[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"vaccination-hesitancy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:vaccination-hesitancy":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":4},"100636230","a-bio-psycho-social-medical-model-based-study-on-adolescent-female-hpv-vaccination-behavior-and-comprehensive-intervention-100636230",false,"NCT07562984","A Bio-Psycho-Social Medical Model-Based Study on Adolescent Female HPV Vaccination Behavior and Comprehensive Intervention","A Bio-Psycho-Social Medical Model-Based Study on Adolescent Female HPV Vaccination Behavior and Comprehensive Intervention: An International Multicenter Randomized Controlled Trial","Inclusion Criteria:\n\n1. Female, aged 9-17 years (inclusive of 9 and 17 years old).\n2. Attending pediatric \\& adolescent gynecology, adolescent health clinics, or related pediatric\u002Fchild healthcare clinics at the research centers; or attending vaccination clinics for non-HPV vaccinations (e.g., influenza, tetanus).\n3. Has not received any dose of HPV vaccine and has no definitive plan for HPV vaccination on the day of the visit (confirmed by investigator inquiry).\n4. Accompanied by at least one primary caregiver (parent or legal guardian) who can comprehend the study content and is willing to participate in shared decision-making interventions.\n5. Plans to reside mostly in the region where the research center is located for the next 12 months to facilitate follow-up.\n6. Caregiver provides written informed consent; adolescent provides informed consent\u002Fassent per local ethical requirements.\n\nExclusion Criteria:\n\n1. Previous completion of or initiation of any HPV vaccine series.\n2. History of severe allergic reaction to any HPV vaccine or its main components, or assessed by a vaccinating physician as currently unsuitable for HPV vaccination.\n3. Comorbid severe physical illness (e.g., severe cardiopulmonary disease, active malignancy) or severe mental disorder, judged by the investigator as unsuitable for participation or likely unable to complete follow-up.\n4. Participation in other clinical studies highly related to HPV vaccination behavior intervention within the past year, which may interfere with the evaluation of this study's intervention effect.\n5. Currently receiving treatment for HPV-related diseases (e.g., genital warts) where the physician considers vaccination currently inadvisable.\n6. History of autoimmune diseases or tumors.\n7. Other situations deemed by the investigator to affect study adherence or interpretation of results (e.g., families with extremely high mobility).",true,"FEMALE","9 Years","17 Years",{"count":21,"type":22},300,"ESTIMATED","INTERVENTIONAL",[25],"NA","Based on the biopsychosocial (BPS) medical model, this study focuses on HPV vaccination behavior among adolescent females. It aims to explore the influence of multidimensional factors-including biological characteristics, psychological factors, and family and social environments-on vaccination behavior, and to evaluate the effectiveness of a comprehensive HPV vaccination intervention program designed for joint participation by adolescents and their parents.\n\nThis study employs a prospective, multicenter, randomized, open-label, parallel-group design. Participants-girls and adolescents aged 9-17 who are scheduled to receive or have not yet completed HPV vaccination, along with their primary caregivers-were recruited from our hospital and collaborating pediatric\u002Fmaternal and child health institutions both domestically and internationally. Participants were randomly assigned in a 1:1 ratio to an intervention group and a control group.\n\nIn addition to routine vaccination clinic counseling, the intervention group received a comprehensive HPV vaccination intervention program based on the BPS model, including: structured health education materials (illustrated booklets\u002Fshort videos); structured communication and shared decision-making support in the clinic setting; continuous information dissemination and vaccination reminders via platforms such as WeChat; and personalized follow-up and Q\\&A sessions for families with high vaccine hesitancy; The control group received standard routine education and vaccination services.\n\nThe primary outcome was the proportion of adolescents who completed the first dose of the HPV vaccine within 3 months of enrollment; secondary outcomes included the proportion completing the full vaccination series within 6 months, changes in vaccine hesitancy levels and HPV-related knowledge, changes in anxiety\u002Fdepression levels among adolescents and caregivers, and changes in the quality of parent-child communication regarding health and vaccination as well as family decision-making patterns.\n\nThis study is expected to identify key bio-psycho-social determinants of HPV vaccination behavior among adolescent females, validate the effectiveness of the comprehensive BPS intervention in increasing vaccination rates and improving decision-making experiences and psychosocial outcomes, and provide evidence-based guidance and scalable practical pathways for pediatric and related specialty clinics to implement adolescent vaccination health promotion and family shared decision-making services.",[28,29,30],"HPV","Vaccination Hesitancy","Biopsychosocial Model","NOT_YET_RECRUITING","2026-04-28",{"date":34,"type":35},"2026-05-01","ACTUAL",{"date":37,"type":22},"2026-04-30",{"date":39,"type":22},"2028-11-30",{"name":41,"class":42},"The Children's Hospital of Zhejiang University School of Medicine","OTHER",{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":16,"sex":50,"minAge":51,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":54,"briefSummary":55,"conditions":56,"keywords":61,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":4},"100632172","media-orientation-to-improve-childhood-vaccine-uptake-and-address-parent-and-caregivers-vaccine-related-anxiety-a-pilot-study-100632172","NCT07510230","Media Orientation to Improve Childhood Vaccine Uptake and Address Parent and Caregivers Vaccine-related Anxiety: A Pilot Study","Media Campaign Intervention to Increase Childhood Immunisation Vaccine Uptake, Access and Reduce Vaccine Hesitancy for Parents\u002FCaregivers With Children: A Pilot Randomised Controlled Trial","Inclusion Criteria:\n\n* Parent or primary caregivers aged 18 years and above\n* Whose child(ren) are not or partially up-to-date with childhood immunisation vaccination\n* Able to provide full consent for their participation.\n* Able to speak the English Language.\n* Able to take part in the intervention and are available for the intervention assessment at baseline and end of intervention.\n\nExclusion Criteria:\n\n* Less than 18 years\n* Parent or Career whose child(ren) are up-to-date with childhood immunisation vaccination\n* Unable to consent.\n* Currently undergoing severe mental health treatment.\n* Unable to speak the English language .","ALL","18 Years",{"count":53,"type":22},74,[25],"Vaccine hesitancy-defined as delayed acceptance or refusal of vaccines despite availability-remains a significant barrier to childhood immunisation uptake in Nigeria, a country with high zero-dose unvaccinated children. Several factors limit vaccine uptake, including poor awareness, misinformation, fear, anxiety and a perceived sense of conspiracy. Yet, a gap exists to address this urgent problem. The proposed study seeks to pilot the feasibility and acceptability of a novel co-produced media campaign intervention called ASSURed awareness campaign to encourage childhood vaccine uptakE (ASSURE) with parent-caregivers who are not or partially up to date with their child's vaccination. The ASSURE intervention is designed to encourage vaccine uptake and access, reduce vaccine hesitancy whilst addressing vaccine-related anxiety. The ASSURE intervention is low-intensity, lasting approximately 3-5-minute designed to raise awareness of the need for vaccination uptake and its implications for children, including their development and well-being whist addressing vaccine related anxiety and fears. The proposed study is also to pilot and test the instrument to determine effectiveness and cost effectiveness including the mechanism on why the intervention might potentially work.",[57,29,58,59,60],"Anxiety","Vaccination Promotion","Vaccine Decision Making","Immunisation Anxiety Related Reaction",[57,62,63,59,58],"Vaccine Hesitancy","Chilhood Vaccination Uptake","2026-03-29",{"date":66,"type":35},"2026-04-03",{"date":68,"type":22},"2026-04-20",{"date":70,"type":22},"2027-02-08",{"name":72,"class":42},"Teesside University"]