[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"valve-replacement\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:valve-replacement":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100577629","prolonged-chest-tube-treatment-to-reduce-rates-of-atrial-fibrillation-following-cardiac-surgery-100577629",false,"NCT06800781","Prolonged Chest Tube Treatment to Reduce Rates of Atrial Fibrillation Following Cardiac Surgery","Prolonged Posterior Pericardial Chest Tube Treatment to Reduce Rates of Postoperative Atrial Fibrillation Following Cardiac Surgery","PROPER","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Undergoing non-emergent surgery (\\>24 hours between decision to operate and surgical procedure) with coronary artery bypass grafting, aortic valve replacement, aortic surgery without the use of circulatory arrest, or any combination of these procedures\n* Able to give written informed consent\n\nExclusion Criteria:\n\n* History of atrial fibrillation (AF) or atrial flutter\n* History of electrophysiological interventions or treatment with antiarrhythmic drugs due to arrhythmias other than AF\n* Pre- or postoperative prophylactic treatment with amiodarone\n* Existing pacemaker, ICD, or CRT device without a functional atrial lead\n* Aortic surgery with hypothermic circulatory arrest\n* Previous cardiac surgery\n* Previous radiation of the chest due to malignancy\n* Ongoing infection at time of surgery\n* Ongoing treatment with immunosuppressants, including oral corticosteroids\n* Patient already included in another interventional clinical trial\n* Patient listed abroad, which would render them to be lost to follow-up after discharge\n* Patient does not understand study information given in the local language or, for other reasons, is deemed unfit to participate according to the investigators.","ALL","18 Years",{"count":20,"type":21},624,"ESTIMATED","INTERVENTIONAL",[24],"NA","Evacuation of pericardial blood by posterior pericardiotomy or use of a posterior pericardial chest tube lowers postoperative atrial fibrillation (POAF) rates after cardiac surgery by 45-68%. Although it cannot be generalized due to trial undersizing, posterior pericardial chest tube treatment may be a superior alternative to pericardiotomy, given its low risk of procedural complications.\n\nThis interventional multicenter trial will assess whether prolonged treatment with a posterior pericardial chest tube lowers POAF rates after cardiac surgery. Investigators will randomize 624 patients undergoing routine cardiac surgery at Nordic sites 1:1 to receive a posterior pericardial chest tube as adjunct to standard care for up to 3 postoperative days or standard care alone. The primary outcome is the proportion of patients with POAF up to 7 days post-surgery; the study will be powered to detect a relative risk reduction of 30% in the intervention arm. Secondary outcomes are AF burden; days with chest tubes and their output; proportion of patients with POAF up to 14 days post-surgery; direct current conversions during hospital admission; length of ICU\u002Fhospital stay; postoperative complications, mortality, ischemic stroke, and major bleeding at 30\u002F90 days and 1\u002F3\u002F5 years; and quality of life\u002Fpostoperative recovery at 90 days and 1 year. This trial may provide quality clinical evidence supporting the adoption of a simple method to prevent POAF, thus reducing healthcare costs.",[27,28,29],"Coronary Arterial Disease (CAD)","Valve Replacement","Aortic Surgery",[31,32],"Posterior pericardial chest tube","Postoperative atrial fibrillation (POAF)","RECRUITING","2026-04-28",{"date":36,"type":37},"2026-04-29","ACTUAL",{"date":39,"type":37},"2025-02-10",{"date":41,"type":21},"2033-12",{"name":43,"class":44},"Region Skane","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":45},"100586608","mosaic-mitral-valve-long-term-outcomes-in-patients-under-65-100586608","NCT06917586","Mosaic Mitral Valve: Long-Term Outcomes in Patients Under 65","Long Term Patient Outcomes and Product Durability of the Mosaic Mitral Valve Bioprosthesis in Patients Under 65","MMV","Inclusion Criteria:\n\n* Received the Mosaic Mitral Valve Bioprosthetic at ProMedica Toledo Hospital\n* Under the age of 65\n\nExclusion Criteria:\n\n* Over the age of 65\n* Under the age of 18\n* Surgery performed at institutions outside of ProMedica Toledo Hospital","65 Years",{"count":56,"type":21},300,"OBSERVATIONAL","The safety and efficacy of the Mosaic bioprosthetic heart valves for cardiac valve replacement in the aortic position has been well documented throughout the literature. However, few studies assessing structural valve deficiency, patient outcomes and overall product performance in patients under the age of 65 exists for the Mosaic mitral valve bioprosthetic. This study aims to assess valve efficacy, stability, and post operative outcomes in patients who have received the Mosaic mitral valve prothesis at ProMedica Toledo Hospital and were under the age of 65.",[60,28,61,62],"Valve Disease, Heart","Valve Regurgitation, Mitral","Valve Heart Stenosis",[64,65,66,67],"Mitral Valve","Bioprosthetic","Mosaic","Valvulopathy","2026-02-18",{"date":70,"type":37},"2026-02-20",{"date":72,"type":37},"2025-01-01",{"date":74,"type":21},"2027-07-01",{"name":76,"class":44},"Michael Moront"]