[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"vascular-stiffness\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:vascular-stiffness":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,50,80,113,139,178,206,228,255,278,303],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100638605","low-energy-availability-and-hypertension-in-division-i-hbcu-athletes-100638605",false,"NCT07583940","Low Energy Availability and Hypertension in Division I HBCU Athletes","Cardiovascular Outcomes and Relative Energy Deficiency in Division I HBCU Athletes: CORE-DI Study","CORE-DI","Inclusion Criteria:\n\nAge: 18-25yrs Sex: Male and Female Training Status\u002FExperience: HBCU Division I collegiate athletes with \\>3yrs of previous competitive experience\n\nExclusion Criteria:\n\n* Persons who self-report any known disease, or unknown issue precluding collegiate competitive participation: Excluded\n* Those who have any orthopedic injuries, concussions, or conditions which would preclude safe testing: Excluded\n* Individuals who are not yet adults \\\u003C18yrs (e.g.: infants, children, teenagers):\n\nExcluded\n\n* Persons who have a pacemaker: Excluded\n* Persons who are pregnant: Excluded",true,"ALL","18 Years","26 Years",{"count":22,"type":23},150,"ESTIMATED","OBSERVATIONAL","Low energy availability (LEA) occurs when the body does not get enough calories to support both daily life and exercise. This can happen when athletes train hard but do not eat enough to match their energy needs. In both 2012 and 2023, the International Olympic Committee on Sports Nutrition recognized LEA as an important factor that can increase the risk of cardiometabolic disease (CMD), which includes conditions like high blood pressure, diabetes, and heart disease. LEA can affect many systems in the body. It may disrupt hormones (such as menstrual cycles), cause changes in blood sugar and cholesterol levels, weaken bones, impair digestion, and negatively impact mental health. Over time, these changes may be linked to chronic inflammation, which plays a key role in the development of disease. Maintaining proper energy balance can be especially challenging for athletes because they often train at levels well above general health recommendations. As a result, even highly fit athletes may unintentionally remain in a calorie deficit. Our recent pilot research found a significant relationship between LEA and high blood pressure in Black Division I collegiate athletes. This is important because this group has historically been understudied and may face a higher risk of serious heart-related events, including sudden cardiac death. Despite assumptions that collegiate athletes are uniformly healthy, there is a need to better understand hidden health risks in this population. Our research aims to improve how we identify and monitor early signs of cardiometabolic disease by examining markers such as inflammation, blood sugar, and cholesterol levels. These insights will help healthcare providers, athletes, and families make more informed decisions about nutrition, training, and long-term health. Ultimately, this work seeks to develop practical, evidence-based strategies to protect athlete health and reduce the risk of serious cardiovascular outcomes.",[27,28,29],"Vascular Stiffness","Hypertension (HTN)","Nutritional Deficiency Related Cardiovascular Risk in Athletes",[31,32,33,34,35,36],"vascular stiffness,","hypertension","nutritional deficiency","energy balance","RED-S","SDOH","RECRUITING","2026-05-06",{"date":40,"type":41},"2026-05-13","ACTUAL",{"date":43,"type":41},"2026-01-06",{"date":45,"type":23},"2028-06-30",{"name":47,"class":48},"North Carolina Agriculture & Technical State University","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":18,"minAge":58,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":68,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":79},"100554178","arterial-stiffness-and-blood-pressure-100554178","NCT06495710","Arterial Stiffness and Blood Pressure","Load-Dependent Arterial Stiffness to Optimize Blood Pressure Management in Older Veterans (LOADED BP)","LOADED-BP","Inclusion Criteria:\n\n* Male and female participants from VA VISN 7, 9, and 12 will be eligible to participate if they are over age 60 years and have a diagnosis of hypertension or take antihypertensive medications (up to 4).