[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"varus-deformity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:varus-deformity":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":33,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100499789","persona-osseoti-keel-compatibility-study-total-knee-arthroplasty-100499789",false,"NCT05787821","Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)","Persona® OsseoTi® Keel Compatibility Study-A Multicenter Cohort Study A Prospective, Post-market Clinical Follow-up Study to Demonstrate Safety, Performance and Clinical Benefits of the Persona Knee System Portfolio and Its Instrumentation","Inclusion Criteria:\n\n1. Patient is of legal age and skeletally mature\n2. Patient is willing and able to provide written Informed Consent by signing and dating the Institutional Review Board (IRB) \u002F Ethics Committee (EC) approved Informed Consent document\n3. Patient is willing and able to complete scheduled follow-up evaluations as defined in the study protocol\n4. Independent of study participation, patient qualifies for either cemented or cementless primary or revision total knee arthroplasty (including salvage of previously failed surgical attempts) based upon physical exam and medical history, and meets the approved indications for use of the commercially available Persona Knee System with appropriately matched Zimmer Biomet components implanted in accordance with product labeling\n\nExclusion Criteria:\n\n1. Patient is currently participating in any other surgical intervention or pain management study\n2. Patient is pregnant or considered a member of a protected (vulnerable) population whose inclusion in the study is inappropriate (e.g. prisoner, mentally incompetent)\n3. Patient has a mental or neurological condition who is unwilling or incapable of following postoperative care instructions\n4. Patient has a condition which would, in the judgment of the investigator, place the patient at undue risk or interfere with the conduct of the study\n5. Patient is institutionalized or is a known drug abuser, a known alcoholic or cannot understand the requirements of study participation\n6. Patient is scheduled to undergo simultaneous bilateral total knee arthroplasty\n7. Previous history of infection in the affected joint and\u002For other local\u002Fsystemic infection that may affect the prosthetic joint\n8. Insufficient bone stock on femoral or tibial surfaces\n9. Neuropathic arthropathy\n10. Osteoporosis or any loss of musculature or neuromuscular disease that compromises the affected limb\n11. A stable, painless arthrodesis in a satisfactory functional position\n12. Severe instability secondary to the absence of collateral ligament integrity\n13. Rheumatoid Arthritis (RA) accompanied by an ulcer of the skin or a history of recurrent breakdown of the skin\n14. Patient has a \\> 5˚ valgus deformity with a medial collateral ligament (MCL) insufficiency, and the surgeon intends to use the personalized alignment surgical technique","ALL","18 Years",{"count":19,"type":20},760,"ESTIMATED","OBSERVATIONAL","The main objective of the study is to evaluate the safety, performance and clinical benefits of the Persona implant and its instrumentation in primary total knee arthroplasty",[24,25,26,27,28,29,30,31,32],"Knee Pain Chronic","Osteoarthritis, Knee","Rheumatoid Arthritis","Traumatic Arthritis","Polyarthritis","Varus Deformity","Valgus Deformity","Flexion Deformity of Knee","Avascular Necrosis",[34,35],"Osteoarthritis","Total Knee Arthroplasty","RECRUITING","2026-01-15",{"date":39,"type":40},"2026-01-20","ACTUAL",{"date":42,"type":40},"2023-06-28",{"date":44,"type":20},"2035-06",{"name":46,"class":47},"Zimmer Biomet","INDUSTRY",16,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":77},"100609888","to-plate-fixation-vs-external-fixator-comparison-hto-plate-vs-exfix-study-100609888","NCT07220434","TO Plate Fixation vs. External Fixator Comparison (HTO Plate vs. ExFix Study)","Medial Opening Wedge High Tibial Osteotomy: A Comparative Study of Plate Fixation and Self-Adjusting HTO External Fixator Techniques","Inclusion Criteria:\n\n* Varus malalignment associated with medial compartment degeneration\u002Fosteoarthritis.\n\nIndication for Medial Opening Wedge HTO. Aged 18 years or older. Willing to participate in the study and provide written informed consent.\n\nExclusion Criteria:\n\n* Advanced-stage osteoarthritis (Indication for Total Knee Arthroplasty). Previous open knee surgery on the same extremity. Inability to comply with follow-up appointments. Significant comorbidities (e.g., uncontrolled diabetes, rheumatoid arthritis).",{"count":57,"type":20},28,"INTERVENTIONAL",[60],"NA","This study aims to compare the efficacy, accuracy, and functional outcomes of two different surgical stabilization techniques for medial opening wedge high tibial osteotomy (HTO) in patients with varus deformity and medial compartment osteoarthritis. Patients will be prospectively randomized into two groups: Group 1 (Plate Fixation) will receive acute (single-stage) correction and stabilization with a medial HTO locking plate. Group 2 (HTO External Fixator) will receive stabilization using a self-adjusting HTO external fixator, followed by gradual correction (hemicallotasis\u002Fdistraction) starting 7 days post-operatively. The study will evaluate radiological correction, functional improvement (using the Oxford Knee Score), and complication rates over a 12-month follow-up period.",[63,64,29,65],"Medial Compartment Osteoarthritis","Genu Varum","High Tibial Osteotomy","NOT_YET_RECRUITING","2025-10-22",{"date":69,"type":40},"2025-10-23",{"date":71,"type":20},"2025-11-15",{"date":73,"type":20},"2028-12-31",{"name":75,"class":76},"Muhammed Cagatay Engin","OTHER",1]