[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"urinary-calculi\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:urinary-calculi":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,47,73,101,123,152,174,202],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100642014","phase-4-fospropofol-disodium-versus-propofol-for-patient-satisfaction-in-ureteroscopy-100642014",false,"NCT07659132","Fospropofol Disodium Versus Propofol for Patient Satisfaction in Ureteroscopy","Fospropofol Disodium Versus Propofol on Patient Satisfaction in Patients Undergoing Ureteroscopy：A Randomized Controlled Trial","Inclusion Criteria:\n\n* Undergoing elective ureteroscopic surgery\n* Aged between 18 and 90 years old\n* American Society of Anesthesiologists (ASA) physical status classification grade I to III\n\nExclusion Criteria:\n\n* Known allergy to propofol, fospropofol or their excipients\n* Severe cardiopulmonary insufficiency\n* Hepatic and renal dysfunction.Hepatic or renal insufficiency. Hepatic dysfunction: alanine aminotransferase (ALT) \\> 50 U\u002FL, or aspartate aminotransferase (AST) \\> 40 U\u002FL, or total bilirubin (TBIL) ≥ 19 μmol\u002FL; Renal dysfunction: serum creatinine (Cr) \\> 112 μmol\u002FL, or blood urea nitrogen (BUN) \\> 7.1 mmol\u002FL, or receiving dialysis within 28 days before surgery.\n* Pregnancy, lactation, potential pregnancy or planned pregnancy\n* Subjects who refuse to participate","ALL","18 Years","90 Years",{"count":20,"type":21},190,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","This single-center single-blind randomized trial compares fospropofol disodium and propofol for anesthesia in elective ureteroscopy patients. A total of 190 eligible adults will be randomly divided into two groups at 1:1 ratio with identical intraoperative maintenance protocols. The primary outcome is 24-hour postoperative anesthesia satisfaction assessed by ISAS scale; secondary and safety endpoints include injection pain, intraoperative hemodynamic events and various perioperative adverse reactions. This study explores the clinical efficacy and safety of the two sedatives to guide rational clinical medication.",[27,28],"Anesthesia for Urologic Endoscopic Surgery","Urinary Calculi",[30,31,32,33,34],"fospropofol disodium","propofol","ureteroscopy","anesthesia satisfaction","sedation","NOT_YET_RECRUITING","2026-06-19",{"date":38,"type":39},"2026-06-24","ACTUAL",{"date":41,"type":21},"2026-06-26",{"date":43,"type":21},"2026-09-26",{"name":45,"class":46},"Shiyou Wei","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":72},"100423662","ultrasound-to-facilitate-stone-passage-100423662","NCT04796792","Ultrasound to Facilitate Stone Passage","Ultrasound Technology to Fragment and Reposition Urinary Stones","Inclusion Criteria:\n\n* Individuals presenting with at least one kidney stone\n* Stone with maximum dimension \\> 2 mm and ≤ 7 mm as determined by clinical imaging\n* Individuals with SCI - (Phase 2b only)\n\nExclusion Criteria:\n\n* Individuals under 18 years of age\n* Individuals who are pregnant or who are trying to get pregnant\n* Prisoners\n* with cognitive impairment that would limit their ability to comprehend their role in consent or participation.\n* Individuals who are unable to read or understand English\n* Individuals who are unable or unwilling to participate in follow up activities\n* Individuals who cannot be positioned for ultrasound imaging\n* Individuals with uncorrected bleeding disorders or coagulopathies\n* Individuals receiving anticoagulants and who are unable or not willing to temporarily cease the medication for the investigational procedure\n* Individuals with a calcified abdominal aortic aneurysm or calcified renal artery aneurysm ipsilateral to the renal stone targeted by the investigational procedure\n* Individuals with a solitary kidney\n* Individuals with an uncorrected urinary tract obstruction\n* Individuals with an untreated infection\n* Individuals with a comorbidity risk which, at the discretion of the physician, would