\n* Veterans will require documented SBP readings on 2 or more office visits that are 140 mmHg or average home blood pressure readings 135 mmHg to be eligible for the trial.\n* Participants must be willing to be randomized to intensive or standard blood pressure treatment and have blood pressure medications adjusted per the study protocol.\n* They must be willing to undergo tonometric evaluation of arterial stiffness, and carotid artery ultrasound.\n\nExclusion Criteria:\n\n* Participants who have an indication for a specific BP lowering medication that is not included in the study protocol or a known secondary cause of hypertension will be excluded.\n* Patients will be excluded if they have:\n\n  * a standing SBP \\\u003C110 mmHg\n  * past history of a recent CVD event in the past 12 months (i.e., coronary artery disease event\u002Fintervention, congestive heart failure exacerbation or heart failure hospitalization, atrial fibrillation, or peripheral arterial disease intervention)\n  * a class I indication for betablocker use including atrial arrhythmias\n  * left-ventricular systolic function \\\u003C50%, \\>moderate aortic stenosis\n  * history of stroke\n  * chronic kidney disease (eGFR\\\u003C30 mL\u002Fmin\u002Fm2) or proteinuria in excess of 1 gram\u002Fday or polycystic kidney disease\n  * active cancer (other than untreated, non-metastatic prostate cancer and non-melanoma skin cancer)\n  * hypoxemic pulmonary disease\n  * active rheumatologic or connective tissue diseases (i.e., systemic lupus erythematosus, rheumatoid arthritis, etc.)\n  * human immunodeficiency virus\n  * illness with any infectious etiology or fever \\>38°C (i.e., upper respiratory illness, gastrointestinal illness, etc.)\n  * hospitalization for any reason within the prior 4 weeks\n* Participants will be excluded if arm circumference is too large\u002Fsmall to allow accurate blood pressure recordings\n* The investigators will also exclude those with factors that may limit adherence to the study interventions or follow-up including active substance abuse, plans to move outside the study catchment areas within 12 months or a history of poor medication adherence or clinic no-shows","60 Years",{"count":60,"type":23},228,"INTERVENTIONAL",[63],"NA","Hypertension is a common and treatable disorder that remains the leading preventable cause of heart disease. Blood pressure treatment relies mainly on upper arm blood pressure readings and ignores blood vessel physiology and underlying individual genetic information. Older Veterans with hypertension are less likely to be treated to goal blood pressure because there are conflicting recommendations for what constitutes \"optimal\" in older adults. The investigators have developed a novel way to non-invasively assess the components of blood vessel stiffness that is related to blood pressure (load-dependent stiffness). This project will generate new knowledge about how different blood pressure treatment goals (intensive vs standard) impact different components of arterial stiffness and if these differences can be explained through genetic analysis. Results from this project will offer the VA an updated blueprint for personalizing blood pressure care in older adults, ultimately improving cardiovascular health.",[66,27,67],"Hypertension","Aging",[32,27,67],"2026-04-06",{"date":71,"type":41},"2026-04-13",{"date":73,"type":41},"2025-05-01",{"date":75,"type":23},"2028-12-31",{"name":77,"class":78},"VA Office of Research and Development","FED",3,{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":17,"sex":87,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":61,"phases":92,"briefSummary":93,"conditions":94,"keywords":98,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":4},"100623994","effects-of-acute-sleep-deprivation-on-health-100623994","NCT07403864","Effects of Acute Sleep Deprivation on Health","Effects of Acute Partial Sleep Deprivation on Metabolic Health and Cognitive Function","Inclusion Criteria:\n\n* Age between 20-45 years.\n* Body Mass Index (BMI) between 18.5-27 kg\u002Fm².