[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"vasomotor-symptoms-vms\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:vasomotor-symptoms-vms":37},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,60],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":46,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":59},"100589690","phase-2-proof-of-concept-trial-to-assess-the-efficacy-and-safety-of-fezolinetant-in-improving-vasomotor-symptoms-in-men-with-prostate-cancer-undergoing-androgen-deprivation-therapy-100589690",false,"NCT06957691","Proof-of-Concept Trial to Assess the Efficacy and Safety of Fezolinetant in Improving Vasomotor Symptoms in Men With Prostate Cancer Undergoing Androgen Deprivation Therapy","Proof-of-Concept Trial to Assess the Efficacy and Safety of Fezolinetant in Improving Vasomotor Symptoms in Men With Prostate Cancer Undergoing Androgen Deprivation Therapy (Fezo-ADT Trial)","Fezo-ADT","Inclusion Criteria:\n\n* Male sex\n* Age 40 years and older\n* Diagnosis of prostate cancer\n* Androgen deprivation therapy\n* Presence of 5 or more moderate-to-severe hot flashes per day or 35 or more moderate-to-severe hot flashes per week\n* Ability to sign the inform consent\n* Willing to use reliable methods of contraception if partner is of childbearing age\n* Ability to record hot flashes electronically\n\nExclusion Criteria:\n\n* Use of abiraterone acetate\n* Use of docetaxel and other chemotherapeutic agents\n* Liver cirrhosis\n* Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) above the upper limit of normal\n* Total bilirubin above the upper limit of normal\n* Glomerular filtration rate \\\u003C 30 mL\u002Fmin\n* Use of selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, tricyclic antidepressants, sedatives, or hypnotics\n* Use of over-the-counter hormonal agents or herbal compounds\n* Current use of CYP1A2 inhibitors\n* Ingestion of alcohol within 2 weeks prior to the baseline visit\n* Inability to abstain from alcohol use during the study period.","MALE","40 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","The goal of this clinical trial is to learn if fezolinetant can treat hot flashes (vasomotor symptoms) in men with prostate cancer undergoing androgen deprivation therapy.\n\nThe main questions it aims to answer are:\n\n* Does fezolinetant improve the frequency and severity of hot flashes?\n* Does fezolinetant cause any harm to the liver?\n* Does fezolinetant improve quality of life, sleep quality, fatigue, mood, sexual function, and metabolic parameters?\n\nResearchers will compare how people respond to fezolinetant versus a placebo, which does not contain any active medicine.\n\nParticipants will:\n\n* Take fezolinetant or a placebo every day for 4 weeks\n* Visit the clinic once every 2 weeks for checkups and tests\n* Keep a diary of the number of times and intensity that they experience hot flashes",[27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45],"Prostate Cancer","Prostate Cancer (Adenocarcinoma)","Prostate Cancer Metastatic Disease","Prostate Cancer Recurrent","Prostate Carcinoma","Prostate Neoplasm","Prostate Adenocarcinoma","Prostate Cancer With Bone Metastasis","Vasomotor Disturbance","Vasomotor Symptoms","Vasomotor Symptoms (VMS)","Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men","Vasomotor Symptoms; Hot Flashes","Androgen Deprivation Therapy","Androgen Ablative Therapy of Advanced Hormone-dependent Prostate Carcinoma","Androgen-deprivation Therapy","Hot Flashes","Hot Flushes","Hot Flushes and\u002For Sweats",[40,43,44,27,36],"RECRUITING","2026-03-05",{"date":50,"type":51},"2026-03-09","ACTUAL",{"date":53,"type":51},"2026-01-14",{"date":55,"type":21},"2028-12-31",{"name":57,"class":58},"Shehzad Basaria, M.D.","OTHER",1,{"id":61,"slug":62,"hasResults":11,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":18,"maxAge":70,"enrollmentInfo":71,"targetDuration":4,"studyType":22,"phases":73,"briefSummary":75,"conditions":76,"keywords":80,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":59},"100591106","impact-of-lean-pork-on-endothelial-function-in-perimenopause-100591106","NCT06976112","Impact