[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"urethral-stricture-male\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:urethral-stricture-male":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100462363","phase-3-peri-operative-oral-pain-control-following-buccal-graft-urethroplasty-100462363",false,"NCT05300685","Peri-operative Oral Pain Control Following Buccal Graft Urethroplasty","Peri-operative Oral Pain Control Following Buccal Graft Urethroplasty: Randomized Control Trial of Harvest Site Anesthetic","Buccal","Inclusion Criteria:\n\n* Men, age 18 or older\n* Undergoing anterior urethroplasty with buccal grafting\n* Able to consent\n\nExclusion Criteria:\n\n* Taking chronic opiates for pain\n* Diagnosis of chronic pain\n* Prior buccal urethroplasty\n* Vulnerable population (e.g. prisoner)\n* Renal dysfunction or allergy preventing NSAID use\n* Liver dysfunction or allergy preventing Tylenol use\n* Medical allergy to local anesthetic\n* Medical allergy to Peridex\u002FMagic Mouthwash\n* NYHA Class III\u002FIV\n* Hematologic condition that excludes patient from surgery\n* Post-operative complication resulting in inpatient stay\n* Anesthetic complication\n* No buccal site surgical complication","MALE","18 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","Patients undergoing buccal urethroplasty will often have significant post-operative oral pain from the graft site. Various graft harvest techniques and methods for post-harvest hemostasis including graft site closure have been explored. Despite the frequency of this clinical scenario there is no established best practice for peri-operative pain management in this patient population. In addition to traditional post operative pain control, groups have sought various peri-operative anesthetic regimens to improve post operative pain. This has led recently to the description of various regional blocks including buccal and periorbital blocks for peri-operative local anesthetic. No study has looked at superiority of regional pain management in this patient population. This study will aim to assess three established anesthetic protocols for oral pain control in a blinded, randomized controlled trial.\n\nHypothesis: Patients who have buccal block will have lower post op pain without any increase adverse oral outcomes.",[27],"Urethral Stricture, Male",[29,30,31,32,33],"buccal urethroplasty","urethral stricture","urethroplasty","buccal block","lidocaine","RECRUITING","2026-06-03",{"date":37,"type":38},"2026-06-05","ACTUAL",{"date":40,"type":38},"2022-02-15",{"date":42,"type":21},"2026-07-01",{"name":44,"class":45},"University of California, San Francisco","OTHER",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":57,"conditions":58,"keywords":62,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":77},"100579662","treatment-of-bulbar-urethral-strictures-with-optilume-drug-coated-balloons-in-an-untreated-population-100579662","NCT06827210","Treatment of Bulbar Urethral Strictures With Optilume Drug-Coated Balloons in an Untreated Population","FIRST-CARE","Inclusion Criteria:\n\n* Male patients aged 18 years or older.\n* Diagnosed with a treatment-naive, single bulbar urethral stricture.\n* Stricture length ≤3 cm.\n* Eligible for local treatment with paclitaxel.\n* Able to provide written informed consent.\n\nExclusion Criteria:\n\n* Female (chromosomal) sex.\n* History of prior urethral stricture or prior treatment thereof.\n* History of hypospadias repair.\n* History of genital lichen sclerosis.\n* Active or unresolved confounding etiology, including bladder neck contracture, neurogenic bladder, known or being evaluated for symptomatic benign prostatic hyperplasia (BPH) or surgical treatment for BPH within the last 5 years.\n* Known allergy or hypersensitivity to paclitaxel or any component of the Optilume DCB.\n* Known peripheral artery disease.\n* Severe comorbidities with an American Society of Anesthesiologists (ASA) score of 4 or higher.\n* Patients unable to comply with follow-up protocols or provide informed consent.",{"count":54,"type":21},140,[56],"NA","This randomized controlled trial investigates the effectiveness and safety of the Optilume® drug-coated balloon (DCB) compared to standard direct visual internal urethrotomy (DVIU) in the treatment of bulbar urethral strictures. The primary objective is to assess freedom from repeat intervention at 12 months. Secondary objectives include evaluating urethral patency, urinary symptoms, and sexual function through objective measures (Qmax, PVR, cystoscopy) and patient-reported outcomes (USS-PROM, IPSS, IIEF-5). The study will recruit 140 participants across multiple sites, with follow-ups conducted at 6 and 12 months. This trial seeks to provide evidence for Optilume DCB as a safe and effective alternative to standard treatment.",[59,60,27,61],"Urethral Stricture","Urethral Stricture, Anterior","Urethral Stricture Less Than 2 cm",[59,63,64,65,66],"Optilume Drug-Coated Balloon","DVIU","Urology","Patient-Reported Outcomes","NOT_YET_RECRUITING","2025-02-13",{"date":70,"type":38},"2025-02-14",{"date":72,"type":21},"2025-02-07",{"date":74,"type":21},"2027-07",{"name":76,"class":45},"Aalborg University Hospital",3]