[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"vasa-previa\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:vasa-previa":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,54],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":32,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100586658","association-of-assisted-reproductive-technologies-parameters-with-the-perinatal-outcome-100586658",false,"NCT06918236","Association of Assisted Reproductive Technologies Parameters With the Perinatal Outcome","Association of Assisted Reproductive Technologies Parameters With the Perinatal Outcome in Singleton and Multiple Pregnancies: A Multicenter Prospective Cohort Study","Inclusion Criteria\n\n* Singleton or multiple pregnancies\n* Live fetus between 11 weeks plus 0 days and 13 weeks plus 6 days of gestation\n\nExclusion Criteria\n\n* Known genetic anomalies diagnosed before or after birth\n* Major fetal defects diagnosed before or after birth, such as acrania, holoprosencephaly, megacystis, exomphalos, congenital heart defects",true,"FEMALE","18 Years",{"count":20,"type":21},12084,"ESTIMATED","9 Months","OBSERVATIONAL","The goal of this prospective cohort study is to examine how different parameters of assisted reproductive technologies (ART) are associated with the perinatal outcome in individuals with singleton or multiple gestations. The main questions it aims to answer are:\n\nAre ART pregnancies associated with a higher risk of:\n\n* Small for gestational age neonates?\n* Fetal growth restriction, either early- or late-onset?\n* Development of preeclampsia?\n* Stillbirth (intrauterine fetal death after 22 weeks not due to known anomalies)?\n* Are certain ART parameters-such as the type of fertilization (e.g., IVF vs. ICSI), embryo stage at transfer, use of fresh vs. frozen embryos, or ovarian stimulation protocols-more strongly associated with adverse outcomes?\n\nAre ART pregnancies associated with placental and umbilical cord abnormalities, including:\n\n* Placenta previa?\n* Vasa previa?\n* Single umbilical artery?\n* Velamentous or marginal cord insertion?\n\nResearchers will compare outcomes between pregnancies conceived through ART and those conceived spontaneously.\n\nParticipants will:\n\n* Be individuals aged 18 or older undergoing routine first-trimester ultrasound between 11 and 14 weeks of gestation\n* Provide detailed medical, obstetric, and ART-related information\n* Undergo routine prenatal assessments, including ultrasound evaluations of fetal growth, Doppler studies, and placental characteristics\n* Have perinatal outcomes such as gestational age at birth, mode of delivery, birthweight, and complications systematically recorded\n\nStatistical models will be used to adjust for confounding factors such as maternal age, BMI, parity, and smoking.\n\nThe aim is to better understand how ART and specific ART parameters may influence maternal and neonatal health and to improve counseling and clinical care for people using fertility treatments.",[26,27,28,29,30,31],"Fetal Growth Restriction (FGR)","Preeclampsia","Stillbirth","Placenta Previa","Vasa Previa","Small for Gestational Age (SGA)",[33,27,34,35,36,37,38,31,39,40],"fetal growth restriction","stillbirth","placenta previa","vasa previa","Assisted reproductive techniques","ART","IVF","ICSI","RECRUITING","2025-04-05",{"date":44,"type":45},"2025-04-09","ACTUAL",{"date":47,"type":45},"2024-10-01",{"date":49,"type":21},"2028-12",{"name":51,"class":52},"Aristotle University Of Thessaloniki","OTHER",6,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":77,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":90},"100520443","a-prospective-study-on-the-role-of-karl-storz-curved-and-straight-fetoscopes-11508aak-and-11506aak-for-fetoscopic-intrauterine-procedures-100520443","NCT06056635","A Prospective Study on the Role of Karl Storz Curved and Straight Fetoscopes (11508AAK and 11506AAK) for Fetoscopic Intrauterine Procedures","Inclusion Criteria:\n\n* Pregnant patient with a condition requiring in-utero surgery\n* Patient must be eligible for anesthesia\n* Patient and father of the fetus (if available) are able to provide signed informed consent\n\nExclusion Criteria:\n\n* Allergy or previous adverse reaction to any ancillary medication specified in this protocol that has no alternative\n* Preterm labor, preeclampsia, or uterine anomaly (e.g., large fibroid tumor) in the index pregnancy\n* Suspicion of major recognized congenital syndrome on ultrasound or MRI that is not compatible with postnatal life\n* Pre-pregnancy maternal BMI greater than 40\n* High risk for fetal hemophilia\n* Fetal aneuploidy or variants of known significance if an amniocentesis was performed\n* Contraindication to abdominal surgery or fetoscopic surgery","45 Years",{"count":62,"type":21},50,"INTERVENTIONAL",[65],"NA","In this research study, the investigators want to learn more about the role of new innovative surgical devices, the Karl Storz Curved and Straight Fetoscopes for in-utero surgery. A fetoscope is like a small telescope that can see inside of the uterus (womb) during minimally invasive surgery. The curved scope is used for patients with an anterior placenta (front of uterus), while the straight scope is used for patients with a posterior placenta (back of uterus). The scopes will be used to assist in procedures involving fetoscopic laser photocoagulation (FLP), which is a minimally invasive surgery that uses a small camera (fetoscope) to locate abnormal blood vessel connections in the placenta and seal them off using laser energy. These fetoscopes will be utilized in the diagnosis and management of various fetal conditions that can arise during pregnancy. Outcome data will be reported in a descriptive statistical analysis. The investigators will assess the surgical outcomes, short and long-term morbidity, complications, and gestational age of participants in order to evaluate the benefit of using these devices.",[68,69,70,71,72,73,74,75,76,30],"Fetal Conditions","Maternal; Procedure","Pregnancy Related","Twin to Twin Transfusion Syndrome","In Utero Procedure Affecting Fetus or Newborn","Chorion; Abnormal","Twin Reversal Arterial Perfusion Syndrome","Twin Monochorionic Monoamniotic Placenta","Chorioangioma",[78,79,80],"Fetoscope","Fetoscopic Laser Ablation","Diagnostic Fetoscopy","2024-09-24",{"date":83,"type":45},"2024-09-25",{"date":85,"type":45},"2024-08-15",{"date":87,"type":21},"2027-05-01",{"name":89,"class":52},"Boston Children's Hospital",1]