[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"vascular-function\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:vascular-function":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,49,82,114,138,169,200,229],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100606197","evaluation-of-adding-nitrate-into-foods-for-regulating-nitric-oxide-bioavailability-in-healthy-individuals-100606197",false,"NCT07172425","Evaluation of Adding Nitrate Into Foods for Regulating Nitric Oxide Bioavailability in Healthy Individuals","An Open-Label, Randomised, Crossover Study to Investigate the Feasibility of Nitrate Fortification in Commonly Consumed Foods for Regulating Nitric Oxide Metabolism in Healthy Individuals","Inclusion Criteria:\n\n1. Healthy volunteer.\n2. Aged ≥18 years and ≤ 60 years.\n3. Willing to provide informed consent.\n4. Able to understand and comply with protocol requirements, instructions, and stated restrictions.\n\nExclusion Criteria:\n\nA volunteer will not be eligible for inclusion in this study if any of the following criteria are met:\n\n1. Unwilling to provide consent.\n2. People with chronic health conditions requiring medication.\n3. Pregnant females, or those with a possibility of being pregnant.\n4. History of hypertension and \u002For diabetes.\n5. History of any serious illnesses, including recent infections or trauma.\n6. History of symptomatic coronary artery disease, stroke, or other known atherosclerotic diseases.\n7. People who will commence or who are likely to commence treatment with non-steroidal anti-inflammatory drugs (NSAIDs) other than aspirin, from screening until study completion.\n8. Self-declared alcohol or drug abuse within the past 6 months.\n9. Three-month prior history of regular alcohol consumption exceeding an average weekly intake of \\> 28 units (or an average daily intake of greater than 3 units) for males, or an average weekly intake of \\> 21 units (or an average daily intake of greater than 2 units) for females. One unit is equivalent to a half pint (284mL) of beer\u002Flager; 25mL of spirits, or 125mL of wine.\n10. Taking systemic medication (other than the oral contraceptive pill).\n11. Recent (within 2 weeks) self-reported use of mouthwash or tongue scrapers.\n12. Recent (within 2 weeks) or current antibiotic use.\n13. Recent (within 1 week) use of NO3- or NO2- supplements.\n14. History, or recent treatment of (within the last 3 months) for any oral condition (excluding caries), including gingivitis, periodontitis and halitosis.\n15. History of, or recent treatment for, any blood-borne infectious disease such Hepatitis B or C virus, or HIV.\n16. Current smokers (including vaping) or have smoked within the last 6 months.\n17. Diagnosis of rheumatoid arthritis, connective tissue disorders, and other conditions known to be associated with chronic inflammation (e.g., Inflammatory Bowel Disease).\n18. People who have donated more than 500mL of blood within 56 days prior to the study commencement.\n19. Known allergy to celery, gluten, crustaceans, eggs, lupin, milk, mustard, peanuts, sesame, soybeans, tree nuts, oats, palm oil, sugar, cranberries, sunflower oil, invert syrup, sodium bicarbonate.",true,"ALL","18 Years","60 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"NA","Inorganic nitrate, found in leafy green vegetables and beetroot, can help lower blood pressure and support heart health. Early experimental work has suggested that dietary nitrate supplementation, in the form of beetroot juice or potassium nitrate capsules, can reduce blood pressure and improve endothelial function. Consequently, concentrated nitrate supplements like beetroot juice have become popular. However, these supplements can be expensive, high in sugar, and not to everyone's taste. Since more than three-quarters of adults with high blood pressure live in low- and middle-income countries, it is important to find safe, affordable ways to add nitrate to commonly eaten foods.