[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"urinary-incontinence--stress\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:urinary-incontinence--stress":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,45,73,99,144,166],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100642554","pilot-study-of-the-artus-artificial-urinary-sphincter-on-women-100642554",false,"NCT07641218","Pilot Study of the ARTUS® Artificial Urinary Sphincter on Women","Pilot Clinical Investigation of the ARTUS® Artificial Urinary SPHincter (AUS) for the Treatment of Stress UrInary iNcontinence (SUI) in Women","SPHIN-X","Inclusion Criteria:\n\n* Female subject over 18 years of age at the time of consent signature\n* Subject with persistent severe urinary incontinence:\n\n  * at least 3 months after failed pelvic floor muscle training OR\n  * at least 6 months after a failed surgical treatment (e.g. slings)\n* Subject with severe Stress Urinary Incontinence, defined as a mean value of 3 consecutive 24-hour Pad Weight Test \\> 100 grams\n* Subject willing and able to provide written informed consent and having signed the informed consent\n* Subject having understood and accepted to be unable to proceed to an MRI examination after the surgical procedure due to the non-MRI compatibility of the device\n* Subject having a life expectancy ≥ 5 years as assessed by the investigator\n\nExclusion Criteria:\n\n* Subject currently enrolled or plans to participate in another investigational study of a drug, biologic, or medical device from the point of enrolment through the 12 months post device activation period\n* Subject deprived of liberty by administrative or judicial decision or under legal guardianship\n* Subject who is unwilling or deemed by the investigator to be unwilling to comply with the clinical study requirements, including attending follow-up visits.\n* Subject having inadequate cognitive or capabilities to use the Artus device as assessed by the investigator\n* Pregnant subject, or subject willing to be pregnant during the study duration, or subject of child-bearing potential with non-stable medication contraception\n* Subject with urge incontinence due to hyperactive bladder not adequately controlled by drug therapy\n* Subject with overflow urinary incontinence\n* Subject with Significant Neuro-urological disorders: elevated detrusor pressure, Detrusor sphincter desinergy\n* Subject with history of pelvic radiotherapy\n* Subject with any planned procedure requiring urethral catheterization 12 months after implant procedure (include intermittent catheterization) except for diagnostic purposes\n* Subject with known allergy to any components of the device\n* Subject with history of Artificial Urinary Sphincter\n* Subject with severe congenital or acquired haemorrhagic disease, haemophilia, or another coagulopathy\n* Subject under anti-coagulation or anti-platelet medication that cannot be discontinued at least 5 days prior to surgery and restarted at least 5 days after surgery\n* Subject having a Body Mass Index (BMI) \\> 40\n* Subject with uncontrolled diabetes, defined as HbA1c \\> 9.0% within the past 6 months\n* Subject with history of urethral fistula\n* Subject with history of bladder tumor\n* Subject with severe urethral stenosis.\n* Subject with currently active infection, including urinary tract infection\n* Subject with severe renal failure or obstructive pathologies of the upper urinary tract with severe renal failure\n* Subject with congenital or acquired immunodeficiency, including those who are immunocompromised or immunosuppressed\n* Subject with post void residual volume greater than 200 mL within the past 6 months\n* Subject with history of recurrent bladder stones or history of failed bladder stone treatment within the past 12 months\n* Subject in emergency situation (caused by a sudden life threatening or other sudden serious medical condition including but not limited to heart attack, stroke, coma, epileptic seizure, heavy bleeding, severe pain, trouble breathing…)","FEMALE","18 Years",{"count":5,"type":20},"ESTIMATED","INTERVENTIONAL",[23],"NA","The subjects will be implanted with the ARTUS® medical device and then be followed up to 2 years post-implantation, with the primary endpoints measured at 3-month post-implantation. Safety and Clinical performance outcomes will be measured for each subject at baseline (before implantation) and post-implantation.",[26],"Urinary Incontinence , Stress",[28,29,30,31],"Urinary Incontinence","Artificial Urinary Sphincter","Women","Stress Urinary Incontinence","NOT_YET_RECRUITING","2026-06-08",{"date":35,"type":36},"2026-06-11","ACTUAL",{"date":38,"type":20},"2026-06-30",{"date":40,"type":20},"2028-12-31",{"name":42,"class":43},"Myopowers Medical Technologies France SAS","INDUSTRY",2,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":54,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":72},"100639952","mobile-app-vs-in-person-pelvic-floor-rehabilitation-for-urinary-leakage-in-adult-women-100639952","NCT07597174","Mobile App vs. In-Person Pelvic Floor