\n* No sleep-related medical conditions and good sleep quality, defined as a Pittsburgh Sleep Quality Index (PSQI) score ≤ 5.\n* Usual bedtime between 22:00-01:00, wake-up time between 06:00-09:00, with an average sleep duration of 7 to 9 hours; chronotype classified as \"definitely not evening type\" (score ≥ 42 on the Morningness-Eveningness Questionnaire), and no changes in sleep patterns over the past 3 months.\n* Without any metabolic or cardiovascular diseases, and not using medications that could affect metabolic responses.\n* No specific dietary habits, such as intermittent fasting or a ketogenic diet.\n* Maintaining a stable weight (no self-reported weight change ± 3 kg) for at least 3 months.\n* Resting blood pressure ≤ 130\u002F80 mmHg.\n* No smoking or excessive alcohol consumption.\n* Not a shift worker.\n* No international travel across time zones has occurred within the past 3 months.\n\nExclusion Criteria:\n\n* Special diets (e.g., intermittent fasting, ketogenic diet)\n* Recent injuries or contraindications to intense exercise.","MALE","20 Years","45 Years",{"count":91,"type":23},48,[63],"This study will investigate whether various types of regular exercise can provide protective effects against metabolic abnormalities induced by sleep restriction. It will examine responses related to metabolic health, cognitive function, energy expenditure, subjective feelings, and human behaviors, including physical activity and energy intake.",[95,96,27,97],"Glucose Intolerance","Energy Expenditure","Cognition",[99,100,101,102],"Partial sleep deprivation","Sleep loss","Physical inactivity","Exercise habits","NOT_YET_RECRUITING","2026-02-04",{"date":106,"type":41},"2026-02-11",{"date":108,"type":23},"2026-03-01",{"date":110,"type":23},"2027-03-01",{"name":112,"class":48},"National Taiwan Normal University",{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":4,"eligibilityCriteria":119,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":120,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":122,"conditions":123,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":49},"100415252","diabetic-neuropathy-in-spinal-cord-stimulator-patients-100415252","NCT04687215","Diabetic Neuropathy in Spinal Cord Stimulator Patients","Spinal Cord Stimulation Improves Pain, Arterial Stiffness and Vascular Flow in Lower Extremities in Patients With Diabetes Mellitus Type II A Multidisciplinary Collaborative Prospective Study","Inclusion Criteria:\n\n1. Patients with DM type 2 of more than 1-year duration\n2. DM stage 3 or less\n3. Patients ≥18 years of age\n4. Refractory painful diabetic peripheral neuropathy of the lower extremities\n5. ABI index \\\u003C0.9\n\nExclusion Criteria:\n\n1. Patients on anticoagulants\n2. Patients with active infections\n3. Patients with HbA1\\>10\n4. Psychiatric disorders and cognitive dysfunctions\n5. Illicit Drug Usage\n6. Patients on dialysis\n7. BMI\\>35.0\n8. Surgery within the last 30 days\n9. Ulcer of the lower extremities\n10. Calcification of the peripheral arteries",{"count":121,"type":23},25,"The objective of this study is to assess the effect Spinal Cord Stimulators have toward improving vascular changes of diabetes mellitus in patients eligible for SCS placement based on their condition of painful diabetic neuropathy; we will evaluate improving their disability and quality of life, improving micro-circulatory changes induced by Diabetes Mellitus (DM), improving macro-circulatory changes induced by DM and improving arterial stiffness of the vessels of the lower extremity.",[124,125,126,127,27,128,129],"Diabetes Mellitus","Neuropathy","Neuropathic Pain","Vascular Diseases","Microvascular Changes","Pain, Chronic","2026-02-03",{"date":132,"type":41},"2026-02-05",{"date":134,"type":41},"2022-01-27",{"date":136,"type":23},"2026-12-01",{"name":138,"class":48},"University of Chicago",{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":4,"eligibilityCriteria":145,"healthyVolunteers":17,"sex":18,"minAge":146,"maxAge":147,"enrollmentInfo":148,"targetDuration":4,"studyType":61,"phases":150,"briefSummary":151,"conditions":152,"keywords":159,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":49},"100548358","nightware-and-cardiovascular-health-in-veterans-with-ptsd-100548358","NCT06419959","NightWare and Cardiovascular Health in Veterans With PTSD","Improving Cardiovascular Health in Veterans With PTSD by Treating Trauma-Related Nightmares With NightWare","Inclusion Criteria:\n\n1. Diagnosis of PTSD via American Psychiatric Association PTSD diagnostic criteria in the fifth edition of its Diagnostic and Statistical Manual of Mental Disorders (DSM-5).