[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"varicose-veins-of-lower-limb\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:varicose-veins-of-lower-limb":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,40,74,102,127,151,171,200,226,257,281,303],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100399906","registry-for-chronic-venous-disease-incidence-and-natural-course-100399906",false,"NCT04487314","Registry for Chronic Venous Disease Incidence and Natural Course","Russian Registry for Chronic Venous Disease Incidence and Natural Course","RRCVD","Inclusion Criteria:\n\n* A family members of the researcher (spouse, childrens, brothers and sisters, parents) or the researcher himself\n* The possibility of annual clinical and ultrasound assessment of the venous system of the observed individuals\n\nExclusion Criteria:\n\n* Any invasive treatment of the chronic venous disorder in anamnesis\n* Venous thrombosis in the anamnesis or at the time of inclusion",true,"ALL","10 Years",{"count":21,"type":22},10000,"ESTIMATED","OBSERVATIONAL","A prospective cohort study of patients with primary varicose veins to assess the morbidity, risk factors and development of chronic lower limb vein disease.",[26],"Varicose Veins of Lower Limb","RECRUITING","2026-06-24",{"date":30,"type":31},"2026-06-29","ACTUAL",{"date":33,"type":31},"2020-08-20",{"date":35,"type":22},"2050-09-01",{"name":37,"class":38},"Russian Phlebological Association","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":18,"minAge":48,"maxAge":4,"enrollmentInfo":49,"targetDuration":51,"studyType":23,"phases":4,"briefSummary":52,"conditions":53,"keywords":55,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":39},"100617351","hemovar-study-on-hemorrhoids-and-varicose-veins-100617351","NCT07317492","HEMOVAR Study on Hemorrhoids and Varicose Veins","Prospective Evaluation of the Association Between Hemorrhoids and Lower Extremity Varicose Veins Using Doppler Ultrasound (HEMOVAR Study)","HEMOVAR","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Patients presenting to the general surgery proctology outpatient clinic of Aydın Adnan Menderes University Hospital\n* Patients diagnosed with hemorrhoidal disease or other non-hemorrhoidal benign proctologic conditions\n* Ability to understand the study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Patients younger than 18 years\n* History of lower extremity varicose vein surgery, endovenous ablation, or sclerotherapy\n* Presence of systemic venous disorders such as portal hypertension or liver cirrhosis\n* Pregnant women\n* Patients with known malignancy or severe comorbid conditions that could interfere with evaluation\n* Refusal or inability to provide written informed consent","18 Years",{"count":50,"type":22},400,"10 Days","The HEMOVAR Study is a prospective observational study designed to evaluate the association between hemorrhoidal disease and lower extremity varicose veins. A total of 400 adult patients presenting to the general surgery proctology outpatient clinic of Aydın Adnan Menderes University Hospital will be included. The study will consist of two groups: 200 patients diagnosed with hemorrhoids and 200 patients with other non-hemorrhoidal benign proctologic conditions serving as controls.\n\nAll participants will undergo routine clinical evaluation and demographic data collection. Cardiovascular surgeons will voluntarily perform physical examination and Doppler ultrasonography of the lower extremities to assess venous insufficiency and varicose veins. No experimental intervention or treatment will be applied. The study will not require any consumable materials and will not impose any additional financial burden on the hospital, patients, or the national health insurance system. The primary outcome is the prevalence of lower extremity venous insufficiency in patients with hemorrhoids compared with controls.",[26,54],"Hemorrhoids",[54,56,57,58,59,60,61,62,63,64],"Varicose Veins","Venous Insufficiency","Doppler Ultrasound","Venous Reflux","Proctology","Pelvic Congestion Syndrome","Prospective Observational Study","Varicocele","HEMOVAR Study","2026-04-28",{"date":67,"type":31},"2026-04-29",{"date":69,"type":31},"2025-12-19",{"date":71,"type":22},"2026-12-31",{"name":73,"class":38},"Aydin