[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"vascular-health\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:vascular-health":37},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,72,108,134,160],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":44,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":71},"100629969","impact-of-training-load-on-the-gut-microbiome-and-its-relation-to-exercise-performance-muscle-phenotype-and-markers-of-overreaching-in-healthy-men-100629969",false,"NCT07481578","Impact of Training Load on the Gut miCrobiome And Its Relation to exeRcise Performance, mUscle Phenotype, and markerS of Overreaching in Healthy Men","ICARUS: Impact of Training Load on the Gut Microbiome and Its Relation to Exercise Performance, Muscle Phenotype, and Markers of Overreaching in Healthy Men: Phase A - Human Trial","ICARUS","Inclusion criteria:\n\n* Males between 18 and 45 years old.\n* Recreationally active individuals, with a weekly exercise training volume between one and six hours per week.\n* Good health status confirmed by a sport medical screening, which includes a sport medical questionnaire and resting electrocardiogram.\n* Body Mass Index (BMI) between 18.5 and 27.5 kg\u002Fm².\n* Masters the Dutch language.\n\nExclusion criteria:\n\n* Engagement in strenuous competitive sports one month prior to or during the study intervention.\n* Medication and vaccination: Pro- or antibiotic treatment during the past three months, non-steroidal anti-inflammatory drugs (NSAIDs) or cholestyramine during the past month, drugs interfering with intestinal permeability (e.g., prokinetics, laxatives, lubiprostone, loperamide, anti-spasmodics, linaclotide, proton pump inhibitors) during the past month. Vaccinations within one month prior to or during the study intervention.\n* Blood donations within three months or plasma donation within one month prior to or during the study intervention.\n* Inflammatory bowel disease (Crohn or colitis ulcerosa) or celiac disease.\n* Diagnosed irritable bowel syndrome.\n* Intake of any performance-enhancing medication or nutritional supplements known to modulate the gut microbiome in the two months prior to or during the study.\n* Substance abuse, including alcohol consumption of more than three units\u002Fday (weekly average).\n* Any injury or pathology considered a contraindication for performing physical exercise, as determined by the medical doctor overseeing the preparticipation medical screening.\n* No access to smartphone and\u002For computer with internet access.\n* No willingness to use the Polar Flow app and MijnEetmeter to collect physical activity, heart rate, sleep, and food intake data.\n* Concomitant participation in another interventional trial, without approval from the research team.\n* Any other reasons considered by the research team that the participant will not complete the study.",true,"MALE","18 Years","45 Years",{"count":22,"type":23},45,"ESTIMATED","INTERVENTIONAL",[26],"NA","The goal of this study is to learn how different amounts of supervised indoor cycling training change gut health (gut bacteria, the substances gut bacteria make, and the gut barrier integrity), and how these changes relate to changes in fitness, muscle health, and signs of doing too much training (a state called 'overreaching'). The study includes healthy, recreationally active men aged 18 to 45 years.\n\nThe primary questions, for which the study is powered (sufficient participants included), are:\n\n1. Does moderate load training change blood and faecal levels of butyrate (a short-chain fatty acid made by gut bacteria) after eight weeks compared with a control group?\n2. Compared to moderate load training, do higher training loads lead to different responses in blood and faecal levels of butyrate?\n\nResearchers will compare:\n\n* A control group that does not complete structured training;\n* A moderate-load training group that completes eight weeks of supervised cycling (4x\u002Fweek);\n* A high-load training group that completes four weeks of moderate-load training followed by four weeks of higher training load (twice the number of training sessions).