Isometric Exercise","Upper Limb","Motor Function","RECRUITING","2026-06-01",{"date":39,"type":40},"2026-06-03","ACTUAL",{"date":42,"type":40},"2026-01-19",{"date":44,"type":22},"2026-06-24",{"name":46,"class":47},"University of Faisalabad","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":58,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":69,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":86},"100488290","nerve-transfer-surgery-to-restore-upper-limb-function-after-cervical-spinal-cord-injury-100488290","NCT05638191","Nerve Transfer Surgery to Restore Upper-limb Function After Cervical Spinal Cord Injury","Inclusion Criteria:\n\n* Traumatic, motor-complete cervical SCI (AIS A or B)\n* Male or female, ages 18-70\n* Consent and plan to undergo nerve transfer to restore grasp function in at least one limb\n* Motor grade 4-5 at C5\n* Motor grade 0-1 at C8\u002FT1\n* Injury duration within 6 months at the time of surgery\n* English-speaking and cognitively intact\n* Able to provide informed written consent\n* Able to attend and comply with the testing protocols\n\nExclusion Criteria:\n\n* Inability or unwillingness to participate in post-operative rehabilitation (in person or virtual)\n* Secondary complication of SCI (e.g., intractable neuropathic pain, edema, contracture) or major medical comorbidity (e.g., traumatic brain injury) that would independently influence response to surgery or ability to participate in rehabilitation","18 Years","70 Years",{"count":21,"type":22},"2 Years","OBSERVATIONAL","The goal of this prospective, open-label cohort study is to assess functional outcomes in individuals with cervical spinal cord injury who have undergone nerve transfer surgery to restore upper limb function. The main questions it aims to answer are:\n\n* Does nerve transfer improve hand function in individuals with cervical spinal cord injury?\n* What factors are associated with functional improvement following nerve transfer? Researchers will compare functional outcomes at 24 months post-surgery to 1) baseline outcomes and 2) individuals with cervical spinal cord injury who did not undergo nerve transfer.\n\nParticipants who have received nerve transfer surgery as part of their regular medical care will complete functional hand tests, electrodiagnostic assessments, and questionnaires on independence and mood every 3 months for 24 months after surgery.",[62,63,64,65,66,67,29,68],"Spinal Cord Injury","Spinal Cord Injury at C5-C7 Level","SCI - Spinal Cord Injury","Upper Extremity Paralysis","Upper Extremity Dysfunction","Tetraplegia","Cervical Spinal Cord Injury",[70,71,72,73,74,75,76],"spinal cord injury","upper extremity nerve transfer","nerve transfer","SCI","nerve reconstruction","quadriplegia","paresis","2026-05-27",{"date":79,"type":40},"2026-05-29",{"date":81,"type":40},"2021-06-03",{"date":83,"type":22},"2028-01",{"name":85,"class":47},"University of British Columbia",4,{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":94,"targetDuration":4,"studyType":23,"phases":96,"briefSummary":97,"conditions":98,"keywords":102,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":112,"leadSponsor":114,"locationsCount":4},"100639040","personalized-robotic-telerehabilitation-for-upper-limb-functional-recovery-after-stroke-in-a-home-based-setting-100639040","NCT07590349","Personalized Robotic Telerehabilitation for Upper Limb Functional Recovery After Stroke in a Home-Based Setting","ROBOHOME","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Diagnosis of stroke with residual upper-limb motor impairment\n* Upper-limb functional impairment defined by a Fugl-Meyer Assessment for Upper Extremity (FMA-UE) score between 20 and 50\n* Ability to understand study procedures and provide written informed consent\n* Availability of a home environment suitable for telerehabilitation\n\nExclusion Criteria:\n\n* Presence of severe neurological or musculoskeletal disorders affecting the upper limb\n* Severe spasticity (Modified Ashworth Scale ≥3)\n* Severe upper-limb pain (Numerical Rating Scale \\>4)\n* Skin lesions, infections, or conditions preventing safe use of wearable devices\n* Participation in another interventional clinical trial\n* Any medical or cognitive condition that may interfere with compliance or safe participation in the study",{"count":95,"type":22},70,[25],"Stroke is a leading cause of long-term disability worldwide, with upper-limb impairment representing a major determinant of functional limitation and reduced independence. Conventional rehabilitation approaches are often limited by accessibility, intensity, and long-term adherence, highlighting the need for innovative, home-based solutions.\n\nThis study aims to evaluate the effectiveness of a personalized robotic telerehabilitation program for upper-limb recovery in individuals with post-stroke motor impairment. The intervention combines a wearable robotic device with a virtual reality-based platform, enabling patients to perform structured, task-oriented exercises in a home environment under remote supervision.\n\nParticipants will be allocated to either a robotic-assisted telerehabilitation program or a control condition based on virtual reality-based rehabilitation alone. Motor recovery will be assessed using standardized clinical scales, including the Fugl-Meyer Assessment for Upper Extremity (FMA-UE), along with measures of functional performance, patient-reported outcomes, and treatment adherence.