[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"varicose-veins\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:varicose-veins":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,42,63,86,110,138,169,196,220],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100495779","phase-4-thromboprophylaxis-in-individuals-undergoing-superficial-endovenous-treatment-thrive-100495779",false,"NCT05735639","THRomboprophylaxis in Individuals Undergoing Superficial endoVEnous Treatment (THRIVE)","THRomboprophylaxis in Individuals Undergoing Superficial endoVEnous Treatment (THRIVE) - a Multi-centre Assessor-blind Randomised-controlled Trial","THRIVE","Inclusion Criteria:\n\n* Adults (\\>18 years)\n* Scheduled to undergo endovenous intervention of truncal varicose veins under local anaesthesia\n* Treatment technologies including radiofrequency, laser, mechanochemical, foam sclerotherapy and cyanoacrylate glue\n\nExclusion Criteria:\n\n* Clinical indication for therapeutic anticoagulation e.g., atrial fibrillation\n* Previous personal or first-degree relative history of VTE\n* Thrombophilia\n* Female patients of childbearing potential who have a positive pregnancy test\n* A history of allergy to heparins or direct oral anticoagulants\n* A history of heparin-induced thrombocytopenia\n* Inherited and acquired bleeding disorders\n* Evidence of active bleeding\n* Concomitant major health problems such as active cancer and chronic renal and\u002For liver impairment\n* Known thrombocytopenia (platelets known to be less than 50 x 109\n\n  \u002Fl)\n* Surgery or major trauma in the previous 90 days\n* Recent ischemic stroke in the previous 90 days\n* Inability to provide consent","ALL","18 Years",{"count":20,"type":21},3175,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","Endovenous interventions are keyhole operations for varicose veins that are carried out from within the vein itself. Varicose veins are enlarged veins close to the surface of the skin. They are connected to the bigger deeper veins in the leg (known as deep veins). Because of this, operations to close the varicose veins can increase the chance of a blood clot forming in the deep veins. Blood clots in the deep veins happen in around 1 in 50 people after endovenous operations. A clot in the leg can cause swelling, pain, and other long-term problems. If a clot in the leg breaks off and travels to the lungs, it can cause problems with the lung' ability to move oxygen from the air into the blood and may, in rare cases, be life threatening.\n\nVaricose vein procedures may carry a slightly higher risk of blood clot formation, and we are currently unsure if current clot reducing medicines are beneficial in preventing blood clots in people having varicose vein procedures.\n\nThis study will investigate if it is worthwhile prescribing medicines to reduce blood clots after varicose vein procedures.",[27,28],"Venous Thromboembolism","Varicose Veins","RECRUITING","2026-06-03",{"date":32,"type":33},"2026-06-04","ACTUAL",{"date":35,"type":33},"2024-01-22",{"date":37,"type":21},"2027-12-31",{"name":39,"class":40},"Imperial College London","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":22,"phases":50,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":41},"100636791","research-on-the-application-of-nursing-intervention-based-on-ithbc-theory-in-postoperative-self-management-of-patients-with-varicose-veins-of-the-lower-extremities-100636791","NCT07570277","Research on the Application of Nursing Intervention Based on ITHBC Theory in Postoperative Self-Management of Patients With Varicose Veins of the Lower Extremities","Inclusion Criteria:\n\n* It meets the diagnostic criteria for varicose veins of the lower extremities in the \"Chinese Guidelines for the Diagnosis and Treatment of Chronic Venous Diseases\";\n* The first surgical treatment for varicose veins of the lower extremities was received;\n* Age \\>18 years old;\n* The patient is conscious, has no language communication barriers, possesses certain reading and writing abilities, and is proficient in using intelligent devices;\n* Informed consent and voluntary participation.