[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"urinary-incontinencestress\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:urinary-incontinencestress":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,50,76,103,132],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100622747","synchronized-core-pelvic-floor-activation-in-urinary-incontinence-100622747",false,"NCT07387640","Synchronized Core-Pelvic Floor Activation in Urinary Incontinence","Synchronized Activation of Core and Pelvic Floor Muscles: A More Effective Strategy for Urinary Incontinence?","Inclusion Criteria:\n\n* Aged between 18 and 65 years\n* Diagnosed with stress, urge, or mixed urinary incontinence\n* Pelvic floor muscle strength grade ≥ 3 according to the Modified Oxford Scale\n* At least one episode of urinary leakage within the last month\n\nExclusion Criteria:\n\n* Pregnancy\n* Childbirth within the previous 6 weeks\n* Severe pelvic organ prolapse\n* Active vaginal or urinary tract infection\n* Presence of neurological or psychiatric disorders\n* Malignancy\n* Inability to cooperate with assessments or interventions","FEMALE","18 Years","65 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to investigate whether co-activation of the pelvic floor and core muscles improves treatment outcomes in individuals with urinary incontinence. Participants diagnosed with stress, or mixed urinary incontinence will undergo a 12-week pelvic floor physiotherapy program, with or without additional core muscle co-activation exercises. Changes in urinary incontinence severity, pelvic floor muscle function, core muscle activation, and quality of life will be evaluated.",[27,28,29,30],"Urinary Incontinence,Stress","Stress Urinary Incontinence","Mixed Incontinence Due to Prolapse of Female Genital Organ","Urinary Incontinence",[32,33,34,35,36],"Pelvic floor muscle training","Core stability exercises","Core Muscle Co-activation","Pelvic floor physiotherapy","Surface Electromyography","NOT_YET_RECRUITING","2026-06-30",{"date":40,"type":41},"2026-07-01","ACTUAL",{"date":43,"type":21},"2026-08-30",{"date":45,"type":21},"2027-08-30",{"name":47,"class":48},"Bezmialem Vakif University","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":75},"100608540","phase-3-a-study-of-orforglipron-in-female-participants-with-stress-urinary-incontinence-who-have-obesity-or-overweight-100608540","NCT07202884","A Study of Orforglipron in Female Participants With Stress Urinary Incontinence Who Have Obesity or Overweight","A Master Protocol to Investigate the Efficacy and Safety of Orforglipron Tablet Once Daily Compared With Placebo in Female Participants With Stress Urinary Incontinence Who Have Obesity or Overweight","RESTRAIN-SUI","Inclusion Criteria:\n\n* Have a body mass index (BMI) of 27 kilograms per square meter (kg\u002Fm2) or higher at screening\n* Have a diagnosis of stress urinary incontinence\n\nExclusion Criteria:\n\n* Have had urinary incontinence surgery\n* Have recently received onabotulinumtoxin A (Botox) bladder injections or currently taking medications for urinary incontinence\n* Have given birth within one year of screening\n* Have had a change in body weight of more than 11 pounds within 90 days prior to screening\n* Have used any anti-obesity medication or alternative weight loss remedies within 180 days prior to screening\n* Have type 1 diabetes, type 2 diabetes, or any other type of diabetes\n* Have had a cardiovascular health condition within 90 days prior to screening\n* Are pregnant, intending to be pregnant, breastfeeding, or intending to breastfeed for the duration of the study",{"count":59,"type":21},1000,[61],"PHASE3","The GZPS master protocol will support two independent studies, J2A-MC-GZS1 and J2A-MC-GZS2. Each study will see how well and safely orforglipron works in adult female participants with stress urinary incontinence (SUI) who have obesity or overweight. SUI is leaking urine during movement or activity such as coughing or exercising. Participation in the study will last about 58 weeks from screening to safety follow-up.",[27],"RECRUITING","2026-06-19",{"date":67,"type":41},"2026-06-23",{"date":69,"type":41},"2025-09-30",{"date":71,"type":21},"2028-03",{"name":73,"class":74},"Eli Lilly and