Adnan Menderes University",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":18,"minAge":48,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":39},"100636102","phase-4-mechanochemical-ablation-versus-ultrasound-guided-foam-sclerotherapy-of-the-great-saphenous-vein-100636102","NCT07561320","Mechanochemical Ablation Versus Ultrasound-Guided Foam Sclerotherapy of the Great Saphenous Vein","Mechanochemical Ablation Versus Ultrasound-Guided Foam Sclerotherapy of the Great Saphenous Vein: Randomized Clinical Trial","Inclusion Criteria:\n\n* CEAP Classification C2, 3 or 4\n* Insufficient great saphenous vein measuring 6-12 mm in the mid-thigh on Doppler ultrasound.\n\nExclusion Criteria:\n\n* Allergy to sclerosing substances\n* Deep venous thrombosis, stroke, or pulmonary embolism\n* Local or generalized infection at the sclerotherapy site\n* Prolonged immobilization\n* Asymptomatic patent foramen ovale\n* Pregnancy Occlusive peripheral arterial disease",{"count":82,"type":22},50,"INTERVENTIONAL",[85],"PHASE4","This study compares two minimally invasive treatments for varicose veins in the legs, specifically the great saphenous vein.\n\nVaricose veins can cause symptoms such as leg pain, swelling, and skin changes. One commonly used treatment is foam sclerotherapy, where a special foam is injected into the vein to close it. This method is simple and allows patients to return quickly to their daily activities, but sometimes the vein can reopen, requiring additional treatments.\n\nAnother option is mechanochemical ablation, which combines a small device with a medication to close the vein. This method also allows for quick recovery and may have a lower chance of the vein reopening.\n\nIn this study, 50 patients with varicose veins will be randomly assigned to receive one of these two treatments. Doctors will follow patients over time to evaluate:\n\nHow well the treated vein stays closed Improvement in quality of life Pain during the procedure Possible complications All procedures are performed with local anesthesia, and additional small varicose veins are treated at the same time.",[88,26],"Varicose Veins of Leg With Long Saphenous Vein Distribution",[90,91,92],"Mechanical chemical ablation","Flebogrif","Sclerotherapy with polidocanol foam","2026-04-23",{"date":95,"type":31},"2026-05-01",{"date":97,"type":22},"2026-05",{"date":99,"type":22},"2027-11",{"name":101,"class":38},"Antonio Eduardo Zerati",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":17,"sex":18,"minAge":48,"maxAge":109,"enrollmentInfo":110,"targetDuration":4,"studyType":83,"phases":112,"briefSummary":114,"conditions":115,"keywords":4,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":126},"100627191","comparison-of-radiofrequency-ablation-with-concomitant-or-staged-treatment-for-tributary-varicose-veins-100627191","NCT07445425","Comparison of Radiofrequency Ablation With Concomitant or Staged Treatment for Tributary Varicose Veins","Comparison of Concomitant or Staged Treatment of Tributary Veins for Lower Extremity Varicose Veins: A Multicenter Randomized Controlled Study","Inclusion Criteria:\n\naged between 18 and 80 years; primary unilateral lower limb GSV varicose; hemodynamic classification I and III involvement in tributary veins, tributary veins originating within 15 cm inferior to the knee joint; clinical grade C2-C4; primary trunk diameter of GSV in thigh segment≥3mm to ≤ 15 mm; agree to participate in this study and voluntarily sign an informed consent form.\n\nExclusion Criteria:\n\nBody Mass Index (BMI) ≥35kg\u002Fm2; severe tortuosity or tight adherence of the trunk of the GSV to the skin in the thigh; history of previous varicose vein surgery on the ipsilateral lower limb (investigator allows to be controlled); previous deep vein thrombosis and\u002For calf muscle venous thrombosis; uncorrectable coagulation disorders or significant blood abnormalities (platelets≤30×109\u002FL); allergy to lidocaine or sclerosing agents; ankle-brachial index (ABI) \\\u003C0.6 and\u002For absolute ankle pressure \\\u003C60mmHg; pregnancy or lactation, or intend to have a child in the next year; participation in other clinical trials; anterior saphenous vein start diameter\\>3.5mm; any other patients investigator considers improper to participate in this study.","80 Years",{"count":111,"type":22},206,[113],"NA","The purpose of this clinical trial is to know which is better to treat the branch vein at the same time or in stages during radiofrequency ablation. The main questions it aims to answer are:\n\nDoes the patient who did not treat the branch vein in the first stage of operation need to intervene again? Are there any differences in patients' indexes between the two surgical strategies?