[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"vaccination-failure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:vaccination-failure":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,39],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100510248","is-a-third-dose-of-mmrv-vaccine-beneficial-for-the-adult-population-in-alberta-100510248",false,"NCT05923970","Is a Third Dose of MMRV Vaccine Beneficial for the Adult Population in Alberta?","Is a Third Dose of Measles-mumps-rubella-(Varicella) Vaccine (MMR(V)) Vaccine Beneficial for the Adult Population in Alberta?","Inclusion Criteria:\n\n* Women who are pregnant and have undergone routine prenatal screening for rubella antibodies.\n\nExclusion Criteria:\n\n* Women younger than 18 years of age","FEMALE","18 Years",{"count":19,"type":20},200,"ESTIMATED","OBSERVATIONAL","The current recommendation for a full course of measles-mumps-rubella-(varicella) vaccine (MMR(V)) is two doses. The problem is, many individuals within the vaccinated cohort show antibody levels that are below the level considered to be protective, even after two doses of vaccine. Because of these waning antibody levels, it is currently unknown whether highly vaccinated populations are protected from infection against measles, mumps, rubella, or varicella should they be exposed to any of these viruses. The uncertainty of a woman's immune status is partly due to the type of testing that is used to indicate protection. While immunity to viral infection requires both a humoral and a cell mediated immune (CMI) response, only humoral (antibody) responses are measured routinely in the laboratory. This study will examine CMI responses and the role of a third dose of vaccine for previously vaccinated women whose antibody levels are below the cut off. This study will not administer vaccine, but rather will include women who have received a third dose of vaccination through routine health care follow up in the study cohort.",[24,25],"Vaccination Failure","Vaccine Response Impaired","RECRUITING","2026-03-12",{"date":29,"type":30},"2026-03-16","ACTUAL",{"date":32,"type":30},"2024-11-09",{"date":34,"type":20},"2027-09-30",{"name":36,"class":37},"University of Alberta","OTHER",1,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":43,"acronym":44,"eligibilityCriteria":45,"healthyVolunteers":46,"sex":47,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":52,"conditions":53,"keywords":56,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":69},"100459749","preterm-immune-system-development-and-response-to-immunization-100459749","NCT05266664","Preterm Immune System Development and Response to Immunization","PRIMI","To be eligible to participate in this study, a preterm infant must meet all following criteria:\n\n* Preterm infant born at gestational age less than 32 weeks (whose mothers did or did not receive a T dap vaccination during pregnancy)\n* Parents\u002F guardians must have sufficient understanding of the Dutch language\n\nTo be eligible to participate in this study, a healthy full-term infant must meet all following criteria:\n\n* healthy full-term infant whose mother received a Tdap vaccination during pregnancy\n* Parents\u002F guardians must have sufficient understanding of the Dutch language\n\nTo be eligible to participate in this study, a mother must meet all following criteria:\n\n\\- Mother of preterm or health full-term infant who are participating in the study\n\nExclusion Criteria:\n\n* Parents\u002Fguardians of the infant are not able or willing to provide informed consent\n* Infant with congenital anomaly which are more likely to cause adverse effects after immunization (for example hemodynamically significant congenital heart defect)\n* Infant with a (possible) HIV infection or immunodeficiency\n* Maternal use of immunosuppressive drugs during pregnancy",true,"ALL","1 Day","2 Months",{"count":51,"type":20},145,"In this study the response to vaccination and development of the immune system in very preterm infants upon the current vaccination schedule will be compared to healthy term infants.",[54,55,24],"Immune System Disorder","Preterm",[57,58,59],"immune system development","preterm infant","vaccination","2024-03-19",{"date":62,"type":30},"2024-03-20",{"date":64,"type":30},"2022-12-08",{"date":66,"type":20},"2026-07",{"name":68,"class":37},"Maastricht University Medical Center",7]