\n\nBy integrating robotic assistance with telemedicine, this study seeks to enhance rehabilitation intensity, improve patient engagement, and facilitate continuity of care beyond traditional clinical settings. The results are expected to support the development of accessible, personalized rehabilitation pathways for individuals with stroke-related upper-limb disability.",[28,99,29,100,101],"Hemiparesis","Motor Impairment","Rehabilitation",[103,104,105,106],"stroke","Robotics","Telerehabilitation","Hemiplegia","NOT_YET_RECRUITING","2026-05-14",{"date":110,"type":40},"2026-05-15",{"date":37,"type":22},{"date":113,"type":22},"2027-05-30",{"name":115,"class":47},"University of Campania Luigi Vanvitelli",{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":4,"eligibilityCriteria":122,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":123,"enrollmentInfo":124,"targetDuration":4,"studyType":23,"phases":126,"briefSummary":127,"conditions":128,"keywords":129,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":48},"100527789","virtual-reality-based-mirror-therapy-100527789","NCT06152328","Virtual Reality Based Mirror Therapy","A New Perspective on Mirror Therapy: The Effect of Leap Motion-Based Multi-Axis Immersive Virtual Reality Mirror Therapy (LISA) on Upper Extremity Functions in Individuals With Stroke","Inclusion Criteria:\n\n* Have a ischemic stroke\n* Stroke duration not less than 2 months and not more than 6 months\n* Individuals with a score of 2b and 3 according to the Thrombolysis in cerebral infarction (TICI) scale\n* A score of 2 and above according to the upper extremity motor assessment of the NIH stroke scale\n* Intact depth perception in the Titmus Stereopsis assessment\n* A score of 24 and above in the Mini-mental test and\n* Independent sitting balance\n\nExclusion Criteria:\n\n* Additional neurologic diseases\n* Have a head injury\n* Have a brain tumor\n* Prior cranial surgery\n* Psychological disorder or mental problem\n* Previous stroke\n* Aphasia and apraxia\n* Upper extremity amputation","80 Years",{"count":125,"type":22},56,[25],"The aim of this study is to examine the effectiveness of 3D virtual reality assisted mirror therapy based rehabilitation applications compared to classical methods used in stroke rehabilitation.",[28,29,65],[101,130,131],"Virtual Reality Immersion Therapy","Mirror Movement Therapy","2026-05-02",{"date":134,"type":40},"2026-05-07",{"date":136,"type":40},"2024-04-01",{"date":138,"type":22},"2026-06-15",{"name":140,"class":47},"Abant Izzet Baysal University",{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":4,"eligibilityCriteria":147,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":148,"enrollmentInfo":149,"targetDuration":4,"studyType":23,"phases":150,"briefSummary":151,"conditions":152,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":48},"100478842","constraint-induced-movement-therapy-plus-sensory-components-after-stroke-100478842","NCT05515237","Constraint-Induced Movement Therapy Plus Sensory Components After Stroke","Constraint-Induced Movement Therapy Plus Sensory Components for Adults With Mild-to-Severe Arm and Hand Impairment After Stroke","Inclusion Criteria:\n\n* At least 6 months post stroke\n* The ability to demonstrate the minimum UE active movement criteria of shoulder ≥ 30 toward flexion or abduction, initiate movement at the elbow for flexion and extension, and initiate movement at the wrist, fingers, or thumb.\n* Mean score of \\\u003C2.5 on the Motor Activity Log\u002F G4\u002F5 Motor Activity Log indicating the participant's use of the more-affected UE.\n\nExclusion Criteria:\n\n* Score\\\u003C 24 on the Mini Mental State Exam\n* Inability to answer the MAL\u002F G4\u002F5 MAL questions and\u002For provide informed consent\n* The inability to come in to the laboratory setting for treatment.","89 Years",{"count":5,"type":22},[25],"Constraint-Induced Movement Therapy or CI Therapy is a form of treatment that systematically employs the application of selected behavioral techniques delivered in intensive treatment over consecutive day with the following strategies utilized: behavioral strategies are implemented to improve the use of the more- affected limb in life situation called a Transfer Package (TP), motor training using a technique called shaping to make progress in successive approximations, repetitive, task oriented training, and strategies to encourage or constrain participants to use the more-affected extremity including restraint of the less-affected arm in the upper extremity (UE) protocol. Numerous studies examining the application of CI therapy with UE rehabilitation after stroke have demonstrated strong evidence for improving the amount of use and the quality of the more-affected UE functional use in the participant's daily life situation.