\n\nParticipants will:\n\nRadiofrequency ablation with or without foam sclerosing agent therapy One week, three months and six months after operation, go to the clinic for a reexamination.\n\nRecord their symptoms",[26],"NOT_YET_RECRUITING","2026-02-26",{"date":119,"type":31},"2026-03-03",{"date":121,"type":22},"2026-03",{"date":123,"type":22},"2026-12",{"name":125,"class":38},"Sir Run Run Shaw Hospital",21,{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":131,"acronym":132,"eligibilityCriteria":133,"healthyVolunteers":11,"sex":18,"minAge":109,"maxAge":4,"enrollmentInfo":134,"targetDuration":135,"studyType":23,"phases":4,"briefSummary":136,"conditions":137,"keywords":4,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":4},"100611338","efficacy-and-safety-of-endovenous-ablation-for-relief-of-knee-pain-in-elderly-patients-with-lower-extremity-varicose-veins-a-prospective-observational-study-100611338","NCT07239284","Efficacy and Safety of Endovenous Ablation for Relief of Knee Pain in Elderly Patients With Lower Extremity Varicose Veins: A Prospective Observational Study","EVA-Knee-Elder","Inclusion Criteria:\n\nAdults aged ≥80 years. Clinical diagnosis of lower limb varicose veins with documented venous reflux on duplex ultrasound (CEAP C2-C4).\n\nPresence of knee pain lasting ≥4 weeks prior to enrollment, confirmed by patient-reported VAS\u002FNRS ≥3 at baseline.\n\nPlanned to undergo standard endovenous treatment (radiofrequency ablation, endovenous laser ablation, or equivalent).\n\nAbility to provide informed consent and complete study questionnaires.\n\nExclusion Criteria:\n\nPrior surgery or endovenous ablation for varicose veins in the same limb. History of inflammatory arthritis (e.g., rheumatoid arthritis, gout) or other systemic rheumatologic disease.\n\nRecent acute knee injury (ligament, meniscus, fracture) within 6 months. Prior knee replacement or major knee surgery. Recent intra-articular injection or arthroscopy (\\\u003C3 months). Known deep vein thrombosis or history of pulmonary embolism within the past 6 months.\n\nSevere peripheral arterial disease (ABI \\\u003C0.8). Pregnancy or breastfeeding. Inability to comply with follow-up schedule or complete questionnaires.",{"count":82,"type":22},"6 Months","Lower extremity varicose veins (LEVV) are common among elderly patients and can cause leg heaviness, pain, and swelling. In some older adults, venous congestion may contribute to knee or peri-knee pain, which is often misattributed to degenerative joint disease alone. Evidence on whether varicose vein treatment can relieve knee pain in very elderly patients (aged 80 years or older) is limited.\n\nThis prospective cohort study aims to evaluate the effectiveness and safety of endovenous ablation (EVA) for improving knee pain in elderly patients with symptomatic varicose veins. The study will include participants aged 80 years or older who present with both lower extremity varicose veins and knee joint pain. Eligible patients will undergo endovenous thermal ablation (radiofrequency or endovenous laser ablation) as the primary intervention.\n\nParticipants will be assessed at baseline, 1 month, 3 months, 6 months, and 12 months after treatment. The primary outcome is the change in knee pain intensity measured by the Visual Analog Scale (VAS) from baseline to 6 months. Secondary outcomes include changes in knee joint function (assessed by the Western Ontario and McMaster Universities Osteoarthritis Index \\[WOMAC\\] or Knee Injury and Osteoarthritis Outcome Score \\[KOOS\\]), venous clinical severity score (VCSS), limb heaviness, quality of life (assessed by EQ-5D), and procedure-related complications.