[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"urinary-incontinence-ui\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:urinary-incontinence-ui":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,17,0,[8,48,77,104,133,155,181,214,243,273,303,324,354,379,421,443,470],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100602506","electroacupuncture-as-a-treatment-for-refractory-overactive-bladder-100602506",false,"NCT07124390","Electroacupuncture as a Treatment for Refractory Overactive Bladder","Electroacupuncture as a Treatment for Refractory Overactive Bladder: A Feasibility \u002FPilot Randomized Controlled Trial","EAOAB","Inclusion Criteria:\n\nParticipants must meet all of the following criteria:\n\n* Female adults aged 18 years or older.\n* Diagnosed with overactive bladder syndrome (ICIQ-OAB score ≥10).\n* Symptoms present for at least three months and refractory to first-line treatments.\n* Willing to refrain from starting new bladder-related treatments during the study period.\n* Able and willing to provide written informed consent.\n\nExclusion Criteria:\n\n* Participants meeting any of the following criteria will be excluded:\n\n  * Pregnant or planning pregnancy during the study period.\n  * Bleeding disorders.\n  * Severe needle phobia.\n  * Presence of a pacemaker.\n  * Active cancer diagnosis.\n  * Active urinary tract infections or other urological conditions requiring urgent intervention.\n  * Participation in another clinical trial for bladder dysfunction within the past six months.\n  * Neurological conditions affecting continence (e.g., diabetic neuropathy, multiple sclerosis, Parkinson's disease).\n  * Life-threatening infections.\n  * Severe cognitive deficits, unconsciousness, dementia (e.g., Alzheimer's or other neurodegenerative diseases).\n  * History of incontinence surgery.\n  * Previous acupuncture for OAB within the past two months.\n  * History of thromboses.\n  * Recovering from or suffering from a serious illness or major surgery.","FEMALE","18 Years",{"count":20,"type":21},32,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study is a single-site feasibility randomised controlled trial evaluating the feasibility and acceptability of electroacupuncture (EA), percutaneous tibial nerve stimulation (PTNS), and sham electroacupuncture in women with refractory overactive bladder (OAB) who have not achieved satisfactory improvement following standard pelvic health physiotherapy.\n\nThe primary aim is to determine whether a larger definitive trial is feasible by assessing recruitment, consent, retention, treatment adherence, data completeness, intervention delivery, blinding credibility, safety, and participant acceptability.\n\nThirty-six participants will be randomly allocated to receive electroacupuncture, PTNS, or sham electroacupuncture over a 12-week treatment period. Outcome assessments will be completed at baseline, 6 weeks, 12 weeks, 6 months, and 12 months.\n\nThe findings will inform the design of a future definitive randomised controlled trial and contribute to the evidence base for non-pharmacological treatment options for overactive bladder.",[27,28,29],"Over Active Bladder","Urinary Incontinence (UI)","Nocturia",[31,32,33,34],"Electric-Acupuncture","Acupuncture","PTNS","Neuromodulation","NOT_YET_RECRUITING","2026-06-13",{"date":38,"type":39},"2026-06-16","ACTUAL",{"date":41,"type":21},"2026-07-01",{"date":43,"type":21},"2027-07-30",{"name":45,"class":46},"Chelsea and Westminster NHS Foundation Trust","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":55,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":62,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":47},"100643510","effectiveness-of-chinese-herbal-medicine-for-older-adults-with-urinary-incontinence-100643510","NCT07637175","Effectiveness of Chinese Herbal Medicine for Older Adults With Urinary Incontinence","Effectiveness of Chinese Herbal Medicine for Older Adults With Urinary Incontinence: A Randomized Double-Blind Placebo-Controlled Clinical Trial","Inclusion Criteria:\n\n* Experience symptoms of urinary incontinence (including stress, urge, or mixed incontinence) as confirmed by clinical assessment or validated screening tools.\n* Able to understand the study procedures and provide informed consent.\n* Willing and able to comply with study requirements, including attending study visits, and completing questionnaires.\n* Stable general medical condition that, in the opinion of the investigator, does not interfere with participation in the study.\n* Not currently participating in another interventional clinical trial that could affect urinary incontinence outcomes.\n\nExclusion Criteria:\n\n* Inability to provide informed consent due to severe cognitive impairment or dementia.\n* Known allergy or hypersensitivity to any component of the Chinese herbal medicine formulation.\n* Presence of severe, unstable, or uncontrolled medical conditions that may pose a safety risk or interfere with participation, as determined by the investigator.\n* Active urinary tract infection at the time of screening (eligible for reconsideration after treatment if appropriate).\n* Current use of treatments for urinary incontinence that cannot be safely maintained at a stable dose throughout the study period.\n* Significant neurological or urological conditions that severely affect bladder function, unless stable and deemed appropriate by the investigator.\n* Participation in another interventional clinical trial that could influence study outcomes or participant safety.\n* Any other condition that, in the opinion of the investigator, would compromise participant safety, study adherence, or data integrity.","ALL","65 Years",{"count":58,"type":21},150,[24],"This study aims to evaluate the effectiveness and safety of Chinese herbal medicine in improving urinary incontinence symptoms among older adults. Urinary incontinence is a common condition in aging populations that can significantly impact quality of life, yet existing treatments are often limited by side effects or insufficient efficacy.\n\nThe primary research question is whether a standardized Chinese herbal formula can reduce the frequency and severity of urinary incontinence compared to a placebo. We hypothesize that participants receiving the herbal intervention will demonstrate greater improvement in urinary symptoms and quality of life measures than those receiving placebo, without significant adverse effects.\n\nTo test this hypothesis, a randomized, double-blind, placebo-controlled clinical trial will be conducted. Eligible older adults will be randomly assigned to receive either the herbal treatment or a matched placebo over a defined study period. Outcomes will include validated measures of urinary incontinence severity, frequency of episodes, and patient-reported quality of life.\n\nPotential benefits of this research include generating high-quality evidence on the effectiveness and safety of Chinese herbal medicine for urinary incontinence, which may inform clinical practice and expand treatment options for older adults. If effective, this intervention could offer a complementary or alternative approach with fewer side effects, contributing to improved symptom management and overall well-being in this population.",[28],[63,64,65,66,67],"Traditional Chinese Medicine","Urinary Incontinence","Herbal Treatment","Stage IV Clinical Trial","Older Adults","2026-06-05",{"date":70,"type":39},"2026-06-09",{"date":72,"type":21},"2026-06-01",{"date":74,"type":21},"2028-05",{"name":76,"class":46},"Kwantlen Polytechnic University",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":17,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":22,"phases":88,"briefSummary":89,"conditions":90,"keywords":91,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":102,"locationsCount":47},"100638002","comparative-effects-of-hypopressive-exercises-and-paula-method-in-postpartum-women-100638002","NCT07628322","Comparative Effects of Hypopressive Exercises and Paula Method in Postpartum Women.","Comparative Effects of Hypopressive Exercises and Paula Method on Urinary Incontinence, Pelvic Floor Muscle Strength and Quality of Life in Postpartum Women","Inclusion Criteria:\n\n* • Multipara women from 25-40 years\n\n  * Six weeks postpartum\n  * Vaginal delivery method\n  * Reported ≥1 episodes of urine leakage per week\n  * Diagnosed with SUI (ICIQ-UI SF ≥6)\n\nExclusion Criteria:\n\n* • No pelvic floor physiotherapy in last 6 months\n\n  * Patients with any medical and gynaecological risk factors and \u002For conditions\n  * Patients with any neurological problems, urinary tract infection, diabetes mellitus, hepatitis and ascites\n  * Pelvic surgery in last 6 months\n  * Mental or cognitive impairment","25 Years","40 Years",{"count":87,"type":21},60,[24],"This study will be a randomized clinical trial with a sample size of 60 postpartum females. The setting of the study will be Bilal Medicare, Sargodha. 