[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ush2a-variant-retinitis-pigmentosa\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ush2a-variant-retinitis-pigmentosa":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":26,"lastUpdatePostDateStruct":27,"startDateStruct":30,"completionDateStruct":32,"leadSponsor":34,"locationsCount":4},"100557987","a-new-diagnostic-paradigm-for-retinitis-pigmentosa-secondary-to-ush2a-pathogenic-variants-100557987",false,"NCT06545253","A New Diagnostic Paradigm for Retinitis Pigmentosa Secondary to USH2A Pathogenic Variants","Inclusion Criteria:\n\n* age \\>18 years\n* genetically confirmed diagnosis of USH2A-RP\n* availability of genetic tests to assess the pathogenic variants\n\nExclusion Criteria:\n\n* inability to understand and sign the written informed consent form\n* any inflammatory, infectious or degenerative eye disease\n* media opacities resulting incompatible with good imaging quality\n* uncontrolled systemic, metabolic, autoimmune neuroinflammatory and neurodegenerative disease\n* ophthalmologic surgery within the previous six months",true,"ALL","18 Years",{"count":19,"type":20},60,"ESTIMATED","OBSERVATIONAL","Aim of the study is to perform a non-invasive multimodal retinal imaging investigation in a cohort of patients affected by USH2A retinitis pigmentosa (USH2A-RP), in order to develop a new diagnostic paradigm to categorize clinically relevant subgroups. All the procedures will be performed according to normal clinical practice. In addition, a novel quantitative profiling of serum microRNAs will be carried out in order to analyze the clinical importance of microRNA biomarkers in the clinical setting of the disease.",[24],"USH2A Variant Retinitis Pigmentosa","NOT_YET_RECRUITING","2024-08-06",{"date":28,"type":29},"2024-08-09","ACTUAL",{"date":31,"type":20},"2024-08",{"date":33,"type":20},"2027-02",{"name":35,"class":36},"IRCCS Ospedale San Raffaele","OTHER"]