[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"upper-gastrointestinal-cancer\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:upper-gastrointestinal-cancer":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,77],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100644984","precision-navigation-to-improve-community-cancer-screening-participation-a-dual-cohort-cluster-randomized-trial-100644984",false,"NCT07676383","Precision Navigation to Improve Community Cancer Screening Participation: A Dual-Cohort Cluster Randomized Trial","Effectiveness and Mechanisms of a Precision Navigation Intervention to Improve Community Cancer Screening Participation: A Dual-Cohort Cluster Randomized Controlled Trial","Inclusion Criteria:\n\n1. Aged 45 to 74 years.\n2. Permanent resident of a participating community, defined as having lived in the community for at least 6 months during the past 12 months.\n3. Participating in the urban cancer screening program.\n4. Identified by the program risk assessment questionnaire as being at high risk for at least one of the following cancers: lung cancer, breast cancer, colorectal cancer, upper gastrointestinal cancer, or liver cancer.\n5. Has not yet completed the corresponding free clinical screening test for the high-risk cancer type or types.\n6. Able to complete electronic questionnaires and read intervention materials independently or with assistance. Paper materials and staff explanation will be provided for participants who do not use smartphones.\n7. Able and willing to provide written informed consent.\n\nExclusion Criteria:\n\n1. Previously diagnosed with any of the target cancers, including lung cancer, breast cancer, colorectal cancer, upper gastrointestinal cancer, or liver cancer.\n2. Severe cognitive impairment, severe mental illness, or other conditions that prevent the participant from receiving the intervention or completing study questionnaires.\n3. Planning to be away from the community for a long period during the next 6 months, defined as cumulative absence of more than 3 months.\n4. Currently participating in another interventional study that may affect cancer screening behavior.",true,"ALL","45 Years","74 Years",{"count":21,"type":22},1500,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study will evaluate whether a precision navigation intervention can help community residents at high risk for cancer complete recommended cancer screening. The study will be conducted in communities participating in an urban cancer screening program in China.\n\nEligible participants will be adults aged 45 to 74 years who are permanent residents of participating communities and have been identified as being at high risk for at least one of five cancers: lung cancer, breast cancer, colorectal cancer, upper gastrointestinal cancer, or liver cancer. Participants must not have completed the corresponding free clinical screening before enrollment.\n\nThis is a dual-cohort, cluster randomized controlled trial. Communities, rather than individual participants, will be assigned to one of three groups: a precision navigation group, a usual health education group, or a waiting control group. Participants will be classified into two cohorts according to the number of cancers for which they are assessed as high risk. Cohort A will include participants at high risk for three or more cancers, and Cohort B will include participants at high risk for one or two cancers.\n\nParticipants in the precision navigation group will receive a personalized navigation report matched to their risk profile. The report will explain the screening tests most relevant to them, help them understand screening choices, and provide practical steps to support screening completion. Participants in the usual health education group will receive general cancer screening education materials. Participants in the waiting control group will not receive active screening promotion during the main intervention period, but will receive general education materials after the primary assessment.\n\nThe main outcome is whether participants complete the recommended cancer screening during follow-up. The study will also assess changes in screening-related decision conflict, anxiety, self-efficacy, and behavioral intention. A subgroup of participants will provide blood samples before and after the intervention to explore possible biological mechanisms related to stress, inflammation, and screening behavior.