[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"vascular\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:vascular":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100645202","ai-technologies-for-enhanced-and-celerated-high-field-wb-mri-100645202",false,"NCT07678320","AI Technologies for Enhanced and Celerated High-Field WB-MRI","AITECH-MRI","Inclusion Criteria:\n\n* Consecutive adults (≥18 y.o.) admitted to the UO for W MRI for screening procedure.\n* Consecutive adult male patients (≥18 y.o.) admitted to the UO for WB-MRI for screening procedure and focus on prostate.\n\nExclusion Criteria:\n\n* refused to consent\n* claustrophobia\n* metal prosthesis potentially affecting image quality",true,"ALL","18 Years",{"count":20,"type":21},600,"ESTIMATED","OBSERVATIONAL","Single-center, cross-sectional observational study assessing the feasibility of advanced accelerated MRI sequences versus standard ones in terms of image quality, diagnostic reliability, and acquisition time.",[25,26,27,28,29],"Whole Body Imaging","Prostate","MRI","Lung","Vascular",[27,31,32,33,29],"Whole Body","Accelerated Imaging","Prostate Imaging","NOT_YET_RECRUITING","2026-06-25",{"date":37,"type":38},"2026-07-01","ACTUAL",{"date":37,"type":21},{"date":41,"type":21},"2029-05-01",{"name":43,"class":44},"IRCCS San Raffaele","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":16,"sex":17,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":73},"100609294","the-role-of-estrogen-and-testosterone-in-determining-brain-blood-flow-and-metabolic-regulation-in-humans-100609294","NCT07212712","The Role of Estrogen and Testosterone in Determining Brain Blood Flow and Metabolic Regulation in Humans","Inclusion Criteria:\n\nThe investigators will recruit healthy young (18-40 years) males (n = 25) and females (n = 25). Females must be naturally cycling (i.e., no oral or hormonal contraceptives), not pregnant, and premenopausal. Participants must be normotensive (\\\u003C140\u002F90 mmHg \\& \\>90\u002F60 mmHg) and have no medical history of cerebrovascular, cardiopulmonary, cardiovascular, neuromuscular, and renal disease assessed by a study questionnaire. A recent physical examination (within 1 year of participation) from a family physician or a completed physical examination by the study doctor is required prior to participation. All subjects will sign an informed consent form prior to participation.\n\nParticipants will be excluded if they meet any of the following criteria:\n\n* Hypertensive (≥140\u002F90 mmHg) or hypotensive (≤90\u002F60 mmHg)\n* BMI ≥ 30 kg\u002Fm2\n* Fasting blood glucose ≥ 100 mg\u002FdL\n* Abnormal results on standard blood hematology tests (e.g., complete blood count, comprehensive metabolic panel)\n* Males with hypogonadism (total testosterone ≤ 262 ng\u002FdL, per Endocrine Society recommendations)\n* Any history of cerebrovascular, cardiopulmonary, cardiovascular, neuromuscular, or renal disease\n* Any liver dysfunction or disease\n* Taking any cardiovascular medications or medications that would interfere with study medications (e.g., strong organic anion transporting polypeptide 1B1 inhibitors)\n* Contraindications or sensitivities to study medications\n* Current eating disorder (defined as \\>2 on the 'SCOFF' questionnaire 67)\n* Current smokers\n* Females with an irregular menstrual cycle or any medical conditions affecting the menstrual cycle (normal cycle defined as 21-35 days from menstrual cycle diary)\n* Females who are pregnant (assessed with pregnancy test at screening and prior to starting medications), breastfeeding, or planning to conceive within 3 months\n* Females using hormonal birth control (Copper intrauterine devices \\[IUDs\\] will be allowed as they do not change systemic hormone levels)\n* Females who are peri- or postmenopausal (as determined by STRAW criteria 68)\n* History of hormone-sensitive cancers (i.e., breast, ovarian, uterine or prostate)\n* Z-score \\\u003C -2 as assessed with DXA scan (to determine risk of decrease in bone mineral density)\n* Assessed using the Center for Epidemiologic Studies Depression (CES-D) scale, participants with a score \\> 16 at screening unless otherwise approved by the study MD","18 Weeks","40 Weeks",{"count":54,"type":21},50,"INTERVENTIONAL",[57],"NA","Due to historical exclusion of females from research, there are gaps in the understanding of female physiology, how it differs from males, and how sex-specific hormones contribute. As a result, many diagnoses and treatments are based on male physiology and may not be appropriate or effective for females. Females consistently experience greater risk and report worse neurological outcomes in many diseases, including stroke, cardiac arrest, and dementia. As research in females progresses, differences between sexes and changes throughout the lifespan (e.g., puberty, menopause) highlight the importance of understanding the effects of sex and sex-specific hormones on the body. The brain is arguably the most important organ in the body, consuming 20% of the body's total energy. Previous research supports higher blood flow to the brain in females, and research in animals suggests hormones such as estrogen, progesterone, and testosterone are responsible. However, it is extremely difficult to isolate these hormones in humans, due to natural fluctuations (i.e., menstrual cycle). Therefore, the investigators plan to explore the direct role of these sex-specific hormones in regulating blood flow to the brain by blocking hormone production in healthy males and females and giving back testosterone and estrogen, respectively. The investigators will then conduct a range of tests to look at blood flow to the brain at rest and during various stressors. This research will provide crucial insight into how males and females differ in regulation of brain blood flow and inform new treatments and therapies to a wide range of brain injuries and diseases, improving outcomes and reducing the sex disparity in clinical pathways.",[60,61,62,63,29],"Cerebral Blood Flow","Cerebral Blood Flow Regulation","Sex Differences","Exercise","2026-02-06",{"date":66,"type":38},"2026-02-10",{"date":68,"type":21},"2026-04-01",{"date":70,"type":21},"2027-12-31",{"name":72,"class":44},"University of British Columbia",1]