[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"vascular-endothelial-function\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:vascular-endothelial-function":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100512002","early-phase-1-oxidative-stress-in-microvascular-dysfunction-following-gestational-diabetes-100512002",false,"NCT05946785","Oxidative Stress in Microvascular Dysfunction Following Gestational Diabetes","Role of Oxidative Stress in Microvascular Dysfunction Following Gestational Diabetes","INCLUSION CRITERIA:\n\n* female sex\n* 18 -50 years old\n* pregnancy history within 5 years of the study visit\n* had gestational diabetes diagnosed by their obstetrician and confirmed according to the American College of Obstetricians and Gynecologists criteria for gestational diabetes\n* or without a history of gestational diabetes\n\nEXCLUSION CRITERIA:\n\n* skin diseases\n* current tobacco\u002Fe-cigarette use\n* diagnosed or suspected hepatic or metabolic disease including diabetes\n* statin or other cholesterol-lowering medication\n* current antihypertensive medication\n* history of preeclampsia or gestational hypertension\n* current pregnancy\n* body mass index \\\u003C18.5 kg\u002Fm2\n* allergy to materials used during the experiment.(e.g. latex), known allergies to study drugs.",true,"FEMALE","18 Years","50 Years",{"count":21,"type":22},28,"ESTIMATED","INTERVENTIONAL",[25],"EARLY_PHASE1","The purpose of this investigation is to examine the role of oxidative stress in aberrant microvascular function in otherwise healthy women with a history of GDM.",[28,29],"Gestational Diabetes","Vascular Endothelial Function",[31,32,33],"gestational diabetes","postpartum","vascular","RECRUITING","2025-05-07",{"date":37,"type":38},"2025-05-13","ACTUAL",{"date":40,"type":38},"2023-07-01",{"date":42,"type":22},"2027-06-01",{"name":44,"class":45},"Anna Stanhewicz, PhD","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":60,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":46},"100512003","early-phase-1-role-of-nadph-oxidase-in-microvascular-dysfunction-following-gdm-100512003","NCT05946798","Role of NADPH Oxidase in Microvascular Dysfunction Following GDM","INCLUSION CRITERIA:\n\n* 18 years or older\n* pregnant within 5 years of the study visit\n* had gestational diabetes diagnosed by their obstetrician and confirmed according to the American College of Obstetricians and Gynecologists criteria for gestational diabetes.\n* or without a history of gestational diabetes\n\nEXCLUSION CRITERIA:\n\n* skin diseases\n* current tobacco or electronic cigarette\u002Fvape pen use,\n* diagnosed or suspected hepatic or metabolic disease including diabetes,\n* statin or other cholesterol-lowering medication,\n* current antihypertensive medication,\n* history of preeclampsia or gestational hypertension,\n* current pregnancy,\n* body mass index \\\u003C18.5 kg\u002Fm2,\n* allergy to materials used during the experiment.(e.g. latex),\n* known allergies to study drugs",{"count":54,"type":22},40,[25],"The purpose of this investigation is to examine NADPH oxidase as a source of reactive oxygen species contributing to aberrant microvascular function in otherwise healthy women with a history of GDM.",[28,58,29],"Oxidative Stress",[31,32,33],{"date":37,"type":38},{"date":62,"type":38},"2023-08-30",{"date":64,"type":22},"2028-06-01",{"name":44,"class":45}]