60 postpartum women will be included based on age, parity, mode of delivery and type of urinary incontinence. Women with primary gravida, cesarean section and urge and mixed urinary incontinence will be excluded. This study aims to compare the effectiveness of Hypopressive Exercises and the Paula Method in improving urinary incontinence severity, pelvic floor muscle strength and quality of life in postpartum women. Patients of both groups receive two treatment sessions per week over an 8-week period. Group A will be given Hypopressive exercise and Group B will be given Paula exercise protocol. Both groups will perform a standardized kegel exercises for pelvic floor muscle activation and strengthening as baseline treatment followed by their assigned interventions.",[28],[64,92,93,94,95],"pelvic floor","muscle strength","Quality of life","postpartum women","RECRUITING","2026-06-04",{"date":68,"type":39},{"date":100,"type":39},"2025-10-01",{"date":41,"type":21},{"name":103,"class":46},"Riphah International University",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":110,"enrollmentInfo":111,"targetDuration":113,"studyType":114,"phases":4,"briefSummary":115,"conditions":116,"keywords":119,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":125,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":132},"100638472","urinary-continence-after-vaginal-surgery-for-genital-prolapse-in-the-spanish-population-100638472","NCT07628036","Urinary Continence After Vaginal Surgery for Genital Prolapse in the Spanish Population.","Inclusion Criteria:\n\n* Women who will undergo vaginal surgery for pelvic organ prolapse\n\nExclusion Criteria:\n\n* inhability to give consent to the study","99 Years",{"count":112,"type":21},1042,"1 Year","OBSERVATIONAL","Surgical correction of pelvic organ prolapse (POP) may be associated with the development of postoperative stress urinary incontinence (SUI). This clearly affects women's satisfaction and their quality of life, and may require subsequent medical and\u002For surgical treatments.\n\nOn the other hand, pre-existing SUI could resolve after corrective prolapse surgery. Similarly, urge urinary incontinence (UUI) could appear or improve after vaginal POP surgery. Therefore, it is of paramount importance to know the prevalence of urinary incontinence after POP vaginal surgery and incontinence resolution in our population. Identifying the risk factors for the development of urinary incontinence may allow to provide individualized treatment.",[117,118,28],"Pelvic Organ Prolapse (POP)","Pelvic Organ Prolapse Vaginal Surgery",[120,121,122,123,124],"Pelvic organ prolapse","Vaginal surgery","Urinary incontinence","Stress urinary incontinence","Urge-urinary incontinence",{"date":97,"type":39},{"date":127,"type":21},"2026-08-01",{"date":129,"type":21},"2028-05-30",{"name":131,"class":46},"Hospital Universitari Vall d'Hebron Research Institute",4,{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":4,"eligibilityCriteria":139,"healthyVolunteers":11,"sex":140,"minAge":85,"maxAge":141,"enrollmentInfo":142,"targetDuration":4,"studyType":22,"phases":144,"briefSummary":145,"conditions":146,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":152,"leadSponsor":153,"locationsCount":47},"100596435","the-effect-of-pelvic-floor-muscle-exercises-after-radical-prostatectomy-100596435","NCT07045415","The Effect of Pelvic Floor Muscle Exercises After Radical Prostatectomy","The Effect of Pelvic Floor Muscle Exercises on Urinary Incontinence Management and Quality of Life in Patients Undergoing Radical Prostatectomy","Inclusion Criteria:\n\n* Being 40 years of age or older Not having urinary incontinence before surgery Having undergone Radical Prostatectomy surgery due to prostate cancer Patients who did not have urinary incontinence before surgery\n\nExclusion Criteria:\n\n* Patients with congenital anomalies of the urinary system, serious organ dysfunctions (liver or kidney failure, advanced heart failure, coagulopathy), neuropsychiatric disorders, presence of active infection, and history of major abdominal or pelvic surgery will not be included in the study.","MALE","90 Years",{"count":143,"type":21},10,[24],"Cancer, a major public health problem worldwide, was one of the leading causes of mortality in 2020, accounting for approximately 10 million deaths. With 1.41 million new cases reported in the same year, prostate cancer is the fourth most common cancer type globally (Ferlay et al., 2021). Prostate cancer is not only one of the most common types of cancer in men, but it also ranks second among cancer-related deaths in men worldwide (Rahnama'i et al., 2021). Radical prostatectomy (RP) is a treatment method that involves the surgical removal of the prostate gland and surrounding tissues, to stop the progression of the disease and improve the patient's quality of life (Göktas et al., 2015; Litwin and Tan, 2017). Following radical prostatectomy, a curative treatment method commonly used to prevent metastasis, mortality rates remain low; however, the procedure carries a relatively high risk of morbidity (Akarken et al., 2020; Evren and Taşcı, 2021).\n\nThe most common complication encountered by patients after RP is urinary incontinence (Choiniere et al., 2022; Rahnama'i et al., 2021). Urinary incontinence (UI) arises due to factors such as damage to the internal sphincter, external rhabdosphincter, and supportive structures of the urethra during surgery, as well as the involvement of the neurovascular bundle and the development of postoperative fibrosis (Castellan et al., 2023). UI developing after radical prostatectomy significantly reduces patients' quality of life and negatively affects their social adaptation. Therefore, understanding the factors influencing the development of UI after radical prostatectomy is of great importance in determining appropriate treatment approaches and optimizing management (Bernardes et al., 2019; Storås et al., 2020). In the literature, the incidence rates of incontinence after radical prostatectomy range from 0.8% to 87%, and these differences are attributed to various factors such as surgical technique, patient characteristics, and evaluation methods (Boorjian et al., 2012; Hodges et al., 2019; Grise et al., 2017; Pastero et al., 2017).\n\nIn the majority of patients, moderate to severe urinary incontinence is observed in the first few weeks after surgery. In some patients, this condition may persist for months or even years. Urinary incontinence can lead to various psychosocial effects such as shame, loss of self-esteem, impaired mental well-being, anxiety, relationship and sexual dysfunction, and social isolation (Kadono et al., 2016; Zachovajeviene et al., 2017). This condition has a significant impact on patients' physical, social, and emotional well-being, as well as their daily activities, and can contribute to social isolation by causing feelings of embarrassment (Castellan et al., 2023; Ouanes et al., 2022).\n\nNurses play an important role in the management of urinary incontinence that develops after RP. Nurses can educate patients about urinary incontinence, teach conservative treatment methods such as pelvic floor muscle exercises (PFME), and provide psychological support to make the process more manageable (Milios et al., 2019; Tosunöz et al., 2018; Wang et al., 2018). PFME is an effective method that stands out in the rehabilitation of incontinence after RP, and it is one of the most common practices aimed at increasing the strength of the pelvic floor muscles to eliminate sphincter weakness (Castellan et al., 2023; Chitre and Kulkarni, 2023; Pratiwi et al., 2020). Studies on the effectiveness of PFME indicate that these exercises can improve patients' urinary control (Azal et al., 2022). Nurses play a significant role in promoting pelvic floor muscle health by providing information and implementing educational programs and practices to ensure that these exercises are taught and performed correctly (Jalalinia et al., 2020; Storås et al., 2020).