make the patient a poor candidate for the investigational procedure\n* Individuals who have received two previous investigational procedures for the same stone target\n* Individuals who have undergone the investigational procedure within the last 21 days or still have unresolved AEs from a previous investigational procedure.",true,{"count":56,"type":21},140,[58],"NA","This is a prospective, open-label, multi-center study to test the clinical feasibility of facilitating stone passage by the combination of breaking and repositioning stones with ultrasound, without the need for anesthesia.",[61,28],"Urinary Stone","RECRUITING","2025-12-02",{"date":65,"type":39},"2025-12-09",{"date":67,"type":39},"2023-04-01",{"date":69,"type":21},"2028-10-31",{"name":71,"class":46},"University of Washington",3,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":22,"phases":82,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":100},"100348007","break-wavetm-extracorporeal-lithotripter-first-in-human-study-100348007","NCT03811171","Break Wave(TM) Extracorporeal Lithotripter First-in-Human Study","A Study of the SonoMotion Break Wave(TM) System for the Comminution of Urinary Tract Stones","Inclusion Criteria:\n\n* Individuals presenting with at least one kidney stone apparent on CT.\n* Stones must be within the upper urinary tract.\n* Stones are indicated for SWL treatment per the American Urology Association (AUA) 2016 guidelines.8\n* Stones must be measured under CT to be within the AUA 2016 SWL guidelines (i.e. ≤ 10 mm for lower pole stones and ≤ 20 mm for non-lower pole stones).\n\nExclusion Criteria:\n\n* Acute untreated urinary tract infection or urosepsis.\n* Uncorrected bleeding disorders or coagulopathies.\n* Pregnancy.\n* Uncorrected obstruction distal to the stone.\n* Patients receiving anticoagulants and who are unable or not willing to cease the medication for the Break Wave procedure.\n* Stones that are not echogenically visible or cannot be positioned within the Break Wave therapy focus.\n* Individuals belonging to a vulnerable group (pregnant, mentally disabled, prisoner, etc.).\n* Patients unwilling to comply with the follow-up protocol, including post-procedure CT.\n* Individuals under 18 years of age.\n* Anatomic presentations preventing adequate positioning or delivery of the Break Wave pulse.\n* Calcified abdominal aortic aneurysms or calcified renal artery aneurysms.\n* Solitary kidney\n* Comorbidity risks which, in at the discretion of the physician, would make the patient a poor candidate for the Break Wave procedure, such as anatomical anomalies that may not be conducive to adequate stone fragment passage.",{"count":81,"type":21},70,[58],"This is a prospective, open-label, multi-center, single-arm (non-randomized) study to assess the safety and effectiveness of breaking stones in the upper urinary tract using the SonoMotion Break Wave technology. Up to 30 subjects will be included. The procedure will be performed in a hospital surgical environment as an outpatient (without being admitted) or in a non-surgical environment such as a clinic or office procedure room. The procedure will be performed under varying levels of anesthesia ranging from no anesthesia to general anesthesia (fully asleep). Stones will be limited to ≤ 10 mm for lower pole stones and ≤ 20 mm everywhere else.\n\nSafety will be measured by the self-reported occurrences of adverse events, unplanned emergency department or clinic visits, and the need for further intervention. Fragmentation will be measured by self-reported stone passage and a comparison of computed tomography (CT) images before and after the procedure.",[85,28],"Renal Calculi",[87,88,89],"Stone","Lithotripsy","Calculi","2025-07-24",{"date":92,"type":39},"2025-07-29",{"date":94,"type":39},"2019-08-20",{"date":96,"type":21},"2027-03-30",{"name":98,"class":99},"SonoMotion","INDUSTRY",6,{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":107,"enrollmentInfo":108,"targetDuration":4,"studyType":22,"phases":110,"briefSummary":111,"conditions":112,"keywords":113,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":119,"leadSponsor":121,"locationsCount":4},"100586408","a-prospective-multicenter-randomized-controlled-trial-of-flexible-and-navigable-suction-ureteral-access-sheath-combined-with-needle-perc-for-the-treatment-of-partial-staghorn-renal-calculi-100586408","NCT06914986","A