[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"vaginal-cuff-complications\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:vaginal-cuff-complications":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100503280","barbed-vs-standard-suture-for-colporrhaphy-at-the-end-of-laparoscopic-hysterectomy-100503280",false,"NCT05833204","BARBED vs. STANDARD Suture for Colporrhaphy at the End of Laparoscopic Hysterectomy","Barbed Versus Standard Suture for Vaginal Cuff Closure After Total Laparoscopic Hysterectomy: a Randomized Controlled Trial","BARD","Inclusion Criteria:\n\n* Patients undergoing elective total laparoscopic hysterectomy\n* Surgery performed for the treatment of benign pathology\n* Age \\> 18 years\n* Surgery performed by laparoscopy\n* Signature of informed consent\n\nExclusion Criteria:\n\n* Patients undergoing emergent surgery\n* Patients candidates for hysterectomy for oncological indication\n* Patients who underwent previous radiation therapy\n* Patients allergic to the suture material used in the study\n* Patients unable to express adequate informed consent to participate in the study","FEMALE","18 Years",{"count":20,"type":21},1614,"ESTIMATED","INTERVENTIONAL",[24],"NA","Hysterectomy is one of the most common surgical procedures performed worldwide, with more than 400,000 hysterectomies performed annually in the United States. As a consequence, even uncommon complications can affect large numbers of patients. Among potentially life-threatening events, vaginal cuff dehiscence complicates 0.14-1.38% of procedures, and any vaginal cuff complications (dehiscence, hematoma, bleeding, infection) are estimated to affect 4.7-9.8% of patients. In this scenario, any preventive strategy can provide clinically relevant benefits. Regarding colporrhaphy, only the adoption of a laparoscopic approach instead of a vaginal approach is supported by high-quality evidence. Our group demonstrated that the laparoscopic closure of the vaginal cuff after total laparoscopic hysterectomy reduces the incidence of vaginal cuff complications.\n\nAmong other potentially effective interventions, the use of barbed sutures was associated with a lower incidence of vaginal cuff dehiscence than the standard suture. In a recent meta-analysis, the use of barbed sutures has been associated with a pooled incidence of vaginal cuff dehiscence of 0.4% versus 2% after a traditional vaginal suture. However, this evidence is limited because most pooled studies were retrospective, and only two were randomized controlled trials. Moreover, these two randomized controlled trials had a very small sample size and were not powered to detect clinically relevant differences. On that basis, despite the promising utility of barbed sutures for vaginal cuff closure after total laparoscopic hysterectomy, the choice of the type of suture is not evidence-based but still guided by personal opinions, as well as by the preference and habits of the operators.\n\nTherefore, this study aims to investigate whether the laparoscopic vaginal cuff closure with barbed suture determines a lower incidence of vaginal cuff dehiscence and complications than conventional sutures after total laparoscopic hysterectomy.",[27],"Vaginal Cuff Complications",[29,30,31,32,33,34],"Laparoscopy","Hysterectomy","Vaginal cuff closure","Barbed sutures","Vaginal cuff complications","Vaginal cuff dehiscence","NOT_YET_RECRUITING","2026-04-28",{"date":38,"type":39},"2026-04-29","ACTUAL",{"date":41,"type":21},"2026-09-01",{"date":43,"type":21},"2028-12-31",{"name":45,"class":46},"Universita di Verona","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":60,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":47},"100606389","post-hysterectomy-vaginal-cuff-prolapse-repair-100606389","NCT07174921","Post-hysterectomy Vaginal Cuff Prolapse Repair","Laparoscopic Lateral Suspension Versus Laparoscopic Sacrocolpopexy for Post-Hysterectomy Vaginal Cuff Prolapse: A Randomized Controlled Trial","Inclusion Criteria:\n\nWomen aged ≥18 years.\n\nHistory of hysterectomy (any approach: abdominal, vaginal, or laparoscopic).\n\nSymptomatic vaginal cuff prolapse (POP-Q stage ≥ II).\n\nAble to provide written informed consent.\n\nWilling and able to comply with study procedures and follow-up visits.\n\nExclusion Criteria:\n\nPrior sacrocolpopexy or lateral suspension surgery.\n\nActive pelvic infection or untreated malignancy.\n\nSevere cardiopulmonary or systemic disease that contraindicates laparoscopic surgery.\n\nKnown allergy to mesh materials used in the procedures.\n\nInability to complete patient-reported questionnaires due to cognitive or language barriers.\n\nConcurrent pelvic organ prolapse requiring additional surgical repair beyond vaginal cuff suspension.",{"count":56,"type":21},50,[24],"This study is a randomized controlled trial comparing two minimally invasive surgeries-laparoscopic lateral suspension and laparoscopic sacrocolporopexy-for women who develop vaginal cuff prolapse after hysterectomy. Vaginal cuff prolapse occurs when the top of the vagina loses support after the uterus is removed, which can cause discomfort, bulging, or urinary and bowel problems.\n\nThe goal of this study is to determine which surgical approach is safer, more effective, and improves quality of life for patients. Women enrolled in the trial will be randomly assigned to one of the two surgeries, and outcomes such as prolapse recurrence, complications, recovery time, and patient satisfaction will be carefully monitored.\n\nBy comparing these two techniques, this study aims to provide clear guidance for surgeons and patients to make informed decisions about the best surgical treatment for post-hysterectomy vaginal cuff prolapse.",[27],[61,62,63,64],"prolapse","vaginal cuff","lateral suspension","sacrocolpopexy","RECRUITING","2025-09-13",{"date":68,"type":39},"2025-09-16",{"date":70,"type":21},"2025-09-30",{"date":72,"type":21},"2026-10-15",{"name":74,"class":46},"Kanuni Sultan Suleyman Training and Research Hospital"]