\n\nThis study aims to evaluate the effects of preoperative and postoperative nursing interventions on urinary incontinence management and quality of life in patients who have undergone RP. In this context, the effects of nursing interventions (education, pelvic floor muscle exercises, bladder training, etc.) on urinary incontinence severity, quality of life, and patient satisfaction will be examined comparatively. The study aims to identify the most effective nursing interventions in the management of urinary incontinence after RP and to integrate these interventions into clinical practice.",[147,28],"Prostate Cancer (Post Prostatectomy)","2026-05-21",{"date":150,"type":39},"2026-05-26",{"date":148,"type":21},{"date":148,"type":21},{"name":154,"class":46},"KTO Karatay University",{"id":156,"slug":157,"hasResults":11,"nctId":158,"briefTitle":159,"officialTitle":160,"acronym":161,"eligibilityCriteria":162,"healthyVolunteers":11,"sex":55,"minAge":4,"maxAge":4,"enrollmentInfo":163,"targetDuration":4,"studyType":22,"phases":164,"briefSummary":165,"conditions":166,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":180},"100640507","essential-oils-for-urinary-symptoms-in-multiple-sclerosis-patients-100640507","NCT07599189","Essential Oils for Urinary Symptoms in Multiple Sclerosis Patients","Efficacy and Safety of Essential Oil Aromatherapy on Neurogenic Lower Urinary Tract Symptoms in Patients With Multiple Sclerosis: A Randomized Single-Blind Placebo-Controlled Clinical Trial.","AROMA-MS","Inclusion Criteria:\n\n* Confirmed diagnosis of Multiple Sclerosis (any form)\n* Documented lower urinary tract symptoms defined by an Overactive Bladder Symptom Score (OABSS) ≥ 3 at screening\n* Age between 18 and 65 years\n* Willing and able to provide written informed consent\n* Capable of performing daily topical self-application of the study oil, or having a caregiver available to assist throughout the study period\n\nExclusion Criteria:\n\n* Active urinary tract infection confirmed by urine culture at screening\n* Pre-existing urological condition unrelated to Multiple Sclerosis (e.g., bladder cancer, benign prostatic hyperplasia, or interstitial cystitis)\n* Known allergy or hypersensitivity to essential oils, apricot kernel oil, lavender, or rosemary\n* Active skin lesions, wounds, or dermatological conditions on the lower abdomen at the intended site of application\n* Pregnancy, breastfeeding, or planning to become pregnant during the study period\n* Significant cognitive impairment preventing understanding of study procedures or completion of questionnaires\n* Current use of an indwelling urinary catheter or practice of intermittent self-catheterization",{"count":87,"type":21},[24],"The goal of this clinical trial is to learn if essential oil aromatherapy works to improve urinary symptoms in adults with multiple sclerosis. It will also learn about the safety of essential oil use in this population.\n\nThe main questions it aims to answer are:\n\n* Does essential oil aromatherapy reduce urinary urgency, frequency, and incontinence episodes in participants with multiple sclerosis?\n* What medical problems do participants have when using essential oil aromatherapy?\n\nResearchers will compare essential oil aromatherapy to a placebo (a look-alike neutral oil with no therapeutic properties) to see if essential oil aromatherapy works to improve urinary symptoms in multiple sclerosis patients.\n\nParticipants will:\n\n* Use essential oil aromatherapy or a placebo oil every day for 6 weeks\n* Complete a urinary symptom scales to record the frequency, urgency, and any leakage episodes each day\n* Fill out quality of life questionnaires at the beginning and end of the study",[167,168,28,169,170],"Multiple Sclerosis (MS)","Neurogenic Bladder Disorder","Urinary Urgency","Lower Urinary Tract Symptoms (LUTS)","2026-05-16",{"date":173,"type":39},"2026-05-20",{"date":175,"type":21},"2026-09",{"date":177,"type":21},"2027-03",{"name":179,"class":46},"University of Oran 1",2,{"id":182,"slug":183,"hasResults":11,"nctId":184,"briefTitle":185,"officialTitle":185,"acronym":186,"eligibilityCriteria":187,"healthyVolunteers":11,"sex":55,"minAge":188,"maxAge":4,"enrollmentInfo":189,"targetDuration":4,"studyType":22,"phases":191,"briefSummary":192,"conditions":193,"keywords":200,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":213},"100625621","ambulatory-long-length-urodynamics-evaluation-100625621","NCT07425015","Ambulatory Long Length URodynamics Evaluation","ALLURE","Inclusion Criteria:\n\n1. Male or female patient must be ≥ 22 years of age.\n2. Patient is a candidate for UDS per standard of care.\n3. Patient is able to provide informed consent.\n\nExclusion Criteria:\n\n1. Patient has one or more symptoms indicative of a urinary tract infection (UTI) (i.e., fever, costovertebral angle pain or tenderness, suprapubic tenderness, worsening urinary frequency, worsening urgency, and\u002For dysuria).\n2. Patient has a history of recurrent UTIs (≥ 3 episodes in previous 12 months).\n3. Patient has used antibiotics within the past 7 days from the baseline\u002Fscreening visit.\n4. Patient diagnosed with neurogenic LUTD (i.e., one or more of these conditions: normal-pressure hydrocephalus, cerebral palsy, spinal cord injuries, traumatic brain injury, stroke, Parkinson's disease, multiple sclerosis, meningomyelocele, spina bifida, dementia, Guillain-Barre syndrome, and tumors involving the central nervous systems or spine).\n5. Patient diagnosed with interstitial cystitis (IC), bladder pain syndrome, painful bladder syndrome or any etiology of chronic pelvic pain syndrome (CPPS).\n6. Patient with a urostomy.\n7. Patient with a colostomy.\n8. Patient has an atypical anatomic structural variation or has had a previous surgical intervention that has permanently changed structural anatomy anywhere along their lower urinary tract (urethra, pelvic floor, urethral sphincter, and\u002For bladder wall) that the principal investigator deems might compromise the placement or retention of the Glean sensors during the study (e.g., strictures).\n9. Patient has a Pelvic Organ Prolapse Quantification (POP-Q) of Grade III or higher (i.e., most distal portion of the prolapse protrudes more than 1 centimeter below the hymen).\n10. Patient with any abnormal or concerning rectal conditions such as ongoing anal fissures, rectocele, fistula, active herpes, or active yeast infections.\n11. Patient has a known inability to void.\n12. Patient has a previous history of radiation leading to bleeding (e.g., hemorrhagic radiation cystitis).\n13. Patient is pregnant (as confirmed by urine pregnancy test or medical history) or breastfeeding, pregnant within the past 6 months, or intending to become pregnant during the study period.\n14. Patients who may not be able to independently use a smart device.\n15. Subjects who, at the principal investigator's determination, would not be appropriate for this study.","22 Years",{"count":190,"type":21},101,[24],"A prospective, open-label, single arm interventional trial evaluating the safety and performance of the in-clinic and extended monitoring of the lower urinary tract using the Glean Urodynamics System.",[194,195,196,197,198,28,199],"Urology","Urinary Bladder, Overactive","Benign Prostatic Hyperplasia","Urodynamics","Home Monitoring","Lower Urinary Tract Dysfunction",[201,202,203],"Bright Uro","Glean Urodynamics System","Uroflowmetry","2026-04-13",{"date":206,"type":39},"2026-04-15",{"date":208,"type":39},"2026-02-17",{"date":210,"type":21},"2027-06",{"name":201,"class":212},"INDUSTRY",7,{"id":215,"slug":216,"hasResults":11,"nctId":217,"briefTitle":218,"officialTitle":218,"acronym":219,"eligibilityCriteria":220,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":221,"targetDuration":4,"studyType":22,"phases":223,"briefSummary":224,"conditions":225,"keywords":227,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":235,"startDateStruct":237,"completionDateStruct":239,"leadSponsor":241,"locationsCount":180},"100577439","reducing-disparities-in-urinary-control-symptoms-for-minority-women-100577439","NCT06798311","Reducing Disparities in Urinary Control Symptoms for Minority Women","SUPPORT","Inclusion Criteria:\n\n* Age 18 years or older\n* Able to