Prospective Multicenter Randomized Controlled Trial of Flexible And Navigable Suction Ureteral Access Sheath Combined With Needle Perc for the Treatment of Partial Staghorn Renal Calculi","Inclusion Criteria:\n\n1. Aged 18-80 years\n2. CT scan indicates partial staghorn calculi\n3. Able to complete the study in accordance with the protocol requirements\n4. Informed about the study and has signed the informed consent form\n\nExclusion Criteria:\n\n1. Severe renal insufficiency (GFR \\\u003C 30 ml\u002Fmin\u002F1.73 m²)\n2. Significant calyceal hydronephrosis (calyceal width ≥ 2 cm)\n3. Renal stone volume \\> 33.5 cm³\n4. Renal stones or nephrocalcinosis caused by genetic diseases or definite metabolic disorders that have not been ruled out, such as renal tubular acidosis, primary hyperoxaluria, primary hyperparathyroidism, etc.\n5. Congenital or structural renal abnormalities: spinal deformity, ankylosing spondylitis, horseshoe kidney, medullary sponge kidney, duplicated kidney, polycystic kidney, ectopic kidney, etc.\n6. History of previous open renal stone surgery\n7. Patients with uncontrolled urinary tract infections\n8. Subjects deemed by the investigator to have other factors that make them unsuitable for participation in this trial","80 Years",{"count":109,"type":21},344,[58],"The goal of this clinical trial is to learn if flexible and navigable suction ureteral access sheath combined with needle perc works to treat partial staghorn renal calculi. It will also learn about the safety of drug ABC. The main questions it aims to answer are:\n\n* Does flexible and navigable suction ureteral access sheath combined with needle perc result in similar stone free rate compared with PCNL\n* Does flexible and navigable suction ureteral access sheath combined with needle perc result in more complications compared with PCNL Researchers will compare flexible and navigable suction ureteral access sheath combined with needle perc result in similar stone free rate compared with PCNL to see if flexible and navigable suction ureteral access sheath combined with needle perc works to treat partial staghorn renal calculi.\n\nParticipants will:\n\n* Performed flexible and navigable suction ureteral access sheath combined with needle perc or PCNL\n* Visit the clinic after surgery 1 month and 3 month for checkups and tests",[28],[114],"partial staghorn renal calculi","2025-04-01",{"date":117,"type":39},"2025-04-07",{"date":115,"type":21},{"date":120,"type":21},"2028-03-01",{"name":122,"class":46},"Beijing Tsinghua Chang Gung Hospital",{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":4,"eligibilityCriteria":129,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":107,"enrollmentInfo":130,"targetDuration":4,"studyType":22,"phases":132,"briefSummary":133,"conditions":134,"keywords":136,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":151},"100483398","tubeless-percutaneous-nephrolithotomy-without-reverse-insertion-of-a-ureteral-catheter-100483398","NCT05574517","Tubeless Percutaneous Nephrolithotomy Without Reverse Insertion of a Ureteral Catheter","A Comparative Study of Tubeless Percutaneous Nephrolithotomy With or Without Reverse Ureteral Catheter Insertion","Inclusion Criteria:\n\n* Participants who met the the applications of PCNL surgery in the 2019 Chinese Guidelines for the Diagnosis and Treatment of Urological Diseases\n* Participants who agree to undergo tubeless PCNL\n* The participants' maximum diameter of the stone should be less than 3.5cm\n\nExclusion Criteria:\n\n* Confirmation by computerized tomography (CT) images and blood biochemical indicators of infectious stones or complex staghorn stones\n* Obvious surgical