\n\nSafety will be evaluated by recording peri-procedural adverse events, including deep vein thrombosis, skin burns, nerve injury, and postoperative infection. The study will also analyze whether preexisting osteoarthritis, venous reflux severity, or body mass index (BMI) affect the magnitude of pain improvement.\n\nThe hypothesis is that endovenous ablation improves knee pain in elderly patients by reducing venous congestion around the knee and improving venous return. This study will help clarify whether treating varicose veins can provide additional benefits for knee pain and mobility in patients aged 80 years and older.",[26,138,139,140,141],"Chronic Venous Insufficiency, CVI","Knee Pain","Knee Osteoarthritis","Elderly Patients","2025-11-16",{"date":144,"type":31},"2025-11-20",{"date":146,"type":22},"2025-12-10",{"date":148,"type":22},"2027-07-10",{"name":150,"class":38},"Chengdu University of Traditional Chinese Medicine",{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":157,"eligibilityCriteria":158,"healthyVolunteers":11,"sex":18,"minAge":48,"maxAge":109,"enrollmentInfo":159,"targetDuration":135,"studyType":23,"phases":4,"briefSummary":160,"conditions":161,"keywords":4,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":4},"100605499","knee-pain-relief-after-endovenous-treatment-for-lower-limb-varicose-veins-a-prospective-observational-study-100605499","NCT07163312","Knee Pain Relief After Endovenous Treatment for Lower Limb Varicose Veins: A Prospective Observational Study","Prospective Observational Cohort Study of Knee Pain and Function After Endovenous Treatment for Lower Limb Varicose Veins","VV-KNEE","Inclusion Criteria:\n\nAdults aged ≥18 years. Clinical diagnosis of lower limb varicose veins with documented venous reflux on duplex ultrasound (CEAP C2-C4).\n\nPresence of knee pain lasting ≥4 weeks prior to enrollment, confirmed by patient-reported VAS\u002FNRS ≥3 at baseline.\n\nPlanned to undergo standard endovenous treatment (radiofrequency ablation, endovenous laser ablation, or equivalent).\n\nAbility to provide informed consent and complete study questionnaires.\n\nExclusion Criteria:\n\nPrior surgery or endovenous ablation for varicose veins in the same limb. History of inflammatory arthritis (e.g., rheumatoid arthritis, gout) or other systemic rheumatologic disease.\n\nRecent acute knee injury (ligament, meniscus, fracture) within 6 months. Prior knee replacement or major knee surgery. Recent intra-articular injection or arthroscopy (\\\u003C3 months). Known deep vein thrombosis or history of pulmonary embolism within the past 6 months.\n\nSevere peripheral arterial disease (ABI \\\u003C0.8). Pregnancy or breastfeeding. Inability to comply with follow-up schedule or complete questionnaires.",{"count":82,"type":22},"This study will observe patients with lower limb varicose veins who also have knee pain. Many patients with varicose veins experience swelling, heaviness, or aching in the legs, and some also report pain in or around the knee. Previous studies suggest that venous reflux and poor circulation may increase discomfort in the knee, especially when knee osteoarthritis is present.\n\nThe purpose of this study is to evaluate whether treatment of varicose veins with standard endovenous procedures can improve knee pain and function. Participants will undergo standard vein treatment as part of their clinical care. We will follow them for changes in knee pain, quality of life, and leg symptoms over time.\n\nThis study does not assign patients to experimental interventions. Instead, it collects information before and after treatment to better understand the relationship between varicose veins and knee pain relief. Findings from this study may help doctors identify which patients are most likely to benefit from venous treatment in terms of both leg and knee symptoms.",[26,138,162,140],"Knee Pain