converse in English\n* A response of at least \"somewhat bothered\" by urinary incontinence, urinary frequency or urgency on the UDI\n* Willing to engage in conservative treatment of their UI\u002FLUTS for 16 weeks\n\nExclusion Criteria:\n\n* Anterior or posterior pelvic organ prolapse beyond the hymen or apical prolapse to the hymen\n* Currently taking medications for their UI\u002FLUTS or history of surgical intervention for UI\n* Patients with abnormal PVR and positive urine culture at time of study entry\n* History of recurrent UTIs\n* History of mobility or neurologic disorders that would prevent ability to complete at home physical therapy\n* Planning to start PT within the next 16 weeks",{"count":222,"type":21},80,[24],"The study is designed to address the disparity in available conservative\u002Fbehavioral treatments for UI\u002FLUTS. The program was developed by experts from urogynecology, psychology, and physical therapy then modified based on focus group feedback from racially minoritized women. The study team created a patient-centered, culturally adapted, self-directed, 8-week, home-based module for women with LUTS\u002FUI. The SUPPORT program combines multiple evidence-based conservative treatments for LUTS\u002FUI including cognitive behavioral therapy, behavioral modifications, and home physical therapy exercise. Progression through the home-based program is supported by research staff. This prospective interventional study aims to evaluate the feasibility and acceptability of the SUPPORT program and its impact on patient-centered treatment outcomes, while enabling comparisons across race and ethnicity. This approach will provide a comprehensive understanding of how to effectively deliver self-management strategies for pelvic floor disorders.\n\nAt the start of the 8 week SUPPORT course participants will also be given access to a custom programmed GPT trained on the SUPPORT workbook and given instructions on empathetic communication techniques and assisting patients in performing the SUPPORT exercises as outlined in the program. At the end of 8 weeks patients will fill out a survey assessing the frequency of use and interactions with the LLM.",[28,170,226],"Pelvic Floor Disorder",[228,229,230,231,92,232,233],"cognitive behavioral therapy","self-directed","physical therapy","behavioral modifications","home-based","health disparities","2026-04-06",{"date":236,"type":39},"2026-04-07",{"date":238,"type":39},"2024-10-28",{"date":240,"type":21},"2027-05",{"name":242,"class":46},"University of Chicago",{"id":244,"slug":245,"hasResults":11,"nctId":246,"briefTitle":247,"officialTitle":248,"acronym":249,"eligibilityCriteria":250,"healthyVolunteers":11,"sex":140,"minAge":18,"maxAge":4,"enrollmentInfo":251,"targetDuration":4,"studyType":22,"phases":253,"briefSummary":254,"conditions":255,"keywords":257,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":264,"lastUpdatePostDateStruct":265,"startDateStruct":267,"completionDateStruct":269,"leadSponsor":271,"locationsCount":47},"100632994","the-effect-of-mobile-based-perioperative-education-on-urinary-incontinence-and-erectile-function-after-radical-prostatectomy-100632994","NCT07520916","The Effect of Mobile-Based Perioperative Education on Urinary Incontinence and Erectile Function After Radical Prostatectomy","The Effect of Mobile-Based Perioperative Education on Urinary Incontinence and Erectile Function After Radical Prostatectomy: A Randomized Controlled Trial","MPE-RP","Inclusion Criteria:\n\n* Patients diagnosed with prostate cancer and scheduled for elective radical prostatectomy (open, laparoscopic, or robotic)\n* Aged 18 years or older\n* Planned to undergo surgery at the study center(s)\n* Able to use a smartphone and having sufficient digital literacy to operate the mobile application\n* Provided written informed consent after being informed about the study\n\nExclusion Criteria:\n\n* Pre-existing urinary incontinence or erectile dysfunction before surgery\n* Severe cognitive impairment or severe visual or hearing impairment\n* Previous pelvic radiotherapy or a history of major pelvic surgery\n* Presence of severe comorbidity or terminal illness that may interfere with adherence to the study protocol\n* Technological insufficiency preventing the use of the mobile application",{"count":252,"type":21},78,[24],"This prospective randomized controlled study aims to evaluate the effect of mobile-based perioperative education on postoperative urinary incontinence and erectile function in patients undergoing radical prostatectomy. Patients scheduled for radical prostatectomy will be assigned to either an intervention group or a control group. The intervention group will receive standard care plus a structured mobile application-based perioperative education program including video-assisted pelvic floor muscle training, perioperative education modules, reminders, and follow-up components. The control group will receive routine perioperative care and standard patient education. Data will be collected preoperatively, after urinary catheter removal, and at 1 month and 3 months after surgery. The primary outcomes are urinary incontinence and erectile function, assessed using the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF), the International Index of Erectile Function-5 (IIEF-5), and a 24-hour pad assessment. Secondary outcomes include lower urinary tract symptoms and disease-specific quality of life assessed by the International Prostate Symptom Score (IPSS), psychological status assessed by the Depression Anxiety Stress Scale-21 (DASS-21), and system usability assessed by the Turkish version of the Computer System Usability Questionnaire-Short Version (T-CSUQ-SV)",[147,28,256],"Erectile Dysfunction Following Radical Prostatectomy",[258,259,260,261,262,64,263],"Radical Prostatectomy","Mobile Health","mHealth","Perioperative Education","Pelvic Floor Muscle Training","Erectile Function","2026-04-03",{"date":266,"type":39},"2026-04-09",{"date":268,"type":39},"2026-04-02",{"date":270,"type":21},"2027-04-02",{"name":272,"class":46},"Giresun University",{"id":274,"slug":275,"hasResults":11,"nctId":276,"briefTitle":277,"officialTitle":278,"acronym":279,"eligibilityCriteria":280,"healthyVolunteers":11,"sex":17,"minAge":281,"maxAge":282,"enrollmentInfo":283,"targetDuration":4,"studyType":114,"phases":4,"briefSummary":285,"conditions":286,"keywords":288,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":294,"lastUpdatePostDateStruct":295,"startDateStruct":297,"completionDateStruct":299,"leadSponsor":301,"locationsCount":47},"100630601","urinary-incontinence-and-pelvic-floor-muscle-activity-in-multiple-sclerosis-100630601","NCT07489794","URINARY INCONTINENCE AND PELVIC FLOOR MUSCLE ACTIVITY IN MULTIPLE SCLEROSIS","FACTORS ASSOCIATED WITH URINARY INCONTINENCE AND EVALUATION OF PELVIC FLOOR MUSCLE ACTIVITY IN PATIENTS WITH MULTIPLE SCLEROSIS: CROSS-SECTIONAL STUDY","MS-UI-PFM","Inclusion Criteria:\n\nDiagnosis of multiple sclerosis (MS) according to the 2017 revised McDonald criteria.\n\nFemale patients aged 30-50 years (age range with higher prevalence of urinary incontinence in MS).\n\nExperiencing urinary incontinence (UI) symptoms according to the International Continence Society (ICS) definition.\n\nEDSS (Expanded Disability Status Scale) score below 6.5.\n\nPatients with no communication difficulties. -\n\nExclusion Criteria:\n\nMS patients who do not provide consent to participate in the study.\n\nMS patients who have had a medication change within the last 6 months.\n\nPregnant MS patients.\n\nHistory of vaginal or cesarean delivery within the last 6 months.\n\nPelvic organ prolapse.