[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"usher-syndromes\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:usher-syndromes":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":5},"100466567","adaptive-optics-imaging-of-outer-retinal-diseases-100466567",false,"NCT05355415","Adaptive Optics Imaging of Outer Retinal Diseases","Inclusion Criteria:\n\n1. Are 21 years of age or older,\n2. Have the ability to cooperate with instructions during adaptive optics imaging (similar to instructions given during a clinical eye exam),\n3. Have the ability to understand and sign an informed consent. (Non-English speaking participants will not be enrolled into the study), and\n4. Have been diagnosed with outer retinal disease or condition (Cohort 2).\n\nExclusion Criteria:\n\n1. Have a condition which prevents adequate images from being obtained (e.g. unstable fixation or media opacity),\n2. Have visual correction outside of the range +4 diopters (D) to -8 D,\n3. Have a history of adverse reaction to mydriatic drops,\n4. Have a predisposition to (i.e., narrow iridocorneal angle) or any history of acute angle closure glaucoma (AACG), or\n5. Are working under the direct supervision of Drs. Hammer, Cukras and Liu, or any of the NIH\u002FNEI AIs.","ALL","21 Years",{"count":18,"type":19},100,"ESTIMATED","OBSERVATIONAL","The objective of the study is to collect adaptive optics (AO) retinal images from human subjects with outer retinal diseases (diseases of the outer retina including photoreceptor, retinal pigment epithelium (RPE), basement membrane or choroidal pathologies) to develop new diagnostic methods, biomarkers, and clinical endpoints.",[23,24,25,26,27,28,29,30,31,32],"Retinal Degeneration","Age-Related Macular Degeneration","Retinitis Pigmentosa","Hydroxychloroquine Retinopathy","Usher Syndromes","Late-Onset Retinal Degeneration","Cone Dystrophy","Cone Rod Dystrophy","Rod Cone Dystrophy","Rod Dystrophy","RECRUITING","2026-05-06",{"date":36,"type":37},"2026-05-08","ACTUAL",{"date":39,"type":37},"2021-08-27",{"date":41,"type":19},"2028-09-30",{"name":43,"class":44},"Food and Drug Administration (FDA)","FED",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":53,"targetDuration":55,"studyType":20,"phases":4,"briefSummary":56,"conditions":57,"keywords":58,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":74},"100413602","natural-history-study-of-usher-syndrome--light4deaf--100413602","NCT04665726","Natural History Study of Usher Syndrome ( Light4Deaf )","Natural History Study of Usher Syndrome in a Cohort of Patients Followed Longitudinally for 5 Years","Light4Deaf","Inclusion Criteria:\n\n* Patient with a molecular diagnosis of Usher syndrome type I, II or III or a clinical diagnosis of Usher syndrome type I, II or III which will then be confirmed by a molecular diagnosis\n* Health insurance beneficiary\n* Informed consent signed by the patient or their legal representatives\n\nExclusion Criteria:\n\n• Patient or his\u002Fher legal representatives unable to understand the study and for whom informed consent cannot be obtained",{"count":54,"type":19},400,"5 Years","Clinical centres in the LIGHT4DEAF consortium have developed and will continue to improve a reliable, early molecular diagnosis and protocols for full clinical characterisation of Usher syndrome, which will be valuable for the foreseen USH clinical trials. The clinical arm of the project aims at performing a deep-phenotyping of retinal degeneration, hearing loss, vestibular dysfunction, neurocognitive ability of subects with a molecular diagnosis of any Usher syndrome. Functional and structural parameters for retinal, auditory, and vestibular impairments are followed overtime to document the natural history of the disease and establish relevant clinical endpoint for disease progression that may be useful for future clinical trials.",[27],[59,60,61,62,63],"Usher syndrome,","Natural history study for retinal degenetation,","Deep-phenotyping,","Hearing loss,","Vestibular dysfunction","2020-12-07",{"date":66,"type":37},"2020-12-14",{"date":68,"type":37},"2017-06-08",{"date":70,"type":19},"2027-06-08",{"name":72,"class":73},"Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts","OTHER",4]