\n\nParticipants will:\n\n* Be randomly assigned to one of the three groups;\n* Complete 8 weeks of supervised indoor cycling sessions if assigned to a training group;\n* Complete four study assessment periods (baseline, after week four, after week eight, and after a short taper (rest period);\n* Provide blood, stool, skeletal muscle, urine, saliva, and breath samples during the assessment periods;\n* Complete fitness and performance tests and questionnaires during the assessment periods.",[29,30,31,32,33,34,35,36,37,38,39,40,41,42,43],"Exercise","Overreaching","Butyrate","Gut Microbiome","Exercise Performance","Skeletal Muscle","Glucose Tolerance","Hormones","Vascular Health","Muscle Adaptation","Physical Fitness","Heart Rate Variability (HRV)","Anthropometric Measurements","Metabolic Health","Food Intake",[45,46,47,48,49,50,51,52,30,53,54,55,40,56,57,58],"Exercise training","Training load","Overload training","Fecal butyrate","Gut health","Exercise performance","Muscle phenotype","Physical fitness","Glucometabolic health","Vascular health","Muscle adaptation","Anthropometrics","Metabolic health","Food intake","RECRUITING","2026-03-16",{"date":62,"type":63},"2026-03-19","ACTUAL",{"date":65,"type":63},"2024-10-07",{"date":67,"type":23},"2027-05-31",{"name":69,"class":70},"Stefan De Smet","OTHER",1,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":17,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":24,"phases":84,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":71},"100623524","sodium-rich-condiments-unifying-health-and-taste-100623524","NCT07397754","Sodium-rich COndiments Unifying Health and Taste","Scout","Inclusion Criteria:\n\n1. ≥ 50, \\\u003C 75 years old\n2. Male or postmenopausal female (self-reported)\n3. ≥ 50 kg body weight\n4. Systolic blood pressure (≥ 130, \\\u003C 160 mmHg) or diastolic blood pressure (≥ 85, \\\u003C 100 mmHg)\n5. Willing and able to follow intervention protocol\n6. Ability to identify basic tastes (determined by taste discrimination test)\n7. English speaking\n\nExclusion Criteria:\n\n1. Prescribed and taking medication which may affect study outcomes (i.e. for blood pressure management, blood thinning etc.) in consultation with study physician (Prof Melvin Leow) and PI(Dr Darel Toh)\n2. Type 1 or type 2 diabetes mellitus (i.e. fasting blood glucose ≥ 7.0 mmol\u002FL or HbA1c ≥ 6.5 %)\n3. Taking dietary supplements which may affect study outcomes one month prior to their first visit in consultation with study physician, PI and study team\n4. Obesity (BMI ≥ 27.5 kg\u002Fm2)\n5. History or known present diagnosis of hematological (G6PD and coagulation disorders), hepatic (hepatitis B and C), renal, gastrointestional or other relevant disease \u002F disorders which may affect the outcomes of interest in consultation with study physician, PI and study team\n6. History of arteriovenous shunt or mastectomy\n7. Women who are pregnant, lactating or planning pregnancy\n8. History or present diagnosis of HIV and\u002For tuberculosis\n9. History of severe vasovagal syncope (blackouts or near faints) following blood draw\n10. Drug abuse within last 5 years\n11. Excessive alcoholic beverage consumption \\> 2 servings per day (1 serving defined as 360 mL beer, 150 mL wine or 45 mL distilled spirits)\n12. Smoking (cigarette, e-cigarette, cigar, pipe, vape)\n13. Engaging in habitual vigorous physical activity (as defined by physical activity questionnaire-PAR)\n14. Allergic or intolerance to intervention foods.\n15. Dislike or unwilling to consume intervention foods\n16. Photophobic (sensitivity to intense lights and colours), particularly to intense red lights\n17. Has sinus problems problems that affect taste and smell\n18. Involvement in other clinical studies that may influence the outcome of the study\n19. An ASTAR Staff.\n20. A study team member or their immediate family member","ALL","50 Years","75 Years",{"count":83,"type":23},32,[26],"This research aims to develop an evidence-based classification for sodium-rich condiments (natremic index) based on their CVD-related risks. It is hypothesised that the acute cardiovascular and physiological response (effectively extrapolated to long-term CVD risks) to meals prepared with various sodium-rich condiments can be leveraged upon for the development of such an index that will systematically classify sodium-rich condiments based on the risk they present to cardiovascular health.",[87,37,88],"Elevated Blood Pressure","Sensory Evaluation",[90,91,92,93,94,95,96,97],"sodium intake","natremic index","elevated blood pressure","cardiometabolic outcomes","condiments","Asian","vascular health","sensory evaluation","2026-02-05",{"date":100,"type":63},"2026-02-09",{"date":102,"type":63},"2025-09-22",{"date":104,"type":23},"2026-09-22",{"name":106,"class":107},"Singapore Institute of Food and Biotechnology Innovation","OTHER_GOV",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":17,"sex":79,"minAge":115,"maxAge":116,"enrollmentInfo":117,"targetDuration":4,"studyType":24,"phases":119,"briefSummary":121,"conditions":122,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":71},"100573344","phase-2-arterial-destiffening-effects-of-sglt2-inhibition-in-veterans-with-obesity-100573344","NCT06745063","Arterial