\n\nUrinary tract infection\n\n\\-","30 Years","50 Years",{"count":284,"type":21},47,"This study aims to investigate the relationship between urinary incontinence severity and surface electromyography (EMG) findings in women with multiple sclerosis. It will also examine the association of urinary incontinence with disability, quality of life, physical activity, and fatigue.",[287,28],"Multiple Sclerosis",[289,290,291,292,293],"multiple sclerosis","urinary incontinence","Electromyography","Fatigue","Physical Activity","2026-03-18",{"date":296,"type":39},"2026-03-24",{"date":298,"type":39},"2026-03-09",{"date":300,"type":21},"2026-10-30",{"name":302,"class":46},"Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization",{"id":304,"slug":305,"hasResults":11,"nctId":306,"briefTitle":307,"officialTitle":307,"acronym":308,"eligibilityCriteria":309,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":310,"targetDuration":4,"studyType":114,"phases":4,"briefSummary":312,"conditions":313,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":316,"lastUpdatePostDateStruct":317,"startDateStruct":319,"completionDateStruct":320,"leadSponsor":322,"locationsCount":47},"100603275","prevalence-and-functional-impact-of-urinary-incontinence-in-women-with-chronic-obstructive-pulmonary-disease-undergoing-rehabilitation-a-cross-sectional-study-100603275","NCT07134400","Prevalence and Functional Impact of Urinary Incontinence in Women With Chronic Obstructive Pulmonary Disease Undergoing Rehabilitation: a Cross-sectional Study","PURGE","Inclusion Criteria:\n\n* Women aged 45 years or older\n* Patients diagnosed with GOLD stage II to IV Chronic Obstructive Pulmonary Disease (COPD)\n* Patients undergoing pulmonary rehabilitation for COPD in a specialized center\n* Patients able to complete the entire pad test\n* Patients with no more than 3 pregnancies in their lifetime \\[9\\]\n* Patients covered by a health insurance plan\n* French-speaking patients\n* Patients who have not objected to participating in this research\n\nExclusion Criteria:\n\n* Patients who have undergone surgery in the pelvic or thoracic region less than one year ago\n* Patients under guardianship or curatorship\n* Patients deprived of liberty\n* Patients under legal protection (safeguarding justice)\n* Pregnant or breastfeeding patients",{"count":311,"type":21},100,"Chronic Obstructive Pulmonary Disease (COPD) is a pathology characterized by progressive bronchial obstruction associated with an abnormal inflammatory response, leading to chronic cough, increased bronchial secretions, and irreversible destruction of alveolar walls according to the French-Language Pulmonology Society, in 2023, over 1.3 million patients were treated for this condition in France. The World Health Organization ranks COPD as the third leading cause of mortality worldwide. Historically, COPD predominantly affected men due to higher smoking rates. However, with the rise in smoking among women, recent studies have shown that the prevalence of COPD in women increased from 28 to41 perr 10,000 between 2006 and 2015. Moreover, the clinical presentation of the disease differs between genders. For equivalent smoking exposure, women appear to be more severely affected than men, experiencing greater dyspnea and a higher risk of exacerbations, leading to more frequent hospitalizations and a generally poorer quality of life.\n\nBeyond pulmonary impairment, another clinically significant but often underestimated symptom affecting quality of life is urinary incontinence. It appears more common in individuals with COPD, particularly due to chronic cough, repeated abdominal hyperpressure, and pelvic floor muscle imbalance. A few studies have investigated the prevalence of urinary incontinence in people with COPD. One study, involving 995 individuals with COPD, suggested that 34.9% experienced urinary leakage. However, this was a subjective measure based on self-reported data via a simple questionnaire in a case-control study.\n\nAnother Swedish study estimated the prevalence of urinary incontinence in individuals with COPD at 49.6% in women and 30.3% in men, indicating that women may be at higher risk of developing this symptom. Beyond these studies, the current scientific literature remains relatively limited on this topic, while the impact on patients' quality of life appears to be significant. Among the available studies, one of the most comprehensive was published in 2013 and relied solely on self-administered questionnaires distributed to a broad population (across all disease stages) outside the rehabilitation setting.\n\nThis overlapping symptomatology-combining COPD and urinary incontinence-profoundly affects patients' quality of life, physically, psychologically, as well as socially. The consequences include limited activities, social withdrawal, diminished self-esteem, and persistent discomfort in daily interactions. This situation can lead to social anxiety or fear of leakage, resulting in absenteeism or abandonment of pulmonary rehabilitation sessions, thereby compromising the effectiveness of treatment. Reduced participation in physical activity perpetuates a vicious cycle: muscle deconditioning, sarcopenia, or even malnutrition, which worsens dyspnea, loss of autonomy, and increases the risks of frailty, infections, and hospitalizations. The study by M. A. Ramon et al. (2018) illustrates this \"vicious cycle,\" where impaired respiratory and physical capacities are self-sustaining. Without specific screening or management strategies for urinary incontinence in this context, breaking this downward spiral and improving overall care trajectories becomes challenging.\n\nRaising awareness about the importance of screening for stress urinary incontinence in women with COPD-particularly during pulmonary rehabilitation sessions, where these symptoms are often overlooked due to lack of knowledge and available treatments-is crucial. Such screening would enhance our understanding of the link between chronic cough, stress urinary incontinence, and quality of life. Establishing a correlation between these factors would allow for tailored care pathways and referral of certain patients to targeted pelvic floor rehabilitation.\n\nA better understanding of this phenomenon is essential to improve functional assessment and propose adapted therapeutic approaches, which could be the subject of an interventional study in the future. This study thus represents an initial exploratory step aimed at better understanding the prevalence of urinary incontinence in women with COPD undergoing rehabilitation, as well as its impact on quality of life and cough function. It is a preliminary, observational study whose results will lay the foundation for future interventional research.",[314,28,315],"COPD (Chronic Obstructive Pulmonary Disease)","Pulmonary Rehabilitation","2026-01-30",{"date":318,"type":39},"2026-02-02",{"date":318,"type":21},{"date":321,"type":21},"2027-11",{"name":323,"class":46},"Fondation Hôpital Saint-Joseph",{"id":325,"slug":326,"hasResults":11,"nctId":327,"briefTitle":328,"officialTitle":329,"acronym":4,"eligibilityCriteria":330,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":56,"enrollmentInfo":331,"targetDuration":4,"studyType":22,"phases":333,"briefSummary":334,"conditions":335,"keywords":340,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":345,"lastUpdatePostDateStruct":346,"startDateStruct":348,"completionDateStruct":350,"leadSponsor":352,"locationsCount":47},"100619994","effects-of-pemm-in-chronic-low-back-pain-women-with-urinary-incontinence-100619994","NCT07351851","Effects of PEMM in Chronic Low Back Pain Women With Urinary Incontinence","Effects of PEMM in Chronic Low Back Pain Women With Urinary Incontinence A Randomised Controlled Trial","Inclusion Criteria:\n\n* Age group of 18 - 65 years\n* Has child\u002Fchildren \\\u003C5 parity\n* CLBP patients with UI referred for physiotherapy for CLBP\n* Patient with low back pain for more than 3 months\n* NRS more than 5\u002F10\n* Patient with complain of urinary incontinence since past 3 months or more\n\nExclusion Criteria:\n\n* Chronic Low Back Pain with red flags\n* Not able to read and write in English \u002FArabic\n* Pregnant ladies and post partum 1 year\n* UTI, Pelvic floor Surgery\n* Any systemic condition of renal and cardiac\n* Patient with active carcinoma or any inflammatory disease",{"count":332,"type":21},200,[24],"Urinary incontinence (UI), Chronic low back pain (CLBP) in women are prevalent and often coexist. Multiple conditions when coexist, it leads to reduced Quality of life in turn causing physical and mental impairment. Musculoskeletal structures and fascial restrictions is one of the attribute to the coexistence of urinary incontinence and chronic back pain in women. External myofascial mobilization (EMM) with core exercises have been proven beneficial for conditions in males that is caused by musculoskeletal and fascial structures. However there are limited research which proves the effect of EMM in conditions involving musculoskeletal and fascial structures . Therefore, the aim of the study is to find the effect of MFTs in reducing the disability in women with CLBP and UI PRIMARY OBJECTIVE To evaluate the effectiveness of PEMM treatment in reducing disability, pain and improving mental health in women with CLBP and UI Study design : Simple randomization Sampling method: Simple Random sampling Random numbers will be generated in Excel, then random numbers will be presented in a concealed envelope for the participants to choose Sample Size : 130 (Experimental 65, Control 65) Sample size was determined using expected effect size i.e., mean change in the primary outcome variable disability index reported in the recent research study . With effect size (change in the disability index score) 3.5 and standard deviation of the change in the outcome 6.45, statistical power 80% and level of significance 5%, the required sample size would be n=55 participants in each group. However, to accounts for multiple secondary outcome measures, possible dropouts and non-response it would be good to increase an additional 20% in calculated sample size i.e., a total of 130 participants (65 participants in each group) will be included in this study.