\n2. Self-report having repetitive nightmares contributing to disrupted sleep;\n3. Age 22 years (rationale is because the device has only been used in adults in 22 years and older);\n4. Resting blood pressure (BP, \\\u003C160\u002F100 mmHg);\n5. Fasted glucose \\\u003C126 mg\u002FdL;\n6. Poor overall sleep quality as indicated by a Pittsburgh Sleep Quality Index (PSQI) score 6 or higher;\n7. Epworth Sleepiness Scale (ESS): Question #8 score above \"0\" will prompt an additional question: Do you drive (\"get behind the wheel\") when you are drowsy? The answer must be \"No\" to be enrolled in the study due to safety concerns;\n8. Wireless Internet and two power outlets in sleeping location;\n9. Willingness not to use any other application which collects heart rate data on the phone and watch that is used for NightWare;\n\nExclusion Criteria:\n\n1. Unstable medical condition (e.g., uncontrolled hypertension or active CVD or cancer);\n2. Active infection (note, anyone with an active infection would become eligible once the infection has ended);\n3. Thyroid dysfunction, defined as an ultrasensitive TSH \\\u003C0.5 or \\>5.0 mU\u002FL; volunteers with abnormal TSH values will be re-considered for participation in the study after follow-up evaluation by the PCP with initiation or adjustment of thyroid hormone replacement; or other problems that would interfere with participation in the study;\n4. Use of insulin or sulfonylureas\n5. Pregnancy or currently breast feeding;\n6. Current history (past 3 months) of substance (excluding marijuana) or alcohol abuse per the SCID-5. Adults with past substance or alcohol use disorders will be allowed to participate;\n7. Participants will be excluded if they report elevated acute risk for suicidal self-directed violence warranting immediate hospitalization (e.g., suicidal ideation with intent, evaluated by the Columbia-Suicide Severity Rating Scale \\[C-SSRS\\]).\n8. Shift workers (due to circadian rhythm disruption);\n9. Diagnosis of active disorder of arousal from non-rapid eye movement sleep, rapid eye movement sleep behavior disorder, or narcolepsy;\n10. Nocturia that causes awakening from sleep;\n11. Known sleep walking or acting out dreams (contraindication to NW use);\n12. Diagnosis or suspicion of dementia;\n13. Seizure disorder\n14. Participants experiencing severe cognitive impairment or current psychiatric symptoms of such severity that would preclude participation (e.g., active psychosis, imminently suicidal)","22 Years","88 Years",{"count":149,"type":23},125,[63],"The purpose of this study is to learn more about the effectiveness of a prescription wrist-wearable device called NightWare (NW) on improving sleep in Veterans with nightmares related to posttraumatic stress disorder (PTSD). The investigators also want to learn whether it improves cardiovascular health among this population.",[153,154,155,27,156,157,158],"Post-traumatic Stress Disorder (PTSD)","Cardiovascular Diseases","Autonomic Dysfunction","Nightmare","Endothelial Dysfunction","Veteran",[160,161,162,163,158,164,165,166,167,168,154,169],"Sleep","Oxidative stress","aging, inflammation","sex\u002Fgender","Trauma and Stressor Related Disorders","Mental Disorders","Nervous System Diseases","Autonomic Nervous System Diseases","Primary Dysautonomias","Stress Disorders, Post-Traumatic","2025-09-11",{"date":172,"type":41},"2025-09-12",{"date":174,"type":41},"2025-09-10",{"date":176,"type":23},"2026-12-31",{"name":77,"class":78},{"id":179,"slug":180,"hasResults":11,"nctId":181,"briefTitle":182,"officialTitle":183,"acronym":4,"eligibilityCriteria":184,"healthyVolunteers":17,"sex":185,"minAge":146,"maxAge":186,"enrollmentInfo":187,"targetDuration":4,"studyType":61,"phases":189,"briefSummary":190,"conditions":191,"keywords":195,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":203,"locationsCount":205},"100594558","nightware-and-cardiovascular-health-in-women-with-ptsd-100594558","NCT07021014","NightWare