[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"urinary-incontinence-stress\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:urinary-incontinence-stress":58},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,41,77,103],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100572846","phase-1-allogeneic-use-of-expanded-mesenchymal-stem-cells-derived-from-adipose-tissue-hc106-female-urinary-incontinence-women-over-50-years-old-100572846",false,"NCT06738576","Allogeneic Use of Expanded Mesenchymal Stem Cells Derived From Adipose Tissue (HC106), Female Urinary Incontinence Women Over 50 Years Old","Phase II Clinical Trial to Determine the Safety and Efficacy of the Allogeneic Use of Expanded Mesenchymal Stem Cells Derived From Adipose Tissue (HC106) in the Local Treatment of Female Urinary Incontinence in Women Over 50 Years of Age","SUITH)","Inclusion Criteria:\n\n* Women over 50 years old\n* Women with a clinical diagnosis of genuine or mixed stress urinary incontinence (SUI) with at least 6 months of evolution. Using the definitions of urinary incontinence internationally accepted by the ICS (International Continence Society): to. SUI: any involuntary loss of urine, immediately preceded by exertion. b. Mixed UI: any involuntary loss of urine, immediately preceded by exertion or an uncontrollable desire to urinate.\n\nThe predominance of effort will be assessed when more than 50% of the patient's daily losses occur preceded by effort.\n\n* Women in whom rehabilitative treatment has failed or patients who refuse to undergo rehabilitative or surgical treatment\n* Patients without active urinary tract infection (negative urine culture) at the time of recruitment and treatment\n* Signing of the informed consent form\n\nExclusion Criteria:\n\n* Patients with a medical history of previous surgery for incontinence, prolapse or urological\u002Fgynecological\u002Fcolorectal surgery\n* Major surgery or serious trauma of the subject in the previous semester\n* Women with mixed urinary incontinence, with predominant symptoms of urgency\n* History of high-pressure detrusor overactivity\n* Present infravesical obstruction, vesico-ureteral reflux or clinical history of urinary fistula (it will be ruled out depending on the case by urethrocystoscopy, urethrocystography and flowmetry).\n* Present any malignant neoplasm, unless it is basal cell or squamous cell carcinoma of the skin, or present a history of malignant tumors, unless they have been in remission during the previous 5 years.\n* Cardiopulmonary disease that, in the opinion of the investigator, is unstable or serious enough to exclude the patient from the study.\n* Medical or psychiatric illness of any type that, in the opinion of the researcher, may be a reason for exclusion from the study.\n* History of alcohol or other addictive substance abuse in the 6 months prior to inclusion\n* Subject's allergy to anesthetics","FEMALE","50 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"PHASE1","Evaluate the feasibility and safety, obtaining initial efficacy data, of expanded allogeneic mesenchymal stem cells derived from adipose tissue (HC106) for the treatment of urinary incontinence in women over 50 years of age.",[27],"Urinary Incontinence Stress","RECRUITING","2025-04-29",{"date":31,"type":32},"2025-05-01","ACTUAL",{"date":34,"type":32},"2024-12-16",{"date":36,"type":21},"2025-12",{"name":38,"class":39},"Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz","OTHER",6,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":17,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":63,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100587824","elastographic-assessment-of-suburethral-tissue-in-continent-and-incontinent-women-100587824","NCT06933407","Elastographic Assessment of Suburethral Tissue in Continent and Incontinent Women","This Study Investigates the Role of Strain Elastography in Assessing Paraurethral Tissue Elasticity in Continent and Incontinent Pre- and Postmenopausal Women. It Also Evaluates the Predictive Value of Strain Elastography Compared to Other Pelvic Imaging Modalities, Including Conventional Ultrasound Examinations, in Supporting Treatment Decision-making for Urinary Incontinence.","SE-inc1","Inclusion Criteria:\n\n* Clinical diagnosis of stress urinary incontinence (SUI) based on patient history, physical examination, and\u002For urodynamic assessment.