[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"vascular-cognitive-impairment\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:vascular-cognitive-impairment":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,49,81,108,131],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100445363","exercise-as-a-primer-for-brain-stimulation-in-vascular-cognitive-impairment-no-dementia-vcind-100445363",false,"NCT05079464","Exercise as a Primer for Brain Stimulation in Vascular Cognitive Impairment No Dementia (VCIND)","Exercise as a Primer for Excitatory Stimulation Study in Vascular Cognitive Impairment No Dementia (EXPRESS-V)","EXPRESS-V","Inclusion Criteria:\n\n* ≥50 years of age; females must be post-menopausal\n* Presence of cerebrovascular and\u002For cardiovascular risk factors or coronary artery disease\n* Montreal Cognitive Assessment (MoCA) \\\u003C27\n* Sufficiently proficient in English\n* Must be able to exercise at a moderate intensity level\n* Presence of modest deficits (1 standard deviation below population norm) in one of the following domains: executive function, verbal memory, working memory, or visuospatial memory\n\nExclusion Criteria:\n\n* History of stroke\n* Change in psychotropics within the last 4 weeks\n* Current benzodiazepine use due\n* Metal implants that would preclude safe use of tDCS or neuroimaging\n* Significant neurological or psychiatric conditions (current major depressive disorder, bipolar disorder, schizophrenia)\n* MoCA \\\u003C18 and\u002For clinical diagnosis of dementia\n* Any medical contraindications to exercise","ALL","50 Years",{"count":20,"type":21},64,"ESTIMATED","INTERVENTIONAL",[24],"NA","People with vascular conditions are at risk of having memory problems, and these memory problems increase the risk for further cognitive decline. Brain stimulation has been used to improve mood and memory. Transcranial direct current stimulation (tDCS) is believed to work best on brain cells that are active or \"primed\" before stimulation. The purpose of this study is to compare the effects of exercise and tDCS on memory performance in patients who have completed cardiac rehabilitation and are at risk of cognitive decline.",[27,28],"Vascular Cognitive Impairment","Mild Cognitive Impairment",[30,31,32,33,34,35],"transcranial direct current stimulation","tDCS","exercise","cognition","vascular cognitive impairment no dementia","vascular mild cognitive impairment","RECRUITING","2026-04-10",{"date":39,"type":40},"2026-04-13","ACTUAL",{"date":42,"type":40},"2021-11-22",{"date":44,"type":21},"2026-12",{"name":46,"class":47},"Sunnybrook Health Sciences Centre","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":17,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":22,"phases":61,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":80},"100612289","adaptation-of-the-mini-mental-state-examination-mmse-for-the-reunion-island-population-100612289","NCT07251647","Adaptation of the Mini-Mental State Examination (MMSE) for the Reunion Island Population","MMSE-RUN","Inclusion criteria:\n\n* For the healthy population : aged 60 to 89 years, residing in Reunion for more than 5 years, able to understand the test instructions, available for a one-hour interview, affiliated with a social security scheme, with informed consent.\n* For the sick population : aged 60 to 89 years, residing in Reunion for more than 5 years, presenting probable or possible Alzheimer's disease and\u002For probable vascular cognitive disorder, able to understand the test instructions, available for a one-hour interview, affiliated with a social security scheme, with informed consent.\n\nExclusion criteria:\n\n* For the healthy populationhistory of neurological pathology, neurodegenerative pathology with cognitive expression, refusing to participate in the study, under legal protection.\n* For the sick population: acute unresolved medical decompensation or acute psychic decompensation, refusing to participate in the study, under legal protection.",true,"60 Years","89 Years",{"count":60,"type":21},400,[24],"The Mini-Mental State Examination (MMSE) is the most widely used cognitive screening and monitoring test for neurocognitive disorders in current clinical practice. Its French version was published in 1998 by the GRECO group (MMSE-GRECO). However, some items of this French version are not adapted to local Reunionese particularities.