and Cardiovascular Health in Women With PTSD","Improving Cardiovascular Health in Women With PTSD by Treating Trauma-Related Nightmares With NightWare","Inclusion Criteria:\n\n* Healthy, as determined by medical history\n* Group Specific Eligibility\n* PTSD Group\n* Lifetime PTSD: screened using Primary Care PTSD Screen for DSM-5 (PC-PTSD-5) and confirmed via Clinician Administered PTSD Scale for DSM-5 (CAPS-5)\n* Prior trauma exposure: screened using Brief Trauma Questionnaire (BTQ)\n* Self-report having repetitive nightmares contributing to disrupted sleep\n* Poor overall sleep quality: PSQI score 6 or higher\n* Control Group\n* No lifetime PTSD: screened using PC-PTSD-5\n* No prior trauma exposure: screened using BTQ\n* Do not self-report having repetitive nightmares contributing to disturbed sleep\n\nExclusion Criteria:\n\n* Pre-existing (e.g., diabetes, liver, kidney disease) or unstable medical condition (e.g., uncontrolled hypertension or active CVD or cancer) or systemic illness that would interfere with interpretation of the study outcomes\n* Body Mass Index ≥ 40 kg\u002Fm2\n* Use of medications that might influence cardiovascular or renal function (i.e., antihypertensive, lipid lowering medications, GLP-1\u002FGIP RAs)\n* Active infection (note, anyone with an active infection would become eligible once the infection has ended)\n* Abnormal thyroid, liver, or kidney function testing during the screening examination or bloodwork. Abnormal kidney function defined as creatinine \\>1.3mg\u002FdL. Abnormal liver function tests within 1.5x ULN. UCH Clinical Lab ULN for AST and ALT are 39 and 52, respectively. Women with TSH levels outside of the normal range (0.5-5.0 mLU\u002FL) will be referred to their PCP and will be allowed study entry once their TSH levels are normalized \\> 3 months\n* Plasma glucose \\>126 mg\u002Fdl under fasting conditions\n* Use of insulin or sulfonylureas\n* Pregnant, within 12 months postpartum or currently breast feeding\n* Current history of substance (excluding marijuana) or alcohol abuse per the SCID-5. Adults with past substance or alcohol use disorders will be allowed to participate.\n* Report elevated acute risk for suicidal self-directed violence warranting immediate hospitalization (e.g., suicidal ideation with intent, evaluated by the C-SSRS).\n* Shift workers\n* Diagnosis of active disorder of arousal from non-rapid eye movement sleep, rapid eye movement sleep behavior disorder, or narcolepsy\n* Nocturia that causes awakening from sleep\n* Epworth Sleepiness Scale: Question #8 score above \"0\" will prompt an additional question: Do you drive (\"get behind the wheel\") when you are drowsy? The answer must be \"No\" to be enrolled in the study due to safety concerns\n* Known sleep walking or acting out dreams (contraindication to NightWare use)\n* Diagnosis or suspicion of dementia\n* Participants experiencing severe cognitive impairment or current psychiatric symptoms of such severity that would preclude participation (e.g., active psychosis, imminently suicidal)\n* Current use of vitamin\u002Fsupplements (including melatonin) or anti-inflammatory medications, participants will be included if they are willing to stop taking vitamin\u002Fsupplements or anti-inflammatory medications 2 weeks prior to the first vascular visit.\n* Current or planned participation in an interventional study during the present study\n* Participants must have access to wireless internet and two power outlets where they sleep","FEMALE","40 Years",{"count":188,"type":23},36,[63],"The purpose of this study is to determine whether NightWare therapeutic intervention improves biomarkers of vascular and renal function in premenopausal women with PTSD-related nightmares, and examine whether these improvements restore them to levels observed in age-matched women without PTSD.",[192,154,155,27,156,157,193,194,164],"Post Traumatic Stress Disorder","Kidney Diseases","Renal