\n\nThe team at Queen Mary University of London has been developing nitrate-fortified products that may be more appealing to a wider population. With support from the food manufacturer Reading Scientific Services Ltd. (RSSL), they have successfully added nitrate to three oat-based products: cereal bar, porridge, and biscuits.\n\nThis study aims to explore whether adding nitrate to commonly eaten foods can improve nitric oxide levels in the body and help lower blood pressure in healthy volunteers. Participants will receive the three nitrate-fortified food products in a randomised, crossover design. Nitrate and nitrite concentrations in biological samples, along with blood pressure, will be measured before and at multiple time points after supplementation with the nitrate-fortified products.",[28,29,30],"Healthy Volunteers","Nitric Oxide","Vascular Function",[32,33,34,35],"Blood pressure","Oral microbiome profiling","Nitric oxide bioavailability","Inorganic nitrate fortification","RECRUITING","2026-06-03",{"date":39,"type":40},"2026-06-04","ACTUAL",{"date":42,"type":40},"2025-10-15",{"date":44,"type":22},"2027-02",{"name":46,"class":47},"Queen Mary University of London","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":56,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":62,"conditions":63,"keywords":68,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":48},"100607902","phase-2-equol-and-vascular-function-in-women-with-chronic-kidney-disease-100607902","NCT07194590","Equol and Vascular Function in Women With Chronic Kidney Disease","Equol Supplementation for Improving Vascular Function in Postmenopausal Women With CKD","Inclusion Criteria:\n\n* Postmenopausal women\n* Aged ≥50 years\n* CKD stage 3 or 4 (eGFR with the CKD-EPI 2021 race-free equation: 15-59 mL\u002Fmin\u002F1.73m2; stable renal function in the past 3 months)\n* Low habitual intake of soy (soy-related food intake \\\u003C 2 times per week assessed by Soy-Specific Food Frequency Questionnaire)\n* Weight stable in the prior 3 months (\\\u003C2 kg weight change) and willing to remain weight stable throughout the study\n* Ability to provide informed consent.\n\nExclusion Criteria:\n\n* Patients with advanced CKD requiring chronic dialysis\n* Uncontrolled hypertension in CKD group (BP \\>140\u002F90 mmHg)\n* Use of any hormone replacement therapy\n* Allergy and\u002For intolerance to soy or soy-based products\n* Aspartate aminotransferase (AST), alanine aminotransferase (ALT), or total bilirubin values 2X upper limit of normal range (upper limit of normal range AST: 117 U\u002FL; ALT: 52 U\u002FL; total bilirubin: 1.3 mg\u002FdL)\n* History of breast cancer\n* Significant co-morbid conditions with a life expectancy of \\\u003C 1 year\n* Current tobacco or nicotine use or history of use in the last 12 months\n* History of kidney transplant\n* History of severe congestive heart failure (i.e., ejection fraction \\\u003C35%)\n* History of hospitalization within the last month\n* Immunosuppressant agents taken in the past 12 months\n* Known malignancy","FEMALE","50 Years",{"count":59,"type":22},74,[61],"PHASE2","The risk of cardiovascular disease (CVD) is significantly elevated in patients with chronic kidney disease (CKD). Notably, women with CKD commonly experience menstrual disturbances induced by CKD, which may contribute to impaired vascular function and elevated CVD risk. However, most of the literature in nephrology focuses on male patients, and studies on women's vascular health are limited. Establishing effective therapies for improving vascular function and reducing CVD risk in women with CKD is a high research priority of the NIH.