\n\nCI Therapy studies with adults, to date, have explored intensive treatment for participants with a range from mild-to-severe motor impairment following stroke with noted motor deficits and limited use of the more-affected arm and hand in everyday activities. Each CI Therapy protocol was designed for the level of impairment demonstrated by participants recruited for the study. However, often following stroke, patients not only have motor deficits but somatosensory impairments as well. The somatosensory issues have not, as yet, been systematically measured and trained in CI Therapy protocols with adults and represent an understudied area of stroke recovery. We hypothesize that participants with mild-to-severe motor impairment and UE functional use deficits can benefit from CI therapy protocols that include somatosensory measurement and training components substituted for portions of motor training without loss in outcome measure gains. Further, we hypothesize that adults can improve somatosensory outcomes as a result of a combined CI therapy plus somatosensory component protocol.",[153,28,29],"CVA (Cerebrovascular Accident)","2026-04-08",{"date":156,"type":40},"2026-04-13",{"date":158,"type":40},"2023-03-30",{"date":160,"type":22},"2027-06",{"name":162,"class":47},"University of Alabama at Birmingham",{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":168,"acronym":4,"eligibilityCriteria":169,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":170,"targetDuration":4,"studyType":23,"phases":172,"briefSummary":173,"conditions":174,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":48},"100477096","constraint-induced-movement-therapy-for-adults-post-stroke-with-mild-upper-extremity-impairment-100477096","NCT05492513","Constraint-Induced Movement Therapy for Adults Post-Stroke With Mild Upper Extremity Impairment","Constraint-Induced Movement Therapy for Adults Post-Stroke With Mild Upper Extremity Impairment and Deficits in Desired Occupational Performance: A Pilot Study","Inclusion Criteria:\n\n* At least 6 months post stroke\n* The ability to demonstrate the minimum UE active movement criteria of 20 degrees of wrist extension from a fully flexed position, 10 degrees of thumb extension or abduction, and 10 degrees of extension of all finger joints.\n* Mean score of \\>2.5 on the Motor Activity Log indicating the participant's use of the more-affected UE.\n\nExclusion Criteria:\n\n* Score\\\u003C 24 on the Mini Mental State Exam\n* Inability to answer the MAL questions and\u002For provide informed consent\n* The inability to come in to the laboratory setting for treatment.",{"count":171,"type":22},12,[25],"Constraint-Induced Therapy (CI Therapy) is a behavioral approach to neurorehabilitation and consists of multi-components that have been applied in a systematic method to improve the use of the limb or function addressed in the intensive treatment. CI Therapy for the more-affected upper extremity (UE) post-stroke is administered in daily treatment sessions over consecutive weekdays. Sessions include motor training with repeated, timed trials using a technique called shaping, a set of behavioral strategies known as the Transfer Package (TP) to improve the use of the more-affected hand in the life situation, and strategies to remind participants to use the more-affected UE including restraint. Robust improvements in the amount and qualify of use have been realized with stroke participants from mild-to-severe UE impairment.",[153,28,29],"2026-02-18",{"date":177,"type":40},"2026-02-20",{"date":179,"type":40},"2022-12-08",{"date":181,"type":22},"2027-03",{"name":162,"class":47},{"id":184,"slug":185,"hasResults":11,"nctId":186,"briefTitle":187,"officialTitle":188,"acronym":189,"eligibilityCriteria":190,"healthyVolunteers":11,"sex":17,"minAge":191,"maxAge":4,"enrollmentInfo":192,"targetDuration":4,"studyType":23,"phases":194,"briefSummary":195,"conditions":196,"keywords":197,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":206,"completionDateStruct":208,"leadSponsor":210,"locationsCount":213},"100493140","pilotpivotal-study-of-dbsrehab-after-stroke-100493140","NCT05701280","Pilot\u002FPivotal Study of DBS+Rehab After Stroke","Rehab With Electrical Stimulation Therapy to Optimize Rehabilitation Effect (RESTORE): A Pivotal Study","RESTORE","Key Inclusion Criteria:\n\n* Ischemic stroke, with an initial incident occurring between 12 months to 6 years before implant, resulting in residual upper extremity hemiparesis.\n\nKey Exclusion Criteria:\n\n* Previous or subsequent cerebrovascular events resulting in residual upper extremity impairment\n* Brain lesions with significant involvement of the brainstem, cerebellum, or thalamus","21 Years",{"count":193,"type":22},202,[25],"The RESTORE Stroke Study will evaluate the safety and effectiveness of DBS+Rehab for treating arm weakness and reduced function after a stroke.",[28,29],[198,199,200,201,101,202],"Ischemic Stroke","Deep Brain Stimulation","DBS","Physical Therapy","Brain Stimulation","2026-01-20",{"date":205,"type":40},"2026-01-21",{"date":207,"type":40},"2023-02-03",{"date":209,"type":22},"2030-06",{"name":211,"class":212},"Enspire DBS Therapy, Inc.","INDUSTRY",10,{"id":215,"slug":216,"hasResults":11,"nctId":217,"briefTitle":218,"officialTitle":218,"acronym":219,"eligibilityCriteria":220,"healthyVolunteers":221,"sex":17,"minAge":55,"maxAge":222,"enrollmentInfo":223,"targetDuration":4,"studyType":23,"phases":225,"briefSummary":226,"conditions":227,"keywords":231,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":238,"lastUpdatePostDateStruct":239,"startDateStruct":241,"completionDateStruct":243,"leadSponsor":245,"locationsCount":48},"100619139","sensory-mechanisms-of-manual-dexterity-recovery-after-stroke-a-prospective-cohort-study-of-prediction-and-cerebral-correlates-100619139","NCT07340736","Sensory Mechanisms of Manual Dexterity Recovery After Stroke: a Prospective Cohort Study of Prediction and Cerebral Correlates","HapticS 2","Inclusion Criteria:\n\n* First symptomatic stroke, ischaemic or haemorrhagic