Dysfunction",[160,164,192,154,193,194,155],"2025-06-05",{"date":198,"type":41},"2025-06-13",{"date":200,"type":23},"2025-07",{"date":202,"type":23},"2028-07",{"name":204,"class":48},"University of Colorado, Denver",2,{"id":207,"slug":208,"hasResults":11,"nctId":209,"briefTitle":210,"officialTitle":211,"acronym":4,"eligibilityCriteria":212,"healthyVolunteers":11,"sex":87,"minAge":213,"maxAge":214,"enrollmentInfo":215,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":217,"conditions":218,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":221,"startDateStruct":223,"completionDateStruct":225,"leadSponsor":227,"locationsCount":49},"100399528","puberty-suppression-and-cardiometabolic-health-100399528","NCT04482374","Puberty Suppression and Cardiometabolic Health","Effects of Puberty and Pubertal Suppression on Insulin Sensitivity, Metabolic Rate and Vascular Health","Inclusion Criteria:\n\n* Identify as a transgender female or cisgender male\n* Age 9-14 years at the time of enrollment\n* Tanner Stage 2-3 baseline pubertal development\n* Plan to start gonadotropin releasing hormone analogue clinically in \\\u003C 2 months (for transgender females only)\n\nExclusion Criteria:\n\n* Cognitive, psychiatric, or physical impairment resulting in inability to tolerate the study procedures\n* Type 1 or 2 diabetes (by medical history)\n* On any medications that affect insulin sensitivity (e.g. metformin, antipsychotics)\n* Hypertension (resting BP ≥ 140\u002F90 mm\u002FHg)\n* Weight \\> 400 lbs\n* On estrogen- or progesterone-containing medications at baseline\n* \\>3 hours of moderate-to-vigorous physical activity on the 3DPAR at the screening visit","9 Years","14 Years",{"count":216,"type":23},30,"This observational study will evaluate the effect of puberty suppression on insulin sensitivity, metabolic rate and vascular health among transgender female youth at baseline and 6 months after initiation of a gondoatropin releasing hormone agonist compared to matched cisgender male controls.",[219,220,157,27],"Transgenderism","Insulin Sensitivity\u002FResistance",{"date":222,"type":41},"2025-06-10",{"date":224,"type":41},"2020-08-10",{"date":226,"type":23},"2026-07-31",{"name":204,"class":48},{"id":229,"slug":230,"hasResults":11,"nctId":231,"briefTitle":232,"officialTitle":233,"acronym":234,"eligibilityCriteria":235,"healthyVolunteers":11,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":236,"targetDuration":4,"studyType":61,"phases":238,"briefSummary":239,"conditions":240,"keywords":242,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":246,"lastUpdatePostDateStruct":247,"startDateStruct":249,"completionDateStruct":251,"leadSponsor":253,"locationsCount":49},"100481762","micro-doses-of-physical-activity-for-copd-100481762","NCT05553223","Micro-doses of Physical Activity for COPD","Can Micro-doses of Physical Activity Offset the Negative Cardiovascular Consequences of Being Sedentary in Patients With COPD?","COPD","Inclusion Criteria:\n\nNon-smoking (\\>6 months) patients with stable moderate-to-severe COPD (post bronchodilator forced expired volume in 1 sec\u002Fforced vital capacity\\\u003C0.7 and \\\u003Clower limit of normal, 30%\\\u003CForced Expired Volume in 1 sec\\\u003C80% predicted and exacerbation free for \\>6 weeks) will be recruited for the study.\n\nExclusion Criteria:\n\n1. performing structured exercise training (or pulmonary rehabilitation)\n2. have a history of deep vein thrombosis\n3. are on anticoagulant medication\n4. have advanced cardiac or cerebrovascular disease (i.e. heart failure, previous stroke or myocardial infarction)\n5. have diabetes\n6. have musculoskeletal contraindications that limit their ability to perform physical activity\n7. vascular ultrasound measurements cannot be obtained.",{"count":237,"type":23},20,[63],"Chronic obstructive pulmonary disease (COPD) is a disease of the lungs that makes it hard for people to breath. Those with COPD spend considerably more time sitting and lying and less time performing physical activity than healthy individuals. Those who are the most sedentary have a greater risk of heart and blood vessel disease, which may lead to an early death. This project will investigate the effect of sitting still for 3 hours on blood vessel health in individuals with COPD. It will