Rehabilitation for Urinary Leakage in Adult Women","Randomized Controlled Non-Inferiority Trial Comparing a Mobile Application Based Program With Conventional Rehabilitation for Stress and Mixed Urinary Incontinence in Adult Women","Inclusion Criteria:\n\n* age \\>18 years\n* stress urinary incontinence (SUI) or mixed urinary incontinence with predominance of SUI\n* more than one urinary incontinence episode for week in the last month\n* pelvic floor muscle strength equal or greater than 2 assessed by Oxford Modified Rating Score\n\nExclusion Criteria:\n\n* indwelling urinary catheter\n* active pelvic neoplasia\n* pelvic organ prolapse grade greater than or equal to 2\n* active urinary tract infection or macroscopic hematuria\n* neurogenic dysfunction of the lower urinary tract\n* cognitive deficit, osteoarticular, neurological or psychiatric pathologies that prevent the realization of the therapeutic program\n* conservative or surgical treatment of UI in the last 12 months\n* pregnancy or recent childbirth (\\\u003C 6 months)\n* impossibility of access or illiteracy to technological means (smartphone)\n* unavailability to attend the supervised program due to accessibility, schedule or economic reasons",{"count":53,"type":20},32,[23],"The goal of this clinical trial is to learn if a mobile app-guided pelvic floor rehabilitation program works as well as standard in-person pelvic floor rehabilitation to treat urinary leakage in adult women.\n\nThe main question it aims to answer is:\n\nDoes the app program improve quality of life related to urinary leakage as much as in-person rehabilitation?\n\nResearchers will compare the app-based program to in-person rehabilitation to see if both lead to similar improvements in quality of life.\n\nParticipants will:\n\nAttend one medical visit before starting to confirm they are eligible Attend one in-person training session with a physiotherapist Follow either an app-based or an in-person pelvic floor rehabilitation program for 3 months Complete quality of life questionnaires at the start and at 4 months",[26],[58,59,60],"mobile app","urinary incontinence","woman","RECRUITING","2026-05-19",{"date":64,"type":36},"2026-05-22",{"date":66,"type":36},"2026-03-26",{"date":68,"type":20},"2026-08-21",{"name":70,"class":71},"Unidade Local de Saúde São João","OTHER_GOV",1,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":17,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":21,"phases":84,"briefSummary":85,"conditions":86,"keywords":87,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":72},"100609277","pelvic-floor-muscle-training-vs-pilates-exercises-for-urinary-incontinence-100609277","NCT07212478","Pelvic Floor Muscle Training vs. Pilates Exercises for Urinary Incontinence","Comparison Between Pelvic Floor Muscle Training and Pilates Exercises for Postmenopausal Women With Urinary Incontinence","Inclusion Criteria:\n\n* Being naturally post-menopause (at least one year without menstruating);\n* Demonstrate independence to carry out activities of daily living;\n* Have a report of urinary loss when performing physical exertion.\n\nExclusion Criteria:\n\n* Women who have had hysterectomy or oophorectomy surgery;\n* Women who underwent cancer treatment with hormone therapy;\n* Present cognitive deficits or neurological diseases;\n* Practice any type of physical activity regularly in the last six months; Present inability to hire PFM (Oxford Scale \\\u003C 1);\n* Report pain or discomfort in the vulva or vagina;\n* Present dyspareunia, vaginismus or pelvic organ prolapse greater than grade II in the Baden-Walker classification;\n* Present symptoms of urinary infection at the time of evaluation;\n* Have participated in previous pelvic floor reeducation programs.","50 Years","70 Years",{"count":83,"type":20},24,[23],"Urinary incontinence (UI) affects approximately 40% of postmenopausal women and is therefore considered a public health problem. Conservative treatment is recommended, and pelvic floor muscle training (PFMT) is considered the gold standard for this condition.\n\nHowever, other exercise options have been studied, such as Pilates exercises, which focus on stabilizing muscles and require voluntary contraction of the pelvic floor muscles. The literature remains inconclusive regarding the effects of Pilates exercises on urinary incontinence and pelvic floor muscle function. Objective: To compare the effects of 3 months of muscle training, through PFMT and Pilates exercises, on improving UI in postmenopausal women. Methods: Twenty-four postmenopausal women with urinary incontinence will be randomized into two intervention groups: pelvic floor muscle training and mat Pilates exercises. Assessments will be conducted before and after three months of intervention and will include the following instruments: urinary incontinence and quality of life, assessed using the International Consultation of Urinary Incontinence Short Form (ICIQ-UI-SF) questionnaire; a 7-day voiding diary to identify potential modifiable factors related to urination and its frequency; a Pad