[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"valve-regurgitation-mitral\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:valve-regurgitation-mitral":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100586608","mosaic-mitral-valve-long-term-outcomes-in-patients-under-65-100586608",false,"NCT06917586","Mosaic Mitral Valve: Long-Term Outcomes in Patients Under 65","Long Term Patient Outcomes and Product Durability of the Mosaic Mitral Valve Bioprosthesis in Patients Under 65","MMV","Inclusion Criteria:\n\n* Received the Mosaic Mitral Valve Bioprosthetic at ProMedica Toledo Hospital\n* Under the age of 65\n\nExclusion Criteria:\n\n* Over the age of 65\n* Under the age of 18\n* Surgery performed at institutions outside of ProMedica Toledo Hospital","ALL","18 Years","65 Years",{"count":21,"type":22},300,"ESTIMATED","OBSERVATIONAL","The safety and efficacy of the Mosaic bioprosthetic heart valves for cardiac valve replacement in the aortic position has been well documented throughout the literature. However, few studies assessing structural valve deficiency, patient outcomes and overall product performance in patients under the age of 65 exists for the Mosaic mitral valve bioprosthetic. This study aims to assess valve efficacy, stability, and post operative outcomes in patients who have received the Mosaic mitral valve prothesis at ProMedica Toledo Hospital and were under the age of 65.",[26,27,28,29],"Valve Disease, Heart","Valve Replacement","Valve Regurgitation, Mitral","Valve Heart Stenosis",[31,32,33,34],"Mitral Valve","Bioprosthetic","Mosaic","Valvulopathy","RECRUITING","2026-02-18",{"date":38,"type":39},"2026-02-20","ACTUAL",{"date":41,"type":39},"2025-01-01",{"date":43,"type":22},"2027-07-01",{"name":45,"class":46},"Michael Moront","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":76,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":5},"100586678","prophylactic-suture-line-sealing-with-nex-glue-r-eco-in-cardiac-and-vascular-surgery-100586678","NCT06918496","Prophylactic Suture Line Sealing With NE'X Glue R-eco in Cardiac and Vascular Surgery","A Prospective ClinicaL investigatiOn Evaluating Prophylactic Sealing of sUture Lines Using the NE'X Glue R-eco Surgical AdhesivE in Cardiac and (Cardio)Vascular Anastomotic Repair Procedures","CLOSURE","Inclusion Criteria:\n\n* Patient ≥ 18 years of age at study entry.\n* Patient is scheduled for open procedures for surgical placement of a prosthetic or biologic graft (patch) or an allograft for cardiac and (cardio)vascular anastomosis repair. Emergency, transplantation and minimally invasive procedures are excluded. Patients receiving long-term anticoagulation, including antiplatelet agent, are included. Choice of graft is at the discretion of the surgeon.\n* Patient is willing and able to be contacted for up to 3 months (± 14 days) follow-up.\n* Patient or legal representative and investigator signed and dated the informed consent form prior to the index-procedure.\n\nExclusion Criteria:\n\n* Patient has a known hypersensitivity, contraindication, or allergic reaction to albumin or glutaraldehyde.\n* Patient has a history of bleeding diathesis or coagulopathy.\n* Presence of active infection or contamination in the to be grafted area or the vicinity.\n* Known vasculitis in the to be grafted area.\n* Patient takes immune suppressive medication like prednisone resulting in weakening of the vessel wall.\n* Patient is refusing blood transfusion.\n* Patient or legal representative is unable \u002F unwilling to provide informed consent.\n* Patient is unable to comply with the protocol or proposed follow-up visits.\n* Female patient is pregnant, lactating, or planning pregnancy during the clinical investigation.\n* Female participants of childbearing age must agree to use safe contraception (e.g., intrauterine devices, hormonal contraceptives: contraceptive pills, implants, transdermal patches hormonal vaginal devices, injections with prolonged release, abstinence).\n* Patients who are currently enrolled in another clinical study, or have recently participated in a clinical study, that could potentially interfere with the outcomes or introduce bias into the results of the current study (as determined by the investigator). This includes studies involving investigational drugs, medical devices, or other interventions that could impact the safety, efficacy, or scientific integrity of this study.",{"count":57,"type":22},60,"INTERVENTIONAL",[60],"NA","This clinical study aims to evaluate the effectiveness and safety of using NE'X Glue R-eco to seal suture lines. The adhesive will be applied to reduce the risk of suture line bleeding in cardiac or vascular repair surgeries, a prosthetic or biologic graft, patch, or allograft.\n\nThe effectiveness of the adhesive will be assessed after restoring blood flow.",[63,64,65,28,66,67,68,69,70,71,72,73,74,75],"Aortic Aneurysm","Aortic Aneurysm Abdominal","Valve Stenoses, Aortic","Valve Regurgitation, Tricuspid","Aneurysm of Ascending Aorta","Aneurysm Abdominal","Artery Diseases, Peripheral","Ventricular Aneurysm","Coronary Artery Disease","Valve Aortic Regurgitation","Aortic Aneurysms Arch","Aortic Aneurysms Descending","Aortic Aneurysms Thoracoabdominal",[77,78,79,80,81],"prophylactic sealing of suture lines","Surgical glue","cardiac and (cardio)vascular anastomotic repair procedures","grafts","NE'X Glue R-eco surgical adhesive","NOT_YET_RECRUITING","2025-04-08",{"date":85,"type":39},"2025-04-09",{"date":87,"type":22},"2025-06-30",{"date":89,"type":22},"2026-03-31",{"name":91,"class":92},"Grena Biomed Limited","INDUSTRY"]