\n\nThe following sample size equation was used to determine adequate sample size:n = \\[2 (Z?\u002F2 + Z?)2 \\* ?2\\] \u002F (m1-m2)2 Where Z? and Z? are the values standard normal variate e.g., at 5% level of significance Z?\u002F2 = 1.96, and with 80% power the value of Z?= 0.84; ? is the polled Standard deviation and m1 and m2 are the mean outcome values s in group 1 and group 2 respectively.\n\nBlinding:\n\nSingle blinding: patient will be blinded to the group allocation. The assessor is blinded to the treatment\n\nMaterial and tools :\n\nTheragun - Theragun Elite, 20 V, Myofascial tools - foam roll, foam ball, Questionnaires - SF 3642,43,44, Oswestry Low back pain questionnaire (ODI)45 and The International Consultation on Incontinence Questionnaire Urinary Incontinence Short Form (ICIQ-UI-SF)46 PROCEDURE In the course of the study the total number of patients referred to physiotherapy department with LBP will be interviewed to identify patients with or without UI having LBP. The data obtained from this will be recoded as prevalence in results. The documents of the patients having LBP with UI will be reviewed to check who fulfills the inclusion criteria. All who meets the inclusion criteria will be approached face to face with the aim of the study. Informed consent form will be given to patients who are volunteering to participate in the study. The data of the participants who do not wish to participate in the study will also be recorded.\n\nThe participants who have consented to participate in the study will be then assessed. Since the participants has UI she will be directed to a Urologist for an assessment. After urologist assessment, patients will be randomly allocated to experimental and control groups. Random allocation will be administered by the random numbers generated and will be presented in a concealed envelope for the participants to choose. 1st week, the demographic data and Outcome measure of pain, SF36, ODI, ICIQ-UI-SF will be recorded (1st time) on the day of assessment. The outcome measures will be printed on paper and will be given to the patients to fill up with a pen, all questionnaires are self reported outcome measures. Treatment will commence a week after, where experimental group will undergo PEMM therapy with strengthening for 6 weeks duration and the control group will have conventional symptomatic pain treatment with strengthening (2nd to 7th week). Treatment will be given for 6 weeks (1 sessions in a week). The treatment day may vary any day between 4th and 7th day post one session. After 6 sessions of treatment, patient will be advised HEP (Home exercise program) to continue at home. Reassessment will be done on the 8th week where the outcome measures of pain, SF36, ODI, ICIQ-UI-SF will be recorded. Participants will be educated and advised regarding HEP. Exercises will be taught to the patient by explanation, demonstration, teach-back method, and printed sheet of exercise. Compliance to HEP will be recorded before final Outcome measure",[336,28,337,338,339],"Chronic Low-back Pain (cLBP)","Pelvic External Myofascial Mobilisation","Myofascial Techniques","Pelvic Pain",[341,290,342,343,344],"chronic low back pain","myofascial mobilisation","PEMM","female pelvic pain","2026-01-11",{"date":347,"type":39},"2026-01-20",{"date":349,"type":39},"2025-09-29",{"date":351,"type":21},"2027-12",{"name":353,"class":212},"Hamad Medical Corporation",{"id":355,"slug":356,"hasResults":11,"nctId":357,"briefTitle":358,"officialTitle":359,"acronym":360,"eligibilityCriteria":361,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":362,"enrollmentInfo":363,"targetDuration":4,"studyType":22,"phases":364,"briefSummary":365,"conditions":366,"keywords":367,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":370,"lastUpdatePostDateStruct":371,"startDateStruct":373,"completionDateStruct":375,"leadSponsor":377,"locationsCount":47},"100612978","hifem-for-incontinence-after-menopause-high-intensity-focused-electromagnetic-hifem-100612978","NCT07260604","HIFEM for Incontinence After Menopause High-Intensity Focused Electromagnetic (HIFEM)","Randomized Trial on Pelvic Floor Training With and Without HIFEM for Stress Urinary Incontinence","HIM2025","Inclusion Criteria:\n\n* Women aged 65-85 ears\n* Having daily stress incontinence requiring use of incontinence aids.\n* Living in ordinary housing without home (health-) care\n* Being physically active and can move independently both indoors and outdoors.\n* Being able to give independent informed consent in speech and writing\n* To understand and follow instructions in one of following languages Swedish, Arabic, French, and\u002For English\n\nExclusion Criteria:\n\n* -Ongoing coached pelvic floor training\n* Heart disease where treatment is contraindicated\n* Lung disease with chronic cough\n* Pacemaker, defibrillator, neurostimulator, medication pump, and implanted devices in the head or spinal cord\n* Electronic or metal implants in the abdomen, hips, or knees\n* Epilepsy\n* Ongoing cancer\n* Stoma or abdominal hernia\n* Ongoing treatment with anticoagulants such as warfarin, medicines affecting the bladder such as muscarin receptor antagonist, diuretics and local oestrogen which affect the bladder and urine production.\n* infection, fever, bleeding, or pain in the lower abdomen\n* Skin diseases or any skin sensitivity\n* BMI exceeding 30 kg\u002Fm2","85 Years",{"count":311,"type":21},[24],"It is not difficult to imagine that leaking urine affects life in many contexts. Unfortunately, it is everyday life for far too many people in our society. According to the National Board of Health and Welfare, incontinence primarily affects older people, and both women and men are vulnerable. In Sweden, just over 530,000 people over the age of 65 have problems and almost 80 percent of all people in special housing have such urine leakage that they need to use incontinence aids. First-line treatment for women with incontinence is local estrogen and pelvic floor training. Surgery may also be considered if this treatment does not provide sufficient effect.\n\nA new type of treatment for stress, urge and mixed incontinence is now on the market, High-Intensity Focused Electromagnetic (HIFEM®) treatment. This involves electromagnetic stimulation that causes contractions in the pelvic floor muscles. The treatment is not painful or invasive and the patient sits clothed in the treatment chair. In Sweden, HIFEM® is mainly available outside of traditional healthcare and is very expensive. It is also often given by unauthorized actors.\n\nWe are now planning a study whose purpose is to evaluate the effect of HIFEM® on women over 65 years of age with stress incontinence. A group of 100 women will be randomized to:\n\n1. Standard treatment, i.e. physiotherapy-led pelvic floor training\n2. As above with the addition of 10 treatments of 30 minutes with HIFEM®.\n\nThe evaluation will be carried out regarding leakage, need for incontinence aids and pelvic floor strength immediately and six months after the intervention. The women will also rate their incontinence symptoms, physical activity level, physical function and quality of life. A group will also be interviewed about their experiences of living with incontinence and the treatment. Before the study start, a case study will be performed in which 10 women will be included. They will receive 10 treatments and measure, with the same outcomes, the effects.