[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"upper-extremity-weakness\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:upper-extremity-weakness":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":5},"100609855","low-intensity-focused-ultrasound-stimulation-in-stroke-patients---parameter-optimization-100609855",false,"NCT07220005","Low Intensity Focused Ultrasound Stimulation in Stroke Patients - Parameter Optimization","LIFUS-OPTIMIZE","Inclusion Criteria:\n\n* age \\>=21 years old of any gender or race\n* First-ever ischemic or hemorrhagic stroke (neuroimaging verified) at least 6 months from the stroke onset of symptoms\n* Unilateral arm weakness measured by the Fugl-Meyer Upper-Extremity Scale ≤ 62\u002F64\n* Inducible rest motor threshold and testing motor threshold recorded from the affected abductor pollicis brevis muscle\n\nExclusion Criteria:\n\n* Bilateral strokes (infarcts and\u002For hematoma)\n* Other co-existent neuromuscular disorders affecting upper extremity motor impairment\n* History of medically uncontrolled depression or other neuropsychiatric disorders despite medications either before or after a stroke that may affect the subject's ability to participate in the study\n* History of confirmed dementia or taking dementia drugs\n* Uncontrolled hypertension despite medical treatment(s) at the time of enrollment, defined as SBP≥185 mmHg or DBP≥110 mmHg (patient can be treated, reassessed and enrolled later)\n* Presence of any MRI\u002FTMS\u002FLIFUS risk factors\n* Concurrent enrollment in another interventional stroke recovery study\n* Concerns that the subject cannot comply with study procedures and visits\n* Pregnant","ALL","21 Years",{"count":19,"type":20},24,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this research study is to optimize the parameter of Low-Intensity Focused Ultrasound Stimulation (LIFUS) that is most effective in changing cortical excitability and motor learning skills in patients who suffered a stroke. The researchers hope to answer two questions.\n\n* with increasing power, would LIFUS be more effective?\n* with the same power, what LIFUS timing is the best\n\nFor Aim 1, the study will compare 8, 4 W\u002Fcm\\^2 to a zero(sham) stimulation to see if higher power is the better.\n\nFor Aim 2, the study will compare 500 vs 1000 vs 2000 Hz \"timing\" to see which one is better.",[26,27,28,29,30],"Stroke","Arm Weakness as a Consequence of Stroke","Upper Extremity Hemiparesis","Upper Extremity Impairments","Upper Extremity Weakness",[32,33,34,35,36,37],"Brain Stimulation","Transcranial Focused Ultrasound Stimulation","Low Intensity Focused Ultrasound Stimulation","Stroke Recovery","Motor Learning","Corticospinal Excitability","RECRUITING","2025-12-19",{"date":41,"type":42},"2025-12-23","ACTUAL",{"date":44,"type":42},"2025-12-10",{"date":46,"type":20},"2026-06-30",{"name":48,"class":49},"Duke University","OTHER"]