Chronic","2025-09-01",{"date":165,"type":31},"2025-09-09",{"date":167,"type":22},"2025-10-01",{"date":169,"type":22},"2026-11-01",{"name":150,"class":38},{"id":172,"slug":173,"hasResults":11,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":177,"eligibilityCriteria":178,"healthyVolunteers":17,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":179,"targetDuration":4,"studyType":83,"phases":181,"briefSummary":183,"conditions":184,"keywords":187,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":196,"leadSponsor":198,"locationsCount":4},"100598611","phase-2-clacs-using-02-aetoxysklerol-foam-and-70-glucose-for-the-treatment-of-lower-limb-telangiectasias-100598611","NCT07073742","CLaCS Using 0.2% Aetoxysklerol Foam and 70% Glucose for the Treatment of Lower Limb Telangiectasias","Randomized, Controlled, Non-Inferiority Trial on the Efficacy of CLaCS Using 0.2% Aetoxysklerol Foam and 70% Glucose for the Treatment of Lower Limb Telangiectasias","CLACSO","Inclusion Criteria:\n\n1. Signed informed consent.\n2. Age \\> 18 years.\n3. CEAP classification C1 (telangiectasias only).\n4. Treated area for the study must be ≤ 20x20 cm on the lower limb - thigh.\n\nExclusion Criteria:\n\n1. Reflux in trunk veins or perforators.\n2. Active skin infection at the treatment site.\n3. Presence of reticular veins.\n4. Previous sclerotherapy\u002FCLaCS in the target area.",{"count":180,"type":22},240,[182],"PHASE2","This randomized, controlled, non-inferiority trial aims to compare the efficacy of two sclerosants used in the CLaCS (CryoLaser and CryoSclerotherapy) method for treating telangiectasias and reticular varicose veins. CLaCS is an advanced outpatient procedure that combines Nd\\\\:YAG laser treatment with sclerotherapy to enhance vein closure and cosmetic outcomes while minimizing side effects. The trial will compare the standard 70% glucose sclerosant with a novel 0.2% Aetoxysklerol (polidocanol) foam prepared using the VARIXIO system. Despite widespread use of CLaCS, no head-to-head studies currently exist comparing these two agents. This study aims to determine whether low-concentration Aetoxysklerol foam is non-inferior to 70% glucose in achieving effective telangiectasia elimination.",[26,185,186],"Spider Veins","Reticular Leg Veins",[188,189,190,191],"Telangiectasia","CryoLaser and CryoSclerotherapy","Cosmetic phlebology","AI prediction","2025-07-17",{"date":194,"type":31},"2025-07-18",{"date":163,"type":22},{"date":197,"type":22},"2028-09-01",{"name":199,"class":38},"Charles University, Czech Republic",{"id":201,"slug":202,"hasResults":11,"nctId":203,"briefTitle":204,"officialTitle":205,"acronym":4,"eligibilityCriteria":206,"healthyVolunteers":11,"sex":18,"minAge":48,"maxAge":109,"enrollmentInfo":207,"targetDuration":4,"studyType":83,"phases":209,"briefSummary":210,"conditions":211,"keywords":214,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":218,"lastUpdatePostDateStruct":219,"startDateStruct":221,"completionDateStruct":223,"leadSponsor":225,"locationsCount":39},"100596501","clinical-outcomes-safety-and-cost-effectiveness-analysis-of-two-catheters-xianrui-da-and-medtronic-in-radiofrequency-ablation-for-varicose-veins-100596501","NCT07046286","Clinical Outcomes, Safety, and Cost-Effectiveness Analysis of Two Catheters (Xianrui Da and Medtronic) in Radiofrequency Ablation for Varicose Veins","Clinical Outcomes, Safety, and Cost-Effectiveness Analysis of Two Catheters (Xianrui and Medtronic) in Radiofrequency Ablation for Varicose Veins","Inclusion Criteria:\n\n1. Age between 18 and 80 years old.\n2. Clinically diagnosed with primary lower extremity varicose veins, with CEAP grade C2 - C5, and requiring treatment of the great saphenous vein segment.\n3. Doppler ultrasound confirms that the reflux time of the saphenofemoral vein valve is \\> 1.0 second.\n4. Doppler ultrasound confirms that the diameter of the great saphenous vein in the supine position is \\> 3mm and \\\u003C 12mm.\n5. Only one limb of each patient is included in the study.\n6. The patient signs the informed consent form and is willing to cooperate with the examinations and follow - ups specified in the protocol.\n\nExclusion Criteria:\n\n1. Thrombosis in the great saphenous vein, or combined with deep vein thrombosis, or a history of deep vein thrombosis or pulmonary embolism.\n2. Recurrent varicose veins after previous treatment.\n3. Severe tortuosity of the great saphenous vein, with the expectation that the catheter cannot pass through.