also investigate whether breaking up the amount of time patients sit with regular short bouts of walking (5 minutes each hour) at a comfortable pace chosen by the patient can have a positive effect on maintaining the health of their blood vessels. It is hypothesized that blood vessel health will be worse after 3 hours of sitting compared to when the sitting is broken up by short bouts of walking.",[241,157,27,66,154],"Chronic Obstructive Pulmonary Disease",[243,244,245],"Microdoses of Physical Activity","Flow Mediated Dilation","Reactive Hyperemia","2025-04-02",{"date":248,"type":41},"2025-04-04",{"date":250,"type":41},"2022-10-12",{"date":252,"type":23},"2026-09-01",{"name":254,"class":48},"University of British Columbia",{"id":256,"slug":257,"hasResults":11,"nctId":258,"briefTitle":259,"officialTitle":260,"acronym":261,"eligibilityCriteria":262,"healthyVolunteers":11,"sex":18,"minAge":186,"maxAge":4,"enrollmentInfo":263,"targetDuration":4,"studyType":61,"phases":265,"briefSummary":266,"conditions":267,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":270,"lastUpdatePostDateStruct":271,"startDateStruct":273,"completionDateStruct":275,"leadSponsor":276,"locationsCount":49},"100469071","sodium-lowering-vascular-effects-trial-100469071","NCT05388032","Sodium Lowering Vascular Effects Trial","A Mechanistic Trial of Dietary Sodium Reduction on Vascular Structure and Function","SOLVE","Inclusion Criteria:\n\n* Men or women aged ≥40 years. Individuals \\\u003C40 years are at a low risk for clinical and subclinical CVD\n* Elevated BP or hypertension (systolic BP ≥120 mmHg and diastolic BP ≥80 mmHg with or without use of antihypertensive medications)\n\nExclusion Criteria:\n\n* Glomerular filtration rate (eGFR) \\\u003C30 or end-stage renal disease (kidney transplant or chronic dialysis)\n* History of cardiovascular disease\n* Shift worker or regularly work at night\n* Cancer requiring chemotherapy or radiation treatment in the previous two years\n* Current pregnancy or breastfeeding or plans to become pregnant during the study\n* Consumption of ≥21 alcoholic drinks\u002Fweek\n* Current participation in another lifestyle intervention or drug trial\n* Current residence or planned residence that makes it difficult to meet trial requirements\n* Other concerns regarding ability to meet trial requirements (at the discretion of the study coordinator)",{"count":264,"type":23},256,[63],"The proposed mechanistic trial will test the effect of dietary sodium reduction on cardiac and vascular structure and function in those with elevated blood pressure or hypertension. Findings from this study will fill the knowledge gap on the underlying mechanisms of dietary sodium intake on cardiovascular disease risk in addition to blood pressure and could provide further evidence on sodium reduction for the prevention of cardiovascular disease.",[157,27,268,269],"Left Ventricular Hypertrophy","Left Ventricular Dysfunction","2024-11-20",{"date":272,"type":41},"2024-11-22",{"date":274,"type":41},"2023-01-25",{"date":176,"type":23},{"name":277,"class":48},"Tulane University",{"id":279,"slug":280,"hasResults":11,"nctId":281,"briefTitle":282,"officialTitle":283,"acronym":284,"eligibilityCriteria":285,"healthyVolunteers":17,"sex":185,"minAge":89,"maxAge":286,"enrollmentInfo":287,"targetDuration":4,"studyType":61,"phases":289,"briefSummary":290,"conditions":291,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":294,"lastUpdatePostDateStruct":295,"startDateStruct":297,"completionDateStruct":299,"leadSponsor":301,"locationsCount":49},"100337385","inspiratory-muscle-training-x-cardiobreath-app-effects-on-vagal-modulation-and-pulse-wave-velocity-100337385","NCT03672760","Inspiratory Muscle Training X CardioBreath App Effects On Vagal Modulation And Pulse Wave Velocity","Inspiratory Muscle Training X CardioBreath App Effects On Vagal Modulation And Pulse Wave Velocity On Normotensive Postmenopause Women : Randomized Clinical Trial","CardioBreath","Inclusion Criteria:\n\n* Follicle Stimulating Hormone (FSH)\\>35mui\u002Fml\n* minimum 12 months amenorrhea\n* sedentary life style (less than 150 minutes per week of exercise)\n\nExclusion Criteria:\n\n* Hypertension\n* Diabetes\n* Obesity\n* Use