[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"upper-limb-motor-impairment\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:upper-limb-motor-impairment":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,47,79,105,132,162],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100639778","robot-assisted-versus-conventional-physical-therapy-for-hand-in-sub-acute-stroke-100639778",false,"NCT07615569","Robot-assisted Versus Conventional Physical Therapy for Hand in Sub-acute Stroke","ROCHAS","Inclusion Criteria:\n\n* Both male and female adults aged 30-50 years diagnosed with post-stroke spastic hemiplegia confirmed by a neurologist.\n* Stroke duration 2 weeks to 6 months (sub acute stage) with medically stable condition.\n* Presence of mild to moderate upper-limb spasticity using screening test(Modified Ashworth Scale score 1-3).\n* Ability to comprehend and follow simple verbal instructions using screening test (MMSE ≥ 24).\n\nExclusion Criteria:\n\n* No history of upper-limb orthopedic surgery or botulinum toxin injections in the last 6 months.\n* History of recurrent or uncontrolled seizure disorders, progressive neurological diseases, or unstable cardiovascular conditions.\n* Participation in any intensive upper-limb rehabilitation program (CIMT, bimanual training, task-specific training, robotic therapy, FES therapy) within the past 6 months.\n* Comorbid conditions affecting upper-limb function (fractures, severe arthritis, peripheral nerve injuries).","ALL","30 Years","50 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized controlled trial aims to compare the effectiveness of robotic-assisted physiotherapy and conventional physiotherapy in improving hand function among patients with sub-acute stroke. Stroke often results in weakness, reduced hand strength, impaired dexterity, and difficulty performing daily activities due to upper-limb motor dysfunction. Early rehabilitation targeting hand recovery is essential to improve independence and quality of life.\n\nA total of 30 participants with sub-acute post-stroke spastic hemiplegia will be recruited from the University of Lahore Hospital and randomly assigned into two groups. The intervention group will receive robotic-assisted physiotherapy focused on repetitive, task-specific wrist and finger extension training using a robotic hand\u002Fwrist device, while the control group will receive conventional therapist-led upper-limb rehabilitation exercises. Both groups will undergo treatment sessions lasting 30-45 minutes, five days per week for four weeks.\n\nOutcome measures will include hand muscle strength assessed using a hand-held dynamometer, hand dexterity evaluated through the Action Research Arm Test (ARAT), and functional improvement measured using the Fugl-Meyer Assessment for Upper Extremity (FMA-UE). Additional measures such as spasticity, activities of daily living, and quality of life will also be recorded. Assessments will be conducted at baseline, during treatment, and after completion of the intervention period by a blinded assessor.\n\nThe study is expected to determine whether robotic-assisted physiotherapy provides greater improvements in hand strength, dexterity, and upper-limb functional recovery compared to conventional physiotherapy in individuals recovering from stroke. Findings from this research may contribute to evidence-based rehabilitation strategies for improving upper-limb outcomes after stroke.",[27,28,29],"Stroke","Spastic Hemiplegia","Upper Limb Motor Impairment",[27,31,32,33],"Robotic-assisted physiotherapy","Conventional physiotherapy","Hand rehabilitation","RECRUITING","2026-05-31",{"date":37,"type":38},"2026-06-03","ACTUAL",{"date":40,"type":21},"2026-05-22",{"date":42,"type":21},"2026-06-23",{"name":44,"class":45},"Montiha Azeem","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":46},"100628920","combined-mirror-therapy-and-soft-robotic-glove-for-hand-recovery-after-stroke-100628920","NCT07467915","Combined Mirror Therapy and Soft Robotic Glove for Hand Recovery After Stroke","Effect of Combining Mirror Therapy With Soft Robotic Glove on Hand Function Recovery in Post-Stroke Hemiplegic Patients: A Randomized Controlled Trial","MT-SRG","Inclusion Criteria:\n\nAdults aged 18-70 years with first-ever ischemic or hemorrhagic stroke confirmed by imaging (CT or MRI)\n\nModerate upper limb motor impairment (Fugl-Meyer Assessment Upper Extremity \\[FMA-UE\\] score 20-50)\n\nAbility to follow simple instructions (Six-Item Cognitive Impairment Test, 6CIT)\n\nAbility to sit independently for at least 30 minutes\n\nMedically stable and cleared to participate in rehabilitation interventions\n\nWillingness to provide informed consent and adhere to the study protocol\n\nExclusion Criteria:\n\nSevere upper limb spasticity (Modified Ashworth Scale ≥ 3)\n\nCognitive or psychiatric disorders interfering with participation\n\nOther neurological or musculoskeletal conditions affecting upper limb function (e.g., Parkinson's disease, multiple sclerosis, fractures)\n\nPrior exposure to intensive Mirror Therapy or Soft Robotic Gloves\n\nVisual impairment that cannot be corrected with glasses or contact lenses\n\nUncontrolled cardiovascular or other medical conditions that would prevent safe participation","18 Years","70 Years",{"count":58,"type":21},104,[24],"Post-stroke hemiplegia frequently results in impaired upper limb function, which significantly affects independence and quality of life. Various rehabilitation approaches have been developed to improve motor recovery, including mirror therapy and robotic-assisted training. Mirror therapy uses visual feedback to stimulate neural plasticity and enhance motor recovery, while soft robotic gloves assist repetitive hand movements and facilitate functional training.