test to identify and quantify UI; the Female Sexual Function Index to assess female sexual function; and pelvic floor muscle strength and endurance by bidigital palpation using the PERFECT test. Shapiro-Wilk tests will be used to assess normality, Student's t-test or Mann-Whitney U test according to parametric or nonparametric distribution, and ANCOVA will be used to compare groups post-intervention, considering a 95% confidence interval (p\\\u003C0.05). Data will be processed using SPSS 25.0.",[26],[88],"Post-menopause; Pilates; Muscle training of pelvic floor","2025-09-30",{"date":91,"type":36},"2025-10-08",{"date":93,"type":20},"2025-09-29",{"date":95,"type":20},"2025-12-26",{"name":97,"class":98},"Universidade Estadual do Norte do Parana","OTHER",{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":105,"eligibilityCriteria":106,"healthyVolunteers":107,"sex":17,"minAge":18,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":111,"phases":4,"briefSummary":112,"conditions":113,"keywords":116,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":72},"100607072","trampoline-induced-changes-in-pelvic-structure-and-continence-100607072","NCT07183800","Trampoline-Induced Changes in Pelvic Structure and Continence","Does a 10-minute Trampoline Protocol Induce Urine Leakage or Changes in Pelvic Morphometry Among Females Who Report That They do Not Experience Symptoms of Urinary Incontinence?","TRAM","Inclusion Criteria:\n\n* Aged 18-40\n* Engage in regular physical activity or sport\n* Do not experience frequent urinary leakage (no more than once per month during exercise, coughing, or sneezing)\n* Can complete a 10-minute jumping protocol\n\nExclusion Criteria:\n\n* Currently pregnant or have been pregnant in the past 6 months\n* Have cardiac, pulmonary, metabolic, and\u002For neurological conditions\n* Have a lower body injury that limits your ability to jump\n* Have had a hysterectomy and\u002For incontinence surgery",true,"40 Years",{"count":110,"type":20},30,"OBSERVATIONAL","The goal of this clinical trial is to evaluate whether a short bout of high-intensity trampoline jumping induces urinary leakage or measurable changes in pelvic floor morphology in active females aged 18-40 who do not report symptoms of urinary incontinence. The main questions it aims to answer are:\n\nHypothesis 1: Does a single 10-minute trampoline protocol result in acute changes in pelvic floor structure, including bladder neck position, levator plate length, and\u002For posterior urethrovesical angle (PUVA)?\n\nHypothesis 2: Do participants report any urinary leakage during the jumping protocol, despite being asymptomatic at baseline?\n\nHypothesis 3: Do pelvic morphology changes recover within 30 minutes post-jumping, or do alterations persist?\n\nResearchers will perform within-subject comparisons at multiple time points (pre-jump, immediately post-jump, and 30 minutes post-jump) using transperineal ultrasound imaging to assess structural changes.\n\nParticipants will:\n\n* Attend one laboratory visit\n* Complete baseline pelvic health questionnaires (ICIQ-UI Short Form and PFD Sentinel).\n* Undergo 2D transperineal ultrasound imaging in the standing position at rest, immediately post-jumping, and 30 minutes post-jumping.\n* Perform a 10-minute high-intensity jumping protocol on a mini-trampoline, while heart rate and perceived exertion are monitored.\n* Verbally report any urine leakage during jumping using standardized descriptors.",[114,28,115,26],"Urinary Continence","Urinary Incontinence (UI)",[117,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135],"stress urinary incontinence","pelvic floor","pelvic floor morphology","high impact exercise","urine leakage","urinary symptoms","levator plate","female athletes","bladder neck","posterior urethro-vesical angle","PUVA","jump","trampoline","high impact","high intensity","healthy female","incontinence","leakage","urinary leakage",{"date":137,"type":36},"2025-10-03",{"date":139,"type":36},"2025-07-16",{"date":141,"type":20},"2026-04-30",{"name":143,"class":98},"University of Ottawa",{"id":145,"slug":146,"hasResults":11,"nctId":147,"briefTitle":148,"officialTitle":149,"acronym":150,"eligibilityCriteria":151,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":152,"targetDuration":4,"studyType":111,"phases":4,"briefSummary":154,"conditions":155,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":4},"100572960","bladder-wall-thickness-in-symptomatic-urinary-stress-incontinence-and-its-correlation-with-urodynamics-results-100572960","NCT06740058","Bladder Wall Thickness in Symptomatic Urinary Stress Incontinence and Its Correlation with Urodynamics Results","Bladder Wall Thickness in Symptomatic Urinary Stress Incontinence and Its Correlation with Urodynamics Results. a Retrospective and Prospective Observational Study","BWT-IUS","Inclusion Criteria:\n\n1. Participant is willing and able to give informed consent for participation in the study.\n2. Women aged \\> 18 y.o.\n3. Women symptomatic for pure or predominant stress incontinence attending the urogynecology outpatient clinic at our institution.