\n\nThe main objective is to propose and validate the psychometric properties of an adapted version of the MMSE, to the Reunionese culture (MMSE-RUN) in a healthy population and in a sick population (Alzheimer's Disease and Vascular Cognitive Disorder), and to compare its performance with the MMSE-GRECO.",[64,27],"Alzheimer s Disease",[66,67,68,69],"Neurocognitive disorder","cognitive test","screening","Reunion Island","NOT_YET_RECRUITING","2026-03-11",{"date":73,"type":40},"2026-03-12",{"date":75,"type":21},"2026-04",{"date":77,"type":21},"2027-07",{"name":79,"class":47},"Centre Hospitalier Universitaire de la Réunion",7,{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":17,"minAge":88,"maxAge":4,"enrollmentInfo":89,"targetDuration":4,"studyType":91,"phases":4,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":107},"100432830","determinants-of-incident-stroke-cognitive-outcomes-and-vascular-effects-on-recovery-100432830","NCT04916210","Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY","DISCOVERY","Inclusion Criteria:\n\n1. Age ≥18 years\n2. Admitted to the enrolling clinical performance site (CPS) hospital with a diagnosis of acute ischemic stroke (AIS), intracerebral hemorrhage (ICH), or aneurysmal subarachnoid hemorrhage (aSAH)\n3. Radiographic confirmatory evidence of: (1) AIS (based on a focal area of restricted diffusion on MRI), (2) non-traumatic primary ICH (based on evidence of acute parenchymal hemorrhage on CT or brain MRI) or (3) non-traumatic acute aSAH (based on evidence of subarachnoid hemorrhage on CT or MRI and evidence of aneurysm on CT angiography, MR angiography, or conventional catheter-based angiography)\n4. Able to complete baseline visit in person or by phone within 6 weeks of stroke onset\n5. Able to provide informed consent by self or proxy\n6. Fluent in English or Spanish prior to stroke onset\n\nExclusion Criteria:\n\n1. Documented history of pre-stroke dementia or fails dementia pre-screen\n2. Concurrently enrolled into a study that is not approved under the DISCOVERY Co-Enrollment Policy\n3. Unable to complete study protocol (advanced directives such as comfort measures only, or inability to complete the study due to severe medical\u002Fbehavioral co-morbidities), as determined by physician investigator during screening process\n\n   Additional exclusion criteria for Tier 2 participants:\n4. Contraindication to MRI: presence of electrically, magnetically, or mechanically activated implants (such as cardiac pacemakers, cochlear implants, implanted pumps); or metallic clips in the brain\n\n   Additional exclusion criteria for Tier 3 participants:\n5. Age \\\u003C50 years\n6. Biologically female individuals who are pregnant or seeking to become pregnant\n7. Known to have one of the following genetic conditions which can increase the risk of developing cancer: Cowden disease, Lynch syndrome, hypogammaglobulinemia, Wiskott-Aldrich syndrome, Down's syndrome.","18 Years",{"count":90,"type":21},8000,"OBSERVATIONAL","The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced a stroke. The purpose of the study is to help doctors identify patients at risk for dementia (decline in memory, thinking and other mental abilities that significantly affects daily functioning) after their stroke so that future treatments may be developed to improve outcomes in stroke patients. For this study, a \"stroke\" is defined as either (1) an acute ischemic stroke (AIS, or blood clot in the brain), (2) an intracerebral hemorrhage (ICH, or bleeding in the brain), (3) or an aneurysmal subarachnoid hemorrhage (aSAH, or bleeding around the brain caused by an abnormal bulge in a blood vessel that bursts).\n\nThe investigators hypothesize that:\n\n1. The size, type and location of the stroke play an important role in recovery of thinking and memory abilities after stroke, and pre-existing indicators of brain health further determine the extent of this recovery.\n2. Specific stroke events occurring in individuals with underlying genetic or biological risk factors can cause further declines in brain heath, leading to changes in thinking and memory abilities after stroke.\n3. Studying thinking and memory alongside brain imaging and blood samples in patients who have had a stroke allows for earlier identification of declining brain health and development of individualized treatment plans to improve patient outcomes in the future.",[94,95,96,97,28,27],"Ischemic Stroke","Intracerebral Hemorrhage","Subarachnoid Hemorrhage","Dementia, Vascular","2025-10-31",{"date":100,"type":40},"2025-11-03",{"date":102,"type":40},"2021-03-05",{"date":104,"type":21},"2026-08-31",{"name":106,"class":47},"Massachusetts General Hospital",31,{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":56,"sex":17,"minAge":114,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":91,"phases":4,"briefSummary":118,"conditions":119,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":48},"100596221","mechanism-of-gamma-oscillation-synchronization-in-the-prefrontal-hippocampal-circuit-for-memory-dysfunction-in-patients-with-white-matter-lesions-of-cerebral-small-vessel-disease-100596221","NCT07042633","Mechanism of Gamma Oscillation Synchronization in the Prefrontal-hippocampal Circuit for Memory Dysfunction in Patients With White Matter Lesions of Cerebral Small Vessel Disease","Inclusion Criteria:\n\n* \\- Individuals with cerebral small vessel disease, normal cognition or mild cognitive impairment subjects;\n* Participants with complete demographic data, neuropsychiatric scale assessments, imaging data, and EEG data.