[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ureteral-obstruction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ureteral-obstruction":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":5},"100624456","an-integrated-multi-omics-study-on-the-molecular-mechanisms-of-ureteral-stricture-100624456",false,"NCT07409870","An Integrated Multi-omics Study on the Molecular Mechanisms of Ureteral Stricture","US-MOP","Inclusion Criteria (Ureteral Stricture Group):\n\nAge between 18 and 75 years, regardless of gender. Diagnosis of ureteral stricture confirmed by clinical symptoms and imaging (e.g., CT, IVP, or retrograde pyelography) or ureteroscopy.\n\nThe patient is scheduled for or undergoing standard clinical evaluation\u002Ftreatment for ureteral stricture.\n\nWillingness to provide stool, urine, and blood samples. Informed consent signed by the participant or their legal representative.\n\nInclusion Criteria (Healthy Control Group):\n\nAge- and sex-matched volunteers (18-75 years). No history of ureteral stricture, urinary tract obstruction, or significant renal disease.\n\nPhysical examination and laboratory tests (renal function, routine urine analysis) are within normal limits.\n\nExclusion Criteria (Applicable to Both Groups):\n\nUse of antibiotics, probiotics, prebiotics, or antifungal medications within the 4 weeks prior to sample collection.\n\nHistory of chronic gastrointestinal diseases (e.g., Inflammatory Bowel Disease (IBD), Irritable Bowel Syndrome (IBS), or chronic diarrhea).\n\nKnown malignant tumors of the urinary tract or other systemic malignancies. History of major abdominal or urinary tract surgery within the last 3 months (excluding the current planned procedure for patients).\n\nPresence of severe systemic diseases, including uncontrolled diabetes, severe hepatic dysfunction, or end-stage heart failure.\n\nPregnancy or breastfeeding. Any other condition that, in the opinion of the investigator, may interfere with the microbiome or metabolomic analysis.",true,"ALL",{"count":19,"type":20},120,"ESTIMATED","3 Months","OBSERVATIONAL","The goal of this observational study is to investigate the systemic pathogenesis and identify potential diagnostic biomarkers in patients with ureteral stricture and healthy volunteers. The main questions it aims to answer are:\n\nWhat are the systemic differences in the gut microbiome, urine microbiome, and metabolomic profiles (fecal, urinary, and serum) between patients with ureteral stricture and healthy controls? What are the correlations between these microbial\u002Fmetabolic alterations and clinical phenotypes, such as stricture severity, inflammatory levels, and renal function? Researchers will compare the biological panoramic profiles of patients with ureteral stricture to those of healthy controls to see if specific \"microbiome-metabolite-disease\" regulatory networks drive the development of the condition.\n\nParticipants will:\n\nProvide stool samples for gut microbiome (16S\u002FMetagenomics) and metabolomic analysis.\n\nProvide urine samples for urine microbiome and metabolomic analysis. Provide blood (serum) samples for systemic metabolomic profiling. Undergo clinical assessments, including medical history collection, imaging (e.g., CT\u002FIVP), and laboratory tests (e.g., renal function, inflammatory markers) to evaluate disease severity.",[25,26,27,28],"Ureteral Stricture","Ureteral Obstruction","Microbiome","Metabolomics","NOT_YET_RECRUITING","2026-02-07",{"date":32,"type":33},"2026-02-13","ACTUAL",{"date":35,"type":20},"2026-02-01",{"date":37,"type":20},"2026-07-31",{"name":39,"class":40},"First Affiliated Hospital of Chongqing Medical University","OTHER"]