contraindications, such as severe heart and lung insufficiency, abnormal coagulatory function\n* Previous PCNL or nephrolithotomy, presence of an indwelling ureteral stent or nephrostomy tube before surgery\n* Renal trauma or congenital malformation of the urinary system",{"count":131,"type":21},200,[58],"Percutaneous nephrolithotomy(PCNL) is a surgical method for upper urinary calculi. The advent of tubeless PCNL (without indwelling nephrostomy tube) has been proved to be safe and effective in reducing postoperative discomfort, shortening hospitalization time and reducing hospitalization costs. Traditional tubeless PCNL usually involves retrograde insertion of the ureteral catheter, which may cause many ureteral related surgical complications. However, there are few reports on tubeless PCNL without reverse ureteral catheter insertion. The goal of this study is to explore the safety and effectiveness of the tubeless PCNL without reverse ureteral catheter insertion.",[28,135],"Percutaneous Nephrolithotomy",[137,138,139,140,141],"Ureteral catheter","Without reverse insertion","Percutaneous nephrolithotomy","Tubeless","Urinary calculi","2024-09-23",{"date":144,"type":39},"2024-09-24",{"date":146,"type":39},"2022-10-07",{"date":148,"type":21},"2024-12-31",{"name":150,"class":46},"The First Affiliated Hospital of University of South China",1,{"id":153,"slug":154,"hasResults":11,"nctId":155,"briefTitle":156,"officialTitle":157,"acronym":4,"eligibilityCriteria":158,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":159,"enrollmentInfo":160,"targetDuration":4,"studyType":22,"phases":162,"briefSummary":163,"conditions":164,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":151},"100556032","endoscopic-combined-intrarenal-surgery-vs-percutaneous-nephrolithotomy-for-treatment-of-staghorn-calculi-100556032","NCT06519812","Endoscopic Combined Intrarenal Surgery vs. Percutaneous Nephrolithotomy for Treatment of Staghorn Calculi","Efficacy and Safety of Endoscopic Combined Intrarenal Surgery vs. Percutaneous Nephrolithotomy for Treatment of Staghorn Calculi, A Prospective Randomized Study","Inclusion Criteria:\n\n* Patients are more than 18 and less than 65 years old.\n* Patients with renal staghorn stones based on imaging modalities (stones occupying the renal pelvis and extending into at least 2 major calyces).\n\nExclusion Criteria:\n\n* Patients with renal insufficiency (serum creatinine \\> 1.6 mg\u002Fdl)\n* patients with active urinary tract infection.\n* Patients with congenital renal anomalies.\n* Morbid obesity (BMI \\> 35 kg\u002Fm2).\n* Pregnancy.\n* Bleeding Coagulopathy.\n* Skeletal deformity","65 Years",{"count":161,"type":21},100,[58],"This is a prospective randomized study to compare endoscopic combined intrarenal surgery and PCNL as modalities of treatment for staghorn stones. In terms of efficacy and safety",[28],"2024-07-20",{"date":167,"type":39},"2024-07-25",{"date":169,"type":39},"2023-07-01",{"date":171,"type":21},"2025-06-30",{"name":173,"class":46},"Al-Azhar University",{"id":175,"slug":176,"hasResults":11,"nctId":177,"briefTitle":178,"officialTitle":179,"acronym":4,"eligibilityCriteria":180,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":181,"targetDuration":4,"studyType":22,"phases":183,"briefSummary":184,"conditions":185,"keywords":188,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":200,"locationsCount":151},"100232038","eswl-for-distal-ureteric-stone-supine-versus-prone-100232038","NCT02298465","ESWL for Distal Ureteric Stone: Supine Versus Prone","Randomized Controlled Study on Extracorporeal Shockwave Lithotripsy for Distal Ureteric Stone: Transgluteal Versus Traditional Prone Approach","Inclusion Criteria:\n\n* All patients, over 18 years of age, with distal ureteric stones with stone size of ≥3mm on kidney-ureter-bladder (KUB) X-ray who opted for ESWL treatment\n\nExclusion Criteria:\n\n* Patients who are unable to provide consent\n* radiolucent stones\n* active urinary tract infections\n* pregnancy\n* uncontrolled hypertension\n* uncontrolled