in the early subacute phase (up to 3 weeks post-stroke)\n* Upper limb paresis (≤4\u002F5 MRC Scale)\n* Ability to grasp, lift and put down 1 block (from the BBT test)\n* Be affiliated to a social security\n\nExclusion Criteria:\n\n* Presence of another neurological or musculoskeletal condition affecting upper limb movement\n* Severe cognitive impairment and\u002For aphasia with inability to understand and carry out instructions\n* Contraindications to MRI (claustrophobia, presence of cochlear implants and\u002For pacemakers)\n* Persons subject to legal protection measures\n* Persons subject to judicial protection measures\n* Pregnancy\n* Life-threatening conditions or conditions requiring follow-up at 6 months\n* Epilepsy\n* Known hypersensitivity or allergy to silicone",true,"85 Years",{"count":224,"type":22},90,[25],"In the proposed research, we will assess motor and sensory functions of the hand using clinical tests and a tool designed to measure manual dexterity combined with vibrotactile stimulation. We will also evaluate the integrity of brain structure and function using MRI.",[28,29,228,229,230],"Manual Dexterity","Sensory Integration Dysfunction","Vibration",[103,232,233,234,235,236,237],"haptic","vibration","sensorimotor impairment","manual dexterity","prediction of recovery","MRI","2026-01-05",{"date":240,"type":40},"2026-01-14",{"date":242,"type":22},"2026-03-01",{"date":244,"type":22},"2028-03-01",{"name":246,"class":47},"Centre Hospitalier St Anne",{"id":248,"slug":249,"hasResults":11,"nctId":250,"briefTitle":251,"officialTitle":252,"acronym":4,"eligibilityCriteria":253,"healthyVolunteers":11,"sex":17,"minAge":191,"maxAge":254,"enrollmentInfo":255,"targetDuration":4,"studyType":23,"phases":257,"briefSummary":258,"conditions":259,"keywords":260,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":272,"startDateStruct":274,"completionDateStruct":276,"leadSponsor":278,"locationsCount":48},"100505793","tdcs--ccfes-mediated-functional-task-practice-for-post-stroke-upper-extremity-hemiplegia-100505793","NCT05866003","tDCS + CCFES-mediated Functional Task Practice for Post-stroke Upper Extremity Hemiplegia","tDCS During Contralaterally Controlled FES for Upper Extremity Hemiplegia","Inclusion Criteria:\n\n1. Age ≥ 21 and ≤ 90\n2. ≥ 6 and ≤ 24 months since first clinical hemorrhagic or nonhemorrhagic stroke\n3. Able to follow 3-stage command\n4. Able to remember 2 of 3 items after 30 minutes\n5. Full volitional elbow extension\u002Fflexion and hand opening\u002Fclosing of unaffected limb\n6. Adequate active movement of shoulder and elbow to position the paretic hand in the workspace for table-top task practice\n7. Patient must be able to sit unassisted in an armless straight-back chair for the duration of the screening portion of the eligibility assessment\n8. Medically stable\n9. ≥ 10° finger and wrist extension\n10. Skin intact on hemiparetic arm, hand and scalp\n11. Muscle contraction can be elicited with Transcranial Magnetic Stimulation\n12. Unilateral upper limb hemiparesis with finger extensor strength of ≤ grade 4\u002F5 on the Medical Research Council (MRC) scale\n13. Score of ≥1\u002F14 and ≤ 11\u002F14 on the hand section of the upper extremity Fugl-Meyer Assessment\n14. While relaxed, surface NMES of finger extensors and thumb extensors and\u002For abductors produces a functional degree of hand opening without pain.\n\nExclusion Criteria:\n\n1. Co-existing neurological condition other than prior stroke involving the hemiparetic upper limb (e.g., peripheral nerve injury, PD, SCI, TBI, MS).\n2. Uncontrolled seizure disorder\n3. Use of seizure lowering threshold medications and the discretion of the study physician\n4. Cardiac pacemaker or other implanted electronic device\n5. Pregnant\n6. IM Botox injections in any UE muscle in the last 3 months\n7. Insensate arm, forearm, or hand\n8. Deficits in communication that interfere with reasonable study participation\n9. Severely impaired cognition and communication\n10. Uncompensated hemi-neglect (extinguishing to double simultaneous stimulation)\n11. Severe shoulder or hand pain (unable to position hand in the workspace without pain)","90 Years",{"count":256,"type":22},63,[25],"After a stroke, it is very common to lose the ability to open the affected hand. Occupational and physical rehabilitation therapy (OT and PT) combined with non-invasive brain stimulation may help a person recover hand movement.\n\nThe purpose of this study is to compare 3 non-invasive brain stimulation protocols combined with therapy to see if they result in different amounts of recovery of hand movement after a stroke.",[28,29,106],[28,101,261,262,263,264,265,266,267,268,269,270,34],"Therapy","Electrical Stimulation","Brain stimulation","Hand","CCFES","Motor Cortex","TMS","Motor Recovery","Central Nervous System","CVA","2025-09-23",{"date":273,"type":40},"2025-09-29",{"date":275,"type":40},"2023-07-01",{"date":277,"type":22},"2028-04",{"name":279,"class":47},"MetroHealth Medical Center",{"id":281,"slug":282,"hasResults":11,"nctId":283,"briefTitle":284,"officialTitle":285,"acronym":286,"eligibilityCriteria":287,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":288,"targetDuration":4,"studyType":23,"phases":290,"briefSummary":291,"conditions":292,"keywords":294,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":299,"lastUpdatePostDateStruct":300,"startDateStruct":302,"completionDateStruct":304,"leadSponsor":306,"locationsCount":48},"100547575","bci-fes-for-upper-limb-rehabilitation-in-chronic-stroke-100547575","NCT06409754","BCI-FES