\n4. Severe lower extremity ischemia (CLI).\n5. Known allergy to drugs or device materials involved in the study.\n6. History of cardiac pacemaker or defibrillator implantation.\n7. Pregnant or breastfeeding women.\n8. Currently participating in other drug or device studies.\n9. Deemed unsuitable for endovenous treatment by the researcher.",{"count":208,"type":22},200,[113],"This study aims to systematically compare the clinical efficacy (venous closure rate and symptom relief rate), safety (perioperative and postoperative complications), and cost-effectiveness (direct medical costs) of domestic Xianruida radiofrequency catheter and imported Medtronic catheter in endovenous radiofrequency ablation for varicose veins through a single-center, prospective, non-inferiority randomized controlled trial.",[26,212,213],"Venous Insufficiency of Leg","Vascular Disease，Peripheral",[215,216,217],"varicose veins of the great saphenous veins","radiofrequency ablation","catheters","2025-06-29",{"date":220,"type":31},"2025-07-01",{"date":222,"type":22},"2025-08-01",{"date":224,"type":22},"2026-10-01",{"name":150,"class":38},{"id":227,"slug":228,"hasResults":11,"nctId":229,"briefTitle":230,"officialTitle":231,"acronym":4,"eligibilityCriteria":232,"healthyVolunteers":11,"sex":233,"minAge":48,"maxAge":234,"enrollmentInfo":235,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":237,"conditions":238,"keywords":242,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":249,"lastUpdatePostDateStruct":250,"startDateStruct":252,"completionDateStruct":254,"leadSponsor":255,"locationsCount":39},"100525663","study-of-venous-outflow-from-the-lower-limbs-in-patients-with-pelvic-varicosities-100525663","NCT06124664","Study of Venous Outflow From the Lower Limbs in Patients With Pelvic Varicosities","Study of Venous Outflow From the Lower Limbs in Patients With Pelvic Varicosities as a New Strategy for Compression Treatment of Pelvic Varicose Veins and Varicose Veins of the Lower Limb","Inclusion Criteria:\n\n* Patient age from 18 to 40 years;\n* Presence of pelvic varicose veins according to DUS data;\n* Reflux in the pelvic veins for more than 1 second before this DUS;\n* Reflux in the superficial veins of the lower limbs.\n\nExclusion Criteria:\n\n* Menopause;\n* Pregnancy;\n* Postthrombotic disease;\n* Suspicion of May-Turner syndrome;\n* Ultrasound signs of nutcracker syndrome","FEMALE","40 Years",{"count":236,"type":22},90,"Compression therapy is basic treatment for chronic venous disease (CVD) of the lower limbs. Numerous studies have demonstrated the efficacy and safety of compression therapy in relieving symptoms such as pain, venous edema, leg heaviness and fatigue, as well as accelerating the healing of venous ulcers. It has been established that сompression therapy is indicated for patients with both minimally expressed manifestations of CVD and severe forms of the disease. At the same only one study has been conducted to assess the correction of venous outflow from the lower limbs and pelvis in patients with pelvic varicose vein (PVV) and pelvic congestion syndrome (PCS). However, the incidence of this pathology ranges from 15 to 30% in the female population. The cost to the healthcare system of treating these patients in the United States exceeds $2 billion. To date, the options and indications for compression therapy in patients with concomitant PVV and CVD have not been defined. The rational use of compression in this cohort of patients may contribute to the improvement of effective conservative treatment. In addition, inappropriate prescription of compression to patients with pelvic venous disease (which can be observed in real clinical practice) may discredit this simple, effective and safe therapeutic method. In addition, the research devoted to the problem of compression treatment of PVV will contribute to the development of new special compression products aimed at accelerating venous outflow from the pelvic organs. It can be assumed that this will serve as a stimulus for obtaining new data on the therapeutic effects of compression and create conditions for the creation of new technological directions in the production of compression knitwear.",[239,26,240,241],"Pelvic