\n\nEquol contributes to improvement in vascular function, mediated in part by its anti-oxidative and anti-inflammatory properties. However, there is no information on the effect of equol on vascular function in women with CKD. The proposed project aims to determine the effect of 12 weeks of oral equol supplementation on vascular function in postmenopausal women with CKD.",[64,30,65,66,67],"Chronic Kidney Disease (Stage 3-4)","Cognitive Functions","Cerebrovascular Function","Blood Pressure",[69,70,71,72,30],"S-equol","Randomized Controlled Trial","Chronic Kidney Disease","Women's Health","2026-06-01",{"date":75,"type":40},"2026-06-02",{"date":77,"type":40},"2026-02-19",{"date":79,"type":22},"2030-11-30",{"name":81,"class":47},"University of Colorado, Denver",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":23,"phases":93,"briefSummary":94,"conditions":95,"keywords":98,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":110,"leadSponsor":112,"locationsCount":48},"100640669","buerger-allen-exercises-and-peripheral-circulation-in-sedentary-office-workers-100640669","NCT07588893","Buerger-Allen Exercises and Peripheral Circulation in Sedentary Office Workers","Acute Effects of Buerger-Allen Exercises on Lower Extremity Circulatory Parameters in Sedentary Office Workers: A Single-Group Pretest-Posttest Clinical Trial","BAE-CIRC","Inclusion Criteria:\n\n* Healthy sedentary office workers\n* Age between 18 and 45 years\n* Sitting for at least 6 hours per day for work-related activities\n* Not meeting regular physical activity recommendations\n* Willing to participate voluntarily and provide written informed consent\n\nExclusion Criteria:\n\n* History of peripheral arterial disease, deep vein thrombosis, or other vascular disorders\n* Cardiovascular, neurological, or musculoskeletal conditions that may affect lower extremity circulation or prevent exercise participation\n* Diabetes mellitus\n* Current smoking\n* Pregnancy\n* Use of medications that may significantly affect peripheral circulation\n* Lower extremity injury or surgery within the previous 6 months\n* Participation in regular structured exercise programs","45 Years",{"count":92,"type":22},35,[25],"This study aims to evaluate the acute effects of Buerger-Allen exercises on lower extremity circulation in sedentary office workers. Prolonged sitting is associated with reduced venous return, impaired peripheral circulation, and endothelial dysfunction. Buerger-Allen exercises are simple position-based exercises designed to enhance arterial blood flow, venous return, and tissue perfusion. Thirty-five healthy sedentary adults aged 18 to 45 years will participate in this single-group pretest-posttest clinical trial. Skin surface temperature, capillary refill time, ankle-brachial index, peripheral oxygen saturation, and heart rate will be measured before and after a single 20-minute exercise session. The findings may support the use of Buerger-Allen exercises as a practical, low-cost physiotherapy strategy to improve peripheral circulation and reduce the adverse vascular effects of prolonged sitting.",[96,97,30],"Sedentary Behavior","Peripheral Circulation",[99,97,96,100,101,102,103,104],"Buerger-Allen Exercise","Office Workers","Capillary Refill Time","Ankle-Brachial Index","Infrared Thermography","Physiotherapy","NOT_YET_RECRUITING","2026-05-09",{"date":108,"type":40},"2026-05-15",{"date":73,"type":22},{"date":111,"type":22},"2026-12-01",{"name":113,"class":47},"Istanbul Gelisim University",{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":16,"sex":56,"minAge":57,"maxAge":121,"enrollmentInfo":122,"targetDuration":4,"studyType":23,"phases":124,"briefSummary":125,"conditions":126,"keywords":129,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":48},"100525941","phase-2-acute-equol-supplementation-and-vascular-function-in-women-with-and-without-ckd-100525941","NCT06128278","Acute Equol Supplementation and Vascular Function in Women With and Without CKD","Acute Equol Supplementation and Vascular Function in Postmenopausal Women With and Without CKD","Inclusion Criteria:\n\n1. Postmenopausal (50-69 y) women\n2. Women with CKD including stage 3-4 (eGFR 15-59 ml\u002Fmin\u002F1.73m2) determined by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) 2021 equation\n3. Women without CKD (eGFR \\>60 ml\u002Fmin\u002F1.73m2) must be healthy (free from hypertension, kidney disease, CVD, diabetes, and other chronic disease as assessed by self-report, medical history, and screening labs).