bleeding tendencies\n* severe skeletal malformations\n* arterial aneurysms within the vicinity of the stone (such as iliac artery aneurysms)\n* unable to assume the appropriate position (prone or supine) for ESWL\n* solitary kidneys\n* transplanted kidneys\n* presence of ureteric stents",{"count":182,"type":21},130,[58],"Extracorporeal shockwave lithotripsy (ESWL) for urinary stone is common and widespread nowadays. Approximately 80% of urinary stones are treated by ESWL. Traditionally distal ureteric stones are treated with ESWL in the prone position. However, as some patients cannot tolerate lying in the prone due to medical illness such as chronic obstructive pulmonary disease (COPD), some authors have reported using the supine approach of ESWL for treatment of distal ureter stones. No serious complications had developed in the patients who underwent supine approach. Only minor complications such as self-limiting blood in the urine, painful passage of urine, or local pain that had responded to oral painkillers. There were no serious complications encountered in children as well. In the most recent retrospective review by Tolley et al, they had revealed that patients who had underwent supine ESWL for distal ureteric stones had an improved stone-free rate compared with the traditional prone approach.\n\nPatient with radio-opaque distal ureteric stones (stones below the sacroiliac joint) on KUB X-ray, who have opted for ESWL treatment, are randomized into two groups: one undergoing ESWL in the supine position and the other undergoing ESWL in the prone position. Patients will be observed for two hours after ESWL before being discharged. Oral painkillers as necessary will be provided to the patient. The patients will have a KUB Xray at 2 weeks post-ESWL, and then monthly afterwards if required. If there are residual stones at the 2-week follow-up, the patient will be offered ESWL again. Patients are free to withdraw from the study at any time and will continue to be managed as per usual.\n\nThe investigators aim to have 130 patients, with 65 patients in each group with an interim analyses to be performed when 66 patients have been recruited (33 patients in each group).",[186,187,28],"Urinary Tract Stones","Urinary Stones",[189,190,191,192],"ESWL","distal ureteric stone","transgluteal","supine ESWL","2023-08-08",{"date":195,"type":39},"2023-08-09",{"date":197,"type":4},"2014-11",{"date":199,"type":21},"2027-11",{"name":201,"class":46},"Queen Mary Hospital, Hong Kong",{"id":203,"slug":204,"hasResults":11,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":208,"eligibilityCriteria":209,"healthyVolunteers":54,"sex":16,"minAge":17,"maxAge":210,"enrollmentInfo":211,"targetDuration":4,"studyType":22,"phases":212,"briefSummary":213,"conditions":214,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":216,"lastUpdatePostDateStruct":217,"startDateStruct":219,"completionDateStruct":221,"leadSponsor":223,"locationsCount":151},"100494024","shuotongo-ureteroscopy-for-upper-urinary-tract-stones-100494024","NCT05712785","Shuotongo Ureteroscopy for Upper Urinary Tract Stones","Clinical Study on the Treatment of Upper Urinary Tract Stones by Shuotong Scope","SFUUTS","Inclusion Criteria:\n\n* Clinical diagnosis of Ureteral calculus Must be able to cooperate with the treatment\n\nExclusion Criteria:\n\n* Patients had severe urinary tract infections; patients had other conditions which investigators thought not suitable for the study.","85 Years",{"count":131,"type":21},[58],"The purpose of this study is to use the Shuotong ureteroscopy for surgical treatment of patients with upper urinary tract stones, taking advantage of the fact that the Shuotong mirror can be used for simultaneous lithotripsy and stone removal, thus maximizing the discharge of stones from the body and improving the stone removal rate.",[28,215],"Ureterocele","2023-03-14",{"date":218,"type":39},"2023-03-16",{"date":220,"type":39},"2020-01-01",{"date":222,"type":21},"2026-12-20",{"name":224,"class":46},"Handan First Hospital"]