Varices","Pelvic Pain Syndrome","Pelvic Congestive Syndrome",[243,244,245,246,247,248],"pelvic varicose vein","venous outflow","chronic venous disease","compression treatment","duplex ultrasound","single-photon emission computed tomography","2024-12-25",{"date":251,"type":31},"2024-12-27",{"date":253,"type":31},"2023-05-12",{"date":249,"type":22},{"name":256,"class":38},"Pirogov Russian National Research Medical University",{"id":258,"slug":259,"hasResults":11,"nctId":260,"briefTitle":261,"officialTitle":262,"acronym":4,"eligibilityCriteria":263,"healthyVolunteers":11,"sex":18,"minAge":48,"maxAge":264,"enrollmentInfo":265,"targetDuration":4,"studyType":83,"phases":267,"briefSummary":268,"conditions":269,"keywords":270,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":276,"completionDateStruct":278,"leadSponsor":280,"locationsCount":39},"100570736","comparative-analysis-of-radiofrequency-ablation-and-microwave-ablation-procedures-for-the-treatment-of-small-saphenous-varicose-veins-100570736","NCT06711120","Comparative Analysis of Radiofrequency Ablation and Microwave Ablation Procedures for the Treatment of Small Saphenous Varicose Veins","Randomized Controlled Study of Radio Frequency and Microwave of the Small Saphenous Vein","Inclusion Criteria:\n\n* Age ≥18 years and ≤90 years;\n* Clinical diagnosis of primary varicose veins of the lower extremities, CEAP clinical classification C2-C6, requiring treatment of the great and\u002For small saphenous vein segments, and at least 1 of the clinical symptoms of swelling, pain, burning sensation, heaviness, easy fatigue, itchy skin, and night cramps;\n* Valve insufficiency of the great saphenous vein, small saphenous vein, or transport vein;\n* Doppler ultrasound confirmation of a saphenous vein diameter greater than 3 mm and less than 12 mm in the standing position;\n* Only one limb per patient was selected for inclusion in the study;\n* Patients signed an informed consent form and were willing to co-operate in completing the protocol-specified investigations and follow-up visits.\n\nExclusion Criteria:\n\n* Thrombosis of the great saphenous or small saphenous vein, or combined deep vein thrombosis, or previous history of deep vein thrombosis or pulmonary embolism.\n* Recurrent varicose veins after previous treatment.\n* Severe distortion of the great saphenous vein with anticipated catheter failure.\n* Severe lower limb ischaemia (CLI) (ABPI \\\u003C0.8).\n* Known allergy to medications and device materials involved in the study.\n* Pre-existing implanted pacemaker, defibrillator, currently on regular anticoagulation therapy (e.g., warfarin, heparin).\n* Women who are pregnant or breastfeeding.\n* Unable or unwilling to complete the questionnaire.\n* Participating in a study of another drug or device.\n* Life expectancy \\\u003C1 year.\n* Those undergoing treatment for skin malignancies other than non-melanoma.\n* Daily use of narcotic drugs or non-steroidal anti-inflammatory drugs to control pain due to venous disease.\n* In the judgement of the investigator, endovenous therapy is not appropriate.","90 Years",{"count":266,"type":22},150,[113],"Objective: To investigate the clinical efficacy of ultrasound-guided radiofrequency ablation and microwave ablation in the treatment of primary saphenous varicose veins.",[26,212,213],[271,216,272],"varicose veins of the small saphenous veins","microwave ablation","2024-11-28",{"date":275,"type":31},"2024-12-02",{"date":277,"type":22},"2024-12-01",{"date":279,"type":22},"2025-12-01",{"name":150,"class":38},{"id":282,"slug":283,"hasResults":11,"nctId":284,"briefTitle":285,"officialTitle":285,"acronym":4,"eligibilityCriteria":286,"healthyVolunteers":11,"sex":18,"minAge":48,"maxAge":264,"enrollmentInfo":287,"targetDuration":289,"studyType":23,"phases":4,"briefSummary":290,"conditions":291,"keywords":292,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":297,"lastUpdatePostDateStruct":298,"startDateStruct":300,"completionDateStruct":301,"leadSponsor":302,"locationsCount":39},"100569361","observation-of-pain-during-the-treatment-of-great-saphenous-vein-using-microwave-ablation-and-analysis-of-related-factors-100569361","NCT06693245","Observation of Pain During