\n\nExclusion Criteria:\n\n* Pelvic malignancy or history of pelvic radiation therapy\n* Urge urinary incontinence (UUI) or detrusor overactivity\n* Pelvic organ prolapse (POP) stage ≥ II (based on POP-Q classification)\n* Pregnancy or recent postpartum status (less than 6 months postpartum)\n* Neurological disorders affecting bladder function\n* Recurrent urinary tract infections (UTIs) or active lower urinary tract infection\n* Inability to undergo study procedures\n* Cognitive impairment or psychiatric conditions affecting informed consent or compliance",true,"18 Years","99 Years",{"count":53,"type":21},80,"OBSERVATIONAL","Strain elastography (SE) will be utilized as a non-invasive imaging technique to evaluate tissue elasticity and biomechanical properties in women with stress urinary incontinence (SUI) and in continent controls. The primary aim is to determine whether SE can detect differences in paraurethral tissue stiffness between these groups. Given the established role of tissue elasticity in the pathophysiology of SUI, SE will be investigated as a potential diagnostic tool in urogynecological evaluations.\n\nThis prospective cohort study will be conducted at a tertiary referral center. All participants will undergo introital two-dimensional (2D) ultrasound in the midsagittal plane at rest. SE will be performed in three predefined suburethral regions of interest (ROIs):\n\n* internal urethral orifice (IUO) level\n* midurethra (MU) level\n* external urethral orifice (EUO) level\n\nThe adipose layer (AL) between the external urethral meatus and the pubic symphysis will serve as the reference tissue, representing the softest anatomical structure in the region.\n\nDescriptive and comparative statistical analyses will be conducted to assess differences in paraurethral tissue stiffness between the study groups.\n\nIt is hypothesized that SE will be able to detect differences in paraurethral tissue elasticity, with SUI being associated with increased tissue compliance. The study also aims to determine whether SE can reliably distinguish between varying degrees of tissue stiffness in women with SUI and continent controls.\n\nPathophysiological focus:\n\nThe study will explore key mechanisms underlying SUI, including:\n\n* Weakened bladder neck support\n* Impaired urethral stabilization due to increased tissue elasticity and collagen degradation\n* While conventional 2D ultrasound provides anatomical information, it does not directly evaluate tissue biomechanics. In contrast, SE enables real-time visualization of tissue elasticity, offering a promising adjunct to traditional urogynecological assessment methods.\n\nStandardization and Protocol\n\nThe study will follow a standardized protocol to ensure reproducibility and high-quality data. Key methodological elements include:\n\n* Minimal probe compression during introital ultrasound to avoid artifacts\n* Bladder emptying prior to examination to eliminate confounding effects\n* Carefully standardized ROI placement across all patients\n* Controlled image acquisition conditions to reduce variability\n\nFuture Directions\n\n* Future research based on this study will aim to:\n* Optimize SE protocols and refine ROI placement strategies\n* Establish clinical cutoff values for differentiating tissue stiffness in SUI vs. continent women\n* Assess the long-term effects of pelvic floor muscle training (PFMT) and vaginal estrogen therapy on paraurethral biomechanics\n* Facilitate the integration of SE into routine urogynecological practice to support early diagnosis and personalized treatment strategies for SUI",[57,58,59,60,61,62],"Urinary Incontinence","Urinary Incontinence, Stress","Urinary Incontinence (UI)","Urinary Bladder, Overactive","Incontinence, Overactive Bladder, Stress Urinary Incontinence","Stress Urinary Incontinence (SUI)",[57,64,65,66],"Bladder dysfunction","Urine leakage","Stress urinary incontinence (SUI)","2025-04-15",{"date":69,"type":32},"2025-04-18",{"date":71,"type":32},"2024-08-16",{"date":73,"type":21},"2030-01-01",{"name":75,"class":39},"Szeged University",1,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":84,"minAge":50,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":87,"conditions":88,"keywords":89,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":102},"100370090","a-3-years-naturalistic-cohort-survey-of-virtue-male-sling-system-for-male-stress-urinary-incontinence-100370090","NCT04098822","A 3 Years Naturalistic Cohort Survey Of Virtue® Male Sling System For Male Stress Urinary Incontinence","A 3 Years Naturalistic Cohort Survey Of Virtue® Male Sling System For Male Stress Urinary Incontinence A Post-marketing and Multicenter Prospective Observational Cohort in Subjects With Male Stress Urinary Incontinence","Inclusion Criteria:\n\n* Implanted with the Virtue® Male Sling System\n\nExclusion Criteria:\n\n* Refuses to be included in the survey or that their medical data will be used for research purposes.