\n4. Patients undergoing urogynecological standard evaluation for their symptoms, including outpatient gynecological visit and a transvaginal ultrasound.\n5. Patients undergoing invasive urodynamic examination for objective assessment of their symptoms or in preparation for possible anti-incontinence surgery.\n\nExclusion Criteria:\n\n1. Patients with pure or predominant OAB symptomatology\n2. Current use of antimuscarinic agents or beta3-agonists (for example Mirabegron)\n3. Presence of urological or gynecological cancer.\n4. Patients with previous anti-incontinence surgery.\n5. Patients with pelvic organ prolapse \\> II stage.\n6. Patients with chronic bladder retention.\n7. Patients with neurological diseases that may affect bladder function and urodynamic results.\n8. Participants unwilling or unable to give informed consent for participation in the study.",{"count":153,"type":20},60,"This clinical study aims to assess the utility of ultrasonographic bladder wall thickness (BWT) measurement in patients suffering from symptomatic stress urinary incontinence (SUI). SUI is a condition characterized by involuntary leakage of urine during activities that increase intra-abdominal pressure and represents a very frequent disorder impacting women's quality of life. To diagnose SUI more accurately and especially before surgical treatment, patients undergo invasive urodynamic examination. This examination allows us to objectify the presence of any bladder dysfunction and, in particular, to evaluate the presence of detrusor overactivity. Detrusor overactivity is defined as any occurrence of detrusor contraction(s) during filing cystometry. These contractions, which may be spontaneous or provoked, produce a waveform on the cystogram, of variable duration and amplitude and may cause or not urgency symptoms. In absence of any urodynamic detrusor overactivity, the patient may be diagnosed with pure SUI. This is essential to assess before surgical treatment to avoid worsening of symptoms and to decide whether to treat the patient with concomitant pharmacological treatment. On the contrary, ultrasonography offers a non-invasive and accessible approach to evaluate bladder function. This study will involve a cohort of patients with SUI, who will undergo ultrasonographic assessment of BWT and preoperative urodynamic assessment. The objective is to determine whether BWT correlates with the urodynamics results and whether it can predict the presence or absence of detrusor overactivity and confirm the pure stress urinary incontinence",[26,156],"Incontinence","2024-12-17",{"date":159,"type":36},"2024-12-18",{"date":161,"type":20},"2025-01",{"date":163,"type":20},"2026-02",{"name":165,"class":98},"IRCCS San Raffaele",{"id":167,"slug":168,"hasResults":11,"nctId":169,"briefTitle":170,"officialTitle":171,"acronym":4,"eligibilityCriteria":172,"healthyVolunteers":11,"sex":173,"minAge":174,"maxAge":4,"enrollmentInfo":175,"targetDuration":4,"studyType":21,"phases":177,"briefSummary":178,"conditions":179,"keywords":181,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":72},"100561415","effect-of-high-intensity-focused-electromagnetic-hifem-technology-in-the-treatment-of-sui-in-chinese-men-undergone-robotic-radical-prostatectomy-100561415","NCT06589869","Effect of High-Intensity Focused Electromagnetic (HIFEM) Technology in the Treatment of SUI in Chinese Men Undergone Robotic Radical Prostatectomy","To Investigate the Effect of High-Intensity Focused Electromagnetic (HIFEM) Technology in the Treatment of Stress Urinary Incontinence Compared With Standard of Care in Chinese Men Who Had Undergone Robotic Radical Prostatectomy","Inclusion Criteria:\n\n* Undergone robotic radical prostatectomy\n* Able to carry out 1-hour pad test\n* Voluntary participation and signing of the informed consent form\n\nExclusion Criteria:\n\n* Pre-existing stress urinary incontinence\n* Post-void residual urine greater than 200ml\n* Active urinary tract infection\n* Urethral or bladder fistula\n* History of pelvic irradiation\n* Neurological condition (Spinal cord problems, stroke with poor neurological recovery, epilepsy, Parkinson disease, multiple sclerosis)\n* Previous surgery for SUI\n* Concurrent medication with diuretics, serotonin-norepinephrine reuptake inhibitors or any other medication known to worsen incontinence\n* Condition contraindicated for electromagnetic therapy i.e. Arrhythmia, on a pacemaker or implanted metallic device; Coagulopathy or on anticoagulant","MALE","18 Months",{"count":176,"type":20},184,[23],"This is a prospective, randomized trial to evaluate the efficacy and safety of High-Intensity Focused Electromagnetic (HIFEM) Technology in the treatment of stress urinary incontinence compared with standard of care in Chinese men who had undergone robotic radical prostatectomy.",[26,180],"Prostatectomy",[117,182],"prostatectomy","2024-09-10",{"date":185,"type":36},"2024-09-19",{"date":187,"type":36},"2022-07-29",{"date":189,"type":20},"2026-06",{"name":191,"class":98},"Chinese University of Hong Kong"]