for Upper Limb Rehabilitation in Chronic Stroke","Application of Functional Electrical Stimulation Therapy Coupled to a P300-based Brain-Computer Interface for Paretic Upper Limb Rehabilitation in Chronic Stroke: A Randomized Controlled Trial","BCI-FES","Inclusion Criteria:\n\n* Patients with ischemic or hemorrhagic stroke (evidenced by CT or MRI)\n* ≥6 months from stroke onset, chronic phase\n* Unilateral lesion\n* Age ≥18 years\n* Moderate-severe hemiparesis (FMA-UE: ≤45)\n* Full passive ranges of motion in the elbow, forearm, wrist, and hand\n* Minimal cognitive level necessary to follow instructions and complete tasks\n* Desire to participate in the study\n\nExclusion Criteria:\n\n* Neurological disorders (Parkinsons disease, epilepsy, dementia)\n* Neurological or musculoskeletal condition directly affecting the upper limb (dystonia, severe spasticity -muscle tone for elbow, wrist and fingers \\> 3 according to modified Ashworth scale-)\n* Contraindications for MRI (implantable devices -pacemakers-, claustrophobia, others)\n* Cognitive deficit (MoCA \\\u003C20 points)\n* Severe aphasia\n* Severe psychiatric disorders\n* More than one stroke",{"count":289,"type":22},26,[25],"The objective of this research is to evaluate the efficacy of an experimental therapy for motor recovery of the arm after a stroke, which includes the application of a functional electrical stimulation therapy coupled to P-300 based Brain-Computer Interface system (BCI-FES). For this purpose, the investigators will compare two groups, the first one will receive only conventional physical therapy, while the second one will receive physical conventional therapy together with BCI-FES therapy.\n\nThe control and experimental group will receive 20 sessions of conventional physical therapy at a rate of five sessions per week for 4 weeks, and the experimental group will receive 20 sessions of rehabilitation with the BCI-FES system at a rate of five sessions per week for 4 weeks. Broadly speaking, the BCI is in charge of determining the movement selected by the individual and assist the hand movement while performing functional tasks. The movements included in the sessions will be hand opening, grasping, pinching, pronation and supination, which are combined to facilitate the execution of functional movements that are performed together with the manipulation of daily used utensils. The visual, sensory and motor feedback provided by the BCI-FES system that enables the individual to replicate the afferent-efferent motor circuit, contributes to the activation and recruitment of neural pathways, which is associated with motor recovery.\n\nIt should be noted that this BCI-FES system has already been tested previously in a study with healthy individuals, and in a non-randomized pilot study that used this therapy for upper limb motor function recovery in chronic post-stroke patients. It showed positive results, and the therapy was safe and tolerated by all the patients. Besides no adverse event related to the intervention occurred.\n\nTo evaluate the results, a series of tests will be applied to assess the motor recovery and level of independence, including the FMA-UE: Fugl-Meyer Assessment Scale of Upper Extremity, ARAT: Action Research Arm Test, MAS: Modified Ashworth Scale, FIM: Functional Independence Measure and MAL: Motor Activity Log. Moreover, to assess neuroplasticity, two neuroimaging techniques including magnetic resonance imaging and electroencephalography will be used.",[28,29,293],"Neuronal Plasticity",[28,29,295,296,297,293,298],"Neurorehabilitation","Brain-Computer Interfaces","Functional Electrical Stimulation","Magnetic Resonance Imaging","2025-02-25",{"date":301,"type":40},"2025-02-27",{"date":303,"type":40},"2024-08-06",{"date":305,"type":22},"2026-06",{"name":307,"class":308},"Instituto Nacional de Rehabilitacion","OTHER_GOV",{"id":310,"slug":311,"hasResults":11,"nctId":312,"briefTitle":313,"officialTitle":314,"acronym":4,"eligibilityCriteria":315,"healthyVolunteers":11,"sex":17,"minAge":316,"maxAge":123,"enrollmentInfo":317,"targetDuration":4,"studyType":23,"phases":319,"briefSummary":320,"conditions":321,"keywords":322,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":327,"lastUpdatePostDateStruct":328,"startDateStruct":330,"completionDateStruct":332,"leadSponsor":334,"locationsCount":336},"100571624","a-trial-of-rehabilitation-paired-with-vns-for-motor-function-in-patients-with-stroke-repair-study-100571624","NCT06722677","A Trial of Rehabilitation Paired with VNS for Motor Function in Patients with Stroke (Repair Study)","A Multi-Center, Triple-Blind, Randomized, Sham-Controlled Trial Assessing the Efficacy and Safety of Rehabilitation Paired with Vagus Nerve Stimulation for Upper Extremity Motor Function in Patients with Ischemic Stroke (Repair Study)","Inclusion Criteria:\n\n1. Age ≥22 years and \\\u003C80 years, all gender is acceptable.\n2. History of unilateral supratentorial ischemic stroke ≥ 9 months but \\\u003C 10 years.\n3. Upper Extremity motor section of the Fugl-Meyer Assessment score ≥20 and ≤50.\n4. Right- or left-sided weakness of upper extremity.\n5. Ability to communicate, understand, and give appropriate consent. Subjects can follow trial commands.\n6. Subjects have good compliance and can complete the visits after surgery.