\n\nExclusion Criteria:\n\n* Secondary varicose veins of the lower extremities ;\n* Patients with a history of severe organ diseases or mental illness;\n* Patients with combined lower extremity arterial diseases, acute infections and malignant tumors;\n* Participate in other researchers.",{"count":49,"type":21},104,[51],"NA","This study constructed a postoperative self-management nursing intervention program for VVLE patients based on the ITHBC theory, and explored the impact of this program on the patients' postoperative self-management ability, self-efficacy, complication rate and quality of life.",[28],"2026-04-29",{"date":56,"type":33},"2026-05-06",{"date":58,"type":33},"2025-05-15",{"date":60,"type":21},"2026-06-01",{"name":62,"class":40},"Second Affiliated Hospital of Nanchang University",{"id":64,"slug":65,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":11,"sex":17,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":4,"studyType":22,"phases":75,"briefSummary":76,"conditions":77,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":41},"100614180","polidocanol-foam-with-or-without-transdermal-laser-in-varicose-veins-100614180","NCT07276243","Polidocanol Foam With or Without Transdermal Laser in Varicose Veins","Comparação da eficácia clínica e estética Entre o Tratamento de Varizes Com Espuma de Polidocanol Associada ou não ao Laser transdérmico: Ensaio clínico Randomizado","FOAM-LASER","Inclusion Criteria:\n\n* Age 21 to 75 years\n* CEAP clinical class 1-3\n* Lower limb tributary varicose veins 2,5 to 4,0 mm in diameter on Doppler ultrasound.\n* Vein depth up to 4 mm from the skin surface.\n* Tributary vein may originate from the great or small saphenous vein as long as the saphenous vein is competent on Doppler.\n* Reflux limited to the target tributary.\n* Body mass index (BMI) \\\u003C 35 km²\u002Fm²\n* Able and willing to provide informed consent.\n\nExclusion Criteria:\n\n* CEAP clinical class ≥ 4\n* Axial reflux of the great or small saphenous vein requiring prior treatment\n* Tributary vein diameter \\\u003C 2.5 mm or \\> 4.0 mm on Doppler\n* Tributary vein depth \\> 4 mm from the skin surface\n* Pregnancy or breastfeeding\n* Known allergy or hypersensitivity to polidocanol\n* History of deep vein thrombosis or pulmonary embolism in the last 6 months\n* Use of anticoagulant therapy that cannot be safely interrupted\n* Active skin infection or ulcer at the treatment site\n* Autoimmune or connective tissue disease with active vasculitis\n* BMI ≥ 35 kg\u002Fm²\n* Inability to comply with follow-up visits\n* Previous treatment of the target vein in the past 6 months (laser, foam, surgery, or microphlebectomy).","21 Years","75 Years",{"count":74,"type":21},102,[51],"This randomized, parallel clinical trial with blinded outcome assessment will compare the clinical and aesthetic outcomes of polidocanol foam sclerotherapy alone versus polidocanol foam associated with long-pulse 1064 nm Nd:YAG transdermal laser in the treatment of lower-limb tributary varicose veins. The primary endpoint is venous occlusion rate at 30 days, assessed by Doppler ultrasound. Secondary outcomes include cutaneous hyperpigmentation, pain, patient satisfaction, and adverse events.",[28],{"date":79,"type":33},"2026-05-05",{"date":81,"type":33},"2026-03-24",{"date":83,"type":21},"2027-12-30",{"name":85,"class":40},"Hospital Universitario Pedro Ernesto",{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":94,"targetDuration":4,"studyType":22,"phases":96,"briefSummary":97,"conditions":98,"keywords":99,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":41},"100490225","study-on-treatment-of-varicose-veins-by-endovenous-laser-1940-nm-vs-1470-nm-100490225","NCT05663359","Study on Treatment of Varicose Veins by Endovenous Laser (1940 nm vs 1470 nm)","Randomized Comparative Study With Two Wavelengths 1470 nm and 1940 nm for the Treatment of Varicose Veins of the Lower Limbs by Endovenous Laser.","NEWWAVE","Inclusion Criteria:\n\n* Primary insufficiency of the great saphenous vein (GSV) and\u002For small saphenous vein (SSV)\n* Patient candidate for endothermic treatment of the lower limbs\n* CEAP: C2 - C6\n* Patient with a target vein diameter (GSV and\u002For SSV) \\>= 3 mm throughout the target vein segment\n* Patient affiliated or