Destiffening Effects of SGLT2 Inhibition in Veterans With Obesity","EMPA","Inclusion Criteria:\n\n* Body mass index (BMI) 30-45 kg\u002Fm2\n* 30-60 years of age at randomization\n* Evidence of arterial stiffening (defined as Carotid femoral PWV\\>age-predicted) at screening visit (PMID: 20530030)\n\nExclusion Criteria:\n\n* Unable to provide consent\n* Diabetes mellitus\n* Uncontrolled hypertension (\\>180\u002F90mmHg) or systolic \\\u003C100mmHg at screening visit\n* Known history of cardiovascular disease: heart failure, ischemic heart disease, peripheral artery disease or stroke\n* Diagnosis of chronic kidney disease\n* Active cancer (excluding basal cell carcinoma or stage 1 squamous cell carcinoma of the skin)\n* Excessive alcohol consumption (\\>14 drinks\u002Fweek for men, \\>7 drinks\u002Fweek for women)\n* Use of GLP-1 analogs or SGLT2 inhibitors\n* Use of hormone replacement therapy\n* Use of pharmacological therapy for weight loss\n* Body weight changes \\>10% within the past 6 months\n* History of hypersensitivity to nitrates\n* History of ketoacidosis\n* History of recurrent UTIs or mycotic genital infections\n* Use of anticoagulants\n* Change in anti-hypertensive medication regimen (if in use) during the last 90 days\n* Pregnancy","30 Years","60 Years",{"count":118,"type":23},50,[120],"PHASE2","The study will assign participants to take either the medication, empagliflozin or a placebo for 12 weeks. The goal of the study is to determine the effects of empagliflozin on arterial health in Veterans with obesity.",[123,37],"Obesity","2025-11-13",{"date":126,"type":63},"2025-11-14",{"date":128,"type":63},"2025-05-30",{"date":130,"type":23},"2029-12-31",{"name":132,"class":133},"VA Office of Research and Development","FED",{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":140,"eligibilityCriteria":141,"healthyVolunteers":17,"sex":79,"minAge":19,"maxAge":80,"enrollmentInfo":142,"targetDuration":4,"studyType":24,"phases":144,"briefSummary":145,"conditions":146,"keywords":150,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":71},"100557212","the-influence-of-sleep-on-cardiovascular-outcomes-100557212","NCT06535178","The Influence of Sleep on Cardiovascular Outcomes","Determining the Influence of Sleep on Cardiovascular Outcomes","DISCO","Inclusion Criteria:\n\n* Ostensibly healthy men and women Subgroup study (chronic pain)\n* Satisfies diagnostic criteria for fibromyalgia according to the Widespread Pain Index - Symptom Severity (WPI-SS) scale with the following three conditions being met:\n\n  1. Widespread pain index (WPI) ≥7 and symptom severity (SS) scale score ≥5 or WPI 3-6 and SS scale score ≥9.\n  2. Symptoms have been present at a similar level for at least 3 months.\n  3. The patient does not have a disorder that would otherwise explain the pain.\n\nExclusion Criteria:\n\n* No history of drug or alcohol dependency.\n* Must be current non-smokers, and are required to have a history of less than 5 pack years of smoking.\n* No history of working irregular day and night hours, regular night work, or rotating shift work for the 1 year prior to the study. In addition to this, individuals must not have traveled across more than 1 time zone during the 3 months prior to the study.\n* Chronobiologic and sleep disorders.\n* Diseases of the cardiovascular system.\n* Hypertension. Individuals will be allowed to be normotensive (resting systolic blood pressure of \\\u003C140\u002F90 mmHg, measured on more than one occasion) or uncomplicated stage 1 hypertension (systolic BP between 140 and 159 mmHg or a diastolic BP between 90 and 99 mmHg).\n* Disorders of the respiratory system.\n* Pre-diabetes\u002FDiabetes. For participants who have self-reported pre-diabetes\u002Fdiabetes.\n* Disorders of the kidney and urinary tract.\n* Infectious diseases.\n* Disorders of the gastrointestinal system.\n* Disorders of the immune system.\n* Disorders of the hematopoietic system.\n* Neoplastic diseases.\n* Endocrine and metabolic diseases.\n* Neurologic disorders.