[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"varus-knee\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:varus-knee":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100609299","precision-of-pacient-specific-instrumented-open-wedge-high-tibial-osteotomy-vs-conventional-technicque-100609299",false,"NCT07212777","Precision of Pacient-specific Instrumented Open Wedge High Tibial Osteotomy vs Conventional Technicque","Precisión de la osteotomía Tibial Proximal Con Instrumental Paciente-específico vs técnica Convencional","AMBE_OR","Inclusion Criteria:\n\n* Informed consent: able to sign informed consent\n* Clinical: predominantly medial pain\u002Flimitation refractory ≥3-6 months\n* Mobility: flexion ≥90º and flexion contracture ≤10º Stability: varus\u002Fvalgus and pivot-shift ≤ grade 1.\n* Radiology:\n\n  * Medial gonarthrosis Ahlbäck I-III with preserved lateral compartment.\n  * Patellofemoral Iwano 0-2 without disabling patellofemoral pain.\n  * Varus alignment: HKA 4-10°.\n  * Predominantly tibial deformity (decreased MPTA; LDFA close to normal) according to planning.\n* Anatomy\u002Ftechnical feasibility: proximal tibial morphology suitable for medial opening osteotomy and PSI guide placement.\n\nExclusion criteria:\n\n* Comorbidity\u002Fclinical situations:\n\n  * Inflammatory arthritis (e.g., RA, spondyloarthropathies), unresolved previous joint infection or osteomyelitis.\n  * Severe peripheral vasculopathy (ABI \\\u003C0.7), advanced peripheral neuropathy or Charcot foot.\n  * Poorly controlled diabetes (HbA1c \\>8.5%), advanced renal\u002Fhepatic failure (eGFR \\\u003C30 ml\u002Fmin\u002F1.73 m²; Child-Pugh B\u002FC).\n  * Smoking \\>20 cigarettes\u002Fday without commitment to cessation; active IV drug use or uncontrolled alcoholism.\n  * BMI \\>35 kg\u002Fm².\n  * Disorder affecting gait (e.g., neurological disease).\n  * Inability to walk at a speed of at least 0.8m\u002Fs\n* Anatomy\u002Fradiology\n\n  * Multiplanar deformities not correctable with isolated medial opening tibial valgus osteotomy (e.g., dominant femoral deformity).\n  * Severe medial subchondral bone defect or extensive necrosis.\n  * Sequelae of proximal tibia fracture or previous ipsilateral HTO that prevent correction or guide use.\n* Treatments\u002Fmedication and logistics\n\n  * Anticoagulation\u002Fantiplatelet therapy that cannot be suspended or bridged.\n  * Systemic corticosteroids \\>10 mg\u002Fday or high-risk immunosuppressants without possibility of adjustment.\n  * Intra-articular infiltration (HA\u002FCS\u002FPRP) within the previous 60 days (respect defined wash-out).\n  * Pregnancy.\n  * Participation in another interfering trial.\n  * Inability to undergo CT (e.g., uncontrollable claustrophobia).\n  * Inability to complete ≥12 months of follow-up.","ALL","18 Years","70 Years",{"count":21,"type":22},50,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study is a randomized clinical trial that will compare two surgical techniques for patients with knee osteoarthritis and varus deformity who are candidates for medial opening wedge high tibial osteotomy. The goal is to evaluate whether using patient-specific 3D-printed surgical guides improves the accuracy of the bone cut compared with the conventional technique performed with anatomical landmarks and fluoroscopy.\n\nA total of 50 adult patients will be randomly assigned to one of two groups: conventional osteotomy or osteotomy assisted by patient-specific instrumentation (PSI). The main outcome is the accuracy of the osteotomy cut, measured by comparing preoperative planning with the postoperative CT scan. Secondary outcomes include leg alignment, surgical time, radiation exposure, complications, and functional recovery assessed with validated questionnaires (KOOS, WOMAC, IKDC, EQ-5D) and gait analysis using depth cameras.\n\nPatients will be followed for up to 12 months after surgery to evaluate clinical and radiological outcomes.",[28,29],"Arthritis (Knee)","Varus Knee",[31,32,33,34],"patient-specific instrumentation","knee osteotomy","Prospective","Randomised Controlled Trial","RECRUITING","2026-04-02",{"date":38,"type":39},"2026-04-03","ACTUAL",{"date":41,"type":39},"2025-11-15",{"date":43,"type":22},"2028-10",{"name":45,"class":46},"University of Malaga","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":47},"100561488","the-effect-of-body-mass-index-on-short-term-results-of-hto-100561488","NCT06590818","The Effect of Body Mass Index on Short-term Results of HTO","The Effect of Body Mass Index on Short-term Results of HTO for Treatment of OA With Varus Knee in Upper Egypt Population","Inclusion Criteria:\n\n* Meet the diagnostic criteria for knee osteoarthritis and only have one knee\n* No serious underlying medical disease\n* Conservative treatment is ineffective and there is a willingness for surgery\n* X-ray shows degeneration limited to the medial joint space (Ahlback grade ≥ grade II)\n* Knee flexion range of motion \\> 90°, varus deformity \\\u003C 15°, flexion contracture \\\u003C 5°.\n* Clinical examination shows intact anterior cruciate ligament and collateral ligament, tenderness point is limited to the medial joint space, and the lateral compartment and patellofemoral joint are intact.\n\nExclusion Criteria:\n\n* knee osteoarthritis caused by infection, blood-related or autoimmune diseases.\n* severe obesity (BMI\\>35 kg\u002Fm 2 ) or morbid obesity (obesity caused by diseases such as hypercortisolism and hypothyroidism, BMI≥30 kg\u002Fm 2 ).","40 Years","60 Years",{"count":21,"type":22},[25],"The knee joint plays a major role in weight transmission of the body in day-to-day activities. The biomechanics of the knee and malalignment in lower limb anatomy are major risk factors for chronic knee pain, leaving Total Knee Arthroplasty (TKA) as the best and most successful option for patients with end-stage osteoarthritis (OA)",[61,29],"Osteo Arthritis Knee","2024-09-06",{"date":64,"type":39},"2024-09-19",{"date":66,"type":39},"2024-07-10",{"date":68,"type":22},"2025-07-10",{"name":70,"class":71},"Egymedicalpedia","INDUSTRY"]