\n\nAlternative treatment methods are important to meet the care needs we have today but also in the future. If treatment with HIFEM® can be effective for women over 65, it could, in addition to reducing incontinence problems and the consequences of these problems, also lead to reduced costs for society regarding care and incontinence products, as well as reduced environmental impact.",[28],[290,368,369],"pelvic floor training","HIFEM-treatment","2025-11-21",{"date":372,"type":39},"2025-12-03",{"date":374,"type":21},"2026-10-15",{"date":376,"type":21},"2028-06-30",{"name":378,"class":46},"Göteborg University",{"id":380,"slug":381,"hasResults":11,"nctId":382,"briefTitle":383,"officialTitle":384,"acronym":385,"eligibilityCriteria":386,"healthyVolunteers":387,"sex":17,"minAge":18,"maxAge":85,"enrollmentInfo":388,"targetDuration":4,"studyType":114,"phases":4,"briefSummary":390,"conditions":391,"keywords":394,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":349,"lastUpdatePostDateStruct":413,"startDateStruct":415,"completionDateStruct":417,"leadSponsor":419,"locationsCount":47},"100607072","trampoline-induced-changes-in-pelvic-structure-and-continence-100607072","NCT07183800","Trampoline-Induced Changes in Pelvic Structure and Continence","Does a 10-minute Trampoline Protocol Induce Urine Leakage or Changes in Pelvic Morphometry Among Females Who Report That They do Not Experience Symptoms of Urinary Incontinence?","TRAM","Inclusion Criteria:\n\n* Aged 18-40\n* Engage in regular physical activity or sport\n* Do not experience frequent urinary leakage (no more than once per month during exercise, coughing, or sneezing)\n* Can complete a 10-minute jumping protocol\n\nExclusion Criteria:\n\n* Currently pregnant or have been pregnant in the past 6 months\n* Have cardiac, pulmonary, metabolic, and\u002For neurological conditions\n* Have a lower body injury that limits your ability to jump\n* Have had a hysterectomy and\u002For incontinence surgery",true,{"count":389,"type":21},30,"The goal of this clinical trial is to evaluate whether a short bout of high-intensity trampoline jumping induces urinary leakage or measurable changes in pelvic floor morphology in active females aged 18-40 who do not report symptoms of urinary incontinence. The main questions it aims to answer are:\n\nHypothesis 1: Does a single 10-minute trampoline protocol result in acute changes in pelvic floor structure, including bladder neck position, levator plate length, and\u002For posterior urethrovesical angle (PUVA)?\n\nHypothesis 2: Do participants report any urinary leakage during the jumping protocol, despite being asymptomatic at baseline?\n\nHypothesis 3: Do pelvic morphology changes recover within 30 minutes post-jumping, or do alterations persist?\n\nResearchers will perform within-subject comparisons at multiple time points (pre-jump, immediately post-jump, and 30 minutes post-jump) using transperineal ultrasound imaging to assess structural changes.\n\nParticipants will:\n\n* Attend one laboratory visit\n* Complete baseline pelvic health questionnaires (ICIQ-UI Short Form and PFD Sentinel).\n* Undergo 2D transperineal ultrasound imaging in the standing position at rest, immediately post-jumping, and 30 minutes post-jumping.\n* Perform a 10-minute high-intensity jumping protocol on a mini-trampoline, while heart rate and perceived exertion are monitored.\n* Verbally report any urine leakage during jumping using standardized descriptors.",[392,64,28,393],"Urinary Continence","Urinary Incontinence , Stress",[395,92,396,397,398,399,400,401,402,403,404,405,406,407,408,409,410,411,412],"stress urinary incontinence","pelvic floor morphology","high impact exercise","urine leakage","urinary symptoms","levator plate","female athletes","bladder neck","posterior urethro-vesical angle","PUVA","jump","trampoline","high impact","high intensity","healthy female","incontinence","leakage","urinary leakage",{"date":414,"type":39},"2025-10-03",{"date":416,"type":39},"2025-07-16",{"date":418,"type":21},"2026-04-30",{"name":420,"class":46},"University of Ottawa",{"id":422,"slug":423,"hasResults":11,"nctId":424,"briefTitle":425,"officialTitle":426,"acronym":4,"eligibilityCriteria":427,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":56,"enrollmentInfo":428,"targetDuration":4,"studyType":22,"phases":429,"briefSummary":430,"conditions":431,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":434,"lastUpdatePostDateStruct":435,"startDateStruct":437,"completionDateStruct":439,"leadSponsor":441,"locationsCount":47},"100589698","preoperative-pelvic-floor-muscle-training-in-female-urinary-incontinence-100589698","NCT06957795","Preoperative Pelvic Floor Muscle Training in Female Urinary Incontinence","Investigation of the Preoperative Effectiveness of Intensive Pelvic Floor Muscle Training in Women With Urinary Incontinence: a Randomized Controlled Trial.","Inclusion criteria for the study:\n\n* Being a woman between the ages of 18-65\n* Being diagnosed with SUI or SUI-predominant mixed type urinary incontinence by an obstetrician-gynecologist\n* Having active pelvic floor muscle contraction\n* No genital anatomical abnormality\n* Being able to understand and follow verbal and written instructions\n* The patient was referred to physiotherapy at least 6 weeks before the planned surgery date\n* Patients performed 75% or more of the given exercises (categorized as adequate compliance)\n\nExclusion criteria for the study:\n\n* Not volunteering to participate\n* Being pregnant\n* Having had previous pelvic floor surgery\n* Having received previous pelvic floor physiotherapy\n* Having a vaginal or urinary infection\n* Being unable to tolerate pelvic floor muscle function measurement\n* Having a neuromuscular or neurological disease that may affect muscle function",{"count":87,"type":21},[24],"Pelvic floor muscles (PFM) play a crucial role in supporting pelvic organs and maintaining continence. Weakness in these muscles can lead to dysfunctions such as pelvic organ prolapse, urinary incontinence (UI), and sexual or anorectal disorders. UI, defined as the involuntary loss of urine, is common globally and classified as stress, urge, or mixed incontinence. Stress urinary incontinence (SUI) - the most prevalent type among women - occurs during activities that increase intra-abdominal pressure. Risk factors include female sex, aging, obesity, smoking, chronic constipation, previous gynecological surgeries, and childbirth. Treatment options for SUI include conservative and surgical methods. Pelvic floor training (PFT), first described by Arnold Kegel in 1948, is a conservative approach that strengthens PFM and alleviates symptoms. Although surgery is often used for SUI, with over 200 procedures described, this study aims to evaluate the preoperative effectiveness of intensive PFT in women with SUI. It will assess changes in muscle function and symptoms before surgery, guiding pelvic rehabilitation strategies to potentially reduce surgical burden and improve outcomes.",[432,28,262,433],"Women","Preoperative Period","2025-05-05",{"date":436,"type":39},"2025-05-08",{"date":438,"type":39},"2025-01-01",{"date":440,"type":21},"2025-09-01",{"name":442,"class":46},"Gulhane School of Medicine",{"id":444,"slug":445,"hasResults":11,"nctId":446,"briefTitle":447,"officialTitle":448,"acronym":449,"eligibilityCriteria":450,"healthyVolunteers":387,"sex":17,"minAge":18,"maxAge":110,"enrollmentInfo":451,"targetDuration":4,"studyType":114,"phases":4,"briefSummary":452,"conditions":453,"keywords":457,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":461,"lastUpdatePostDateStruct":462,"startDateStruct":464,"completionDateStruct":466,"leadSponsor":468,"locationsCount":47},"100587824","elastographic-assessment-of-suburethral-tissue-in-continent-and-incontinent-women-100587824","NCT06933407","Elastographic Assessment of Suburethral Tissue in Continent and Incontinent Women","This Study Investigates the Role of Strain Elastography in Assessing Paraurethral Tissue Elasticity in Continent and Incontinent Pre- and Postmenopausal Women. It Also Evaluates the Predictive Value of Strain Elastography Compared to Other Pelvic Imaging Modalities, Including Conventional Ultrasound Examinations, in Supporting Treatment Decision-making for Urinary Incontinence.","SE-inc1","Inclusion Criteria:\n\n* Clinical diagnosis of stress urinary incontinence (SUI) based on patient history, physical examination, and\u002For urodynamic assessment.