\n\nThis randomized controlled trial aims to investigate the effect of combining mirror therapy with a soft robotic glove on hand function recovery in patients with post-stroke hemiplegia. Participants will be randomly assigned to different intervention groups receiving mirror therapy, soft robotic glove training, combined therapy, or conventional rehabilitation.\n\nThe primary outcome will assess improvement in upper limb motor function using validated clinical assessment tools. Secondary outcomes will evaluate functional hand performance and activities of daily living. The findings of this study may contribute to improving rehabilitation strategies for stroke survivors and provide evidence for integrating innovative rehabilitation technologies into clinical practice.",[27,62,29],"Hemiplegia",[64,65,66,67,68,69],"Mirror Therapy","Soft Robotic Glove","Stroke Rehabilitation","Hand Function Recovery","Upper Limb Rehabilitation","Post-Stroke Hemiplegia","2026-05-08",{"date":72,"type":38},"2026-05-13",{"date":74,"type":38},"2026-04-08",{"date":76,"type":21},"2026-12-17",{"name":78,"class":45},"University of Baghdad",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":86,"sex":16,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":22,"phases":91,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":46},"100632972","neurophysiological-markers-for-prediction-of-rehabilitation-outcomes-after-ischemic-stroke-100632972","NCT07520630","Neurophysiological Markers for Prediction of Rehabilitation Outcomes After Ischemic Stroke","Neurophysiological Markers for Developing an Integrative Model of Rehabilitation Prognosis in Patients With Ischemic Stroke","Experimental phase:\n\nwill include healthy volunteers without contradictions to TMS\n\nClinical phase:\n\nInclusion Criteria:\n\n* First-ever ischemic stroke confirmed by CT\u002FMRI\n* 5 days - 6 months post-stroke\n* Age 40-65\n* MoCA ≥20\n* HADS \\\u003C11 for anxiety and depression\n* MRC 2-4 in upper limb\n* Modified Ashworth Scale ≤3\n* Signed informed consent\n\nExclusion Criteria:\n\n* Implanted electronic devices\n* Epilepsy\n* Severe cardiac arrhythmias\n* Intracranial aneurysm\n* Decompensated somatic disease\n* Pregnancy\u002Flactation",true,"40 Years","65 Years",{"count":90,"type":21},120,[24],"The goal of this randomized controlled study is to develop and validate an integrated neurophysiological model for predicting rehabilitation potential in patients with ischemic stroke. The study focuses on identifying objective markers of brain activity associated with motor preparation and recovery.\n\nThe project includes two stages. First, healthy volunteers will participate in experimental motor and mental tasks to establish reference patterns of brain activity using electroencephalography and transcranial magnetic stimulation. These data will be used to define stable neurophysiological markers of motor network function.\n\nIn the second stage, patients in the acute and early recovery phases after ischemic stroke will be randomly assigned to receive either active intermittent theta-burst stimulation of the motor cortex or a sham procedure, in addition to standard rehabilitation. Brain activity and clinical motor function will be assessed before and after the intervention.\n\nThe study aims to determine which neurophysiological measures are sensitive to neuromodulation and are associated with clinical improvement, in order to construct a predictive model of rehabilitation outcome.\n\nParticipants will \\[describe the main tasks participants will be asked to do, interventions they'll be given and use bullets if it is more than 2 items\\].",[94,29],"Ischemic Stroke","NOT_YET_RECRUITING","2026-04-02",{"date":98,"type":38},"2026-04-09",{"date":100,"type":21},"2026-05",{"date":102,"type":21},"2027-06",{"name":104,"class":45},"Moscow Scientific and Practical Center of Medical Rehabilitation, Restorative and Sports Medicine",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":111,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":16,"minAge":87,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":22,"phases":116,"briefSummary":117,"conditions":118,"keywords":120,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":46},"100628197","tdcs-combined-with-constraint-induced-therapy-in-post-stroke-upper-limb-rehabilitation-100628197","NCT07458503","tDCS Combined With Constraint-Induced Therapy in Post-Stroke Upper Limb Rehabilitation","Effects of Transcranial Direct Current Stimulation Combined With Constraint-Induced Therapy on Upper Limb Motor Function in Individuals