Company","INDUSTRY",137,{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":83,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":22,"phases":86,"briefSummary":87,"conditions":88,"keywords":89,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":5},"100381567","adjustable-continence-therapy-act-for-the-treatment-of-female-sui-100381567","NCT04248283","Adjustable Continence Therapy (ACT) for the Treatment of Female SUI","A Clinical Investigation of the Adjustable Continence Therapy (ACT) for Female Stress Urinary Incontinence Due to Intrinsic Sphincter Deficiency","Inclusion Criteria:\n\n1. Female at least 22 years old\n2. Diagnosed with stress urinary incontinence with primary Intrinsic Sphincter Deficiency\n3. Provocative pad weight of greater than 11.0 grams\n4. Candidate for surgical intervention\n5. Negative urinalysis\n6. Normal cystourethroscopy\n7. Failed at least 6 months of previous treatment(s) for stress urinary incontinence (e.g., exercise regimen, electrical stimulation, surgical procedures, etc). Note: patients may have failed prior anti-incontinence procedures for SUI (e.g., suspension, sling, or urethral bulking agent)\n8. Willing and able to sign informed consent and comply with trial follow-up requirements\n\nExclusion Criteria:\n\n1. Pregnant or lactating\n2. Life expectancy of less than 5 years\n3. Has uncontrolled diabetes as evidenced by HbA1c over 6.5% and fasting plasma glucose over 130 mg\u002FdL\n4. Has auto-immune disease\n5. Undergoing radiation therapy\n6. Active urinary tract infection\n7. Detrusor instability refractory to medication\n8. Reduced bladder compliance as defined by a cystometrogram\n9. Significant residual volume (greater than 100 ml) after voiding in which detrusor contraction is weak, when the bladder volume is greater than or equal to 250 ml\n10. Has, had, or is suspected of having bladder cancer\n11. History of bladder stones\n12. Urethral stricture evidenced during cystourethroscopy\n13. Has a neurogenic bladder that is atonic or has detrusor sphincter dyssynergia\n14. Has a diathesis, hemophilia, or a bleeding disorder\n15. Has a rectocele, cystocele, urethrocele, enterocele, or pelvic prolapse of grade 3 or higher\n16. Had prior pelvic radiotherapy\n17. Had a prior artificial urinary sphincter implanted\n18. Has a neurogenic condition known to affect bladder\u002Fsphincter function","22 Years",{"count":85,"type":21},167,[24],"A prospective, single arm, non-randomized, multicenter, prospective case-series trial. The purpose of this trial is to demonstrate the safety and effectiveness of using the Adjustable Continence Therapy (ACT) to provide a clinically relevant improvement in stress urinary incontinence.",[30,27],[30,90,91,92,93],"Urination Disorders","Urination Involuntary","Urologic Diseases","Lower Urinary Tract Symptoms","2026-06-15",{"date":96,"type":41},"2026-06-17",{"date":98,"type":41},"2021-01-26",{"date":100,"type":21},"2032-05-31",{"name":102,"class":74},"Uromedica",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":111,"targetDuration":4,"studyType":22,"phases":113,"briefSummary":114,"conditions":115,"keywords":119,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":49},"100544518","tens-analgesia-during-outpatient-urethral-bulking-for-stress-urinary-incontinence-100544518","NCT06369922","TENS Analgesia During Outpatient Urethral Bulking for Stress Urinary Incontinence.","Transcutaneous Electrical Nerve Stimulation Analgesia During Outpatient Urethral Bulking for Stress Urinary Incontinence.","TENSUB","Inclusion Criteria:\n\n* • Women, Age ≥18 years\n\n  * Diagnosis of SUI\n  * Scheduled to undergo transurethral bulking in the office\n  * Able to read\u002Fwrite English\n\nExclusion Criteria:\n\n* • Cutaneous damage such as ulcers or broken skin on target treatment area\n\n  * Currently implanted cardiac pacemaker or defibrillator\n  * Pre-procedural use of opioids for pain management, less than 8 hours from last dose\n  * Participants with altered sensation below the umbilicus",{"count":112,"type":21},100,[24],"This will be a double-blind randomized control trial in women with stress urinary incontinence who are undergoing an outpatient transurethral bulking procedure for stress urinary incontinence. Subjects will be identified by the University