\n\nExclusion Criteria:\n\n1. History of hemorrhagic stroke.\n2. Presence of ongoing dysphagia or aspiration difficulties.\n3. Prior injury to vagus nerve, either bilateral or unilateral.\n4. Subject receiving medication that may significantly interfere with actions of VNS on neurotransmitter systems at study entry, clinic rehabilitation follow-up timepoint, or home rehabilitation follow-up timepoint, such as centrally acting cholinoceptor blockers, centrally acting adrenoceptor blockers, norepinephrine re-uptake inhibitors, etc.\n5. Botox injections within 4 weeks prior to enrollment through the unmasking follow-up timepoint (Visit 6).\n6. Severe spasticity of the upper extremity (Modified Ashworth ≥ 3).\n7. Significant sensory loss of the upper extremity (Upper Extremity sensory section of the Fugl-Meyer Assessment score \\\u003C 6).\n8. Severe depression (Beck Depression Scale \\> 29).\n9. Current requirement, or likely future requirement, of diathermy.\n10. Current use of any other stimulation device, such as a pacemaker or other neurostimulator.\n11. Pregnancy or plans to become pregnant or to breastfeed during the study period.\n12. Participated in any other clinical trials within the preceding 3 months.\n13. Not considered to be applicable by the investigator.","22 Years",{"count":318,"type":22},99,[25],"The goal of this clinical trial is to investigate the efficacy and safety of vagus nerve stimulation (VNS) paired with rehabilitation for enhancing upper extremity motor function after ischemic stroke.\n\nResearchers will compare the outcomes of active VNS paired with rehabilitation against sham VNS (the actual intensity is 0 mA) also paired with rehabilitation, in order to assess improvements in arm motor function post-stroke.\n\nParticipants in this study will undergo a surgical procedure to implant the VNS system and will subsequently recieve a 6 weeks in-clinic therapy, followed by an additional 6 weeks home exercise. During the final 6 weeks, participants will either recieve in-clinic therapy or maintain their home exercise, depending on their assigned group.",[198,29],[28,198,323,29,324,325,326,101],"Paresis","Vagus Nerve Stimulation","Neuromodulation","Randomized Controlled Trial","2024-12-09",{"date":329,"type":40},"2024-12-10",{"date":331,"type":40},"2024-11-19",{"date":333,"type":22},"2025-11",{"name":335,"class":212},"Beijing Pins Medical Co., Ltd",16,{"id":338,"slug":339,"hasResults":11,"nctId":340,"briefTitle":341,"officialTitle":342,"acronym":343,"eligibilityCriteria":344,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":345,"enrollmentInfo":346,"targetDuration":4,"studyType":23,"phases":348,"briefSummary":349,"conditions":350,"keywords":357,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":359,"lastUpdatePostDateStruct":360,"startDateStruct":362,"completionDateStruct":364,"leadSponsor":366,"locationsCount":368},"100560284","associative-peripheral-stimulation-for-reduction-of-motor-impairment-during-acute-period-of-stroke-recovery-100560284","NCT06575140","Associative Peripheral Stimulation for Reduction of Motor Impairment During Acute Period of Stroke Recovery","Pilot Randomized Controlled Trial Assessing Associative Peripheral Stimulation (APS) for Reduction of Motor Impairment During Acute Period of Stroke Recovery","APS-PILOT","Inclusion Criteria:\n\n1. Confirmed ischemic or hemorrhagic stroke no earlier than 7 days prior to enrollment;\n2. Presentation of hemiparesis or paralysis of the upper extremity due to stroke;\n3. Ability to comprehend and follow study instructions;\n4. Ability to initiate finger extension (≥3°) at least three times per minute;\n5. Fugl-Meyer Assessment (Upper Extremity) score of \\\u003C47.\n\nExclusion Criteria:\n\n1. Contraindications, intolerance, or high sensitivity to the experimental protocol;\n2. History of upper-extremity disability prior to the index stroke;\n3. Neurological conditions (other than stroke) affecting motor function;\n4. Treatment of spasticity\u002Fincreased tone in the affected upper extremity (e.g., with Botox injection);\n5. Lack of access to a safe and suitable place of discharge for experimental sessions and follow-up visits.","79 Years",{"count":347,"type":22},20,[25],"Associative Peripheral Stimulation (APS) is a non-invasive therapy intended for stroke rehabilitation involving transcutaneous electrical muscle stimulation paired with voluntary movement. This pilot study investigates whether APS applied during the acute phase of stroke recovery may reduce impairment and improve function in the affected upper extremity.",[28,351,352,353,99,354,355,356,29],"Stroke, Acute","Stroke, Ischemic","Stroke, Hemorrhagic","Hemiparesis;Poststroke\u002FCVA","Weakness of Extremities as Sequela of Stroke","Stroke Sequelae",[31,358],"Associative Peripheral Stimulation","2024-08-28",{"date":361,"type":40},"2024-08-30",{"date":363,"type":40},"2021-12-18",{"date":365,"type":22},"2024-12",{"name":367,"class":47},"Ahmed A. Rahim",3,{"id":370,"slug":371,"hasResults":11,"nctId":372,"briefTitle":373,"officialTitle":373,"acronym":4,"eligibilityCriteria":374,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":375,"targetDuration":377,"studyType":59,"phases":4,"briefSummary":378,"conditions":379,"keywords":381,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":385,"lastUpdatePostDateStruct":386,"startDateStruct":388,"completionDateStruct":390,"leadSponsor":392,"locationsCount":48},"100560253","use-of-surface-electromyography-as-a-tools-to-predict-upper-extremity-recovery-function-after-stroke-100560253","NCT06574737","Use