beneficiary of a social security scheme\n* Patient having signed the informed consent\n\nExclusion Criteria:\n\n* Patient with a current serious pathology and\u002For a life expectancy of less than 5 years\n* Patient who has had a deep or superficial vein thrombosis in the previous 6 months\n* Obliterating arteriopathy of the lower limb concerned, with an IPS \\\u003C 0.8 or \\> 1.3\n* Patient with post-thrombotic obstructive syndrome at the popliteal and\u002For femoral and\u002For iliac stage on the ipsilateral lower limb\n* Patient with primary or post-thrombotic axial deep venous reflux on the ipsilateral lower limb\n* Suspicion of non-post-thrombotic iliac compression on echo-doppler\n* Contraindication to the planned treatment technique\n* Patient whose geographical distance is not compatible with the follow-up of the study\n* Pregnant or breastfeeding women\n* Patient linguistically or psychologically unable to understand the information given, to give informed consent or to answer the study questionnaires.\n* Protected patients: Adults under guardianship, or other legal protection; Hospitalized without consent.",{"count":95,"type":21},280,[51],"The goal of this clinical trial is to compare efficacy of two wavelength for EndoVenous Laser Ablation (EVLA) in treatment of varicose veins of the lower limbs.\n\nThe main questions it aims to answers are :\n\n1. Is the increase of wavelength form 1470 nm to 1940 nm affect the efficacy of varicose veins treatment ?\n2. Is the increase of wavelength reduce complication or pain ? Participants are patients with varicose veins of lower limbs and candidate for endovenous laser ablation.\n\nAfter laser ablation patients will be followed during 5 years for clinical evaluation, recording potential treatment complications and quality of life evaluation.\n\nResearchers will compare strategy 1(EVLA with an endovenous laser at 1940 nm) vs strategy 2 (EVLA with an endovenous laser at 1470 nm) in varicose veins treatment to see if efficacy of treatment is not reduce, and to see if complications of EVLA treatment can be reduced.",[28],[100],"Endovenous laser ablation (EVLA)","2026-03-05",{"date":103,"type":33},"2026-03-06",{"date":105,"type":33},"2023-02-24",{"date":107,"type":21},"2032-02",{"name":109,"class":40},"Clinique Pasteur",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":117,"targetDuration":4,"studyType":22,"phases":119,"briefSummary":120,"conditions":121,"keywords":123,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":41},"100627522","the-influence-of-laser-crossectomy-with-different-wavelengths-on-varicose-vein-progression-100627522","NCT07449728","The Influence of Laser Crossectomy With Different Wavelengths on Varicose Vein Progression","LACROSS-VVP","Inclusion Criteria:\n\n* Age \\>18 years\n* Primary VVs of Clinical Etiology Anatomy Pathophysiology (CEAP) clinical class of C2-C6\n* Reflux along the GSV trunk lasting \\>0.5 sec.\n* GSV trunk diameter ≤12 mm\n* Informed consent to participate in the study\n\nExclusion Criteria:\n\n* Primary reflux outside the GSV trunk (including combined reflux)\n* History of deep or superficial vein thrombosis\n* Deep vein reflux\n* Non-thrombotic or post-thrombotic venous obstruction\n* Pelvic venous insufficiency\n* Use of oral anticoagulants\n* Indication for pharmacological prophylaxis after EVLT\n* Inability to use radial fiber of 1.4-1.57 mm at the surgeon's discretion\n* Refusal to participate in the study",{"count":118,"type":21},400,[51],"Technically successful laser crossectomy will reduce the risk of reflux recurrence at the sapheno-femoral junction without increasing the risk of endovenous heat-induced thrombosis, which may positively impact the likelihood of ultrasound- or clinical-recurrence of varicose veins. Similar technical efficacy is expected for laser crossectomy at 1940 nm and 1470 nm. A possible advantage of the 1940 nm wavelength in terms of postoperative pain intensity and the risk of adverse events cannot be ruled out.",[28,122],"Chronic Venous Insufficiency",[124,125,126,127,128],"Varicose veins","Endovenous laser treatment","Reflux","Recurrence","Crossectomy","2026-02-26",{"date":131,"type":33},"2026-03-04",{"date":133,"type":33},"2026-01-20",{"date":135,"type":21},"2029-01-20",{"name":137,"class":40},"Pirogov