After Stroke: A Randomized Controlled Trial","tDCS-CIT Strok","Inclusion Criteria:\n\n* (1) present a clinical diagnosis of stroke confirmed by imaging examination and\u002For report issued by a neurologist; (2) are in the chronic phase of the lesion with an occurrence time greater than six months; (3) hemiparesis with brachial predominance, mild to moderate motor deficit in the affected upper limb defined by a score between 19 and 55 points on the FMA-UE; (4) have minimum joint integrity to perform the movements required in the protocol with an active range of motion of at least 20° of wrist extension, 10° of extension of the metacarpophalangeal and interphalangeal joints and 20° of elbow extension considering the standard position of 90° elbow flexion, measured with a Carci® goniometer; (5) demonstrate the ability to understand and follow simple commands on the Mini Mental State Examination (MMSE) (ANNEX II) with a score higher than 23 points for literate persons and lower than 15 points for illiterate persons.\n\nExclusion Criteria:(1) diagnosis of epilepsy; (2) intracranial metallic implants or implantable electronic devices; (3) contraindications to transcranial direct current stimulation (tDCS), including skin lesions on the scalp; (4) severe musculoskeletal limitations that prevent the execution of tasks; (5) history of recurrent stroke; (6) associated disabling musculoskeletal and neurological pathologies; (7) use of botulinum toxin in the previous three months; (8) uncontrolled systemic arterial hypertension or diabetes mellitus; (9) clinically relevant heart disease; (10) apraxia and aphasia of comprehension; (11) fracture and pain during movement or displacement of the affected limb, or pain related to shoulder subluxation. Those who feel uncomfortable, drop out of the research, do not respect the rules established in the Informed Consent Form (APPENDIX C), or do not attend the stages of the study will also be excluded.","80 Years",{"count":115,"type":21},40,[24],"The objective of this clinical trial is to evaluate the effects of transcranial direct current stimulation (tDCS) combined with constraint-induced therapy (CIT) on upper limb motor recovery in individuals after stroke.\n\nThe main questions it aims to answer are:\n\nDoes the combination of tDCS and CIT improve upper limb motor function compared to CIT alone?\n\nDoes the combined intervention promote changes in muscle morphology and electromyographic activity?\n\nResearchers will compare the group receiving tDCS combined with constraint-induced therapy to the group receiving constraint-induced therapy alone to determine whether the addition of cortical neuromodulation enhances motor recovery outcomes.\n\nThis is a randomized, controlled, and blinded clinical trial in which participants will be divided into two groups: one group will receive tDCS combined with CIMT, and the other will undergo only CIMT. The protocol will include 18 sessions over six weeks, three times a week.\n\nClinical and instrumental assessments will be performed before, during, and after the intervention, including the Fugl-Meyer scale for the upper limb, musculoskeletal ultrasound for morphological analysis, and surface electromyography for muscle activity assessment.",[27,29,119],"Post-Stroke Hemiparesis",[27,121,122],"Transcranial Direct Current Stimulation","Upper Limb","2026-03-03",{"date":125,"type":38},"2026-03-09",{"date":127,"type":21},"2026-04-15",{"date":129,"type":21},"2027-04-10",{"name":131,"class":45},"Universidade do Estado do Pará",{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":4,"enrollmentInfo":139,"targetDuration":4,"studyType":22,"phases":141,"briefSummary":142,"conditions":143,"keywords":148,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":46},"100624063","safety-and-effectiveness-of-spatial-stimelmd-ssmd-in-subjects-with-upper-limb-neuromotor-impairments-100624063","NCT07404761","Safety and Effectiveness of Spatial StimelMD (SSMD) in Subjects With Upper Limb Neuromotor Impairments","A Multicenter, Randomized, Controlled Study to Evaluate the Efficacy and Safety of the SSMD in Neuromotor Rehabilitation","Inclusion Criteria:\n\n1. Adults aged 18-80 years.\n2. Clinically confirmed diagnosis of stroke or TBI within the past 12 months.\n3. Presence of moderate to severe neuromotor impairment in at least one limb, as evidenced by medical evaluation and a score \\\u003C35 on the Fugl-Meyer Upper Extremity motor subscale (FMA-UE).\n4. Capacity and willingness to provide informed consent, indicating understanding of the study purpose, procedures, and potential risks and benefits.\n5. Subject is able to adhere to the study schedule and cognitively capable to perform the treatment.\n6. Stable medical condition without ongoing acute complications that could interfere with participation.\n\nExclusion Criteria:\n\n1. Presence of contraindications to electrical stimulation (ES), including implanted electronic medical devices (e.g., pacemakers, insulin pumps) or conditions that may be exacerbated by electrical stimulation (e.g., uncontrolled epilepsy).\n2. Individuals with medical conditions, which are prone to seizures or motion sensitivity, at the investigator's discretion.