\n\nExclusion Criteria:\n\n1. Use of HRT or has used HRT for \\\u003C6 months prior to enrollment\n2. Advanced CKD requiring dialysis\n3. History of kidney transplant\n4. Use of immunosuppressant medications (unless taking a stable dosage for a quiescent disease)\n5. Current tobacco or nicotine use or history of use in the last 12 months\n6. Antioxidant and\u002For omega-3 fatty acid use within the 2 weeks prior to testing\n7. Marijuana use within 2 weeks prior to testing\n8. Consumption of soy and soy-based products 3 days prior to testing\n9. Uncontrolled hypertension in CKD group (BP\\>140\u002F90 mmHg)\n10. Atrial fibrillation\n11. Active infection or antibiotic therapy\n12. Hospitalization in the last month","69 Years",{"count":123,"type":22},38,[61],"The risk of cardiovascular disease (CVD) is significantly elevated in patients with chronic kidney disease (CKD). Notably, women with CKD commonly experience menstrual disturbances induced by CKD, which may contribute to impaired vascular function and elevated CVD risk. However, most of the literature in nephrology focuses on male patients, and studies on women's vascular health are limited. Establishing effective therapies for improving vascular function and reducing CVD risk in women with CKD is a high research priority of the NIH.\n\nEquol contributes to improvement in vascular function, mediated in part by its anti-oxidative and anti-inflammatory properties. However, there is no information on the effect of equol on vascular function in women with CKD. The proposed project aims to determine the acute effect (1-hour, 2-hours, and 3-hours post ingestion) of oral equol supplementation on vascular function in postmenopausal women with and without CKD.",[127,30,128],"Chronic Kidney Diseases","Women",[69,71,30,128],"2025-09-23",{"date":132,"type":40},"2025-09-30",{"date":134,"type":40},"2023-03-07",{"date":136,"type":22},"2026-12-31",{"name":81,"class":47},{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":16,"sex":56,"minAge":90,"maxAge":146,"enrollmentInfo":147,"targetDuration":4,"studyType":23,"phases":149,"briefSummary":150,"conditions":151,"keywords":153,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":48},"100598372","abertay-tea-for-cardiovascular-health-during-menopause-100598372","NCT07070635","Abertay Tea for Cardiovascular Health During Menopause","The Effect of the Fermented Seaweed Enriched Abertay Tea on Vascular Function and Markers of Cardiovascular Risk During Menopause","AberTeaM","Inclusion Criteria:\n\n* Postmenopausal status: no menstrual period over the last 12 months\n* Regular tea drinkers (at least once a week), willingness to consume 3 cups of English breakfast tea per day for 8 weeks\n* BMI between 18.5 and 39.99 kg\u002Fm2\n\nExclusion Criteria:\n\n* Reported history of CVD (myocardial infarction, angina, venous thrombosis, stroke, dyslipidemia), diabetes (or fasting glucose ≥ 6.1 mmol\u002FL), kidney, liver or bowel disease.\n* Recent history of cancer (\\\u003C1y)\n* History indicative of a congenital or acquired platelet or haemostatic defect.\n* Presence of gastrointestinal disorder or use of drug, which is likely to alter gastrointestinal motility or nutrient absorption.\n* Recent use of hypolipidaemic, antiplatelet or antithrombotic medications\n* Impairment of thyroid function\n* Current smokers or vapers\n* Current self-reported weekly alcohol intake exceeding 14 units\n* Current or recent use of hormone replacement therapy (\\\u003C3 months)\n* Recent participation in another clinical trial (\\\u003C3 months)\n* Allergy or intolerance to crustaceans or iodine","74 Years",{"count":148,"type":22},44,[25],"The regular consumption of seaweed, as observed in Japan, is associated to a reduced cardiovascular risk and prolonged life expectancy. Interventional studies have shown that brown seaweed consumption can reduce blood pressure, improve glycaemic control and lipoprotein profiles, although this varies with population, dose, duration and the type of seaweed. Brown seaweed appears the most promising to improve cardiovascular risk, due to the presence of specific antioxidants (polyphenols called phlorotannins), pigments (fucoxanthin) and fibre (alginate, fucoidan).