\n* Indication for the Virtue® Male Sling System implantation is not for the treatment of male urinary incontinence","MALE",{"count":86,"type":21},130,"The purpose of this study is to monitor the use of Virtue® Male Sling in a real world population and collect medical data on effectiveness and to monitor safety of Virtue® at 12 and 36 months post device implantation in men with post-prostatectomy urinary incontinence.",[58],[58,90,91],"Suburethral Slings","Prostatectomy","2023-02-17",{"date":94,"type":32},"2023-02-21",{"date":96,"type":32},"2017-06-29",{"date":98,"type":21},"2026-12",{"name":100,"class":101},"Coloplast A\u002FS","INDUSTRY",13,{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":84,"minAge":50,"maxAge":4,"enrollmentInfo":110,"targetDuration":112,"studyType":54,"phases":4,"briefSummary":113,"conditions":114,"keywords":115,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":76},"100278211","fundacin-ivo-registry-for-patients-undergoing-sling-or-artificial-urinary-sphincter-after-prostate-cancer-treatment-100278211","NCT02901392","Fundación IVO Registry for Patients Undergoing Sling or Artificial Urinary Sphincter After Prostate Cancer Treatment","Fundación Instituto Valenciano de Oncología Prospective Registry for Patients Undergoing Male Sling or Artificial Urinary Sphincter After Prostatectomy or Radiation Therapy for Prostate Cancer.","Inclusion Criteria:\n\n1. The subject has agreed to be treated with the male Incontinence surgery devices\n2. The subject is willing and able to give valid informed consent.\n3. The subject is \\> 18 years of age.\n4. The subject has confirmed stress urinary incontinence for at least 12 months after prostatectomy or radiotherapy.\n5. It has been confirmed the stress urinary incontinence with 24-Hour Pad Weight test\n6. Pre-operative urodynamic assessment and flexible cystoscopy were performed in all cases\n7. The subject is willing and able to return for follow-up evaluations and questionnaire completion according to the study protocol.\n8. There are no surgical contraindications.\n\nExclusion Criteria:\n\n1. The subject has an active urinary tract infection or active skin infection in region of surgery\n2. The subject has serious bleeding disorders\n3. The subject has unstable bladder neck stricture disease\n4. The subject has Neurogenic bladder condition that is not treatable or controllable by pharmacological or alternative methods.\n5. The subject has Detrusor-external sphincter dyssynergia.\n6. The subject is unable or unwilling to sign the informed consent form (ICF)and\u002For comply with all follow-up requirements according to the study protocol\n7. The subject is likely to undergo radiation therapy within the next 6 months\n8. The subject has a history of connective tissue or autoimmune conditions.\n9. The subject has a compromised immune system.\n10. The subject has renal insufficiency, and upper and\u002For lower urinary tract relative obstruction.\n11. The subject's reading level is judged inadequate for reading and understanding the quality of life questionnaires and other study materials",{"count":111,"type":21},400,"15 Years","Stress urinary incontinence is a significant potential source of morbidity after radical prostatectomy or radiation therapy for prostate cancer. At present, artificial urinary sphincter remains the preferred therapeutic option. However, this technique is not free from complications. In an attempt to avoid such complications, male sling has been suggested for use in patients with mild degrees of stress incontinence.",[58],[116,117,91,118],"Male Urethral Slings","Artificial Urinary Sphincter","Radiotherapy","2018-07-31",{"date":121,"type":32},"2018-08-02",{"date":123,"type":4},"2004-04",{"date":125,"type":21},"2031-04",{"name":127,"class":39},"Fundación Instituto Valenciano de Oncología"]