[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"urethral-diseases\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:urethral-diseases":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":5},"100631530","phase-4-reducer-trial-txa-in-urethroplasty-100631530",false,"NCT07501884","REDUCER Trial (TXA in Urethroplasty)","Reduction of Perioperative Blood Loss in Urethral Reconstruction Using Tranexamic Acid (REDUCER Trial): A Multicenter Pragmatic Randomized Study","REDUCER","Inclusion Criteria:\n\n* Adult patients (≥18 years old)\n* Undergoing urethroplasty for urethral stricture disease\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Known contraindication to tranexamic acid (TXA)\n* History of thromboembolic disease (e.g., deep vein thrombosis, pulmonary embolism, stroke)\n* Known bleeding disorder or coagulopathy\n* Current use of anticoagulation that cannot be safely held perioperatively\n* Severe renal impairment\n* Allergy or hypersensitivity to tranexamic acid\n* History of seizures\n* Inability to provide informed consent","MALE","18 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","This study will test whether tranexamic acid (TXA), a medication used to reduce bleeding, can decrease blood loss in patients having urethroplasty. Participants will be randomly assigned to receive either a single intravenous dose of TXA at the start of anesthesia or standard care without TXA. Researchers will compare hemoglobin change after surgery as well as estimated blood loss and complications.",[27,28],"Urethral Stricture","Urethral Diseases",[30,31,32,33,34],"Tranexamic Acid","Urethroplasty","Blood Loss","Hemoglobin","Reconstructive Urology","NOT_YET_RECRUITING","2026-03-25",{"date":38,"type":39},"2026-03-30","ACTUAL",{"date":41,"type":21},"2026-05-01",{"date":43,"type":21},"2027-03-30",{"name":45,"class":46},"Amjad Alwaal, MD, MSc, FRCSC, FACS","OTHER"]