\n\nExclusion Criteria:\n\n* Severe aphasia, physical disability, or other conditions preventing completion of neuropsychological assessments;\n* History of cerebrovascular stroke with documented neurological deficits during onset and corresponding lesions on neuroimaging;\n* Neurological disorders that may cause cognitive impairment, including alcohol abuse, drug addiction, traumatic brain injury, epilepsy, encephalitis, or normal-pressure hydrocephalus;\n* Systemic diseases potentially contributing to mild cognitive impairment (e.g., hepatic\u002Frenal insufficiency, endocrine disorders, vitamin deficiencies);\n* Current diagnosis of major depressive disorder or psychiatric disorders.","55 Years","75 Years",{"count":117,"type":21},150,"The mechanism underlying memory impairment caused by white matter lesions of cerebral small vessel disease is still unclear. The disrupted synchronization of gamma oscillations in the prefrontal-hippocampal circuit is a potential key mechanism. Our study has demonstrated that white matter lesions lead to demyelination of the connection tracts between the prefrontal lobe and hippocampus, which is closely related to memory dysfunction. However, further studies are required to explore if these microstructural changes in white matter tracts influence memory function by affecting gamma oscillations. Thus, this project will use the previously established episodic memory task and event-related potential to determine the changes in gamma oscillations in the prefrontal-hippocampal circuit and the effects on memory encoding and retrieval. Combining multimodal imaging, we will explore the mediating role of white matter microstructure damage, and establish a machine learning prediction model for memory impairment. In addition, transcranial alternation current stimulation (tACS) will be used to investigate the mechanisms of memory improvement by regulating the prefrontal-hippocampal gamma oscillations. This project will clarify the neural oscillation mechanism underlying memory impairment caused by white matter lesions of cerebral small vessel disease, with the expectation of providing new predictive indicators and interventions.",[27,120,121],"White Matter Lesions","Gamma Oscillation","2025-06-26",{"date":124,"type":40},"2025-06-29",{"date":126,"type":40},"2024-03-07",{"date":128,"type":21},"2027-12-31",{"name":130,"class":47},"Xuanwu Hospital, Beijing",{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":56,"sex":17,"minAge":57,"maxAge":138,"enrollmentInfo":139,"targetDuration":4,"studyType":22,"phases":141,"briefSummary":142,"conditions":143,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":48},"100507340","a-multi-domain-lifestyle-intervention-among-aged-community-residents-in-zhejiang-china-100507340","NCT05886114","A Multi-domain Lifestyle Intervention Among Aged Community-residents in Zhejiang, China","HERITAGE","Inclusion Criteria:\n\n* At risk of cognitive decline: cognitive performance at the mean level or slightly lower than expected for age with no dementia (AD8\\>=3 and\u002For 5-min MoCA \\>, \\\u003C 11)\n* Free of physical disabilities that preclude participation in the study\n* Willing to complete all study-related activities for 24 months\n* Willing to be randomized to either lifestyle intervention group\n\nExclusion Criteria:\n\n* Diagnosed dementia patients\n* Diagnosed major depression or other neuropsychological diseases\n* Malignant diseases\n* Symptomatic cardiovascular disease\n* Revascularization within one year\n* Severe loss of vision, hearing or communicative ability","80 Years",{"count":140,"type":21},1200,[24],"A study conducted in Finland discovered that a multidomain intervention, consisting of physical activity, nutritional guidance, cognitive training, social activities, and management of vascular risk factors, effectively decelerated cognitive decline in healthy older adults who were at an increased risk of cognitive decline. The HERITAGE study is a 2-year clustered randomized controlled trial (clustered-RCT) that explores the efficacy of a multidomain intervention among 1200 elderly residents with a higher risk of cognitive decline and dementia in Zhejiang Province, China",[144,145,27,146,147,148,149,150,151,152],"Cognitive Impairment","Alzheimer Disease","Dement","Brain Diseases","Central Nervous System Diseases","Nervous System Diseases","Neurocognitive Disorders","Mental Disorder","Cognition Disorder","2023-06-04",{"date":155,"type":40},"2023-06-06",{"date":157,"type":21},"2023-05-28",{"date":159,"type":21},"2027-04-28",{"name":161,"class":47},"Zhejiang University"]