Russian National Research Medical University",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":146,"targetDuration":4,"studyType":148,"phases":4,"briefSummary":149,"conditions":150,"keywords":151,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":41},"100288981","caprini-score-in-venous-surgery-a-prospective-cohort-study-100288981","NCT03041805","Caprini Score in Venous Surgery: a Prospective Cohort Study","A Prospective Cohort Register Study for Validation of Caprini Score in Patients Undergoing Varicose Vein Surgery","CAPSIVS","Inclusion Criteria:\n\n* age over 18 years\n* any kind of varicose vein surgery\n* follow up for 4 weeks after the procedure\n* examination for VTE at 2-4 weeks after the procedure, including duplex ultrasound\n\nExclusion Criteria:\n\n\\- lost for follow-up during 4 weeks",{"count":147,"type":21},3000,"OBSERVATIONAL","The aim of the study is to make a validation of Caprini score in patients undergoing varicose veins surgery, especially endovascular procedures (endovascular laser treatment - EVLT, radiofrequency ablation - RFA, ultrasound-guided foam sclerotherapy - USFS) and to identify patients with elevated risk of postoperative venous thromboembolism (VTE) who will benefit from prophylactic anticoagulation.",[27,28],[152,153,154,155,156,157,158,159,160,161],"venous thromboembolism","deep vein thrombosis","pulmonary embolism","varicose veins","surgery","endovenous laser treatment","radiofrequency ablation","ultrasound-guided foam sclerotherapy","register","anticoagulation",{"date":163,"type":33},"2026-03-02",{"date":165,"type":33},"2017-01-01",{"date":167,"type":21},"2027-01-01",{"name":137,"class":40},{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":174,"acronym":4,"eligibilityCriteria":175,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":176,"enrollmentInfo":177,"targetDuration":4,"studyType":22,"phases":179,"briefSummary":180,"conditions":181,"keywords":182,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":5},"100590718","vacuum-assisted-laser-ablation-vala-for-treatment-of-large-saphenous-veins-100590718","NCT06971068","Vacuum-assisted Laser Ablation (VALA) for Treatment of Large Saphenous Veins","Endovenous Vacuum-assisted Laser Ablation (VALA) in the Treatment of Large Saphenous Veins (> 15 mm)","Inclusion Criteria:\n\n* Age over 18 years\n* Varicose veins of the lower extremities with clinical class C2-C6 with a diameter of the GSV or SSV ≥ 15 mm in a standing position\n* Informed consent\n\nExclusion Criteria:\n\n* pregnancy or lactation\n* malignant neoplasms\n* inability or unwillingness of any patient to wear compression stockings\n* hypersensitivity to lidocaine\n* concomitant diseases: diabetes mellitus, bronchial asthma, severe liver and kidney diseases, acute thrombosis and thrombophlebitis, skin and\u002For soft tissue infection, infectious diseases, obliterating peripheral arteriosclerosis, diabetic angiopathy, heart defects requiring surgical intervention, fever, toxic hyperthyroidism, obesity, tuberculosis, sepsis, blood cell composition disorder, all diseases requiring bed rest, heart disease with decompensation, known hereditary thrombophilia\n* period after treatment for alcohol addiction\n* sedentary lifestyle\n* history of acute deep vein thrombosis\n* history of superficial thrombophlebitis\n* history of drug or other addiction\n* use of oral contraceptives or other hormonal drugs","90 Years",{"count":178,"type":21},184,[51],"Endovenous thermal ablation (EVTA), including radiofrequency ablation (RFA) and endovenous laser ablation (EVLA), is considered the main method for the treatment of symptomatic truncal vein reflux. However, there are controversial data concerning their efficacy and safety in ablating large saphenous veins because of high risk of heat-induced thrombosis (EHIT), incomplete ablation and recanalization.1-5 The use of vacuum evacuation of the remaining intraluminal blood during endovenous laser ablation allows to decrease the risk of intraoperative (carbonization and destruction of the fiber lens) and postoperative complications (EHIT, hyperpigmentation, \"string\" feeling) and