of Lean Pork on Endothelial Function in Perimenopause","Effects of Lean Pork Intake on Endothelial Function and Vasomotor Symptoms in Perimenopausal Women","LEAP","Inclusion Criteria:\n\n* Are female\n* Are between 40 and 55 years of age\n* Have a BMI (a number calculated from participant height and weight) between 28 and45 kg\u002Fm2\n* Are experiencing irregular menstrual cycles but have not gone longer than 12 consecutive months without a period\n* Are experiencing severe vasomotor (menopause) symptoms\n* Are doing less than 3 hours per week of structured exercise\n* Have systolic blood pressure between 120 and 140 mmHg and\u002For diastolic blood pressure between 80 and 90 mmHg\n* Have \"sugary\" hemoglobin called hemoglobin A1c less than or equal to 6.5%\n* Are willing and able to refrain from using oral mouth wash for the duration of the study because the alcohol in mouth wash inhibits nitrate synthesis\n* Are willing and able to comply with both the study diets\n* Are willing to collect blood for future research\n* Can read, speak, and understand English\n\nExclusion Criteria:\n\n* Hysterectomy (partial or full) or oophorectomy\n* Using hormone replacement therapy use and\u002For hormonal contraception use 6 months prior to study start\n* Has systolic blood pressure ≥140 mmHg and\u002For diastolic blood pressure ≥ 90 mmHg)\n* Triglycerides ≥350 mg\u002FdL, low-density lipoprotein cholesterol (LDL-C) ≥190 mg\u002FdL, and\u002For taking a lipid-lowering medication -Diagnosed cardiovascular disease, diabetes (type 1 or 2), or endocrine- related disease (e.g. thyroid, PCOS), unstable gastrointestinal disease, kidney, liver, and\u002For pancreatic disease\n* Diagnosed cancer (except skin cancer) in the last 5 years\n* Taking \\>1 blood pressure medication and\u002For taking 1 blood pressure medication for \\\u003C3 months\n* Taking phosphodiesterase-5 inhibitors, anti-coagulants, corticosteroids, metformin, or insulin.\n* Weight change ≥6.6 pounds in the past 3 months, actively trying to lose weight, or unwilling to remain weight stable throughout the study\n* Current smoking or vaping, Binge and\u002For heavy drinker\n* Food allergies or other reasons preventing consumption of study foods with both study diets",true,"FEMALE","55 Years",{"count":72,"type":21},30,[74],"NA","The goal of this study is to examine the impact of a diet high in fresh lean pork, compared to a plant-based diet, on cardiovascular function and vasomotor symptoms in perimenopausal women with overweight and obesity. The main questions it aims to answer are:\n\n1. How does a diet high in pork, compared to a plant-based diet, affects blood lipids, endothelial function, and blood pressure?\n2. How does a diet high in pork, compared to a plant-based diet, affects blood nitrate, cardiometabolic biomarkers, inflammatory biomarkers, and vasomotor symptoms?\n\nResearchers will compare the diet high in pork to a plant-based diet to see if pork helps improve cardiovascular and mesopause symptoms.\n\nParticipants will:\n\n* Consume both of the diets, each for 4 weeks, with a washout period between 2 and 6 weeks in between the diets trials\n* Visit the clinic 5 times with weekly meal pick ups during the diet trials\n* Undergo testing procedures including: weight and body composition, blood pressure and pulse, endothelial function using ultrasound of upper arm, microvascular blood flow, blood draws, physical activity measurements, and questionnaires.",[77,78,79,37],"Cardiovascular Outcome","Overweight and Obese Women","Perimenopausal Women",[81,82,36,83,84,85,86,87,88],"Perimenopause","Perimenopausal","VMS","Menopause","Cardiovascular Health","Blood pressure","Pork","Vegetarian","2025-11-26",{"date":91,"type":51},"2025-11-28",{"date":93,"type":51},"2025-08-01",{"date":95,"type":21},"2027-05",{"name":97,"class":58},"Pennington Biomedical Research Center"]