\n\nWomen see their cardiovascular risk greatly increased when they reach menopause, and seaweed consumption may provide benefits for this population. In the UK, 98% of UK residents drink tea daily (Source UKTIA), with English breakfast tea being the most popular. Providing a tea enriched with beneficial compounds has the potential to improve cardiovascular health in a wide range of the population, including postmenopausal women. Abertay university (Dundee, UK) has recently developed an English Breakfast tea enriched with fermented seaweed, which was found to taste like English breakfast tea. We hypothesise that the consumption of 3 cups a day of the Abertay-developed Tea (AberTea) for 8 weeks, with each tea bag containing 1g of fermented seaweed, will improve vascular function and cardiovascular risk factors in postmenopausal women.",[152,30],"Cardiovascular Risk Factor",[154,155,156,157,158,159],"seaweed","fermented","menopause","vascular function","cardiovascular risk","continuous non invasive arterial pressure","2025-07-08",{"date":162,"type":40},"2025-07-17",{"date":164,"type":40},"2025-06-16",{"date":166,"type":22},"2025-11",{"name":168,"class":47},"Abertay University",{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":174,"acronym":175,"eligibilityCriteria":176,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":177,"targetDuration":4,"studyType":23,"phases":179,"briefSummary":180,"conditions":181,"keywords":185,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":48},"100579382","anti-hypertensive-therapy-and-exercise-treatment-to-improve-vascular-health-in-patients-with-hypertension-100579382","NCT06823570","Anti-hypertensive Therapy and Exercise Treatment to Improve Vascular Health in Patients With Hypertension.","Anti-hypertensive Therapy and Exercise Treatment to Improve Vascular Health in Patients With Hypertension. A Randomized Controlled Trial.","Antitension","Inclusion Criteria:\n\n\\- systolic hypertension grade I-II (BP values \\>140 mmHg to \\\u003C180 mmHg) without anti-hypertensive medication treatment\n\nExclusion Criteria:\n\n* no written informed consent\n* age \\\u003C18 years\n* isolated diastolic hypertension\n* medical contraindications for the exercise treatment (for example orthopedic problems or an abnormal ECG during the cardio respiratory exercise test)\n* chronic eye diseases on both eyes (for example macular degeneration or glaucoma) or high intraocular pressure (\\>20 mmHg)",{"count":178,"type":22},60,[25],"This is a prospective, monocentric, randomized controlled trial to investigate the effect of anti-hypertensive treatment and\u002For individualized exercise training intervention on blood pressure and vascular health. Furthermore the investigators want to decipher mechanisms, which contribute to vascular health by analyzing changes in metabolism and cell function in relation to vascular reaction.",[182,30,183,184],"Hypertension","Fitness Testing","Metabolism Changes",[186,187,188,189,190],"cardiorespiratory fitness","retinal microcirculation","endothelial function","exercise training","lifestyle treatment","2025-03-11",{"date":193,"type":40},"2025-03-12",{"date":195,"type":22},"2025-04-01",{"date":197,"type":22},"2028-12-31",{"name":199,"class":47},"Heinrich-Heine University, Duesseldorf",{"id":201,"slug":202,"hasResults":11,"nctId":203,"briefTitle":204,"officialTitle":205,"acronym":4,"eligibilityCriteria":206,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":207,"targetDuration":4,"studyType":23,"phases":209,"briefSummary":210,"conditions":211,"keywords":216,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":220,"lastUpdatePostDateStruct":221,"startDateStruct":223,"completionDateStruct":225,"leadSponsor":227,"locationsCount":48},"100579699","heat-therapy-and-peripheral-artery-disease-100579699","NCT06827691","Heat Therapy and Peripheral Artery Disease","Heat Therapy for People with Peripheral Artery Disease: a Randomised Wait-List Controlled