of Rochester urologists and urogynecologists participating in the study who currently oversee stress incontinence care. Subjects will be randomized into two groups. One group will be undergoing the cystoscopy with transcutaneous electrical nerve stimulation (TENS) for analgesia, and the second group will have the cystoscopy with placebo TENS.",[116,30,27,117,118],"Stress Incontinence Female","Pain","Pain Acute",[120,121,122],"TENS","pain","Transcutaneous Electrical Nerve Stimulation Analgesia","2026-05-11",{"date":125,"type":41},"2026-05-13",{"date":127,"type":41},"2024-07-01",{"date":129,"type":21},"2027-06-01",{"name":131,"class":48},"University of Rochester",{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":139,"enrollmentInfo":140,"targetDuration":4,"studyType":22,"phases":142,"briefSummary":143,"conditions":144,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":49},"100581300","synchronous-and-asynchronous-telerehabilitation-for-women-with-urinary-incontinence-100581300","NCT06848517","Synchronous and Asynchronous Telerehabilitation for Women With Urinary Incontinence","The Effectiveness of a Blended Synchronous and Asynchronous Telerehabilitation Program for Greek Adult Women With Urinary Incontinence. A Randomized Controlled Trial","Inclusion Criteria:\n\n* Greek women,\n* 18-75 years old,\n* Diagnosis of Stress Urinary Incontinence (SUI) or Mixed UI (via Urodynamic examination).\n* Writing and reading of the Greek language\n* Having ease in using synchronous communication platforms (e.g., Zoom) and asynchronous educational videos via smart phones, tablets, computers etc\n* Able to voluntarily contract the PFM, during the initial clinical examination.\n\nExclusion Criteria:\n\n* 6 months after postpartum,\n* Systemic diseases\n* Malignancy,\n* Major gynecological surgery (i.e. total hysterectomy) over the last 10 years,\n* Neurological dysfunction,\n* Mental impairment","75 Years",{"count":141,"type":21},60,[24],"In the adult female Greek population,approximately 27% suffer from urinary incontinence (UI). Nowadays, the conservative, evidence-based and 'gold standard' therapy of UI involves pelvic floor muscles (PFM) training programs, which are effective when performed intensively (daily) and for at least three months' duration. Unfortunately, patients' adherence to PFM exercises programs is often compromised for various reasons (lack of patient interest, inability to exercise daily etc.). Therefore, the development of synchronous and asynchronous telerehabilitation programs has revolutionized UI treatment, because they offer an interactive environment which might increase patient motivation and improve patient's adherence to this demanding PFM exercise regime. Synchronous Telerehabilitation Programs (STP) have developed via communication platforms that allow users to connect with video, audio, phone, and chat applications (e.g. Zoom), where users can interact in real time with their therapist and follow their treatment through the PFM exercise program. Furthermore, Asynchronous Telerehabilitation Programs (ATP) have emerged via mobile applications, educational videos etc., where users can follow their treatment using the PFM exercise program at a more convenient time that fits into their personal schedule. Although some studies have examined either STP or ATP with or without face-to-face sessions, no study has investigated a blended approach of STP and ATP for the management of UI.\n\nGiven the above, the primary aim of this study is to evaluate the effectiveness of a blended STP and ATP, in comparison to face-to-face therapy sessions. A secondary objective is to investigate the level of patients' adherence, and the amount of supervision required, in a blended STP and ATP. Furthermore, the necessity of telerehabilitation programs (whether provided in a synchronous or asynchronous manner) in the field of pelvic floor dysfunctions specifically in UI, will be explored. Finally, the study will assess the usability of a telerehabilitation program (whether provided in a synchronous or asynchronous manner) in women with UI.",[27],"2025-02-21",{"date":147,"type":41},"2025-02-27",{"date":149,"type":41},"2025-02-15",{"date":151,"type":21},"2026-05-30",{"name":153,"class":48},"University of Patras"]