leads to reduction of recovery because of short period of vein resorption. The aim of the study is to evaluate the safety and effectiveness of endovenous thermal ablation with or without vacuum evacuation for the treatment of incompetent large saphenous veins (\\>15 mm).",[28],[183,184,155,185],"Vacuum-assisted Laser Ablation","large saphenous veins","EVLA","2025-05-10",{"date":188,"type":33},"2025-05-14",{"date":190,"type":33},"2025-03-15",{"date":192,"type":21},"2026-02-15",{"name":194,"class":195},"Center Of Phlebology","NETWORK",{"id":197,"slug":198,"hasResults":11,"nctId":199,"briefTitle":200,"officialTitle":201,"acronym":202,"eligibilityCriteria":203,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":176,"enrollmentInfo":204,"targetDuration":4,"studyType":148,"phases":4,"briefSummary":206,"conditions":207,"keywords":4,"overallStatus":210,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":212,"startDateStruct":214,"completionDateStruct":216,"leadSponsor":218,"locationsCount":4},"100567520","evaluating-qol-and-postoperative-complications-using-tetha-technique-in-the-treatment-of-tributary-veins-100567520","NCT06669260","Evaluating QoL and Postoperative Complications Using TEThA Technique in the Treatment of Tributary Veins","Prospective Study to Evaluate QoL Scores and Post-operative Complications Using TEThA (Transfixing Endovenous Thermal Ablation) Technique in Tributary Veins Treatment","TEThA","Inclusion Criteria:\n\nPatients with varicose veins \\> 2mm associated with reflux of great or small saphenous veins with CEAP C2 to C6\n\nExclusion Criteria:\n\nPatients under 18 years Acute or previous thrombophlebitis or deep vein thrombosis. Pregnant patient. Reject the Informed Consent Form.",{"count":205,"type":21},20,"Endovenous laser thermoablation is a well-established alternative for the treatment of tributary veins. We believe that it is possible to improve the techniques described in the literature, aiming not only to allocate the laser fiber within the venous lumen, but mainly to transfix the vessel walls - a technique called TEThA (Transfixing Endovenous Thermal Ablation).",[28,208,209],"Quality of Life","Laser","NOT_YET_RECRUITING","2024-10-30",{"date":213,"type":33},"2024-11-01",{"date":215,"type":21},"2024-11-21",{"date":217,"type":21},"2025-07-22",{"name":219,"class":40},"Nara Medeiros Cunha de Melo Vasconcelos",{"id":221,"slug":222,"hasResults":11,"nctId":223,"briefTitle":224,"officialTitle":225,"acronym":4,"eligibilityCriteria":226,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":227,"targetDuration":4,"studyType":22,"phases":229,"briefSummary":230,"conditions":231,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":235,"completionDateStruct":237,"leadSponsor":239,"locationsCount":41},"100317727","phase-4-study-of-foam-sclerotherapy-versus-ambulatory-phlebectomy-100317727","NCT03416413","Study of Foam Sclerotherapy Versus Ambulatory Phlebectomy","Randomised Controlled Trial of Foam Sclerotherapy Versus Ambulatory Phlebectomy for the Treatment of Varicose Vein Tributaries","Inclusion Criteria:\n\n* Adults over 18 years of age\n* Symptomatic GSV or SSV vein reflux \\> 0.5 seconds on colour Duplex\n* Varicose vein tributary requiring treatment\n\nExclusion Criteria:\n\n* Current DVT\n* Recurrent varicose veins\n* Arterial disease (ABPI\\\u003C0.8)\n* Vein diameter \\\u003C 3mm\n* Preference for one of the treatment options\n* Patient who are unwilling to participate\n* Inability or unwillingness to complete questionnaires\n* Inability to attend follow-up appointments\n* Patient currently included in a study of varicose vein treatment",{"count":228,"type":21},160,[24],"This study will be comparing the treatment of varicose vein tributaries using either foam sclerotherapy or ambulatory phlebectomies. Patients will be randomised to having either ambulatory phlebectomy (group A) or foam sclerotherapy (group B) following treatment of their saphenous vein.\n\nThe re-intervention rates, safety, patient experience as well as the cost effectiveness of each intervention will be assessed.",[28],"2024-07-03",{"date":234,"type":33},"2024-07-05",{"date":236,"type":33},"2018-02-01",{"date":238,"type":21},"2025-06-30",{"name":39,"class":40}]