Feasibility Trial.","Inclusion Criteria:\n\n* • Aged \\> 18 years\n\n  * ABPI \\\u003C 0.9 at rest or a drop of 20mmHG after exercise testing\n  * Diagnosed with IC\n  * Able to walk unaided\n  * English-speaking and able to follow instructions\n  * No previous history of heat syncope\n  * Post-Menopausal or not on hormone therapy\n  * Able to provide informed consent\n\nExclusion Criteria:\n\n* • Walking impairment for a reason other than PAD\n\n  * Critical limb ischaemia\u002Frest pain\n  * Asymptomatic PAD\n  * Active cancer treatment\n  * Clinically diagnosed diabetes or those with peripheral neuropathy\n  * Recent \u002F frequent heat exposure (e.g., sauna or hot tubs).\n  * severe aortic stenosis, unstable angina, recent MI, stroke or TIA",{"count":208,"type":22},70,[25],"The purpose of the study is to assess the efficacy of a novel 8 week heat therapy intervention in intermittent claudication compared to usual care controls. Participants will be enrolled on a wait-list control randomised trial testing physiological, mechanistic, and health related outcome measures.",[212,213,30,214,215],"Peripheral Arterial Disease","Cardiovascular Health","Intermittent Claudication","Peripheral Vascular Diseases",[217,218,188,219],"heat therapy","cardiovascular health","heat intervention","2025-02-10",{"date":222,"type":40},"2025-02-14",{"date":224,"type":22},"2025-05-01",{"date":226,"type":22},"2028-01-01",{"name":228,"class":47},"Manchester Metropolitan University",{"id":230,"slug":231,"hasResults":11,"nctId":232,"briefTitle":233,"officialTitle":234,"acronym":4,"eligibilityCriteria":235,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":236,"targetDuration":4,"studyType":23,"phases":238,"briefSummary":239,"conditions":240,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":243,"lastUpdatePostDateStruct":244,"startDateStruct":246,"completionDateStruct":248,"leadSponsor":249,"locationsCount":48},"100475233","the-impact-of-removal-of-exercise-on-glycemic-control-and-vascular-health-in-older-active-adults-100475233","NCT05468255","The Impact of Removal of Exercise on Glycemic Control and Vascular Health in Older Active Adults","The Impact of Removal of Exercise on Glycemic Control and Vascular Health in Older Active","Inclusion Criteria:\n\n1. 55 years and older, 18-40 years old\n2. Healthy, physically active, performing at least 90 min\u002Fweek of physical activity\n3. Free of physical limitations that may interfere with alterations in daily physical activity levels\n\nExclusion Criteria:\n\n1. Physician diagnosed HIV, hepatitis, or tuberculosis.\n2. Body weight change of greater than 5% within the previous 2 months\n3. Smoking within the previous 2 months.\n4. Taking medications that alter blood glucose levels",{"count":237,"type":22},40,[25],"The purpose of this study is to determine if an acute bout of removal of exercise reduces enothelial function and glycemic control in an active, older adult population; and whether a 3 day return to exercise restores this response. Glycemic control is the blood glucose response following the consumption of a meal. It is an indicator of insulin resistance (or type 2 diabetes) and impaired glycemic control has been suggested to lead to cardiovascular disease. Endothelial function has been shown to be improved by chronic or acute increases in physical activity. Both of these have been shown to be impaired to acute bouts of inactivity in young populations; however the impact of acute inactivity in older adults is less understood. In this proposal the investigators will examine 1)how quickly impairments in glycemic control occur to acute physical inactivity in older adults who exercise, 2) how quickly impairments in endothelial function occur to acute inactivity in older adults who exercise, and 3) whether 3 days of a return to exercise restores these responses.",[241,242,30],"Glucose Intolerance","Exercise","2024-04-09",{"date":245,"type":40},"2024-04-10",{"date":247,"type":40},"2022-07-25",{"date":195,"type":22},{"name":250,"class":47},"Old Dominion University"]