of Surface Electromyography as a Tools to Predict Upper Extremity Recovery Function After Stroke","Inclusion Criteria:\n\n1. Patients who are hospitalized with upper extremity weakness due to stroke on the same side which confirmed with computed tomography (CT) scan or structural magnetic resonance imaging (MRI), in the acute phase\n2. Men and women aged more than 18 years old\n3. Willing to participate\n\nExclusion Criteria:\n\n1. Cognitive impairment (MoCA-Ina score less than 26)\n2. Impaired consciousness (GCS score less than 15)\n3. Unstable medical conditions at time of hospitalization\n4. Patients with pacemaker\n5. Having other injury or dysfunction in the impaired side of upper extremity that caused restrictions on the range of joint movement and muscle weakness, such as fractures, periarthritis, or moderate-severe pain\n6. Diagnosis of other neurological disease or disorders in addition to stroke (e.g., traumatic brain injury, neuropathy or radiculopathy)\n7. Get treated in isolation room\n8. Hypersensitivity to gel electrodes",{"count":376,"type":22},30,"3 Months","Hypothesis :\n\nBased on the framework and premises above, the hypothesis is formulated as follows: H0 : surface electromyography parameters cannot predicts upper extremity motor function recovery in stroke patients H1: surface electromyography parameters can predicts upper extremity motor function recovery in stroke patients",[29,380,28],"Muscle Contracture Upper Arm",[382,383,384],"Surface electromyography","Predictor Stroke","Upper Extremity Recovery","2024-08-27",{"date":387,"type":40},"2024-08-29",{"date":389,"type":40},"2024-05-01",{"date":391,"type":22},"2025-07-31",{"name":393,"class":47},"Universitas Padjadjaran",{"id":395,"slug":396,"hasResults":11,"nctId":397,"briefTitle":398,"officialTitle":399,"acronym":4,"eligibilityCriteria":400,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":123,"enrollmentInfo":401,"targetDuration":4,"studyType":23,"phases":403,"briefSummary":404,"conditions":405,"keywords":406,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":409,"lastUpdatePostDateStruct":410,"startDateStruct":412,"completionDateStruct":414,"leadSponsor":416,"locationsCount":48},"100554426","deep-brain-stimulation-of-the-dentate-nucleus-for-motor-rehabilitation-after-stroke-100554426","NCT06498934","Deep Brain Stimulation of the Dentate Nucleus for Motor Rehabilitation After Stroke","Deep Brain Stimulation of Cerebellar Dentate Nucleus Promotes Upper Limb Motor Function Recovery After Ischemic Stroke: a Randomized, Double-blind, Sham-controlled Trial","Inclusion Criteria:\n\n1. Within the first year to 3 years after the first stroke;\n2. Unilateral infarction located in the territory of the middle cerebral artery, but not involving the cerebellum, thalamus, and brainstem;\n3. Aged 18-80 years;\n4. TMS standard: TMS induces muscle evoked potential (MEP). In the contracted state of the paralyzed muscle (maximum voluntary contraction of 20-50%), a reliable standard MEP (in 5\u002F10 trials with 50-100uv) can be induced;\n5. Researchers determine the medical and neurological condition of the participant to be stable based on the participant's medical history, physical examination, and neurological examination;\n6. Moderate-severe unilateral upper limb paralysis, i.e., the Fugl-Meyer Assessment (FMA-UE) scale score is ≤47;\n7. The distal extremity of the limb has some degree of motor function (flexion of the elbow joint or extension of the elbow joint or partial finger flexion with FMA-UE ≥1);\n8. mRS\\\u003C4 points, able to cooperate with assessment and rehabilitation;\n9. No spasticity or mild spasticity in any part of the affected limb (intramuscular rotator muscle and adductor muscle of the shoulder joint, flexor muscle of the elbow joint, flexor muscle of the wrist joint or finger flexor muscle), modified Ashworth scale (MAS) \\\u003C4 points;\n10. MMSE\\>24 points.\n\nExclusion Criteria:\n\n1. Primary hemorrhagic stroke or severe hemorrhagic conversion;\n2. Any progressive neurological or somatic disease that impairs the function of the affected limb other than stroke;\n3. Moderate to severe neglect or disinhibition of the affected limb;\n4. Any other neurological disorder that may compromise study safety, including central nervous system vasculitis, intracranial tumors, intracranial aneurysms, multiple sclerosis, or arteriovenous malformations;\n5. Pain intensity on the affected limb NRS ≥5 or severe sensory disturbance, NIHSS (item 8) = 2;\n6. Exclusion of cardioembolic stroke, patients requiring long-term anticoagulation;\n7. Unable to stop anticoagulation treatment at least 10 days prior to surgery (i.e., antiplatelet and\u002For anticoagulant therapy);\n8. Seizure(s) after stroke or potential risk of seizure(s);\n9. Switching to oral spasticity medication within 2 weeks of enrollment, or injection of botulinum toxin in the affected arm within 4 months, and\u002For intention to start taking spasticity medication or inject botulinum toxin during the study follow-up period or within 12 months after implantation;\n10. The presence of active psychosis that may affect treatment effect, such as psychosis or severe personality disorder;\n11. Untreated or inadequately treated depression, i.e., Beck Depression Inventory score of 20 or more at