the Treatment of Great Saphenous Vein Using Microwave Ablation， and Analysis of Related Factors","Inclusion Criteria:\n\n1. Age≥ 18 years old, ≤ 90 years old;\n2. the patient's life expectancy is greater than 12 months;\n3. The clinical diagnosis is primary VVs, CEAP classification C2-C6, and the GSV segment needs to be treated, including pain, burning sensation, heaviness, fatigue, itchy skin, night cramps and other clinical symptoms;\n4. Doppler ultrasound confirmed that the diameter of GSV was greater than 3mm and less than 12mm when standing;\n5. Doppler ultrasound confirms that GSV is located in the saphenofascia or the distance between GSV and the skin surface is \\>1cm;\n6. endovenous microwave ablation treatment only for unilateral GSV walking area;\n7. The patient is willing to cooperate with the completion of the examination specified in the protocol.\n\nExclusion Criteria:\n\n1. GSV thrombosis, or combined with deep vein thrombosis, or previous history of deep vein thrombosis and pulmonary embolism;\n2. patients with recurrence after prior VVs-related surgery (C2r);\n3. the GSV trunk is severely distorted, and it is expected that the catheter will not be able to pass;\n4. Severe ischemia of the lower limbs, Ankle brachial pressure index (ABPI) \\\u003C 0.8;\n5. Known allergy to the drugs and device materials involved in the study;\n6. Previously implanted with a pacemaker or defibrillator, and currently receiving regular anticoagulation therapy (such as warfarin, heparin);\n7. Pregnant or lactating females;\n8. Patients who are unable or unwilling to participate in the study;\n9. Participating in the research of other drugs or devices;\n10. Skin malignancies other than non-melanoma that are being treated;\n11. daily use of narcotic drugs or non-steroidal anti-inflammatory drugs to control pain caused by venous disease;\n12. The investigator judged that endovenous treatment was not suitable;",{"count":288,"type":22},155,"1 Day","Objective: This study is a single-center prospective observational research that recorded patients' pain scores at four time points during surgery (puncture and catheter insertion, swelling fluid injection, microwave generator operation, and end of surgery). It analyzed the correlation between pain during microwave ablation treatment for great saphenous vein varicosities and factors such as age, gender, body mass index, volume of swelling fluid used, and others, in order to summarize and improve surgical details to reduce patients' intraoperative pain.",[213,212,26],[293,294,295,296],"Varicose veins of the lower extremities","Endovenous Microwave Ablation","intraoperative pain","visual analogue scale of pain","2024-11-15",{"date":299,"type":31},"2024-11-18",{"date":277,"type":22},{"date":279,"type":22},{"name":150,"class":38},{"id":304,"slug":305,"hasResults":11,"nctId":306,"briefTitle":307,"officialTitle":308,"acronym":309,"eligibilityCriteria":310,"healthyVolunteers":11,"sex":18,"minAge":48,"maxAge":4,"enrollmentInfo":311,"targetDuration":313,"studyType":23,"phases":4,"briefSummary":314,"conditions":315,"keywords":316,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":324,"lastUpdatePostDateStruct":325,"startDateStruct":327,"completionDateStruct":329,"leadSponsor":331,"locationsCount":39},"100288518","ongoing-registry-of-treatment-of-chronic-venous-diseases-100288518","NCT03035747","Ongoing Registry of Treatment of Chronic Venous Diseases","Russian Registry of Treatment of Chronic Venous Diseases","RRT CVD","Inclusion Criteria:\n\n* Varicose veins with any source of pathological reflux, C2 - C6 according to the CEAP classification\n\nExclusion Criteria:\n\n* no exclusion criteria",{"count":312,"type":22},5000,"12 Months","Ongoing registration of patients with varicose veins disease treated by means of conventional surgery, endovenous thermal ablations, sclerotherapy, non-tumescent non-thermal methods",[26],[317,318,319,320,321,322,323],"registry","varicose veins","conventional surgery","thermal ablation","radiofrequency","laser","sclerotherapy","2024-03-11",{"date":326,"type":31},"2024-03-13",{"date":328,"type":31},"2016-07",{"date":330,"type":22},"2036-07",{"name":332,"class":38},"Medalp Private Surgery Clinic"]