\n3. Individuals with light sensitivity, as the AR component may involve visual stimuli that could cause discomfort or adverse reactions in these patients.\n4. Individuals with acute physical conditions or injuries that could interfere with the proper placement of the electrodes or safe use of the device.\n5. Presence of spinal shock or unresolved acute spinal cord dysfunction, characterized by complete loss of reflexes, flaccid paralysis, or autonomic instability.\n6. Current participation in other clinical trials that could confound the study results.\n7. Severe cognitive impairment that precludes the ability to provide informed consent or reliably adhere to the study protocol, as determined by cognitive screening and clinical judgment.\n8. Women who are pregnant, nursing, or who plan to become pregnant while in the trial.",{"count":140,"type":21},150,[24],"This is a multicenter, randomized, controlled clinical study evaluating the safety and effectiveness of the Spatial StimelMD (SSMD) device for upper-limb neuromotor rehabilitation in adults with impairment following stroke or traumatic brain injury (TBI).\n\nParticipants will be randomized to receive either SSMD therapy plus standard rehabilitation care or standard functional electrical stimulation (FES) plus standard care. Subjects will complete approximately 25 supervised treatment sessions over 5-6 weeks, with assessments at baseline, mid-treatment, post-treatment (primary endpoint), and a 1-month follow-up.\n\nThe primary effectiveness endpoint is improvement in upper-limb motor function measured by the Fugl-Meyer Upper Extremity (FMA-UE) assessment. Secondary outcomes include movement metrics, EMG signal strength, functional independence, usability measures, and adverse event monitoring.\n\nThe study plans to enroll approximately 150 subjects to achieve 126 completers, across 2-6 clinical sites.",[27,144,145,146,147],"Upper-limb Motor Impairment","Hemiparesis","Spinal Cord Injury","Traumatic Brain Injury",[149,150,151],"randomized","ssmd","neuromotor rehabilitation","2026-02-08",{"date":154,"type":38},"2026-02-11",{"date":156,"type":38},"2025-12-22",{"date":158,"type":21},"2026-12-30",{"name":160,"class":161},"Motion Informatics LTD","INDUSTRY",{"id":163,"slug":164,"hasResults":11,"nctId":165,"briefTitle":166,"officialTitle":166,"acronym":4,"eligibilityCriteria":167,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":113,"enrollmentInfo":168,"targetDuration":4,"studyType":170,"phases":4,"briefSummary":171,"conditions":172,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":174,"lastUpdatePostDateStruct":175,"startDateStruct":177,"completionDateStruct":179,"leadSponsor":181,"locationsCount":46},"100621136","beyond-observation-validating-the-ecological-relevance-of-the-ad-aha-stroke-using-sensor-based-measures-100621136","NCT07366697","Beyond Observation: Validating the Ecological Relevance of the Ad-AHA Stroke Using Sensor-Based Measures","Inclusion Criteria:\n\n* Written informed consent obtained prior to any study procedures.\n* Age between 18 and 80 years (inclusive).\n* Unilateral supratentorial stroke involving cortical or subcortical structures.\n* At least 6 months post-stroke at the time of inclusion.\n* Community-dwelling (discharged from hospital and currently living at home).\n* Able and willing to wear bilateral wrist-worn sensors (triaxial accelerometers) for three consecutive days.\n* Presence of clinically observable bimanual impairment.\n\nExclusion Criteria:\n\n* Severe upper limb impairment, defined as a Fugl-Meyer Assessment of Upper Extremity (FMA-UE) score ≤ 15.\n* Severe cognitive or language comprehension impairment interfering with understanding of study instructions or task performance, as judged during screening.\n* Presence of other neurological or orthopedic conditions affecting upper limb function (e.g., Parkinson's disease, multiple sclerosis, severe osteoarthritis, brachial plexus injury).",{"count":169,"type":21},32,"OBSERVATIONAL","After a stroke, many people experience difficulty using both hands together in daily life. Most rehabilitation assessments, however, only measure how the affected arm performs in one-handed tasks. This makes it difficult to understand how well people actually use their hands in real-world activities, which are usually bimanual.\n\nThe Adult Assisting Hand Assessment - Stroke version (Ad-AHA Stroke) is a new clinical test that evaluates how the affected hand performs during two-handed tasks. While promising, it is still unknown whether the score on this test truly reflects how stroke survivors use their hands in daily life.\n\nThis study aims to investigate this question by comparing Ad-AHA Stroke scores with real-life data on hand use, recorded over three days using wrist-worn sensors on both arms. By combining clinical and sensor-based measures, this study will help determine whether the Ad-AHA Stroke can accurately represent everyday bimanual performance after stroke.",[27,29,173],"Bimanual Function","2026-01-16",{"date":176,"type":38},"2026-01-26",{"date":178,"type":38},"2025-12-10",{"date":180,"type":21},"2026-07",{"name":182,"class":45},"KU Leuven"]