admission;\n12. Diagnosis of dementia;\n13. Uncontrolled hypertension or history of cardiovascular disease for a long time;\n14. MRI contraindications, such as implanted metal devices or electronic devices (pacemakers, defibrillators, spinal cord stimulators);\n15. Participated in another device, biological, or drug study within 30 days of consenting to participate in the current study;\n16. Non-pregnant or fertile women must use acceptable contraception, and pregnant women are excluded or terminated from the study;\n17. Received decompressive craniectomy;\n18. The patient has severe cerebral small vessel disease, basilar artery vascular disease, and\u002For any other structural abnormalities of the cerebellum, cerebellar peduncles, and brainstem that prevent safe placement of DBS;\n19. The investigator determines that the patient has a condition that would significantly increase the risk of study non-compliance, study safety, and\u002For study integrity. For the safety of the subject, for example, if the subject experiences an exacerbation of their condition, a serious adverse event, or poor compliance.",{"count":402,"type":22},52,[25],"The goal of this clinical trial is to learn if deep brain stimulation of the dentate nucleus (DN-DBS) works to promote chronic post-stroke upper limb motor function in adults. It will also learn about the safety of DN-DBS. The main questions it aims to answer are:\n\nDoes DN-DBS paired with rehabilitation improve the upper limb motor function of participants more than rehabilitation only? What medical problems do participants have when using DN-DBS for post-stroke rehabilitation?\n\nResearchers will compare real DN-DBS+rehabilitation to sham DN-DBS+rehabilitation (electrodes will be implanted, but no electrical current is given) to see if DN-DBS works to promote chronic post-stroke upper limb motor function.\n\nParticipants will:\n\nUndergo unilateral DN-DBS surgery Take real DN-DBS+rehabilitation or sham DN-DBS+rehabilitation as treatment for 6 months Visit the clinic every month during the DN-DBS+rehabilitation (treatment) period for programing, checkups and tests Visit the clinic at Day 1, 30, 90 and 365 after treatment period for checkups and tests",[28,29],[407,408],"deep brain stimulation","the dentate nucleus","2024-07-17",{"date":411,"type":40},"2024-07-18",{"date":413,"type":22},"2024-09-01",{"date":415,"type":22},"2027-12-31",{"name":417,"class":308},"Beijing Municipal Administration of Hospitals",{"id":419,"slug":420,"hasResults":11,"nctId":421,"briefTitle":422,"officialTitle":422,"acronym":4,"eligibilityCriteria":423,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":123,"enrollmentInfo":424,"targetDuration":4,"studyType":23,"phases":426,"briefSummary":427,"conditions":428,"keywords":429,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":433,"lastUpdatePostDateStruct":434,"startDateStruct":436,"completionDateStruct":437,"leadSponsor":439,"locationsCount":48},"100527392","effects-of-individualized-itbs-on-upper-limb-function-after-stroke-100527392","NCT06147167","Effects of Individualized iTBS on Upper Limb Function After Stroke","Inclusion Criteria:\n\n1. aging from 18-80\n2. diagnosed as first-happened stroke,duration of the disease ranged from 1-3 months\n3. upper extremity impairment\n4. with mini-mental state examination\\>15\n5. agree to participate in this study and sigh the informed consent\n\nExclusion Criteria:\n\n1. with stroke history\n2. have metal device within the body\n3. with history of upper extremity trauma,fracture, and\u002For burn\n4. serious conditions and can not finish the examination and treatment",{"count":425,"type":22},159,[25],"The primary objective of this clinical study is to assess the comparative efficacy of individualized intermittent theta burst stimulation (iTBS) in contrast to standard iTBS for individuals post-stroke experiencing upper limb impairment. The key inquiries addressed in this study encompass:\n\nEnhancement of Upper Limb Function: The primary investigation seeks to determine whether individualized iTBS yields superior improvements in upper limb functionality compared to standard iTBS.\n\nLong-Term Effects: This study endeavors to explore the sustained effects of both individualized and standard iTBS on upper limb function over an extended duration.\n\nNeural Mechanisms Investigation: Functional near-infrared spectroscopy (fNIRS) will be employed to elucidate the neural mechanisms underlying the impact of iTBS on the enhancement of upper limb function.\n\nPost-stroke individuals with upper limb impairment will undergo pre-treatment assessments, including motor function evaluations and fNIRS tests. Subsequently, they will be randomized into three groups: individualized iTBS, standard iTBS, and sham stimulation. Participants will undergo post-treatment assessments and follow-up evaluations.\n\nThe research team aims to discern disparities in the efficacy of different iTBS modalities. The central hypothesis posits that individualized iTBS will demonstrate superior efficacy in enhancing post-stroke upper limb function, with sustained effects persisting for a minimum of one month.",[29,28],[430,431,432],"intermittent theta burst stimulation;","upper extremity paresis;","functional nearinfrared spectroscopy","2024-04-18",{"date":435,"type":40},"2024-04-22",{"date":389,"type":22},{"date":438,"type":22},"2026-09-30",{"name":440,"class":47},"Qilu Hospital of Shandong University"]