of Betablockers\n* recent cardiovascular events or surgery\n* renal alterations\n* respiratory and\u002For motor pathologies\n* smoking\n* BMI\\>29,9","65 Years",{"count":288,"type":23},24,[63],"Existing data points to relevant beneficial effects of respiratory exercises on cardiovascular health, with special regards to decreases on arterial pressure and improves on autonomic and vascular profiles, though mechanistics of such results have not yet been cleared. Among the available ways to perform respiratory exercises, there is the highly recommended Inspiratory Muscle Training (IMT) and slow breathing exercises like Yoga pranayamas. Lately, the development of new technologies has allowed the use of Apps to perform respiratory exercises. This study will be take the just developed CardioBreath®App to validate it as a tool to perform respiratory exercises. Therefore, it will be compared to IMT on cardiac vagal modulation and pulse wave velocity on normotensive post menopause women.",[292,293,27],"Postmenopausal Disorder","Autonomic Imbalance","2024-06-20",{"date":296,"type":41},"2024-06-21",{"date":298,"type":41},"2023-09-01",{"date":300,"type":23},"2025-07-30",{"name":302,"class":48},"Instituto de Cardiologia do Rio Grande do Sul",{"id":304,"slug":305,"hasResults":11,"nctId":306,"briefTitle":307,"officialTitle":308,"acronym":309,"eligibilityCriteria":310,"healthyVolunteers":11,"sex":185,"minAge":311,"maxAge":4,"enrollmentInfo":312,"targetDuration":314,"studyType":24,"phases":4,"briefSummary":315,"conditions":316,"keywords":319,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":346,"lastUpdatePostDateStruct":347,"startDateStruct":349,"completionDateStruct":351,"leadSponsor":353,"locationsCount":49},"100357753","womens-advanced-risk-assessment-in-manitoba-100357753","NCT03938155","Women's Advanced Risk-assessment in Manitoba","Women's Advanced Risk-assessment in Manitoba (WARM) Hearts - Examining Cardiovascular Disease Risk in Middle Aged and Older Women","WARM","Inclusion Criteria:\n\n* women aged 55 and older\n* possess a Manitoba Personal Health Information Number\n\nExclusion Criteria:\n\nPrevious hospitalization or treatment for:\n\n* Ischemic heart disease\n* Acute myocardial infarction\n* Stroke\u002FTransient ischemic attack\n* Percutaneous coronary intervention\n* Coronary artery bypass surgery\n* Congestive heart failure\n* Peripheral artery disease\n* Congenital heart defects\n* Arrhythmia\n\nAdditional exclusion:\n\n* Medical advice against physical activity\n* Previous participant in the Assessment of Large and Small Artery Elasticity for the Early Detection of Cardiovascular Disease (NCT02863211)","55 Years",{"count":313,"type":23},1000,"5 Years","The main objective of this study is to test the ability of novel cardiovascular disease (CVD) prognostic tools to identify women at risk for future CVD. We plan to establish a cardiovascular health screening program at the St. Boniface Hospital and to test the efficacy of these tests for predicting adverse cardiovascular outcomes amongst a cohort of 1000 Manitoban women aged 55 years and older in the 5-year period after screening.\n\nA second purpose of this project is to identify novel CVD biomarkers that may indicate a person is at risk for cardiovascular disease. Therefore, we plan to ask participants for permission to collect and store a sample of both their blood and stool for future research.",[317,318,27],"Cardiovascular Disease (CVD)","Cardiovascular Risk Factor",[320,321,322,323,324,325,326,327,328,329,330,331,332,333,334,335,336,337,338,339,340,341,342,343,344,345],"female","humans","aged","cardiovascular system","cardiovascular diseases","cardiovascular diseases\u002Fepidemiology","early diagnosis","frailty","frailty elderly","prospective studies","Manitoba\u002Fepidemiology","gastrointestinal microbiome","cohort studies","cause of death","risk assessment","biomarkers","risk factors","pulse wave analysis","accelerometry","exercise","physical fitness","gender","sex","women","early detection","screening program","2021-01-25",{"date":348,"type":41},"2021-01-28",{"date":350,"type":41},"2019-10-01",{"date":352,"type":23},"2026-10",{"name":354,"class":48},"St. Boniface Hospital"]