\n* Must not be participating in another research study that would influence their safe participation in the study.",{"count":143,"type":23},30,[26],"The goal of this study is to identify the effects of sleep regularity on cardiovascular regulatory mechanisms. The investigators are hoping to discover if improving the regularity of sleep timing will improve metabolic and vascular health markers. The protocol is a 12-week prospective cohort study that includes both field and in-laboratory data collection in ostensibly healthy male and female adults, aged 18-40years. We will also have a sub-group of individuals with chronic pain to examine the effects of sleep regularity on pain outcomes.",[147,148,37,149],"Circadian Rhythm","Cardiometabolic Health","Pain",[147,148,37,149],"2025-11-05",{"date":153,"type":63},"2025-11-10",{"date":155,"type":63},"2024-07-01",{"date":157,"type":23},"2026-09-30",{"name":159,"class":70},"Oregon Health and Science University",{"id":161,"slug":162,"hasResults":11,"nctId":163,"briefTitle":164,"officialTitle":165,"acronym":166,"eligibilityCriteria":167,"healthyVolunteers":17,"sex":79,"minAge":19,"maxAge":4,"enrollmentInfo":168,"targetDuration":4,"studyType":24,"phases":170,"briefSummary":171,"conditions":172,"keywords":175,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":71},"100586254","heterogeneity-of-vascular-adaptations-to-exercise-with-aging-in-women-and-men-100586254","NCT06912984","Heterogeneity of Vascular Adaptations to Exercise With Aging in Women and Men","Exerkines and the Heterogeneity of Peripheral and Cerebral Vascular Adaptations to Exercise Training With Aging in Women and Men","ELEVATE","Inclusion Criteria:\n\n* Ability to provide consent;\n* Man or woman \\>= 18 years;\n* Willing to be randomized to an exercise or control intervention;\n* No orthopedic limitations that would prevent the volunteer from performing treadmill or cycling exercise;\n* No use of hormone therapy in postmenopausal women or in men (note, hormonal contraceptives in premenopausal women will be allowed);\n* Healthy, as determined by medical history, physical examination, standard blood chemistries and ECG at rest and during a physician monitored graded exercise treadmill test;\n* Sedentary or recreationally active (\\\u003C2 days\u002Fwk vigorous activity);\n* No use of medications that might influence cardiovascular function (e.g., blood pressure and lipid lowering medications, metformin, insulin, sulfonylureas, etc.);\n* No use of vitamins, supplements or anti-inflammatory medications, or willing to stop 1 month prior to enrollment and for the duration of the study;\n\nExclusion Criteria:\n\n* Contraindications to aerobic exercise;\n* Diabetic or fasted glucose \\>126 mg\u002FdL;\n* Resting blood pressure \\>= 140\u002F90 mmHg;\n* Current or past history of cancer other than skin cancer;\n* Preexisting or active cardiac, renal or hepatic disease;\n* History of stomach ulcer or bleeding or epilepsy or nervous system and\u002For seizure disorder;\n* Active or chronic infection;\n* An abnormal resting ECG, angina and\u002For ECG evidence of acute myocardial ischemia during the exercise test (development of ST-segment depression of more than 0.3 mV that is either horizontal, downsloping, or slowly upsloping- less than 1 mvolt\u002Fsec and lasts more than 0.08 sec; ST elevation; chest pain or discomfort), bundle branch block, AV block greater than first degree, arrhythmias;\n* Thyroid dysfunction, defined as ultrasensitive TSH \\\u003C0.5 or \\>5 mU\u002FL. Participants with abnormal TSH values will be reconsidered for participation after follow-up with their PCP and initiation of thyroid replacement medications for at least 3 months;\n* Smoking or tobacco use;\n* Alcohol consumption \\> 14 drinks\u002Fweek;\n* Body mass index \\> 39kg\u002Fm2;",{"count":169,"type":23},242,[26],"The goal of the proposed study is to understand the reasons for the variability in aerobic exercise (AE) training benefits on the vasculature in middle-age and older (MA\u002FO) adults, including differences between men and women. To achieve this goal, a mechanistic randomized controlled (RCT) will be conducted, in which adults are randomized to 12-weeks intervention of AE or no-exercise Control. Our overall hypothesis is that the exercise response variation in vascular benefits is related to age and sex differences in the biological changes underlying vascular aging and\u002For the molecular transducers (i.e., circulating molecules) that communicate and coordinate the effects of AE on the vasculature in the periphery and brain. Because this is a mechanistic trial, the overall goal is not a single health-related outcome. Rather, the goal is to advance our understanding of the molecular signals and pathways underlying the systemic and local effects of AE on vascular health that may explain the variability in AE responses with age and sex. This knowledge will allow for the development of personalized age- and sex-specific AE recommendations, and\u002For provide insights into molecular targets that can be manipulated to enhance and\u002For mimic exercise in non-responders or in persons unable to exercise.",[173,174,37],"Aging","Physical Activity",[176,37,45],"Healthy","2025-06-04",{"date":179,"type":63},"2025-06-05",{"date":181,"type":63},"2025-05-28",{"date":183,"type":23},"2029-07-31",{"name":185,"class":70},"University of Colorado, Denver"]