\n\nExclusion Criteria:\n\n* Pelvic malignancy or history of pelvic radiation therapy\n* Urge urinary incontinence (UUI) or detrusor overactivity\n* Pelvic organ prolapse (POP) stage ≥ II (based on POP-Q classification)\n* Pregnancy or recent postpartum status (less than 6 months postpartum)\n* Neurological disorders affecting bladder function\n* Recurrent urinary tract infections (UTIs) or active lower urinary tract infection\n* Inability to undergo study procedures\n* Cognitive impairment or psychiatric conditions affecting informed consent or compliance",{"count":222,"type":21},"Strain elastography (SE) will be utilized as a non-invasive imaging technique to evaluate tissue elasticity and biomechanical properties in women with stress urinary incontinence (SUI) and in continent controls. The primary aim is to determine whether SE can detect differences in paraurethral tissue stiffness between these groups. Given the established role of tissue elasticity in the pathophysiology of SUI, SE will be investigated as a potential diagnostic tool in urogynecological evaluations.\n\nThis prospective cohort study will be conducted at a tertiary referral center. All participants will undergo introital two-dimensional (2D) ultrasound in the midsagittal plane at rest. SE will be performed in three predefined suburethral regions of interest (ROIs):\n\n* internal urethral orifice (IUO) level\n* midurethra (MU) level\n* external urethral orifice (EUO) level\n\nThe adipose layer (AL) between the external urethral meatus and the pubic symphysis will serve as the reference tissue, representing the softest anatomical structure in the region.\n\nDescriptive and comparative statistical analyses will be conducted to assess differences in paraurethral tissue stiffness between the study groups.\n\nIt is hypothesized that SE will be able to detect differences in paraurethral tissue elasticity, with SUI being associated with increased tissue compliance. The study also aims to determine whether SE can reliably distinguish between varying degrees of tissue stiffness in women with SUI and continent controls.\n\nPathophysiological focus:\n\nThe study will explore key mechanisms underlying SUI, including:\n\n* Weakened bladder neck support\n* Impaired urethral stabilization due to increased tissue elasticity and collagen degradation\n* While conventional 2D ultrasound provides anatomical information, it does not directly evaluate tissue biomechanics. In contrast, SE enables real-time visualization of tissue elasticity, offering a promising adjunct to traditional urogynecological assessment methods.\n\nStandardization and Protocol\n\nThe study will follow a standardized protocol to ensure reproducibility and high-quality data. Key methodological elements include:\n\n* Minimal probe compression during introital ultrasound to avoid artifacts\n* Bladder emptying prior to examination to eliminate confounding effects\n* Carefully standardized ROI placement across all patients\n* Controlled image acquisition conditions to reduce variability\n\nFuture Directions\n\n* Future research based on this study will aim to:\n* Optimize SE protocols and refine ROI placement strategies\n* Establish clinical cutoff values for differentiating tissue stiffness in SUI vs. continent women\n* Assess the long-term effects of pelvic floor muscle training (PFMT) and vaginal estrogen therapy on paraurethral biomechanics\n* Facilitate the integration of SE into routine urogynecological practice to support early diagnosis and personalized treatment strategies for SUI",[64,454,28,195,455,456],"Urinary Incontinence, Stress","Incontinence, Overactive Bladder, Stress Urinary Incontinence","Stress Urinary Incontinence (SUI)",[64,458,459,460],"Bladder dysfunction","Urine leakage","Stress urinary incontinence (SUI)","2025-04-15",{"date":463,"type":39},"2025-04-18",{"date":465,"type":39},"2024-08-16",{"date":467,"type":21},"2030-01-01",{"name":469,"class":46},"Szeged University",{"id":471,"slug":472,"hasResults":11,"nctId":473,"briefTitle":474,"officialTitle":475,"acronym":4,"eligibilityCriteria":476,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":477,"targetDuration":4,"studyType":114,"phases":4,"briefSummary":479,"conditions":480,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":481,"lastUpdatePostDateStruct":482,"startDateStruct":484,"completionDateStruct":485,"leadSponsor":487,"locationsCount":47},"100582709","examination-of-the-effect-of-nocturia-on-pelvic-floor-symptoms-sleep-parameters-and-quality-of-life-in-women-with-urinary-incontinence-100582709","NCT06866834","Examination of the Effect of Nocturia on Pelvic Floor Symptoms, Sleep Parameters and Quality of Life in Women with Urinary Incontinence","Examination of the Effect of Nocturia on Pelvic Floor Symptoms, Chronotype, Sleepiness, Sleep Quality, Fatigue and Quality of Life in Women with Urinary Incontinence","Inclusion Criteria:\n\nInclusion Criteria for the Group with Nocturia:\n\n* Being 18 years of age or older\n* Being female\n* Have been diagnosed with urinary incontinence\n* Wake up during the main sleep period to relieve the need to urinate, with the intention of returning to sleep or falling asleep again after each urination\n\nInclusion Criteria for the Group without Nocturia:\n\n* Being 18 years of age or older\n* Being female\n* Have been diagnosed with urinary incontinence\n\nExclusion Criteria:\n\nExclusion Criteria for the Group with Nocturia:\n\n* Diagnosis of a sleep disorder\n* Diagnosis of any neurological disease\n* Chronic kidney disease\n* Diagnosis of diabetes\n* Use of sleep medications\n* Use of antidepressants\n* Use of diuretic medications\n* Use of any medication for urinary incontinence\n* Hormone replacement therapy\n* Pregnancy or having given birth within the last six months\n* Having had a urinary tract infection in the last three months\n* Presence of prolapse greater than stage 2\n* History of orthopedic trauma to the pelvic region\n* Pelvic surgery within the last six months\n* History of cancer\n\nExclusion Criteria for the Group without Nocturia:\n\n* Waking up during the main sleep period to relieve the need to urinate, with the intention of returning to sleep or falling asleep again after each urination\n* Diagnosis of a sleep disorder\n* Diagnosis of any neurological disease\n* Chronic kidney disease\n* Diagnosis of diabetes\n* Use of sleep medications\n* Use of antidepressants\n* Use of diuretic medications\n* Use of any medication for urinary incontinence\n* Hormone replacement therapy\n* Pregnancy or having given birth within the last six months\n* Having had a urinary tract infection in the last three months\n* Presence of prolapse greater than stage 2\n* History of orthopedic trauma to the pelvic region\n* Pelvic surgery within the last six months\n* History of cancer",{"count":478,"type":21},102,"Urinary incontinence (UI), a common issue, is the involuntary leakage of urine that negatively affects individuals socially, physically, and psychologically, leading to a decreased quality of life. Nocturia, which is often seen alongside UI, has similar adverse effects. Nocturia refers to the number of urinations during the main sleep period, and it should be accompanied by the intention to fall back asleep after waking up. Nocturia can arise from factors such as sleep disorders and circadian rhythm disturbances. The circadian rhythm regulates the body's biological functions, and this rhythm varies from person to person, creating chronotypes. There is a strong relationship between sleep and nocturia because nocturia leads to deep sleep loss, an increased risk of metabolic diseases, decreased sleep quality and sleep efficiency, and an increase in the number of awakenings after sleep onset. It is necessary to distinguish whether nocturia, which has a comprehensive impact, affects pelvic floor symptoms, chronotype, sleep quality, fatigue, sleepiness, and quality of life in women with UI. Therefore, the aim of this study is to examine the effect of nocturia on pelvic floor symptoms, chronotype, sleepiness, sleep quality, fatigue, and quality of life in women with UI.",[432,28,29],"2025-03-04",{"date":483,"type":39},"2025-03-10",{"date":438,"type":39},{"date":486,"type":21},"2025-06-01",{"name":442,"class":46}]