\n\nThe results may help improve community-based cancer screening programs and provide evidence for using personalized navigation strategies to increase screening participation among high-risk populations.",[28,29,30,31,32,33],"Cancer Screening","Lung Cancer","Breast Cancer","Colorectal Cancer","Upper Gastrointestinal Cancer","Liver Cancer","NOT_YET_RECRUITING","2026-06-24",{"date":37,"type":38},"2026-06-30","ACTUAL",{"date":40,"type":22},"2026-06",{"date":42,"type":22},"2027-02",{"name":44,"class":45},"Hunan Cancer Hospital","OTHER",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100636142","exercise-training-after-upper-gastrointestinal-cancer-surgery-100636142","NCT07561840","Exercise Training After Upper Gastrointestinal Cancer Surgery","Exercise and Cardiorespiratory Fitness Improvement Through Supervised Training in Upper Gastrointestinal Cancer Surgery Patients (EXCITING-UGI)","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Diagnosed with esophageal or gastric cancer\n* Received curative surgery\n* 6 ± 2 weeks after surgery\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Communication difficulties\n* Poor general status\n* Undergone combined laryngopharyngectomy\n* Unsuitable for evaluation or exercise intervention\n* Unsuitable for the study as determined by the primary physician","18 Years",{"count":55,"type":22},171,[25],"This randomized controlled trial aims to determine the optimal exercise intensity for improving postoperative recovery in patients with upper gastrointestinal cancer. Participants who have undergone curative surgery will be randomly assigned to high-intensity interval training (HIIT), low-intensity continuous training (LICT), or usual care. The exercise interventions will be performed under supervision three times per week for eight weeks. The primary outcome is peak oxygen uptake (VO₂peak), assessed using cardiopulmonary exercise testing. Secondary outcomes include physical function, body composition, patient-reported outcomes, and biological and mechanistic markers such as inflammatory biomarkers, muscle-related factors, and gut microbiota. This study will also explore potential mechanisms underlying exercise-induced adaptations and their association with clinical outcomes.",[59,60,32],"Esophageal Cancer","Gastric Cancer (Diagnosis)",[62,63,64,65,66],"upper gastrointestinal cancers","exercise","high-intensity interval training","randomized controlled trial","exercise oncology","RECRUITING","2026-05-15",{"date":70,"type":38},"2026-05-19",{"date":68,"type":38},{"date":73,"type":22},"2029-11",{"name":75,"class":45},"Kansai Medical University",2,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":85,"phases":4,"briefSummary":86,"conditions":87,"keywords":90,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":97,"leadSponsor":99,"locationsCount":101},"100628485","establishment-of-image-database-for-early-upper-gastrointestinal-cancer-precancerous-lesions-and-precancerous-conditions-100628485","NCT07462247","Establishment of Image Database for Early Upper Gastrointestinal Cancer, Precancerous Lesions, and Precancerous Conditions","Inclusion Criteria:\n\n1. Male or female participants aged ≥ 18 years\n2. Patients with early upper gastrointestinal cancer referred for endoscopic submucosal dissection (ESD), or patients with upper gastrointestinal precancerous lesions or precancerous conditions referred for biopsy by esophagogastroduodenoscopy (EGD)\n3. Participants who are willing and able to participate in this study, complete all required examinations and follow-up visits, and who have provided written informed consent\n\nExclusion Criteria:\n\n1. Patients who are not eligible for surgery or who refuse any abdominal surgery in case of capsule retention and endoscopic retrieval failure\n2. Patients with cardiac pacemaker or other implanted electromedical devices which could interfere with magnetic resonance\n3. Suspected or known intestinal stenosis or other known risk factors for capsule retention\n4. Patients with dysphagia\n5. Pregnancy\n6. Allergy to polymeric materials, latex, simethicone, or pronase\n7. Patients plan to undergo magnetic resonance imaging examination before excretion of the capsule\n8. Patients with any condition that precludes compliance with the study",{"count":84,"type":22},500,"OBSERVATIONAL","The study is designed to collect magnetically-controlled capsule endoscopy (MCE) images, esophagogastroduodenoscopy (EGD) images, CT images, and histopathology results to establish a database for early upper gastrointestinal cancer, precancerous lesions, and precancerous conditions.",[32,88,89],"Upper Gastrointestinal Precancerous Lesions","Upper Gastrointestinal Precancerous Conditions",[91,92],"image database","upper gastrointestinal cancer","2026-03-11",{"date":95,"type":38},"2026-03-12",{"date":93,"type":38},{"date":98,"type":22},"2030-12",{"name":100,"class":45},"Changhai Hospital",1]